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Search results 1 to 100 out of 217 for Scn1a

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0.047s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication  
First Author: Dutton SBB
Year: 2017
Journal: Exp Neurol
Title: Early-life febrile seizures worsen adult phenotypes in Scn1a mutants.
Volume: 293
Pages: 159-171
Publication
First Author: Ohno Y
Year: 2011
Journal: Neurobiol Dis
Title: Scn1a missense mutation causes limbic hyperexcitability and vulnerability to experimental febrile seizures.
Volume: 41
Issue: 2
Pages: 261-9
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Martin MS
Year: 2010
Journal: J Biol Chem
Title: Altered function of the SCN1A voltage-gated sodium channel leads to gamma-aminobutyric acid-ergic (GABAergic) interneuron abnormalities.
Volume: 285
Issue: 13
Pages: 9823-34
Publication
First Author: Sawyer NT
Year: 2016
Journal: Genes Brain Behav
Title: Scn1a dysfunction alters behavior but not the effect of stress on seizure response.
Volume: 15
Issue: 3
Pages: 335-47
Publication
First Author: Ricobaraza A
Year: 2019
Journal: Sci Rep
Title: Epilepsy and neuropsychiatric comorbidities in mice carrying a recurrent Dravet syndrome SCN1A missense mutation.
Volume: 9
Issue: 1
Pages: 14172
Publication  
First Author: Yamagata T
Year: 2020
Journal: Neurobiol Dis
Title: CRISPR/dCas9-based Scn1a gene activation in inhibitory neurons ameliorates epileptic and behavioral phenotypes of Dravet syndrome model mice.
Volume: 141
Pages: 104954
Publication  
First Author: Tatsukawa T
Year: 2018
Journal: Neurobiol Dis
Title: Impairments in social novelty recognition and spatial memory in mice with conditional deletion of Scn1a in parvalbumin-expressing cells.
Volume: 112
Pages: 24-34
Publication
First Author: Chen YH
Year: 2017
Journal: Biochim Biophys Acta
Title: MDH2 is an RNA binding protein involved in downregulation of sodium channel Scn1a expression under seizure condition.
Volume: 1863
Issue: 6
Pages: 1492-1499
Publication  
First Author: Makinson CD
Year: 2016
Journal: Exp Neurol
Title: An Scn1a epilepsy mutation in Scn8a alters seizure susceptibility and behavior.
Volume: 275 Pt 1
Pages: 46-58
Publication
First Author: Yuan Y
Year: 2019
Journal: Sci Rep
Title: Delayed maturation of GABAergic signaling in the Scn1a and Scn1b mouse models of Dravet Syndrome.
Volume: 9
Issue: 1
Pages: 6210
Publication  
First Author: Tsai MS
Year: 2015
Journal: Neurobiol Dis
Title: Functional and structural deficits of the dentate gyrus network coincide with emerging spontaneous seizures in an Scn1a mutant Dravet Syndrome model during development.
Volume: 77
Pages: 35-48
Publication
First Author: Ogiwara I
Year: 2007
Journal: J Neurosci
Title: Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.
Volume: 27
Issue: 22
Pages: 5903-14
Publication
First Author: Kang SK
Year: 2019
Journal: Epilepsia Open
Title: C57BL/6J and C57BL/6N substrains differentially influence phenotype severity in the Scn1a +/- mouse model of Dravet syndrome.
Volume: 4
Issue: 1
Pages: 164-169
Publication  
First Author: Teran FA
Year: 2019
Journal: Front Neurol
Title: Time of Day and a Ketogenic Diet Influence Susceptibility to SUDEP in Scn1a R1407X/+ Mice.
Volume: 10
Pages: 278
Publication
First Author: Tang B
Year: 2009
Journal: Neurobiol Dis
Title: A BAC transgenic mouse model reveals neuron subtype-specific effects of a Generalized Epilepsy with Febrile Seizures Plus (GEFS+) mutation.
Volume: 35
Issue: 1
Pages: 91-102
Publication
First Author: Ritter-Makinson S
Year: 2019
Journal: Cell Rep
Title: Augmented Reticular Thalamic Bursting and Seizures in Scn1a-Dravet Syndrome.
Volume: 26
Issue: 1
Pages: 54-64.e6
Publication
First Author: Malo MS
Year: 1994
Journal: Cytogenet Cell Genet
Title: Localization of a putative human brain sodium channel gene (SCN1A) to chromosome band 2q24.
Volume: 67
Issue: 3
Pages: 178-86
Publication
First Author: Stein RE
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Hippocampal deletion of NaV1.1 channels in mice causes thermal seizures and cognitive deficit characteristic of Dravet Syndrome.
Volume: 116
Issue: 33
Pages: 16571-16576
Publication
First Author: Han S
Year: 2012
Journal: Nature
Title: Autistic-like behaviour in Scn1a+/- mice and rescue by enhanced GABA-mediated neurotransmission.
Volume: 489
Issue: 7416
Pages: 385-90
Publication
First Author: Miller AR
Year: 2014
Journal: Genes Brain Behav
Title: Mapping genetic modifiers of survival in a mouse model of Dravet syndrome.
Volume: 13
Issue: 2
Pages: 163-72
Publication
First Author: Auerbach DS
Year: 2013
Journal: PLoS One
Title: Altered cardiac electrophysiology and SUDEP in a model of Dravet syndrome.
Volume: 8
Issue: 10
Pages: e77843
Publication
First Author: Han S
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Na(V)1.1 channels are critical for intercellular communication in the suprachiasmatic nucleus and for normal circadian rhythms.
Volume: 109
Issue: 6
Pages: E368-77
Publication
First Author: Hedrich UB
Year: 2014
Journal: J Neurosci
Title: Impaired action potential initiation in GABAergic interneurons causes hyperexcitable networks in an epileptic mouse model carrying a human Na(V)1.1 mutation.
Volume: 34
Issue: 45
Pages: 14874-89
Publication
First Author: Anderson LL
Year: 2017
Journal: Sci Rep
Title: Unexpected Efficacy of a Novel Sodium Channel Modulator in Dravet Syndrome.
Volume: 7
Issue: 1
Pages: 1682
Publication  
First Author: Hatini PG
Year: 2019
Journal: Brain Res
Title: Serotonin abnormalities in Dravet syndrome mice before and after the age of seizure onset.
Volume: 1724
Pages: 146399
Publication
First Author: Hawkins NA
Year: 2017
Journal: Sci Rep
Title: The synthetic neuroactive steroid SGE-516 reduces seizure burden and improves survival in a Dravet syndrome mouse model.
Volume: 7
Issue: 1
Pages: 15327
Publication  
First Author: Hawkins NA
Year: 2019
Journal: Exp Neurol
Title: Gene expression profiling in a mouse model of Dravet syndrome.
Volume: 311
Pages: 247-256
Publication
First Author: Beckers MC
Year: 1996
Journal: Genomics
Title: A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2.
Volume: 36
Issue: 1
Pages: 202-5
Publication    
First Author: Kuo FS
Year: 2019
Journal: Elife
Title: Disordered breathing in a mouse model of Dravet syndrome.
Volume: 8
Publication
First Author: Hawkins NA
Year: 2017
Journal: Ann Clin Transl Neurol
Title: Screening of conventional anticonvulsants in a genetic mouse model of epilepsy.
Volume: 4
Issue: 5
Pages: 326-339
Publication  
First Author: Mistry AM
Year: 2014
Journal: Neurobiol Dis
Title: Strain- and age-dependent hippocampal neuron sodium currents correlate with epilepsy severity in Dravet syndrome mice.
Volume: 65
Pages: 1-11
Publication
First Author: Cheah CS
Year: 2019
Journal: J Neurosci
Title: Impairment of Sharp-Wave Ripples in a Murine Model of Dravet Syndrome.
Volume: 39
Issue: 46
Pages: 9251-9260
Publication    
First Author: Goff KM
Year: 2019
Journal: Elife
Title: Vasoactive intestinal peptide-expressing interneurons are impaired in a mouse model of Dravet syndrome.
Volume: 8
Publication
First Author: Cheah CS
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Specific deletion of NaV1.1 sodium channels in inhibitory interneurons causes seizures and premature death in a mouse model of Dravet syndrome.
Volume: 109
Issue: 36
Pages: 14646-51
Publication
First Author: Aiba I
Year: 2015
Journal: Sci Transl Med
Title: Spreading depolarization in the brainstem mediates sudden cardiorespiratory arrest in mouse SUDEP models.
Volume: 7
Issue: 282
Pages: 282ra46
Publication  
First Author: Williams AD
Year: 2019
Journal: J Neurosci Methods
Title: A more efficient conditional mouse model of Dravet syndrome: Implications for epigenetic selection and sex-dependent behaviors.
Volume: 325
Pages: 108315
Publication
First Author: De Stasi AM
Year: 2016
Journal: Cereb Cortex
Title: Unaltered Network Activity and Interneuronal Firing During Spontaneous Cortical Dynamics In Vivo in a Mouse Model of Severe Myoclonic Epilepsy of Infancy.
Volume: 26
Issue: 4
Pages: 1778-94
Publication
First Author: Kalume F
Year: 2013
Journal: J Clin Invest
Title: Sudden unexpected death in a mouse model of Dravet syndrome.
Volume: 123
Issue: 4
Pages: 1798-808
Publication
First Author: Martin MS
Year: 2007
Journal: Hum Mol Genet
Title: The voltage-gated sodium channel Scn8a is a genetic modifier of severe myoclonic epilepsy of infancy.
Volume: 16
Issue: 23
Pages: 2892-9
Publication
First Author: Calhoun JD
Year: 2017
Journal: Epilepsia
Title: Cacna1g is a genetic modifier of epilepsy in a mouse model of Dravet syndrome.
Volume: 58
Issue: 8
Pages: e111-e115
Publication
First Author: Favero M
Year: 2018
Journal: J Neurosci
Title: A Transient Developmental Window of Fast-Spiking Interneuron Dysfunction in a Mouse Model of Dravet Syndrome.
Volume: 38
Issue: 36
Pages: 7912-7927
Publication
First Author: Ogiwara I
Year: 2013
Journal: Hum Mol Genet
Title: Nav1.1 haploinsufficiency in excitatory neurons ameliorates seizure-associated sudden death in a mouse model of Dravet syndrome.
Volume: 22
Issue: 23
Pages: 4784-804
Publication  
First Author: Makinson CD
Year: 2014
Journal: Neurobiol Dis
Title: Role of the hippocampus in Nav1.6 (Scn8a) mediated seizure resistance.
Volume: 68
Pages: 16-25
Protein
Organism: Mus musculus
Length: 169  
Fragment?: true
Publication
First Author: Hawkins NA
Year: 2016
Journal: PLoS Genet
Title: Fine Mapping of a Dravet Syndrome Modifier Locus on Mouse Chromosome 5 and Candidate Gene Analysis by RNA-Seq.
Volume: 12
Issue: 10
Pages: e1006398
Publication
First Author: Hawkins NA
Year: 2011
Journal: Neurobiol Dis
Title: Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus.
Volume: 41
Issue: 3
Pages: 655-60
Publication
First Author: Yamagata T
Year: 2017
Journal: Biochem Biophys Res Commun
Title: Nav1.2 is expressed in caudal ganglionic eminence-derived disinhibitory interneurons: Mutually exclusive distributions of Nav1.1 and Nav1.2.
Volume: 491
Issue: 4
Pages: 1070-1076
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Yu FH
Year: 2006
Journal: Nat Neurosci
Title: Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy.
Volume: 9
Issue: 9
Pages: 1142-9
Publication
First Author: Osteen JD
Year: 2016
Journal: Nature
Title: Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain.
Volume: 534
Issue: 7608
Pages: 494-9
Publication
First Author: Kim Y
Year: 2018
Journal: J Clin Invest
Title: Severe peri-ictal respiratory dysfunction is common in Dravet syndrome.
Volume: 128
Issue: 3
Pages: 1141-1153
Publication
First Author: Oakley JC
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Temperature- and age-dependent seizures in a mouse model of severe myoclonic epilepsy in infancy.
Volume: 106
Issue: 10
Pages: 3994-9
Publication  
First Author: Kalume F
Year: 2015
Journal: Neurobiol Dis
Title: Sleep impairment and reduced interneuron excitability in a mouse model of Dravet Syndrome.
Volume: 77
Pages: 141-54
Publication  
First Author: Rubinstein M
Year: 2015
Journal: Neurobiol Dis
Title: Genetic background modulates impaired excitability of inhibitory neurons in a mouse model of Dravet syndrome.
Volume: 73
Pages: 106-17
Publication
First Author: Anderson LL
Year: 2014
Journal: Epilepsia
Title: Antiepileptic activity of preferential inhibitors of persistent sodium current.
Volume: 55
Issue: 8
Pages: 1274-83
Publication  
First Author: Denomme N
Year: 2020
Journal: Neurosci Lett
Title: The voltage-gated sodium channel inhibitor, 4,9-anhydrotetrodotoxin, blocks human Nav1.1 in addition to Nav1.6.
Volume: 724
Pages: 134853
Publication
First Author: Nomura T
Year: 2019
Journal: J Physiol
Title: Potentiating α2 subunit containing perisomatic GABAA receptors protects against seizures in a mouse model of Dravet syndrome.
Volume: 597
Issue: 16
Pages: 4293-4307
Publication
First Author: Patra PH
Year: 2020
Journal: Br J Pharmacol
Title: Cannabidiol improves survival and behavioural co-morbidities of Dravet syndrome in mice.
Volume: 177
Issue: 12
Pages: 2779-2792
Publication
First Author: Richards KL
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Selective NaV1.1 activation rescues Dravet syndrome mice from seizures and premature death.
Volume: 115
Issue: 34
Pages: E8077-E8085
Publication
First Author: Cestèle S
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Nonfunctional NaV1.1 familial hemiplegic migraine mutant transformed into gain of function by partial rescue of folding defects.
Volume: 110
Issue: 43
Pages: 17546-51
GXD Expression    
Probe: MGI:3055546
Assay Type: RT-PCR
Annotation Date: 2004-10-28
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754421
Stage: TS21
Assay Id: MGI:3055554
Age: embryonic day 13.0
Image: 5
Detected: false
Specimen Num: 6
GXD Expression    
Probe: MGI:3055546
Assay Type: RT-PCR
Annotation Date: 2004-10-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691021
Stage: TS21
Assay Id: MGI:3055554
Age: embryonic day 13.0
Image: 5
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3804411
Assay Type: RT-PCR
Annotation Date: 2008-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3804652
Age: postnatal day 76
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3804403
Assay Type: RT-PCR
Annotation Date: 2008-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3804649
Age: postnatal day 76
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3804483
Assay Type: RT-PCR
Annotation Date: 2008-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3804639
Age: postnatal adult
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3804411
Assay Type: RT-PCR
Annotation Date: 2008-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3804474
Age: postnatal day 126
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:3804411
Assay Type: RT-PCR
Annotation Date: 2008-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3804474
Age: postnatal day 76
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3804411
Assay Type: RT-PCR
Annotation Date: 2008-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3804474
Age: postnatal day 38
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3804411
Assay Type: RT-PCR
Annotation Date: 2008-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3804474
Age: postnatal day 9
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3804411
Assay Type: RT-PCR
Annotation Date: 2008-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610527
Stage: TS27
Assay Id: MGI:3804474
Age: postnatal day 1
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3804411
Assay Type: RT-PCR
Annotation Date: 2008-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610523
Stage: TS23
Assay Id: MGI:3804474
Age: embryonic day 15.0
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3804403
Assay Type: RT-PCR
Annotation Date: 2008-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3804461
Age: postnatal day 126
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:3804403
Assay Type: RT-PCR
Annotation Date: 2008-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3804461
Age: postnatal day 76
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3804403
Assay Type: RT-PCR
Annotation Date: 2008-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3804461
Age: postnatal day 38
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3804403
Assay Type: RT-PCR
Annotation Date: 2008-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3804461
Age: postnatal day 9
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3804403
Assay Type: RT-PCR
Annotation Date: 2008-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610527
Stage: TS27
Assay Id: MGI:3804461
Age: postnatal day 1
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3804403
Assay Type: RT-PCR
Annotation Date: 2008-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610523
Stage: TS23
Assay Id: MGI:3804461
Age: embryonic day 15.0
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3707864
Assay Type: RT-PCR
Annotation Date: 2007-05-16
Strength: Present
Sex: Male
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3708950
Age: postnatal adult
Detected: true
Specimen Num: 3