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Search results 1 to 100 out of 203 for Scn9a

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0.02s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Domain
Type: Family
Description: Sodium channel protein type 9 subunit alpha (also known as Nav1.7 or SCN9A) is strongly expressed in nociceptive neurons and plays a role in pain mechanisms, especially in the development of inflammatory pain [, , ]. It interacts with the ubiquitin-protein ligases Nedd4 and Nedd4-2, known to regulate receptors and ion transporters [].Nine voltage-gated sodium channels (Navs) are expressed in complex patterns in mammalian nerve and muscle. These channels mediate the influx of Na+ ions in response to local depolarising stimuli. Nav channels are composed of a pore-forming alpha-subunit associated with one or more auxiliary beta-subunits. The pore-forming alpha subunit is sufficient for functional expression, but the localisation, kinetics and voltage dependence of channel gating are modified by the beta subunits [, ].
Publication
First Author: Nassar MA
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain.
Volume: 101
Issue: 34
Pages: 12706-11
Publication
First Author: Cox JJ
Year: 2006
Journal: Nature
Title: An SCN9A channelopathy causes congenital inability to experience pain.
Volume: 444
Issue: 7121
Pages: 894-8
Publication
First Author: Zhang Q
Year: 2014
Journal: J Physiol
Title: Na+ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression.
Volume: 592
Issue: 21
Pages: 4677-96
Publication
First Author: Cox JJ
Year: 2010
Journal: Hum Mutat
Title: Congenital insensitivity to pain: novel SCN9A missense and in-frame deletion mutations.
Volume: 31
Issue: 9
Pages: E1670-86
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Kozak CA
Year: 1996
Journal: Mamm Genome
Title: Genetic mapping of the peripheral sodium channel genes, Scn9a and Scn10a, in the mouse.
Volume: 7
Issue: 10
Pages: 787-8
Publication
First Author: Singh NA
Year: 2009
Journal: PLoS Genet
Title: A role of SCN9A in human epilepsies, as a cause of febrile seizures and as a potential modifier of Dravet syndrome.
Volume: 5
Issue: 9
Pages: e1000649
Publication
First Author: Fotia AB
Year: 2004
Journal: J Biol Chem
Title: Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.
Volume: 279
Issue: 28
Pages: 28930-5
Protein
Organism: Mus musculus
Length: 1984  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1973  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1975  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1973  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1973  
Fragment?: false
Protein
Organism: Mus musculus
Length: 478  
Fragment?: true
Protein
Organism: Mus musculus
Length: 1973  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1932  
Fragment?: false
Protein
Organism: Mus musculus
Length: 118  
Fragment?: true
Protein
Organism: Mus musculus
Length: 1984  
Fragment?: false
Publication
First Author: Catterall WA
Year: 2000
Journal: Neuron
Title: From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels.
Volume: 26
Issue: 1
Pages: 13-25
Publication
First Author: Catterall WA
Year: 2005
Journal: Pharmacol Rev
Title: International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.
Volume: 57
Issue: 4
Pages: 397-409
Publication
First Author: Branco T
Year: 2016
Journal: Cell
Title: Near-Perfect Synaptic Integration by Nav1.7 in Hypothalamic Neurons Regulates Body Weight.
Volume: 165
Issue: 7
Pages: 1749-1761
Publication
First Author: Beckers MC
Year: 1996
Journal: Genomics
Title: A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2.
Volume: 36
Issue: 1
Pages: 202-5
Publication  
First Author: Minett MS
Year: 2015
Journal: Nat Commun
Title: Endogenous opioids contribute to insensitivity to pain in humans and mice lacking sodium channel Nav1.7.
Volume: 6
Pages: 8967
Publication
First Author: Weiss J
Year: 2011
Journal: Nature
Title: Loss-of-function mutations in sodium channel Nav1.7 cause anosmia.
Volume: 472
Issue: 7342
Pages: 186-90
Publication  
First Author: Minett MS
Year: 2012
Journal: Nat Commun
Title: Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons.
Volume: 3
Pages: 791
Publication
First Author: Shields SD
Year: 2018
Journal: J Neurosci
Title: Insensitivity to Pain upon Adult-Onset Deletion of Nav1.7 or Its Blockade with Selective Inhibitors.
Volume: 38
Issue: 47
Pages: 10180-10201
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Kanellopoulos AH
Year: 2018
Journal: EMBO J
Title: Mapping protein interactions of sodium channel NaV1.7 using epitope-tagged gene-targeted mice.
Volume: 37
Issue: 3
Pages: 427-445
Publication
First Author: Alles SRA
Year: 2020
Journal: Sci Adv
Title: Sensory neuron-derived NaV1.7 contributes to dorsal horn neuron excitability.
Volume: 6
Issue: 8
Pages: eaax4568
Publication
First Author: Gingras J
Year: 2014
Journal: PLoS One
Title: Global Nav1.7 knockout mice recapitulate the phenotype of human congenital indifference to pain.
Volume: 9
Issue: 9
Pages: e105895
Publication
First Author: D'Arcangelo G
Year: 1993
Journal: J Cell Biol
Title: Neuronal growth factor regulation of two different sodium channel types through distinct signal transduction pathways.
Volume: 122
Issue: 4
Pages: 915-21
Publication
First Author: McCormack K
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels.
Volume: 110
Issue: 29
Pages: E2724-32
Publication
First Author: Yang S
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Discovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models.
Volume: 110
Issue: 43
Pages: 17534-9
GXD Expression      
Probe: MGI:3625118
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:3625119
Age: postnatal
Detected: true
Specimen Num: 15
GXD Expression      
Probe: MGI:3625118
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3625119
Age: postnatal
Detected: false
Specimen Num: 14
GXD Expression      
Probe: MGI:3625118
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:3625119
Age: postnatal
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:3625118
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267828
Stage: TS28
Assay Id: MGI:3625119
Age: postnatal
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3625118
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1755028
Stage: TS28
Assay Id: MGI:3625119
Age: postnatal
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3625118
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3519728
Stage: TS28
Assay Id: MGI:3625119
Age: postnatal
Detected: true
Specimen Num: 30
GXD Expression      
Probe: MGI:3625118
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1925228
Stage: TS28
Assay Id: MGI:3625119
Age: postnatal
Detected: true
Specimen Num: 29
GXD Expression      
Probe: MGI:3625118
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3552328
Stage: TS28
Assay Id: MGI:3625119
Age: postnatal
Detected: true
Specimen Num: 17
GXD Expression      
Probe: MGI:3625118
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1720228
Stage: TS28
Assay Id: MGI:3625119
Age: postnatal
Detected: true
Specimen Num: 20
GXD Expression      
Probe: MGI:3625118
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:3625119
Age: postnatal
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3625118
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:3625119
Age: postnatal
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3625118
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:3625119
Age: postnatal
Detected: false
Specimen Num: 11
GXD Expression      
Probe: MGI:3625118
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:3625119
Age: postnatal
Detected: true
Specimen Num: 25
GXD Expression      
Probe: MGI:3625118
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3625119
Age: postnatal
Detected: true
Specimen Num: 10
GXD Expression      
Probe: MGI:3625118
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3283428
Stage: TS28
Assay Id: MGI:3625119
Age: postnatal
Detected: true
Specimen Num: 28
GXD Expression      
Probe: MGI:3625118
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1842628
Stage: TS28
Assay Id: MGI:3625119
Age: postnatal
Detected: true
Specimen Num: 23
GXD Expression      
Probe: MGI:3625118
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3276028
Stage: TS28
Assay Id: MGI:3625119
Age: postnatal
Detected: false
Specimen Num: 18
GXD Expression      
Probe: MGI:3625118
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Male
Emaps: EMAPS:2979428
Stage: TS28
Assay Id: MGI:3625119
Age: postnatal
Detected: true
Specimen Num: 34
GXD Expression      
Probe: MGI:3625118
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3625119
Age: postnatal
Detected: false
Specimen Num: 12
GXD Expression      
Probe: MGI:3625118
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1718528
Stage: TS28
Assay Id: MGI:3625119
Age: postnatal
Detected: true
Specimen Num: 26
GXD Expression      
Probe: MGI:3625118
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Male
Emaps: EMAPS:1918028
Stage: TS28
Assay Id: MGI:3625119
Age: postnatal
Detected: true
Specimen Num: 33
GXD Expression      
Probe: MGI:3625118
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750328
Stage: TS28
Assay Id: MGI:3625119
Age: postnatal
Detected: true
Specimen Num: 13
GXD Expression      
Probe: MGI:3625118
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1775128
Stage: TS28
Assay Id: MGI:3625119
Age: postnatal
Detected: true
Specimen Num: 24
GXD Expression      
Probe: MGI:3625118
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3625119
Age: postnatal
Detected: true
Specimen Num: 31
GXD Expression      
Probe: MGI:3625118
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Male
Emaps: EMAPS:1928728
Stage: TS28
Assay Id: MGI:3625119
Age: postnatal
Detected: true
Specimen Num: 35
GXD Expression      
Probe: MGI:3625118
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:3625119
Age: postnatal
Detected: true
Specimen Num: 16
GXD Expression      
Probe: MGI:3625118
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1832128
Stage: TS28
Assay Id: MGI:3625119
Age: postnatal
Detected: true
Specimen Num: 21
GXD Expression      
Probe: MGI:3625118
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3599828
Stage: TS28
Assay Id: MGI:3625119
Age: postnatal
Detected: true
Specimen Num: 22
GXD Expression      
Probe: MGI:3625118
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280928
Stage: TS28
Assay Id: MGI:3625119
Age: postnatal
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3625118
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:3625119
Age: postnatal
Detected: true
Specimen Num: 19
GXD Expression      
Probe: MGI:3625118
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1702128
Stage: TS28
Assay Id: MGI:3625119
Age: postnatal
Detected: true
Specimen Num: 27
GXD Expression      
Probe: MGI:3625118
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Male
Emaps: EMAPS:1929028
Stage: TS28
Assay Id: MGI:3625119
Age: postnatal
Detected: true
Specimen Num: 32
GXD Expression      
Probe: MGI:3625118
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915328
Stage: TS28
Assay Id: MGI:3625119
Age: postnatal
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:3625118
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3592628
Stage: TS28
Assay Id: MGI:3625119
Age: postnatal
Detected: true
Specimen Num: 38
GXD Expression      
Probe: MGI:3625118
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Stage: TS28
Assay Id: MGI:3625119
Age: postnatal
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:3625118
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Absent
Sex: Female
Emaps: EMAPS:2991528
Stage: TS28
Assay Id: MGI:3625119
Age: postnatal
Detected: false
Specimen Num: 37
GXD Expression      
Probe: MGI:3625118
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3625119
Age: postnatal
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3625118
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:3625119
Age: postnatal
Detected: true
Specimen Num: 36
GXD Expression        
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Male
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:3639215
Age: postnatal day 56
Detected: false
Specimen Num: 10
GXD Expression        
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Male
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3639215
Age: postnatal day 56
Detected: false
Specimen Num: 10
GXD Expression        
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Female
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:3639215
Age: postnatal day 56
Detected: false
Specimen Num: 11
GXD Expression  
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Weak
Sex: Male
Emaps: EMAPS:3267828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3639215
Age: postnatal day 56
Image: Mouse 214956 - Image 96548023
Note: There is occasional staining in the brainstem.
Detected: true
Specimen Num: 3
GXD Expression  
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Weak
Sex: Male
Emaps: EMAPS:3267828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3639215
Age: postnatal day 56
Image: Mouse 214956 - Image 96550319
Note: There is occasional staining in the brainstem.
Detected: true
Specimen Num: 4
GXD Expression  
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Moderate
Sex: Male
Emaps: EMAPS:3267828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3639215
Age: postnatal day 68
Image: Mouse 215796 - Image 96571818
Note: There is scattered expression in the brainstem.
Detected: true
Specimen Num: 13
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Weak
Sex: Female
Emaps: EMAPS:3267828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3639215
Age: postnatal day 56
Note: There is scattered expression in the brainstem.
Detected: true
Specimen Num: 11