Type |
Details |
Score |
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
97
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
425
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
432
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
204
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Röseler S |
Year: |
2011 |
Journal: |
Biol Chem |
Title: |
Lethal phenotype of mice carrying a Sept11 null mutation. |
Volume: |
392 |
Issue: |
8-9 |
Pages: |
779-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bläser S |
Year: |
2006 |
Journal: |
J Pathol |
Title: |
Human endothelial cell septins: SEPT11 is an interaction partner of SEPT5. |
Volume: |
210 |
Issue: |
1 |
Pages: |
103-10 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
431
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
425
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
429
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Buser AM |
Year: |
2009 |
Journal: |
Mol Cell Neurosci |
Title: |
The septin cytoskeleton in myelinating glia. |
Volume: |
40 |
Issue: |
2 |
Pages: |
156-66 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shen YR |
Year: |
2020 |
Journal: |
Mol Hum Reprod |
Title: |
The SEPT12 complex is required for the establishment of a functional sperm head-tail junction. |
Volume: |
26 |
Issue: |
6 |
Pages: |
402-412 |
|
•
•
•
•
•
|
Publication |
First Author: |
Beites CL |
Year: |
1999 |
Journal: |
Nat Neurosci |
Title: |
The septin CDCrel-1 binds syntaxin and inhibits exocytosis. |
Volume: |
2 |
Issue: |
5 |
Pages: |
434-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Amin ND |
Year: |
2008 |
Journal: |
J Neurosci |
Title: |
Cyclin-dependent kinase 5 phosphorylation of human septin SEPT5 (hCDCrel-1) modulates exocytosis. |
Volume: |
28 |
Issue: |
14 |
Pages: |
3631-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Taniguchi M |
Year: |
2007 |
Journal: |
J Biol Chem |
Title: |
Phosphorylation of adult type Sept5 (CDCrel-1) by cyclin-dependent kinase 5 inhibits interaction with syntaxin-1. |
Volume: |
282 |
Issue: |
11 |
Pages: |
7869-76 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Septin 5 (SEPT5) belongs to the septin family. Septin 5, also known as CDCrel-1, is predominantly expressed in the nervous system, co-localises with synaptic vesicles and is involved in exocytosis []. In humans, its role in exocytotic secretion that is modulated by Cdk5 phosphorylation [, ]. SEPT5 interacts with SEPT8 and SEPT11. The complex formed by SEPT5 and SEPT11 is involved in the exocytosis mechanism in human umbilical vein endothelial cells (HUVECs) [].Septins were first discovered in budding yeast as a major component of bud neck filaments during cell septation [, ]. Later, its homologues were identified in nearly all eukaryotes, including humans. They are all GTP-binding proteins that are involved in diverse cellular functions, including cell cycle progression, vesicle trafficking, cytokinesis, cell migration, membrane dynamics, and chromosome segregation [, ]. Similar to cytoskeleton components such as actins and tubulins, they can assemble into filaments and bundles. However, unlike actin filaments and microtubules, septin filaments are not polar, similarly to intermediate filaments []. The number of septin genes per organism is variable: S. cerevisiae has seven and humans have 13 (SEPT1-12 and SEPT14; SEPT13 is a pseudogene now called SEPT7P2) []. All septins can form heteromeric complexes, which associate to form higher-order structures, including filaments, rings and cage-like formations [, ]. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
169
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
369
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
248
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
378
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
268
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
365
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
381
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Byers B |
Year: |
1976 |
Journal: |
J Cell Biol |
Title: |
A highly ordered ring of membrane-associated filaments in budding yeast. |
Volume: |
69 |
Issue: |
3 |
Pages: |
717-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mostowy S |
Year: |
2012 |
Journal: |
Nat Rev Mol Cell Biol |
Title: |
Septins: the fourth component of the cytoskeleton. |
Volume: |
13 |
Issue: |
3 |
Pages: |
183-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hall PA |
Year: |
2012 |
Journal: |
J Pathol |
Title: |
Mammalian septins: dynamic heteromers with roles in cellular morphogenesis and compartmentalization. |
Volume: |
226 |
Issue: |
2 |
Pages: |
287-99 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhai G |
Year: |
2014 |
Journal: |
Mol Cell Biol |
Title: |
Sept6 is required for ciliogenesis in Kupffer's vesicle, the pronephros, and the neural tube during early embryonic development. |
Volume: |
34 |
Issue: |
7 |
Pages: |
1310-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hartwell LH |
Year: |
1971 |
Journal: |
Exp Cell Res |
Title: |
Genetic control of the cell division cycle in yeast. IV. Genes controlling bud emergence and cytokinesis. |
Volume: |
69 |
Issue: |
2 |
Pages: |
265-76 |
|
•
•
•
•
•
|