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Search results 1 to 81 out of 81 for Scnm1

0.035s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Domain
Type: Family
Description: SCNM1 (sodium channel modifier 1) is an accessory component of the U1 splicesome protein complex. It interacts with the spliceosomal Sm and U1-70K proteins and has a direct role in splicing []. It was originally identified as a disease modifier gene required forefficient splicing of a mutant splice donor site in the sodium channel Scn8a [].
Publication
First Author: Howell VM
Year: 2007
Journal: Hum Mol Genet
Title: Evidence for a direct role of the disease modifier SCNM1 in splicing.
Volume: 16
Issue: 20
Pages: 2506-16
Publication
First Author: Buchner DA
Year: 2003
Journal: Science
Title: SCNM1, a putative RNA splicing factor that modifies disease severity in mice.
Volume: 301
Issue: 5635
Pages: 967-9
Publication
First Author: Howell VM
Year: 2008
Journal: Genetics
Title: A targeted deleterious allele of the splicing factor SCNM1 in the mouse.
Volume: 180
Issue: 3
Pages: 1419-27
Publication
First Author: Sprunger LK
Year: 1999
Journal: Hum Mol Genet
Title: Dystonia associated with mutation of the neuronal sodium channel Scn8a and identification of the modifier locus Scnm1 on mouse chromosome 3.
Volume: 8
Issue: 3
Pages: 471-9
Publication
First Author: Buchner DA
Year: 2003
Journal: Genomics
Title: High-resolution mapping of the sodium channel modifier Scnm1 on mouse chromosome 3 and identification of a 1.3-kb recombination hot spot.
Volume: 82
Issue: 4
Pages: 452-9
Protein
Organism: Mus musculus
Length: 186  
Fragment?: false
Protein
Organism: Mus musculus
Length: 229  
Fragment?: false
Publication
First Author: Kearney JA
Year: 2002
Journal: Hum Mol Genet
Title: Molecular and pathological effects of a modifier gene on deficiency of the sodium channel Scn8a (Na(v)1.6).
Volume: 11
Issue: 22
Pages: 2765-75
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Koay G
Year: 2002
Journal: Hear Res
Title: Behavioral audiograms of homozygous med(J) mutant mice with sodium channel deficiency and unaffected controls.
Volume: 171
Issue: 1-2
Pages: 111-118
Publication  
First Author: Michaud EJ
Year: 2005
Journal: BMC Genomics
Title: Efficient gene-driven germ-line point mutagenesis of C57BL/6J mice.
Volume: 6
Pages: 164
Publication      
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication          
First Author: MGD Nomenclature Committee
Year: 1995
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics, the Protein Information Resource and the Protein Ontology Consortium
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Protein Domain
Type: Domain
Description: This entry represents the C-terminal acidic region of eukaryotic sodium channel modifier protein 1 (SCNM1). Deletion of this region affects the splicing and normal activity of the sodium channel Nav1.6 from gene Scn8a []. SCNM1 belongs to the U1C subfamily of RNA binding proteins that is commonly found in RNA-processing proteins, suggesting that SCNM1 is involved in splicing activities. SCNM1 and LUC7L2 associate with the mammalian spliceosomal subunit U1 snRNP [].
Protein Domain
Type: Domain
Description: This C2H2 type zinc-finger is found at the N terminus of SCNM1, sodium channel modifier protein 1 []. Phylogenetic analysis of these zinc finger sequences places SCNM1 within the U1C subfamily of RNA binding proteins that is commonly found in RNA-processing proteins, suggesting that SCNM1 is involved in splicing activities [].
Publication  
First Author: Buchner DA
Year: 2003
Journal: Gene
Title: TSRC1, a widely expressed gene containing seven thrombospondin type I repeats.
Volume: 307
Pages: 23-30
Allele  
Name: sodium channel, voltage-gated, type VIII, alpha; motor end plate disease Jackson
Allele Type: Spontaneous
Publication categories: ProxyCollection
Publication
First Author: Kohrman DC
Year: 1996
Journal: J Biol Chem
Title: Mutation detection in the med and medJ alleles of the sodium channel Scn8a. Unusual splicing due to a minor class AT-AC intron.
Volume: 271
Issue: 29
Pages: 17576-81
Strain
Attribute String: mutant strain
Strain
Attribute String: mutant strain
Publication  
First Author: Sidman RL
Year: 1979
Journal: Ann N Y Acad Sci
Title: Inherited muscle and nerve diseases in mice: a tabulation with commentary.
Volume: 317
Pages: 497-505
Publication
First Author: Pal D
Year: 2015
Journal: PLoS One
Title: Reduced Nav1.6 Sodium Channel Activity in Mice Increases In Vivo Sensitivity to Volatile Anesthetics.
Volume: 10
Issue: 8
Pages: e0134960
Publication
First Author: Chen K
Year: 1999
Journal: Brain Res
Title: Reduced spontaneous activity in the dorsal cochlear nucleus of Scn8a mutant mice.
Volume: 847
Issue: 1
Pages: 85-9
Publication  
First Author: Lane PW
Year: 1976
Journal: Mouse News Lett
Title: Scn8a - motor end-plate disease-Jackson
Volume: 54
Pages: 40
Publication  
First Author: Sun Y
Year: 2007
Journal: Brain Res
Title: Comparison of gamma-aminobutyrate receptors in the medial vestibular nucleus of control and Scn8a mutant mice.
Volume: 1186
Pages: 188-93
Publication
First Author: Hamann M
Year: 2003
Journal: Exp Neurol
Title: Motor disturbances in mice with deficiency of the sodium channel gene Scn8a show features of human dystonia.
Volume: 184
Issue: 2
Pages: 830-8
Publication
First Author: Papiernik M
Year: 1982
Journal: Clin Exp Immunol
Title: Impairment of T lymphocyte functions in mice with motor end-plate disease.
Volume: 48
Issue: 2
Pages: 429-36
Genotype
Symbol: Scn8a/Scn8a Scnm1/Scnm1
Background: involves: C57BL/6J
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Scn8a/Scn8a Scnm1/Scnm1
Background: involves: C57BL/6 * FVB * SJL * STOCK Krt71
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Scn8a/Scn8a Scnm1/Scnm1
Background: involves: C57BL/6J * STOCK Krt71
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Scn8a/Scn8a Scnm1/Scnm1<+>
Background: involves: C3HeB/FeJ * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Scn8a/Scn8a Scnm1/Scnm1
Background: involves: C57BL/6 * STOCK Krt71
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Scn8a/Scn8a
Background: involves: STOCK Krt71
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Scn8a/Scn8a
Background: involves: C3H
Zygosity: hm
Has Mutant Allele: true