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Search results 1 to 100 out of 548 for Scn5a

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Hits by Strain

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Type Details Score
Gene
6331 | SCN5A
Type: gene
Organism: human
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Gene
282061 | SCN5A
Type: gene
Organism: cattle
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Gene
395947 | SCN5A
Type: gene
Organism: chicken
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Gene
695085 | SCN5A
Type: gene
Organism: macaque, rhesus
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Gene
100485924 | scn5a
Type: gene
Organism: frog, western clawed
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Gene
25665 | Scn5a
Type: gene
Organism: rat
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Gene
403497 | SCN5A
Type: gene
Organism: dog, domestic
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Gene
747523 | SCN5A
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:98251 | Scn5a
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
30371314 | J:279087
First Author: Pang PD
Year: 2018
Journal: J Am Heart Assoc
Title: CRISPR -Mediated Expression of the Fetal Scn5a Isoform in Adult Mice Causes Conduction Defects and Arrhythmias.
Volume: 7
Issue: 19
Pages: e010393
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Publication
22728936 | J:190765
First Author: Arnolds DE
Year: 2012
Journal: J Clin Invest
Title: TBX5 drives Scn5a expression to regulate cardiac conduction system function.
Volume: 122
Issue: 7
Pages: 2509-18
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Publication
21824921 | J:189389
First Author: Watanabe H
Year: 2011
Journal: Circulation
Title: Striking In vivo phenotype of a disease-associated human SCN5A mutation producing minimal changes in vitro.
Volume: 124
Issue: 9
Pages: 1001-11
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Publication
24642470 | J:209588
First Author: van den Boogaard M
Year: 2014
Journal: J Clin Invest
Title: A common genetic variant within SCN10A modulates cardiac SCN5A expression.
Volume: 124
Issue: 4
Pages: 1844-52
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Publication
17157817 | J:116505
First Author: Tian XL
Year: 2007
Journal: Biochem Biophys Res Commun
Title: Optical mapping of ventricular arrhythmias in LQTS mice with SCN5A mutation N1325S.
Volume: 352
Issue: 4
Pages: 879-83
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Publication
17118339 | J:116497
First Author: Yong SL
Year: 2007
Journal: Biochem Biophys Res Commun
Title: Characterization of the cardiac sodium channel SCN5A mutation, N1325S, in single murine ventricular myocytes.
Volume: 352
Issue: 2
Pages: 378-83
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Publication
27063795 | J:236898
 
First Author: Freyermuth F
Year: 2016
Journal: Nat Commun
Title: Splicing misregulation of SCN5A contributes to cardiac-conduction delay and heart arrhythmia in myotonic dystrophy.
Volume: 7
Pages: 11067
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Publication
26392562 | J:227075
First Author: Musa H
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: SCN5A variant that blocks fibroblast growth factor homologous factor regulation causes human arrhythmia.
Volume: 112
Issue: 40
Pages: 12528-33
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Publication
14736542 | J:134567
First Author: Tian XL
Year: 2004
Journal: Cardiovasc Res
Title: Mechanisms by which SCN5A mutation N1325S causes cardiac arrhythmias and sudden death in vivo.
Volume: 61
Issue: 2
Pages: 256-67
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Publication
17300750 | J:118632
First Author: Zhang T
Year: 2007
Journal: Biochem Biophys Res Commun
Title: Cardiac-specific overexpression of SCN5A gene leads to shorter P wave duration and PR interval in transgenic mice.
Volume: 355
Issue: 2
Pages: 444-50
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Publication
16403066 | J:127879
First Author: Head CE
Year: 2005
Journal: J Cardiovasc Electrophysiol
Title: Paced electrogram fractionation analysis of arrhythmogenic tendency in DeltaKPQ Scn5a mice.
Volume: 16
Issue: 12
Pages: 1329-40
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Publication
31125670 | J:333144
First Author: Daniel LL
Year: 2019
Journal: Heart Rhythm
Title: SCN5A variant R222Q generated abnormal changes in cardiac sodium current and action potentials in murine myocytes and Purkinje cells.
Volume: 16
Issue: 11
Pages: 1676-1685
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Publication
28779003 | J:342506
First Author: Shen C
Year: 2017
Journal: J Med Genet
Title: Novel idiopathic DCM-related SCN5A variants localised in DI-S4 predispose electrical disorders by reducing peak sodium current density.
Volume: 54
Issue: 11
Pages: 762-770
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GXD Expression
GXD Expression
     
Probe: MGI:6182858
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689419
Stage: TS19
Assay Id: MGI:6191259
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Scn5a
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6182858
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6191259
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Scn5a
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6182858
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6191259
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Scn5a
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6182858
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6191259
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Scn5a
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6182858
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191259
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Scn5a
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6182858
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191259
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Scn5a
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6182858
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191259
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Scn5a
Detected: true
Specimen Num: 7
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Publication
12650887 | J:162749
First Author: Fabritz L
Year: 2003
Journal: Cardiovasc Res
Title: Effect of pacing and mexiletine on dispersion of repolarisation and arrhythmias in DeltaKPQ SCN5A (long QT3) mice.
Volume: 57
Issue: 4
Pages: 1085-93
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Publication
17110414 | J:134138
First Author: Thomas G
Year: 2007
Journal: J Physiol
Title: Effects of L-type Ca2+ channel antagonism on ventricular arrhythmogenesis in murine hearts containing a modification in the Scn5a gene modelling human long QT syndrome 3.
Volume: 578
Issue: Pt 1
Pages: 85-97
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Publication
21097662 | J:166438
First Author: Martin CA
Year: 2011
Journal: Am J Physiol Heart Circ Physiol
Title: Spatial and temporal heterogeneities are localized to the right ventricular outflow tract in a heterozygotic Scn5a mouse model.
Volume: 300
Issue: 2
Pages: H605-16
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Publication
34248669 | J:312594
 
First Author: Schroder EA
Year: 2021
Journal: Front Physiol
Title: Cardiomyocyte Deletion of Bmal1 Exacerbates QT- and RR-Interval Prolongation in Scn5a +/ΔKPQ Mice.
Volume: 12
Pages: 681011
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Publication
31666509 | J:281596
First Author: Man JCK
Year: 2019
Journal: Nat Commun
Title: An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo.
Volume: 10
Issue: 1
Pages: 4943
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Publication
26595809 | J:229825
First Author: Wan E
Year: 2016
Journal: J Clin Invest
Title: Aberrant sodium influx causes cardiomyopathy and atrial fibrillation in mice.
Volume: 126
Issue: 1
Pages: 112-22
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Publication
8541846 | J:45859
First Author: Wang Q
Year: 1995
Journal: Hum Mol Genet
Title: Cardiac sodium channel mutations in patients with long QT syndrome, an inherited cardiac arrhythmia.
Volume: 4
Issue: 9
Pages: 1603-7
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Publication
11533705 | J:71542
First Author: Nuyens D
Year: 2001
Journal: Nat Med
Title: Abrupt rate accelerations or premature beats cause life-threatening arrhythmias in mice with long-QT3 syndrome.
Volume: 7
Issue: 9
Pages: 1021-7
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Publication
22562703 | J:202661
First Author: Lowe JS
Year: 2012
Journal: Cardiovasc Res
Title: Increased late sodium current contributes to long QT-related arrhythmia susceptibility in female mice.
Volume: 95
Issue: 3
Pages: 300-7
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Publication
17145985 | J:128657
First Author: Remme CA
Year: 2006
Journal: Circulation
Title: Overlap syndrome of cardiac sodium channel disease in mice carrying the equivalent mutation of human SCN5A-1795insD.
Volume: 114
Issue: 24
Pages: 2584-94
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Publication
31614475 | J:290393
 
First Author: Casini S
Year: 2019
Journal: Int J Mol Sci
Title: Functional Consequences of the SCN5A-p.Y1977N Mutation within the PY Ubiquitylation Motif: Discrepancy between HEK293 Cells and Transgenic Mice.
Volume: 20
Issue: 20
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Publication
20110334 | J:175883
First Author: Fabritz L
Year: 2010
Journal: Cardiovasc Res
Title: Autonomic modulation and antiarrhythmic therapy in a model of long QT syndrome type 3.
Volume: 87
Issue: 1
Pages: 60-72
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Publication
28339646 | J:260835
First Author: Derangeon M
Year: 2017
Journal: Cardiovasc Res
Title: Transforming growth factor β receptor inhibition prevents ventricular fibrosis in a mouse model of progressive cardiac conduction disease.
Volume: 113
Issue: 5
Pages: 464-474
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Publication
17083109 | J:115269
First Author: Liu K
Year: 2006
Journal: Genesis
Title: Recombinase-mediated cassette exchange to rapidly and efficiently generate mice with human cardiac sodium channels.
Volume: 44
Issue: 11
Pages: 556-64
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Publication
16172272 | J:116845
First Author: van Veen TA
Year: 2005
Journal: Circulation
Title: Impaired impulse propagation in Scn5a-knockout mice: combined contribution of excitability, connexin expression, and tissue architecture in relation to aging.
Volume: 112
Issue: 13
Pages: 1927-35
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Publication
29457789 | J:260801
First Author: Zhang X
Year: 2018
Journal: J Clin Invest
Title: A common variant alters SCN5A-miR-24 interaction and associates with heart failure mortality.
Volume: 128
Issue: 3
Pages: 1154-1163
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Publication
20042427 | J:184957
First Author: Valdivia CR
Year: 2010
Journal: Cardiovasc Res
Title: Loss-of-function mutation of the SCN3B-encoded sodium channel {beta}3 subunit associated with a case of idiopathic ventricular fibrillation.
Volume: 86
Issue: 3
Pages: 392-400
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Publication
20174578 | J:301953
First Author: Leoni AL
Year: 2010
Journal: PLoS One
Title: Variable Na(v)1.5 protein expression from the wild-type allele correlates with the penetrance of cardiac conduction disease in the Scn5a(+/-) mouse model.
Volume: 5
Issue: 2
Pages: e9298
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Publication
29267949 | J:268240
First Author: Kelly A
Year: 2018
Journal: Cardiovasc Res
Title: Normal interventricular differences in tissue architecture underlie right ventricular susceptibility to conduction abnormalities in a mouse model of Brugada syndrome.
Volume: 114
Issue: 5
Pages: 724-736
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Publication
30144447 | J:266290
 
First Author: Montnach J
Year: 2018
Journal: J Mol Cell Cardiol
Title: Arrhythmias precede cardiomyopathy and remodeling of Ca2+ handling proteins in a novel model of long QT syndrome.
Volume: 123
Pages: 13-25
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Publication
38214908 | J:345780
First Author: Blair GA
Year: 2024
Journal: Am J Physiol Heart Circ Physiol
Title: Mannitol and hyponatremia regulate cardiac ventricular conduction in the context of sodium channel loss of function.
Volume: 326
Issue: 3
Pages: H724-H734
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Publication
22287583 | J:186583
First Author: Wu J
Year: 2012
Journal: Am J Physiol Heart Circ Physiol
Title: Altered sinoatrial node function and intra-atrial conduction in murine gain-of-function Scn5a+/ΔKPQ hearts suggest an overlap syndrome.
Volume: 302
Issue: 7
Pages: H1510-23
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Publication
21672931 | J:191708
First Author: Lemoine MD
Year: 2011
Journal: Cardiovasc Res
Title: Arrhythmogenic left atrial cellular electrophysiology in a murine genetic long QT syndrome model.
Volume: 92
Issue: 1
Pages: 67-74
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Publication
21566215 | J:185686
First Author: Atack TC
Year: 2011
Journal: Circ Res
Title: Informatic and functional approaches to identifying a regulatory region for the cardiac sodium channel.
Volume: 109
Issue: 1
Pages: 38-46
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Publication
32778883 | J:320917
First Author: Rivaud MR
Year: 2020
Journal: Europace
Title: Functional modulation of atrio-ventricular conduction by enhanced late sodium current and calcium-dependent mechanisms in Scn5a1798insD/+ mice.
Volume: 22
Issue: 10
Pages: 1579-1589
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Publication
21673812 | J:174959
First Author: Stein M
Year: 2011
Journal: PLoS One
Title: A 50% reduction of excitability but not of intercellular coupling affects conduction velocity restitution and activation delay in the mouse heart.
Volume: 6
Issue: 6
Pages: e20310
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Publication
15932895 | J:151611
First Author: Lei M
Year: 2005
Journal: J Physiol
Title: Sinus node dysfunction following targeted disruption of the murine cardiac sodium channel gene Scn5a.
Volume: 567
Issue: Pt 2
Pages: 387-400
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Publication
23872634 | J:280846
First Author: Bezzina CR
Year: 2013
Journal: Nat Genet
Title: Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death.
Volume: 45
Issue: 9
Pages: 1044-9
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Publication
23364267 | J:198010
First Author: Schroder EA
Year: 2013
Journal: Am J Physiol Cell Physiol
Title: The cardiomyocyte molecular clock, regulation of Scn5a, and arrhythmia susceptibility.
Volume: 304
Issue: 10
Pages: C954-65
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Publication
18591664 | J:198910
First Author: Ueda K
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Syntrophin mutation associated with long QT syndrome through activation of the nNOS-SCN5A macromolecular complex.
Volume: 105
Issue: 27
Pages: 9355-60
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Publication
24687990 | J:216531
First Author: Hartman ME
Year: 2014
Journal: FASEB J
Title: Myocardial deletion of transcription factor CHF1/Hey2 results in altered myocyte action potential and mild conduction system expansion but does not alter conduction system function or promote spontaneous arrhythmias.
Volume: 28
Issue: 7
Pages: 3007-15
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Publication
26187182 | J:239053
First Author: Glynn P
Year: 2015
Journal: Circulation
Title: Voltage-Gated Sodium Channel Phosphorylation at Ser571 Regulates Late Current, Arrhythmia, and Cardiac Function In Vivo.
Volume: 132
Issue: 7
Pages: 567-77
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Publication
19389723 | J:162186
First Author: Stein M
Year: 2009
Journal: Cardiovasc Res
Title: Combined reduction of intercellular coupling and membrane excitability differentially affects transverse and longitudinal cardiac conduction.
Volume: 83
Issue: 1
Pages: 52-60
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Publication
23661717 | J:213278
First Author: Boukens BJ
Year: 2013
Journal: Circ Res
Title: Reduced sodium channel function unmasks residual embryonic slow conduction in the adult right ventricular outflow tract.
Volume: 113
Issue: 2
Pages: 137-41
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Publication
18178574 | J:161910
First Author: Domínguez JN
Year: 2008
Journal: Cardiovasc Res
Title: Tissue distribution and subcellular localization of the cardiac sodium channel during mouse heart development.
Volume: 78
Issue: 1
Pages: 45-52
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Publication
19255801 | J:152116
First Author: Remme CA
Year: 2009
Journal: Basic Res Cardiol
Title: The cardiac sodium channel displays differential distribution in the conduction system and transmural heterogeneity in the murine ventricular myocardium.
Volume: 104
Issue: 5
Pages: 511-22
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Publication
24956219 | J:323796
 
First Author: Cai B
Year: 2014
Journal: J Mol Cell Cardiol
Title: Deletion of FoxO1 leads to shortening of QRS by increasing Na(+) channel activity through enhanced expression of both cardiac NaV1.5 and β3 subunit.
Volume: 74
Pages: 297-306
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Publication
- | J:2513
First Author: Klocke R
Year: 1992
Journal: Mouse Genome
Title: Chromosomal mapping of muscle-expressed sodium channel genes in the mouse
Volume: 90
Issue: 3
Pages: 433-35
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Publication
27766308 | J:243706
 
First Author: Choy L
Year: 2016
Journal: Int J Cardiol Heart Vasc
Title: Cardiac disease and arrhythmogenesis: Mechanistic insights from mouse models.
Volume: 12
Pages: 1-10
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Protein Coding Gene
MGP_CAROLIEiJ_G0032803 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0035421 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0035402 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0035335 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0035398 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0035106 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_98251 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0035921 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0034409 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0035073 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0035232 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0035179 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0035311 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0035220 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0035940 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0034115 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0034530 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0015670 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0033951 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
24705556 | J:212400
First Author: Zhang Y
Year: 2014
Journal: Am J Physiol Heart Circ Physiol
Title: Measurement and interpretation of electrocardiographic QT intervals in murine hearts.
Volume: 306
Issue: 11
Pages: H1553-7
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Publication
19407241 | J:172111
First Author: Remme CA
Year: 2009
Journal: Circ Res
Title: Genetically determined differences in sodium current characteristics modulate conduction disease severity in mice with cardiac sodium channelopathy.
Volume: 104
Issue: 11
Pages: 1283-92
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Publication
20854825 | J:171025
First Author: Scicluna BP
Year: 2011
Journal: J Mol Cell Cardiol
Title: Quantitative trait loci for electrocardiographic parameters and arrhythmia in the mouse.
Volume: 50
Issue: 3
Pages: 380-9
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Publication
28430892 | J:263303
First Author: Portero V
Year: 2017
Journal: Cardiovasc Res
Title: Anti-arrhythmic potential of the late sodium current inhibitor GS-458967 in murine Scn5a-1798insD+/- and human SCN5A-1795insD+/- iPSC-derived cardiomyocytes.
Volume: 113
Issue: 7
Pages: 829-838
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Publication
17082480 | J:129060
First Author: Fredj S
Year: 2006
Journal: Circ Res
Title: Altered Na+ channels promote pause-induced spontaneous diastolic activity in long QT syndrome type 3 myocytes.
Volume: 99
Issue: 11
Pages: 1225-32
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Publication
17023504 | J:134141
First Author: Stokoe KS
Year: 2007
Journal: J Physiol
Title: Effects of flecainide and quinidine on arrhythmogenic properties of Scn5a+/Delta murine hearts modelling long QT syndrome 3.
Volume: 578
Issue: Pt 1
Pages: 69-84
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Publication
25343952 | J:220782
First Author: Schroder EA
Year: 2014
Journal: Am J Physiol Heart Circ Physiol
Title: Light phase-restricted feeding slows basal heart rate to exaggerate the type-3 long QT syndrome phenotype in mice.
Volume: 307
Issue: 12
Pages: H1777-85
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Publication
28894151 | J:255390
First Author: Chadda KR
Year: 2017
Journal: Sci Rep
Title: The effects of ageing and adrenergic challenge on electrocardiographic phenotypes in a murine model of long QT syndrome type 3.
Volume: 7
Issue: 1
Pages: 11070
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Publication
11972032 | J:76331
First Author: Papadatos GA
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Slowed conduction and ventricular tachycardia after targeted disruption of the cardiac sodium channel gene Scn5a.
Volume: 99
Issue: 9
Pages: 6210-5
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Publication
15809371 | J:109689
First Author: Royer A
Year: 2005
Journal: Circulation
Title: Mouse model of SCN5A-linked hereditary Lenègre's disease: age-related conduction slowing and myocardial fibrosis.
Volume: 111
Issue: 14
Pages: 1738-46
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Publication
31291141 | J:279268
First Author: Finlay M
Year: 2019
Journal: Am J Physiol Cell Physiol
Title: Autonomic modulation of the electrical substrate in mice haploinsufficient for cardiac sodium channels: a model of the Brugada syndrome.
Volume: 317
Issue: 3
Pages: C576-C583
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Publication
19745168 | J:169955
First Author: Liu M
Year: 2009
Journal: Circ Res
Title: Cardiac Na+ current regulation by pyridine nucleotides.
Volume: 105
Issue: 8
Pages: 737-45
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Publication
23836691 | J:214178
First Author: Matthews GD
Year: 2013
Journal: J Physiol
Title: Action potential wavelength restitution predicts alternans and arrhythmia in murine Scn5a(+/-) hearts.
Volume: 591
Issue: 17
Pages: 4167-88
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