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Search results 1 to 69 out of 69 for Scgb1c1

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: macaque, rhesus
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Reynolds SD
Year: 2002
Journal: Am J Respir Crit Care Med
Title: Secretoglobins SCGB3A1 and SCGB3A2 define secretory cell subsets in mouse and human airways.
Volume: 166
Issue: 11
Pages: 1498-509
Publication      
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Function or Process or Component Unknown following Literature Review
Publication      
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Protein Domain
Type: Family
Description: Secretoglobins are relatively small, secreted, disulphide-bridged dimeric proteins with encoding genes sharing substantial sequence similarity [, ]. Secretoglobin have a four-helical structure, and in the case of uteroglobin, form homodimers, whereas allergen Fel d 1 forms a tetramer of two heterodimers (chains 1 and 2). The conservation of this primary and quaternary structure indicates that the genome of the eutherian common ancestor of cats, rodents, and primates contained a similar gene pair.Uteroglobin (blastokinin or Clara cell protein CC10) is a mammalian steroid-inducible secreted protein originally isolated from the uterus of rabbits during early pregnancy []. The mucosal epithelia of several organs that communicate with the external environment express uteroglobin. Its tissue-specific expression is regulated by steroid hormones, and is augmented in the uterus by non-steroidal prolactin. Uteroglobin may be a multi-functional protein with anti-inflammatory/immunomodulatory properties, acting to inhibit phospholipase A2 activity [, ], and binding to (and possibly sequestering) several hydrophobic ligands such as progesterone, retinols, polychlorinated biphenyls, phospholipids and prostaglandins [, ]. In addition, uteroglobin has anti-chemotactic, anti-allergic, anti-tumourigenic and embryo growth-stimulatory properties. Uteroglobin may have a homeostatic role against oxidative damage, inflammation, autoimmunity and cancer [, , , ]. However, the true biological function of uteroglobin is poorly understood. Uteroglobin consists of a disulphide-linked homodimer with a large hydrophobic pocket located between the two dimers []. Each monomer being composed of four helices that do not form a canonical four helix-bundle motif but rather a boomerang-shaped structure in which helices H1, H3, and H4 are able to bind a homodimeric partner []. The hydrophobic pocket binds steroids, particularly progesterone, with high specificity. It is a member of the secretoglobin superfamily.This entry represents the uteroglobin and secretoglobin family 1C (SCGB1C). SCGB1C1 has been shown to be localised to Bowman's glands in the olfactory mucosa []. It is thought to act as an odorant-binding protein, with ligands appearing to be small, hydrophobic molecules [].
Publication
First Author: Dear TN
Year: 1991
Journal: EMBO J
Title: Novel genes for potential ligand-binding proteins in subregions of the olfactory mucosa.
Volume: 10
Issue: 10
Pages: 2813-9
Publication
First Author: Jackson BC
Year: 2011
Journal: Hum Genomics
Title: Update of the human secretoglobin (SCGB) gene superfamily and an example of 'evolutionary bloom' of androgen-binding protein genes within the mouse Scgb gene superfamily.
Volume: 5
Issue: 6
Pages: 691-702
Publication
First Author: Miele L
Year: 1994
Journal: J Endocrinol Invest
Title: Uteroglobin and uteroglobin-like proteins: the uteroglobin family of proteins.
Volume: 17
Issue: 8
Pages: 679-92
Publication  
First Author: Klug J
Year: 2000
Journal: Ann N Y Acad Sci
Title: Uteroglobin/Clara cell 10-kDa family of proteins: nomenclature committee report.
Volume: 923
Pages: 348-54
Protein
Organism: Mus musculus/domesticus
Length: 95  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 96  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 95  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 96  
Fragment?: false
Publication
First Author: Dunkel R
Year: 1995
Journal: Protein Eng
Title: Progesterone binding to uteroglobin: two alternative orientations of the ligand.
Volume: 8
Issue: 1
Pages: 71-9
Publication
First Author: Morize I
Year: 1987
Journal: J Mol Biol
Title: Refinement of the C222(1) crystal form of oxidized uteroglobin at 1.34 A resolution.
Volume: 194
Issue: 4
Pages: 725-39
Publication
First Author: Mukherjee AB
Year: 2007
Journal: Endocr Rev
Title: Uteroglobin: a steroid-inducible immunomodulatory protein that founded the Secretoglobin superfamily.
Volume: 28
Issue: 7
Pages: 707-25
Publication
First Author: Li C
Year: 2007
Journal: Peptides
Title: Interaction of antiflammin-1 with uteroglobin-binding protein induces phosphorylation of ERK1/2 in NIH 3T3 cells.
Volume: 28
Issue: 11
Pages: 2137-45
Publication  
First Author: Kundu GC
Year: 2000
Journal: Ann N Y Acad Sci
Title: Uteroglobin binding proteins: regulation of cellular motility and invasion in normal and cancer cells.
Volume: 923
Pages: 234-48
Publication  
First Author: Callebaut I
Year: 2000
Journal: Ann N Y Acad Sci
Title: The uteroglobin fold.
Volume: 923
Pages: 90-112
Publication
First Author: Singh G
Year: 1990
Journal: Biochim Biophys Acta
Title: Clara cell 10 kDa protein (CC10): comparison of structure and function to uteroglobin.
Volume: 1039
Issue: 3
Pages: 348-55
Publication
First Author: Miele L
Year: 1987
Journal: Endocr Rev
Title: Uteroglobin: structure, molecular biology, and new perspectives on its function as a phospholipase A2 inhibitor.
Volume: 8
Issue: 4
Pages: 474-90
Publication  
First Author: Beier HM
Year: 2000
Journal: Ann N Y Acad Sci
Title: The discovery of uteroglobin and its significance for reproductive biology and endocrinology.
Volume: 923
Pages: 9-24
Publication  
First Author: Chowdhury B
Year: 2000
Journal: Ann N Y Acad Sci
Title: Amino acid residues in alpha-helix-3 of human uteroglobin are critical for its phospholipase A2 inhibitory activity.
Volume: 923
Pages: 307-11
Publication  
First Author: Pattabiraman N
Year: 2000
Journal: Ann N Y Acad Sci
Title: Crystal structure analysis of recombinant human uteroglobin and molecular modeling of ligand binding.
Volume: 923
Pages: 113-27