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Search results 1 to 91 out of 91 for Secisbp2

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Domain
Type: Family
Description: Selenocysteine insertion sequence-binding protein 2 (SECISBP2) is required for the incorporation of the amino acid selenocysteine (Sec) into proteins during translation. The mRNA triplet UGA is usually a stop codon, but the presence of a Sec insertion sequence element (SECIS) in the 3'-untranslated region of an mRNA, and its binding to SECISBP2, leads to insertion of Sec into the protein instead. Mutations in the SECISBP2 gene that alter the amino acid sequence or cause splicing defects lead to abnormal thyroid hormone metabolism. A splice variant of SECISBP2 is localized to the mitochondrion rather than the nucleus [].This entry also includes selenocysteine insertion sequence-binding protein 2-like (SECISBP2L), which also binds SECIS, but in mammals does not lead to incorporation of Sec into proteins, because it lacks the SECIS dependent domain association that is found in SECISBP2. An invertebrate orthologue is fully competent for Sec incorporation, however [].Homologues are also known from bacteria.
Publication
First Author: Seeher S
Year: 2014
Journal: Antioxid Redox Signal
Title: Secisbp2 is essential for embryonic development and enhances selenoprotein expression.
Volume: 21
Issue: 6
Pages: 835-49
Publication
First Author: Papp LV
Year: 2008
Journal: Nucleic Acids Res
Title: Functional characterization of alternatively spliced human SECISBP2 transcript variants.
Volume: 36
Issue: 22
Pages: 7192-206
Publication
First Author: Fradejas-Villar N
Year: 2017
Journal: Nucleic Acids Res
Title: The RNA-binding protein Secisbp2 differentially modulates UGA codon reassignment and RNA decay.
Volume: 45
Issue: 7
Pages: 4094-4107
Publication
First Author: Zhao W
Year: 2019
Journal: J Biol Chem
Title: Ribosome profiling of selenoproteins in vivo reveals consequences of pathogenic Secisbp2 missense mutations.
Volume: 294
Issue: 39
Pages: 14185-14200
Protein
Organism: Mus musculus
Length: 473  
Fragment?: false
Protein
Organism: Mus musculus
Length: 414  
Fragment?: false
Protein
Organism: Mus musculus
Length: 556  
Fragment?: true
Protein
Organism: Mus musculus
Length: 491  
Fragment?: false
Publication
First Author: Donovan J
Year: 2012
Journal: PLoS One
Title: Selenocysteine insertion sequence binding protein 2L is implicated as a novel post-transcriptional regulator of selenoprotein expression.
Volume: 7
Issue: 4
Pages: e35581
Protein
Organism: Mus musculus
Length: 1086  
Fragment?: false
Protein
Organism: Mus musculus
Length: 427  
Fragment?: true
Protein
Organism: Mus musculus
Length: 1089  
Fragment?: false
Protein
Organism: Mus musculus
Length: 858  
Fragment?: false
Protein
Organism: Mus musculus
Length: 858  
Fragment?: false
Protein
Organism: Mus musculus
Length: 428  
Fragment?: true
Publication
First Author: Seeher S
Year: 2014
Journal: Biochem J
Title: Impaired selenoprotein expression in brain triggers striatal neuronal loss leading to co-ordination defects in mice.
Volume: 462
Issue: 1
Pages: 67-75
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Chellan B
Year: 2020
Journal: Sci Rep
Title: Selenocysteine insertion sequence binding protein 2 (Sbp2) in the sex-specific regulation of selenoprotein gene expression in mouse pancreatic islets.
Volume: 10
Issue: 1
Pages: 18568
Publication  
First Author: Fujisawa H
Year: 2020
Journal: Endocrinology
Title: Role of the Thyroid Gland in Expression of the Thyroid Phenotype of Sbp2-Deficient Mice.
Volume: 161
Issue: 5
GXD Expression  
Probe: MGI:3585043
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3586126
Age: postnatal day 6-7
Image: P6/7
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:3585043
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3586126
Age: postnatal day 8-10
Image: P8/10
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:3585043
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3586126
Age: postnatal day 6
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:3585043
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915727
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3586126
Age: postnatal day 2-3
Note: Expression was detected in the outer neuroblastic layer.
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:3585043
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3586126
Age: postnatal day 4-5
Image: P4/5
Note: Expression was detected in the outer neuroblastic layer.
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:3585043
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:3586126
Age: postnatal day 6-7
Image: P6/7
Note: Expression was detected in the inner segment.
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:3585043
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3586126
Age: postnatal day 8-10
Image: P8/10
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:3585043
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Male
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3586126
Age: postnatal adult
Detected: true
Specimen Num: 5
Publication
First Author: Gonzalez-Flores JN
Year: 2012
Journal: J Biol Chem
Title: The selenocysteine-specific elongation factor contains a novel and multi-functional domain.
Volume: 287
Issue: 46
Pages: 38936-45
Publication
First Author: Fu J
Year: 2017
Journal: Endocrinology
Title: Thyroid Hormone Metabolism Defects in a Mouse Model of SBP2 Deficiency.
Volume: 158
Issue: 12
Pages: 4317-4330
Publication
First Author: Wang N
Year: 2019
Journal: Sci Adv
Title: SBP2 deficiency in adipose tissue macrophages drives insulin resistance in obesity.
Volume: 5
Issue: 8
Pages: eaav0198
Publication
First Author: Gribling-Burrer AS
Year: 2017
Journal: Nucleic Acids Res
Title: SECIS-binding protein 2 interacts with the SMN complex and the methylosome for selenoprotein mRNP assembly and translation.
Volume: 45
Issue: 9
Pages: 5399-5413
Publication      
First Author: Mouse Genome Informatics and the Europhenome Mouse Phenotyping Resource
Year: 2010
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from Europhenome
Publication
First Author: Cobellis G
Year: 2005
Journal: Nucleic Acids Res
Title: Tagging genes with cassette-exchange sites.
Volume: 33
Issue: 4
Pages: e44
Publication
First Author: Pagliarini DJ
Year: 2008
Journal: Cell
Title: A mitochondrial protein compendium elucidates complex I disease biology.
Volume: 134
Issue: 1
Pages: 112-23
Publication        
First Author: Mouse Genome Database and National Center for Biotechnology Information Editorial Staff Collaboration
Year: 2001
Title: LocusLink Collaboration
Publication
First Author: Blackshaw S
Year: 2004
Journal: PLoS Biol
Title: Genomic analysis of mouse retinal development.
Volume: 2
Issue: 9
Pages: E247
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
Publication
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
Publication
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication
First Author: Copeland PR
Year: 2019
Journal: J Biol Chem
Title: Gained in translation: The power of digging deep into disease models.
Volume: 294
Issue: 39
Pages: 14201-14202