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Search results 1 to 100 out of 109 for Scn2b

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Categories

Hits by Category

Hits by Strain

Type Details Score
Gene
6327 | SCN2B
Type: gene
Organism: human
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Gene
100144663 | scn2b
Type: gene
Organism: frog, western clawed
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Gene
25349 | Scn2b
Type: gene
Organism: rat
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Gene
466796 | SCN2B
Type: gene
Organism: chimpanzee
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Gene
403485 | SCN2B
Type: gene
Organism: dog, domestic
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Gene
538722 | SCN2B
Type: gene
Organism: cattle
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Gene
419776 | SCN2B
Type: gene
Organism: chicken
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Gene
777666 | scn2b
Type: gene
Organism: zebrafish
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Gene
678698 | SCN2B
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR029873 | SCN2B
Type: Family
Description: Sodium channels consist of a pore-forming alpha subunit and at least one beta regulatory subunit. Sodium channel subunit beta-2 (SCN2B) belongs to the beta subunit family and is also a member of the immunoglobulin superfamily of cell adhesion. It interacts with NrCAM, Nf186, contactin, and Nf155. It may be involved in heterophilic cell-adhesive interactions with cell adhesion molecules found in the axo-glial complex [, ]. This subunit associates with alpha subunits during neuronal voltage-gated sodium channels biosynthesis and allows the insertion of the complex into the plasma membrane, playing an important role in stabilizing channel expression at the cell surface, and thereby maintaining normal action potential threshold [].
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Protein Coding Gene
MGI:106921 | Scn2b
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q1MXF8
Organism: Mus musculus/domesticus
Length: 215  
Fragment?: false
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Publication
27932425 | J:266728
 
First Author: Bao Y
Year: 2016
Journal: Circ Arrhythm Electrophysiol
Title: Scn2b Deletion in Mice Results in Ventricular and Atrial Arrhythmias.
Volume: 9
Issue: 12
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Publication
32124967 | J:298554
First Author: Tan YX
Year: 2020
Journal: Int J Mol Med
Title: MicroRNA‑449a regulates the progression of brain aging by targeting SCN2B in SAMP8 mice.
Volume: 45
Issue: 4
Pages: 1091-1102
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Protein
Q56A07
Organism: Mus musculus/domesticus
Length: 215  
Fragment?: false
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Publication
22007171 | -
 
First Author: Brackenbury WJ
Year: 2011
Journal: Front Pharmacol
Title: Na Channel β Subunits: Overachievers of the Ion Channel Family.
Volume: 2
Pages: 53
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Publication
15466474 | -
First Author: McEwen DP
Year: 2004
Journal: J Biol Chem
Title: Heterophilic interactions of sodium channel beta1 subunits with axonal and glial cell adhesion molecules.
Volume: 279
Issue: 50
Pages: 52744-52
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Publication
11779698 | -
 
First Author: Isom LL
Year: 2002
Journal: Front Biosci
Title: The role of sodium channels in cell adhesion.
Volume: 7
Pages: 12-23
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Publication
19013247 | J:146950
First Author: O'Malley HA
Year: 2009
Journal: Mol Cell Neurosci
Title: Loss of Na+ channel beta2 subunits is neuroprotective in a mouse model of multiple sclerosis.
Volume: 40
Issue: 2
Pages: 143-55
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Publication
25575679 | J:333607
First Author: XiYang YB
Year: 2016
Journal: Mol Neurobiol
Title: Sodium Channel Voltage-Gated Beta 2 Plays a Vital Role in Brain Aging Associated with Synaptic Plasticity and Expression of COX5A and FGF-2.
Volume: 53
Issue: 2
Pages: 955-967
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Protein Coding Gene
MGP_CAROLIEiJ_G0032138 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0034731 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0034712 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0034639 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0034703 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0034414 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_106921 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0035224 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0033736 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0034386 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0034545 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0034486 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0034626 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0034530 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0035245 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0033441 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0033849 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0015008 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0033277 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
12481039 | J:82050
First Author: Chen C
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits.
Volume: 99
Issue: 26
Pages: 17072-7
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Publication
16306410 | J:123446
First Author: Pertin M
Year: 2005
Journal: J Neurosci
Title: Upregulation of the voltage-gated sodium channel beta2 subunit in neuropathic pain models: characterization of expression in injured and non-injured primary sensory neurons.
Volume: 25
Issue: 47
Pages: 10970-80
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Publication
16870743 | J:111057
First Author: Lopez-Santiago LF
Year: 2006
Journal: J Neurosci
Title: Sodium channel beta2 subunits regulate tetrodotoxin-sensitive sodium channels in small dorsal root ganglion neurons and modulate the response to pain.
Volume: 26
Issue: 30
Pages: 7984-94
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Publication
8521473 | J:45864
First Author: Isom LL
Year: 1995
Journal: Cell
Title: Structure and function of the beta 2 subunit of brain sodium channels, a transmembrane glycoprotein with a CAM motif.
Volume: 83
Issue: 3
Pages: 433-42
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GXD Expression
GXD Expression
 
Probe: MGI:4425752
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827902
Age: embryonic day 14.5
Image: euxassay_010925_05
Specimen Label: euxassay_010925_05
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4425752
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827902
Age: embryonic day 14.5
Image: euxassay_010925_06
Specimen Label: euxassay_010925_06
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:4425752
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827902
Age: embryonic day 14.5
Image: euxassay_010925_07
Specimen Label: euxassay_010925_07
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:4425752
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827902
Age: embryonic day 14.5
Image: euxassay_010925_08
Specimen Label: euxassay_010925_08
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:4425752
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827902
Age: embryonic day 14.5
Image: euxassay_010925_09
Specimen Label: euxassay_010925_09
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:4425752
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827902
Age: embryonic day 14.5
Image: euxassay_010925_13
Specimen Label: euxassay_010925_13
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:4425752
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827902
Age: embryonic day 14.5
Image: euxassay_010925_14
Specimen Label: euxassay_010925_14
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
   
Probe: MGI:3819465
Assay Type: RNA in situ
Annotation Date: 2009-01-23
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1603911
Pattern: Ubiquitous
Stage: TS11
Assay Id: MGI:3828773
Age: embryonic day 7.5
Specimen Label: E7.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:3819465
Assay Type: RNA in situ
Annotation Date: 2009-01-23
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1603913
Pattern: Ubiquitous
Stage: TS13
Assay Id: MGI:3828773
Age: embryonic day 8.5
Specimen Label: E8.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4425752
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827902
Age: embryonic day 14.5
Image: euxassay_010925_04
Specimen Label: euxassay_010925_04
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4425752
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827902
Age: embryonic day 14.5
Image: euxassay_010925_05
Specimen Label: euxassay_010925_05
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4425752
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827902
Age: embryonic day 14.5
Image: euxassay_010925_06
Specimen Label: euxassay_010925_06
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:4425752
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827902
Age: embryonic day 14.5
Image: euxassay_010925_07
Specimen Label: euxassay_010925_07
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:4425752
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827902
Age: embryonic day 14.5
Image: euxassay_010925_08
Specimen Label: euxassay_010925_08
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:4425752
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827902
Age: embryonic day 14.5
Image: euxassay_010925_16
Specimen Label: euxassay_010925_16
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
 
Probe: MGI:4425752
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827902
Age: embryonic day 14.5
Image: euxassay_010925_17
Specimen Label: euxassay_010925_17
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
 
Probe: MGI:4425752
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827902
Age: embryonic day 14.5
Image: euxassay_010925_18
Specimen Label: euxassay_010925_18
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
 
Probe: MGI:4425752
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827902
Age: embryonic day 14.5
Image: euxassay_010925_19
Specimen Label: euxassay_010925_19
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
 
Probe: MGI:4425752
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827902
Age: embryonic day 14.5
Image: euxassay_010925_20
Specimen Label: euxassay_010925_20
Detected: true
Specimen Num: 13
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GXD Expression
GXD Expression
 
Probe: MGI:4425752
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1756923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827902
Age: embryonic day 14.5
Image: euxassay_010925_17
Specimen Label: euxassay_010925_17
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
 
Probe: MGI:4425752
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1756923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827902
Age: embryonic day 14.5
Image: euxassay_010925_18
Specimen Label: euxassay_010925_18
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
 
Probe: MGI:4425752
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827902
Age: embryonic day 14.5
Image: euxassay_010925_05
Specimen Label: euxassay_010925_05
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4425752
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827902
Age: embryonic day 14.5
Image: euxassay_010925_06
Specimen Label: euxassay_010925_06
Detected: true
Specimen Num: 3
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Publication
20573896 | J:161515
First Author: Uebachs M
Year: 2010
Journal: J Neurosci
Title: Efficacy loss of the anticonvulsant carbamazepine in mice lacking sodium channel beta subunits via paradoxical effects on persistent sodium currents.
Volume: 30
Issue: 25
Pages: 8489-501
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Publication
8661062 | J:33369
First Author: Jones JM
Year: 1996
Journal: Genomics
Title: Scn2b, a voltage-gated sodium channel beta2 gene on mouse chromosome 9.
Volume: 34
Issue: 2
Pages: 258-9
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Publication
21190943 | J:170564
First Author: Kim DY
Year: 2011
Journal: J Biol Chem
Title: Reduced sodium channel Na(v)1.1 levels in BACE1-null mice.
Volume: 286
Issue: 10
Pages: 8106-16
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Publication
19228957 | J:146591
First Author: Aman TK
Year: 2009
Journal: J Neurosci
Title: Regulation of persistent Na current by interactions between beta subunits of voltage-gated Na channels.
Volume: 29
Issue: 7
Pages: 2027-42
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Publication
15664175 | J:98459
First Author: Grieco TM
Year: 2005
Journal: Neuron
Title: Open-channel block by the cytoplasmic tail of sodium channel beta4 as a mechanism for resurgent sodium current.
Volume: 45
Issue: 2
Pages: 233-44
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Publication
30175250 | J:268565
   
First Author: Ogiwara I
Year: 2018
Journal: Commun Biol
Title: Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.
Volume: 1
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Publication
18973680 | J:141291
 
First Author: Tamplin OJ
Year: 2008
Journal: BMC Genomics
Title: Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives.
Volume: 9
Pages: 511
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Publication
20562862 | J:161922
First Author: Tang T
Year: 2010
Journal: Nat Biotechnol
Title: A mouse knockout library for secreted and transmembrane proteins.
Volume: 28
Issue: 7
Pages: 749-55
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Publication
- | J:171883
     
First Author: Lexicon Genetics, Inc
Year: 2011
Journal: Database Download
Title: MGI download of Lexicon knockout data
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Publication
- | J:94790
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
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Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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First Author: The Gene Ontology Consortium
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First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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