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Search results 1 to 100 out of 102 for Secisbp2

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Hits by Strain

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Type Details Score
Gene
79048 | SECISBP2
Type: gene
Organism: human
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Gene
511202 | SECISBP2
Type: gene
Organism: cattle
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Gene
426815 | SECISBP2
Type: gene
Organism: chicken
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Gene
553399 | secisbp2
Type: gene
Organism: zebrafish
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Gene
697442 | SECISBP2
Type: gene
Organism: macaque, rhesus
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Gene
100036714 | secisbp2
Type: gene
Organism: frog, western clawed
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Gene
79049 | Secisbp2
Type: gene
Organism: rat
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Gene
476351 | SECISBP2
Type: gene
Organism: dog, domestic
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Gene
464583 | SECISBP2
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:1922670 | Secisbp2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR040051 | SECISBP2
Type: Family
Description: Selenocysteine insertion sequence-binding protein 2 (SECISBP2) is required for the incorporation of the amino acid selenocysteine (Sec) into proteins during translation. The mRNA triplet UGA is usually a stop codon, but the presence of a Sec insertion sequence element (SECIS) in the 3'-untranslated region of an mRNA, and its binding to SECISBP2, leads to insertion of Sec into the protein instead. Mutations in the SECISBP2 gene that alter the amino acid sequence or cause splicing defects lead to abnormal thyroid hormone metabolism. A splice variant of SECISBP2 is localized to the mitochondrion rather than the nucleus [].This entry also includes selenocysteine insertion sequence-binding protein 2-like (SECISBP2L), which also binds SECIS, but in mammals does not lead to incorporation of Sec into proteins, because it lacks the SECIS dependent domain association that is found in SECISBP2. An invertebrate orthologue is fully competent for Sec incorporation, however [].Homologues are also known from bacteria.
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Publication
24274065 | J:213080
First Author: Seeher S
Year: 2014
Journal: Antioxid Redox Signal
Title: Secisbp2 is essential for embryonic development and enhances selenoprotein expression.
Volume: 21
Issue: 6
Pages: 835-49
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Publication
19004874 | -
First Author: Papp LV
Year: 2008
Journal: Nucleic Acids Res
Title: Functional characterization of alternatively spliced human SECISBP2 transcript variants.
Volume: 36
Issue: 22
Pages: 7192-206
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Publication
27956496 | J:247130
First Author: Fradejas-Villar N
Year: 2017
Journal: Nucleic Acids Res
Title: The RNA-binding protein Secisbp2 differentially modulates UGA codon reassignment and RNA decay.
Volume: 45
Issue: 7
Pages: 4094-4107
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Publication
31350336 | J:282851
First Author: Zhao W
Year: 2019
Journal: J Biol Chem
Title: Ribosome profiling of selenoproteins in vivo reveals consequences of pathogenic Secisbp2 missense mutations.
Volume: 294
Issue: 39
Pages: 14185-14200
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Protein
Q8C7M0
Organism: Mus musculus/domesticus
Length: 491  
Fragment?: false
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Protein
Q8BYU9
Organism: Mus musculus/domesticus
Length: 414  
Fragment?: false
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Protein
Q501P3
Organism: Mus musculus/domesticus
Length: 473  
Fragment?: false
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Protein
Q3TEC4
Organism: Mus musculus/domesticus
Length: 556  
Fragment?: true
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Publication
22530054 | -
First Author: Donovan J
Year: 2012
Journal: PLoS One
Title: Selenocysteine insertion sequence binding protein 2L is implicated as a novel post-transcriptional regulator of selenoprotein expression.
Volume: 7
Issue: 4
Pages: e35581
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Protein
Q6A098
Organism: Mus musculus/domesticus
Length: 1086  
Fragment?: false
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Protein
Q3U1C4
Organism: Mus musculus/domesticus
Length: 858  
Fragment?: false
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Protein
F6QQ13
Organism: Mus musculus/domesticus
Length: 428  
Fragment?: true
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Protein
Q6IR00
Organism: Mus musculus/domesticus
Length: 427  
Fragment?: true
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Protein
Q3TGQ4
Organism: Mus musculus/domesticus
Length: 858  
Fragment?: false
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Protein
A2AQE2
Organism: Mus musculus/domesticus
Length: 1089  
Fragment?: false
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Publication
38042913 | J:343229
First Author: Schoenmakers E
Year: 2023
Journal: Nat Commun
Title: Selenoprotein deficiency disorder predisposes to aortic aneurysm formation.
Volume: 14
Issue: 1
Pages: 7994
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Publication
24844465 | J:213480
First Author: Seeher S
Year: 2014
Journal: Biochem J
Title: Impaired selenoprotein expression in brain triggers striatal neuronal loss leading to co-ordination defects in mice.
Volume: 462
Issue: 1
Pages: 67-75
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Protein Coding Gene
MGP_CAROLIEiJ_G0018518 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0020552 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0020506 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0020484 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0020502 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0020301 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1922670 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0020936 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0019815 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0020261 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0020384 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0020363 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0020460 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0020392 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0020979 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0019572 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0019877 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0019584 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0019399 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
33122797 | J:298925
First Author: Chellan B
Year: 2020
Journal: Sci Rep
Title: Selenocysteine insertion sequence binding protein 2 (Sbp2) in the sex-specific regulation of selenoprotein gene expression in mouse pancreatic islets.
Volume: 10
Issue: 1
Pages: 18568
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Publication
31826256 | J:296085
 
First Author: Fujisawa H
Year: 2020
Journal: Endocrinology
Title: Role of the Thyroid Gland in Expression of the Thyroid Phenotype of Sbp2-Deficient Mice.
Volume: 161
Issue: 5
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GXD Expression
GXD Expression
 
Probe: MGI:3585043
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3586126
Age: postnatal day 6-7
Image: P6/7
Specimen Label: P6/7
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:3585043
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3586126
Age: postnatal day 8-10
Image: P8/10
Specimen Label: P8/10
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:3585043
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3586126
Age: postnatal day 6
Specimen Label: CNS
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:3585043
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915727
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3586126
Age: postnatal day 2-3
Note: Expression was detected in the outer neuroblastic layer.
Specimen Label: P2/3
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:3585043
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3586126
Age: postnatal day 4-5
Image: P4/5
Note: Expression was detected in the outer neuroblastic layer.
Specimen Label: P4/5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:3585043
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:3586126
Age: postnatal day 6-7
Image: P6/7
Note: Expression was detected in the inner segment.
Specimen Label: P6/7
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:3585043
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3586126
Age: postnatal day 8-10
Image: P8/10
Specimen Label: P8/10
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:3585043
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Male
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3586126
Age: postnatal adult
Specimen Label: Adult
Detected: true
Specimen Num: 5
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Publication
22992746 | J:192960
First Author: Gonzalez-Flores JN
Year: 2012
Journal: J Biol Chem
Title: The selenocysteine-specific elongation factor contains a novel and multi-functional domain.
Volume: 287
Issue: 46
Pages: 38936-45
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Publication
29029094 | J:251875
First Author: Fu J
Year: 2017
Journal: Endocrinology
Title: Thyroid Hormone Metabolism Defects in a Mouse Model of SBP2 Deficiency.
Volume: 158
Issue: 12
Pages: 4317-4330
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Publication
31453320 | J:287692
First Author: Wang N
Year: 2019
Journal: Sci Adv
Title: SBP2 deficiency in adipose tissue macrophages drives insulin resistance in obesity.
Volume: 5
Issue: 8
Pages: eaav0198
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Publication
28115638 | J:249583
First Author: Gribling-Burrer AS
Year: 2017
Journal: Nucleic Acids Res
Title: SECIS-binding protein 2 interacts with the SMN complex and the methylosome for selenoprotein mRNP assembly and translation.
Volume: 45
Issue: 9
Pages: 5399-5413
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:165965
     
First Author: Mouse Genome Informatics and the Europhenome Mouse Phenotyping Resource
Year: 2010
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from Europhenome
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Publication
15741177 | J:126097
First Author: Cobellis G
Year: 2005
Journal: Nucleic Acids Res
Title: Tagging genes with cassette-exchange sites.
Volume: 33
Issue: 4
Pages: e44
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Publication
18614015 | J:151002
First Author: Pagliarini DJ
Year: 2008
Journal: Cell
Title: A mitochondrial protein compendium elucidates complex I disease biology.
Volume: 134
Issue: 1
Pages: 112-23
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Publication
- | J:66660
       
First Author: Mouse Genome Database and National Center for Biotechnology Information Editorial Staff Collaboration
Year: 2001
Title: LocusLink Collaboration
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Publication
30973865 | J:274872
First Author: Ingham NJ
Year: 2019
Journal: PLoS Biol
Title: Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Volume: 17
Issue: 4
Pages: e3000194
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Publication
15226823 | J:93300
First Author: Blackshaw S
Year: 2004
Journal: PLoS Biol
Title: Genomic analysis of mouse retinal development.
Volume: 2
Issue: 9
Pages: E247
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
- | J:80001
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:155856
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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HT Experiment
GSE84112 | Global analysis of selenoprotein expression reveals differential roles for Secisbp2 in UGA redefinition and mRNA stabilization
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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