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Search results 1 to 100 out of 179 for Scn2a

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0.03s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Kearney JA
Year: 2006
Journal: Hum Mol Genet
Title: Severe epilepsy resulting from genetic interaction between Scn2a and Kcnq2.
Volume: 15
Issue: 6
Pages: 1043-8
Publication
First Author: Gould E
Year: 2021
Journal: Cell Rep
Title: SCN2A contributes to oligodendroglia excitability and development in the mammalian brain.
Volume: 36
Issue: 10
Pages: 109653
Publication  
First Author: Wang HG
Year: 2021
Journal: JCI Insight
Title: Scn2a severe hypomorphic mutation decreases excitatory synaptic input and causes autism-associated behaviors.
Volume: 6
Issue: 15
Publication
First Author: Kile KB
Year: 2008
Journal: Epilepsia
Title: Scn2a sodium channel mutation results in hyperexcitability in the hippocampus in vitro.
Volume: 49
Issue: 3
Pages: 488-99
Publication
First Author: Spratt PWE
Year: 2019
Journal: Neuron
Title: The Autism-Associated Gene Scn2a Contributes to Dendritic Excitability and Synaptic Function in the Prefrontal Cortex.
Volume: 103
Issue: 4
Pages: 673-685.e5
Publication  
First Author: Ma Z
Year: 2022
Journal: Neurobiol Dis
Title: Deficiency of autism-related Scn2a gene in mice disrupts sleep patterns and circadian rhythms.
Volume: 168
Pages: 105690
Publication
First Author: Léna I
Year: 2019
Journal: Sci Rep
Title: NaV1.2 haploinsufficiency in Scn2a knock-out mice causes an autistic-like phenotype attenuated with age.
Volume: 9
Issue: 1
Pages: 12886
Publication
First Author: Nelson AD
Year: 2024
Journal: Neuron
Title: Physical and functional convergence of the autism risk genes Scn2a and Ank2 in neocortical pyramidal cell dendrites.
Volume: 112
Issue: 7
Pages: 1133-1149.e6
Publication
First Author: Mishra V
Year: 2017
Journal: Hum Mol Genet
Title: Scn2a deletion improves survival and brain-heart dynamics in the Kcna1-null mouse model of sudden unexpected death in epilepsy (SUDEP).
Volume: 26
Issue: 11
Pages: 2091-2103
Publication
First Author: Indumathy J
Year: 2021
Journal: Brain Behav
Title: Kv1.1 deficiency alters repetitive and social behaviors in mice and rescues autistic-like behaviors due to Scn2a haploinsufficiency.
Volume: 11
Issue: 4
Pages: e02041
Publication
First Author: Middleton SJ
Year: 2018
Journal: Nat Neurosci
Title: Altered hippocampal replay is associated with memory impairment in mice heterozygous for the Scn2a gene.
Volume: 21
Issue: 7
Pages: 996-1003
Publication
First Author: Eaton M
Year: 2021
Journal: Genes Brain Behav
Title: Generation and basic characterization of a gene-trap knockout mouse model of Scn2a with a substantial reduction of voltage-gated sodium channel Na(v) 1.2 expression.
Volume: 20
Issue: 4
Pages: e12725
Publication  
First Author: Tatsukawa T
Year: 2019
Journal: Mol Autism
Title: Scn2a haploinsufficient mice display a spectrum of phenotypes affecting anxiety, sociability, memory flexibility and ampakine CX516 rescues their hyperactivity.
Volume: 10
Pages: 15
Publication  
First Author: Shin W
Year: 2019
Journal: Front Mol Neurosci
Title: Scn2a Haploinsufficiency in Mice Suppresses Hippocampal Neuronal Excitability, Excitatory Synaptic Drive, and Long-Term Potentiation, and Spatial Learning and Memory.
Volume: 12
Pages: 145
Publication
First Author: Zhang J
Year: 2021
Journal: Cell Rep
Title: Severe deficiency of the voltage-gated sodium channel NaV1.2 elevates neuronal excitability in adult mice.
Volume: 36
Issue: 5
Pages: 109495
Publication      
First Author: Wang C
Year: 2024
Journal: Neuron
Title: Impaired cerebellar plasticity hypersensitizes sensory reflexes in SCN2A-associated ASD.
Publication
First Author: Spratt PWE
Year: 2021
Journal: Cell Rep
Title: Paradoxical hyperexcitability from NaV1.2 sodium channel loss in neocortical pyramidal cells.
Volume: 36
Issue: 5
Pages: 109483
Publication
First Author: Gazina EV
Year: 2015
Journal: Hum Mol Genet
Title: 'Neonatal' Nav1.2 reduces neuronal excitability and affects seizure susceptibility and behaviour.
Volume: 24
Issue: 5
Pages: 1457-68
Publication
First Author: Echevarria-Cooper DM
Year: 2022
Journal: Hum Mol Genet
Title: Cellular and behavioral effects of altered NaV1.2 sodium channel ion permeability in Scn2aK1422E mice.
Volume: 31
Issue: 17
Pages: 2964-2988
Publication
First Author: Miyamoto H
Year: 2019
Journal: Nat Commun
Title: Impaired cortico-striatal excitatory transmission triggers epilepsy.
Volume: 10
Issue: 1
Pages: 1917
Publication    
First Author: Ogiwara I
Year: 2018
Journal: Commun Biol
Title: Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.
Volume: 1
Publication
First Author: Hawkins NA
Year: 2011
Journal: Neurobiol Dis
Title: Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus.
Volume: 41
Issue: 3
Pages: 655-60
Publication
First Author: Yamagata T
Year: 2017
Journal: Biochem Biophys Res Commun
Title: Nav1.2 is expressed in caudal ganglionic eminence-derived disinhibitory interneurons: Mutually exclusive distributions of Nav1.1 and Nav1.2.
Volume: 491
Issue: 4
Pages: 1070-1076
Publication
First Author: Malo D
Year: 1991
Journal: Genomics
Title: Three brain sodium channel alpha-subunit genes are clustered on the proximal segment of mouse chromosome 2.
Volume: 10
Issue: 3
Pages: 666-72
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Perrot R
Year: 2007
Journal: J Neurosci
Title: Axonal neurofilaments control multiple fiber properties but do not influence structure or spacing of nodes of Ranvier.
Volume: 27
Issue: 36
Pages: 9573-84
Publication
First Author: Martínez-Hernández J
Year: 2013
Journal: Cerebellum
Title: Polarised localisation of the voltage-gated sodium channel Na(v)1.2 in cerebellar granule cells.
Volume: 12
Issue: 1
Pages: 16-26
Publication
First Author: Sashihara S
Year: 1992
Journal: Neuroscience
Title: Overproduction of voltage-dependent Na+ channels in the developing brain of genetically seizure-susceptible E1 mice.
Volume: 48
Issue: 2
Pages: 285-91
Publication
First Author: González-Cabrera C
Year: 2017
Journal: J Comp Neurol
Title: Characterization of the axon initial segment of mice substantia nigra dopaminergic neurons.
Volume: 525
Issue: 16
Pages: 3529-3542
Publication
First Author: Nunes D
Year: 2018
Journal: PLoS Biol
Title: Axonal sodium channel NaV1.2 drives granule cell dendritic GABA release and rapid odor discrimination.
Volume: 16
Issue: 8
Pages: e2003816
GXD Expression    
Probe: MGI:3055546
Assay Type: RT-PCR
Annotation Date: 2004-10-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691021
Stage: TS21
Assay Id: MGI:3055555
Age: embryonic day 13.0
Image: 5
Specimen Label: H
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:3055546
Assay Type: RT-PCR
Annotation Date: 2004-10-28
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754421
Stage: TS21
Assay Id: MGI:3055555
Age: embryonic day 13.0
Image: 5
Specimen Label: Cx
Detected: false
Specimen Num: 6
GXD Expression      
Probe: MGI:3804403
Assay Type: RT-PCR
Annotation Date: 2008-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610523
Stage: TS23
Assay Id: MGI:3804460
Age: embryonic day 15.0
Specimen Label: E15
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3804403
Assay Type: RT-PCR
Annotation Date: 2008-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610527
Stage: TS27
Assay Id: MGI:3804460
Age: postnatal day 1
Specimen Label: P1
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3804403
Assay Type: RT-PCR
Annotation Date: 2008-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3804460
Age: postnatal day 9
Specimen Label: P9
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3804403
Assay Type: RT-PCR
Annotation Date: 2008-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3804460
Age: postnatal day 38
Specimen Label: P38
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3804403
Assay Type: RT-PCR
Annotation Date: 2008-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3804460
Age: postnatal day 76
Specimen Label: P76
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3804403
Assay Type: RT-PCR
Annotation Date: 2008-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3804460
Age: postnatal day 126
Specimen Label: P126
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:3804411
Assay Type: RT-PCR
Annotation Date: 2008-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610523
Stage: TS23
Assay Id: MGI:3804475
Age: embryonic day 15.0
Specimen Label: E15
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3804411
Assay Type: RT-PCR
Annotation Date: 2008-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610527
Stage: TS27
Assay Id: MGI:3804475
Age: postnatal day 1
Specimen Label: P1
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3804411
Assay Type: RT-PCR
Annotation Date: 2008-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3804475
Age: postnatal day 9
Specimen Label: P9
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3804411
Assay Type: RT-PCR
Annotation Date: 2008-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3804475
Age: postnatal day 38
Specimen Label: P38
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3804411
Assay Type: RT-PCR
Annotation Date: 2008-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3804475
Age: postnatal day 76
Specimen Label: P76
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3804411
Assay Type: RT-PCR
Annotation Date: 2008-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3804475
Age: postnatal day 126
Specimen Label: P126
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:3804484
Assay Type: RT-PCR
Annotation Date: 2008-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3804640
Age: postnatal adult
Specimen Label: None
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3804403
Assay Type: RT-PCR
Annotation Date: 2008-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1715728
Stage: TS28
Assay Id: MGI:3804654
Age: postnatal day 76
Specimen Label: G
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3804403
Assay Type: RT-PCR
Annotation Date: 2008-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1857728
Stage: TS28
Assay Id: MGI:3804654
Age: postnatal day 76
Specimen Label: N
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3804403
Assay Type: RT-PCR
Annotation Date: 2008-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3804654
Age: postnatal day 76
Specimen Label: H
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3804411
Assay Type: RT-PCR
Annotation Date: 2008-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1715728
Stage: TS28
Assay Id: MGI:3804656
Age: postnatal day 76
Specimen Label: G
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3804411
Assay Type: RT-PCR
Annotation Date: 2008-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1857728
Stage: TS28
Assay Id: MGI:3804656
Age: postnatal day 76
Specimen Label: N
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3804411
Assay Type: RT-PCR
Annotation Date: 2008-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3804656
Age: postnatal day 76
Specimen Label: H
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:4360788
Assay Type: Northern blot
Annotation Date: 2009-10-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689423
Stage: TS23
Assay Id: MGI:4360789
Age: embryonic day 15.0
Specimen Label: F15 d
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:4360788
Assay Type: Northern blot
Annotation Date: 2009-10-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689423
Stage: TS23
Assay Id: MGI:4360789
Age: embryonic day 15.0
Specimen Label: F15 El
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:4360788
Assay Type: Northern blot
Annotation Date: 2009-10-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:4360789
Age: postnatal day 1
Specimen Label: 1d d
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:4360788
Assay Type: Northern blot
Annotation Date: 2009-10-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:4360789
Age: postnatal day 1
Specimen Label: 1d El
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:4360788
Assay Type: Northern blot
Annotation Date: 2009-10-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:4360789
Age: postnatal week 1
Specimen Label: 1w d
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:4360788
Assay Type: Northern blot
Annotation Date: 2009-10-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:4360789
Age: postnatal week 1
Specimen Label: 1w El
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:4360788
Assay Type: Northern blot
Annotation Date: 2009-10-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:4360789
Age: postnatal week 2
Specimen Label: 2w d
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:4360788
Assay Type: Northern blot
Annotation Date: 2009-10-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:4360789
Age: postnatal week 2
Specimen Label: 2w El
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:4360788
Assay Type: Northern blot
Annotation Date: 2009-10-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:4360789
Age: postnatal week 3
Specimen Label: 3w d
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:4360788
Assay Type: Northern blot
Annotation Date: 2009-10-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:4360789
Age: postnatal week 3
Specimen Label: 3w El
Detected: true
Specimen Num: 10
GXD Expression      
Probe: MGI:4360788
Assay Type: Northern blot
Annotation Date: 2009-10-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:4360789
Age: postnatal week 4
Specimen Label: 4w d
Detected: true
Specimen Num: 11
GXD Expression      
Probe: MGI:4360788
Assay Type: Northern blot
Annotation Date: 2009-10-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:4360789
Age: postnatal week 4
Specimen Label: 4w El
Detected: true
Specimen Num: 12
GXD Expression      
Probe: MGI:4360788
Assay Type: Northern blot
Annotation Date: 2009-10-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:4360789
Age: postnatal week 15
Specimen Label: 15w d
Detected: true
Specimen Num: 13
GXD Expression      
Probe: MGI:4360788
Assay Type: Northern blot
Annotation Date: 2009-10-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:4360789
Age: postnatal week 15
Specimen Label: 15w El
Detected: true
Specimen Num: 14
GXD Expression    
Probe: MGI:4426967
Assay Type: RNA in situ
Annotation Date: 2023-09-26
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3271122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7530877
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
UniProt Feature
Begin: 56
Description: Binds SCN2A
Type: site
End: 56
UniProt Feature
Begin: 135
Description: Binds SCN2A
Type: site
End: 135
Publication
First Author: Planells-Cases R
Year: 2000
Journal: Biophys J
Title: Neuronal death and perinatal lethality in voltage-gated sodium channel alpha(II)-deficient mice.
Volume: 78
Issue: 6
Pages: 2878-91
Publication
First Author: Vega AV
Year: 2008
Journal: Neurosci Lett
Title: Reduced expression of Na(v)1.6 sodium channels and compensation by Na(v)1.2 channels in mice heterozygous for a null mutation in Scn8a.
Volume: 442
Issue: 1
Pages: 69-73
Publication
First Author: Bergren SK
Year: 2005
Journal: Mamm Genome
Title: Genetic modifiers affecting severity of epilepsy caused by mutation of sodium channel Scn2a.
Volume: 16
Issue: 9
Pages: 683-90
Publication
First Author: Litt M
Year: 1989
Journal: Genomics
Title: Localization of a human brain sodium channel gene (SCN2A) to chromosome 2.
Volume: 5
Issue: 2
Pages: 204-8
Publication
First Author: Katz E
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Role of sodium channel subtype in action potential generation by neocortical pyramidal neurons.
Volume: 115
Issue: 30
Pages: E7184-E7192