Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
The class F scavenger receptor 1 (SCARF1/SREC-I) contains epidermal growth factor (EGF)-like repeats in its extracellular domain, followed by a long C-terminal cytoplasmic tail composed of serine and proline-rich regions. SCARF1 is an endocytic receptor for acetylated low density lipoprotein, HSP70, HSP90, calreticulin, gp96, and GP2 [, , , , ]. Dendritic cells (DCs),macrophages and endothelial cells use SCARF1 to recognize and engulf apoptotic cells via the complement component C1q; this mediates apoptotic cells clearance, antigen clearance and prevents autoimmunity []. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Ramirez-Ortiz ZG |
Year: |
2013 |
Journal: |
Nat Immunol |
Title: |
The scavenger receptor SCARF1 mediates the clearance of apoptotic cells and prevents autoimmunity. |
Volume: |
14 |
Issue: |
9 |
Pages: |
917-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Murshid A |
Year: |
2010 |
Journal: |
J Immunol |
Title: |
Heat shock protein 90 mediates efficient antigen cross presentation through the scavenger receptor expressed by endothelial cells-I. |
Volume: |
185 |
Issue: |
5 |
Pages: |
2903-17 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tamura Y |
Year: |
2004 |
Journal: |
J Biol Chem |
Title: |
Scavenger receptor expressed by endothelial cells I (SREC-I) mediates the uptake of acetylated low density lipoproteins by macrophages stimulated with lipopolysaccharide. |
Volume: |
279 |
Issue: |
30 |
Pages: |
30938-44 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
474
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Means TK |
Year: |
2009 |
Journal: |
J Exp Med |
Title: |
Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36. |
Volume: |
206 |
Issue: |
3 |
Pages: |
637-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hölzl MA |
Year: |
2011 |
Journal: |
Cell Immunol |
Title: |
The zymogen granule protein 2 (GP2) binds to scavenger receptor expressed on endothelial cells I (SREC-I). |
Volume: |
267 |
Issue: |
2 |
Pages: |
88-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Berwin B |
Year: |
2004 |
Journal: |
J Biol Chem |
Title: |
SREC-I, a type F scavenger receptor, is an endocytic receptor for calreticulin. |
Volume: |
279 |
Issue: |
49 |
Pages: |
51250-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Murshid A |
Year: |
2014 |
Journal: |
Immunobiology |
Title: |
Hsp90-peptide complexes stimulate antigen presentation through the class II pathway after binding scavenger receptor SREC-I. |
Volume: |
219 |
Issue: |
12 |
Pages: |
924-31 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
820
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
478
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Ishii J |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
SREC-II, a new member of the scavenger receptor type F family, trans-interacts with SREC-I through its extracellular domain. |
Volume: |
277 |
Issue: |
42 |
Pages: |
39696-702 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3513329 |
Assay Type: |
Western blot |
Annotation Date: |
2005-01-07 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:3513338 |
Age: |
postnatal adult |
Image: |
5 |
|
Specimen Label: |
Brain |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3513329 |
Assay Type: |
Western blot |
Annotation Date: |
2005-01-07 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689426 |
|
Stage: |
TS26 |
Assay Id: |
MGI:3513338 |
Age: |
embryonic day 18.0 |
Image: |
5 |
|
Specimen Label: |
Brain |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3513329 |
Assay Type: |
Western blot |
Annotation Date: |
2005-01-07 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757728 |
|
Stage: |
TS28 |
Assay Id: |
MGI:3513338 |
Age: |
postnatal adult |
Image: |
5 |
|
Specimen Label: |
Spinal cord |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3513329 |
Assay Type: |
Western blot |
Annotation Date: |
2005-01-07 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757726 |
|
Stage: |
TS26 |
Assay Id: |
MGI:3513338 |
Age: |
embryonic day 18.0 |
Image: |
5 |
|
Specimen Label: |
Spinal cord |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3513329 |
Assay Type: |
Western blot |
Annotation Date: |
2005-01-07 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1666828 |
|
Stage: |
TS28 |
Assay Id: |
MGI:3513338 |
Age: |
postnatal adult |
Image: |
5 |
|
Specimen Label: |
DRG |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3513329 |
Assay Type: |
Western blot |
Annotation Date: |
2005-01-07 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1666826 |
|
Stage: |
TS26 |
Assay Id: |
MGI:3513338 |
Age: |
embryonic day 18.0 |
Image: |
5 |
|
Specimen Label: |
DRG |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6780101 |
Assay Type: |
RT-PCR |
Annotation Date: |
2021-10-19 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360464 |
|
Stage: |
TS04 |
Assay Id: |
MGI:6780122 |
Age: |
embryonic day 3.5 |
Image: |
6 |
|
Specimen Label: |
Bl |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6780101 |
Assay Type: |
RT-PCR |
Annotation Date: |
2021-10-19 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:2576528 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6780122 |
Age: |
postnatal adult |
Image: |
6 |
|
Specimen Label: |
PC |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shibata M |
Year: |
2004 |
Journal: |
J Biol Chem |
Title: |
Type F scavenger receptor SREC-I interacts with advillin, a member of the gelsolin/villin family, and induces neurite-like outgrowth. |
Volume: |
279 |
Issue: |
38 |
Pages: |
40084-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ishii J |
Year: |
2007 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Scavenger receptor expressed by endothelial cells (SREC)-I interacts with protein phosphatase 1alpha in L cells to induce neurite-like outgrowth. |
Volume: |
360 |
Issue: |
1 |
Pages: |
269-74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hasegawa H |
Year: |
2007 |
Journal: |
J Neurosci |
Title: |
Analyzing somatosensory axon projections with the sensory neuron-specific Advillin gene. |
Volume: |
27 |
Issue: |
52 |
Pages: |
14404-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pisko J |
Year: |
2021 |
Journal: |
Sci Rep |
Title: |
Apoptotic cells in mouse blastocysts are eliminated by neighbouring blastomeres. |
Volume: |
11 |
Issue: |
1 |
Pages: |
9228 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
Data Curation Using Mouse Genome Assembly |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2016 |
|
Title: |
Automatic assignment of GO terms using logical inference, based on on inter-ontology links |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Lennon G |
Year: |
1999 |
Journal: |
Database Download |
Title: |
WashU-HHMI Mouse EST Project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Helmholtz Zentrum Muenchen GmbH |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
|
Title: |
Cyagen Biosciences Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
The class F scavenger receptors (SCARFs or SRECs) have two isoforms, SCARF1/SREC-I and SCARF2/SREC-II. Similar to SREC-I, SREC-II contains multiple epidermal growth factor-like repeats in its extracellular domain. However, in contrast to SREC-I, SREC-II had little activity to internalize modified low density lipoproteins (LDL). SREC-II and SREC-I display strong heterophilic trans-interaction through the extracellular domains []. They are expressed in a specific temporal and spatial pattern during epidermal development [].Mutations in the SCARF2 gene cause Van den Ende-Gupta syndrome (VDEGS), a syndrome characterised by craniofacial and skeletal abnormalities []. The class F scavenger receptor 1 (SCARF1/SREC-I) contains epidermal growth factor (EGF)-like repeats in its extracellular domain, followed by a long C-terminal cytoplasmic tail composed of serine and proline-rich regions. SCARF1 is an endocytic receptor for acetylated low density lipoprotein, HSP70, HSP90, calreticulin, gp96, and GP2 [, , , , ]. Dendritic cells (DCs), macrophages and endothelial cells use SCARF1 to recognize and engulf apoptotic cells via the complement component C1q; this mediates apoptotic cells clearance, antigen clearance and prevents autoimmunity []. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
141
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Hwang M |
Year: |
2005 |
Journal: |
Gene Expr Patterns |
Title: |
The temporal and spatial expression of the novel Ca++-binding proteins, Scarf and Scarf2, during development and epidermal differentiation. |
Volume: |
5 |
Issue: |
6 |
Pages: |
801-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Anastasio N |
Year: |
2010 |
Journal: |
Am J Hum Genet |
Title: |
Mutations in SCARF2 are responsible for Van Den Ende-Gupta syndrome. |
Volume: |
87 |
Issue: |
4 |
Pages: |
553-9 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
833
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
566
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
833
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
|
•
•
•
•
•
|