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Search results 1 to 45 out of 45 for Sept5

0.042s

Type

Details

Score

Protein Domain

IPR030647 | SEPT5

Type:

Family

Description:

Septin 5 (SEPT5) belongs to the septin family. Septin 5, also known as CDCrel-1, is predominantly expressed in the nervous system, co-localises with synaptic vesicles and is involved in exocytosis []. In humans, its role in exocytotic secretion that is modulated by Cdk5 phosphorylation [, ]. SEPT5 interacts with SEPT8 and SEPT11. The complex formed by SEPT5 and SEPT11 is involved in the exocytosis mechanism in human umbilical vein endothelial cells (HUVECs) [].Septins were first discovered in budding yeast as a major component of bud neck filaments during cell septation [, ]. Later, its homologues were identified in nearly all eukaryotes, including humans. They are all GTP-binding proteins that are involved in diverse cellular functions, including cell cycle progression, vesicle trafficking, cytokinesis, cell migration, membrane dynamics, and chromosome segregation [, ]. Similar to cytoskeleton components such as actins and tubulins, they can assemble into filaments and bundles. However, unlike actin filaments and microtubules, septin filaments are not polar, similarly to intermediate filaments []. The number of septin genes per organism is variable: S. cerevisiae has seven and humans have 13 (SEPT1-12 and SEPT14; SEPT13 is a pseudogene now called SEPT7P2) []. All septins can form heteromeric complexes, which associate to form higher-order structures, including filaments, rings and cage-like formations [, ].

•

Protein

Q68FM0

Organism:	Mus musculus/domesticus
Length:	169
Fragment?:	true

•

Protein

A0A338P729

Organism:	Mus musculus/domesticus
Length:	248
Fragment?:	false

•

Protein

A0A338P769

Organism:	Mus musculus/domesticus
Length:	378
Fragment?:	false

•

Protein

B7ZNM7

Organism:	Mus musculus/domesticus
Length:	381
Fragment?:	false

•

Protein

Q52KH2

Organism:	Mus musculus/domesticus
Length:	268
Fragment?:	true

•

Publication

17224448 | J:120894

First Author:	Taniguchi M
Year:	2007
Journal:	J Biol Chem
Title:	Phosphorylation of adult type Sept5 (CDCrel-1) by cyclin-dependent kinase 5 inhibits interaction with syntaxin-1.
Volume:	282
Issue:	11
Pages:	7869-76

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Publication

18385322 | -

First Author:	Amin ND
Year:	2008
Journal:	J Neurosci
Title:	Cyclin-dependent kinase 5 phosphorylation of human septin SEPT5 (hCDCrel-1) modulates exocytosis.
Volume:	28
Issue:	14
Pages:	3631-43

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Protein

Q9Z2Q6

Organism:	Mus musculus/domesticus
Length:	369
Fragment?:	false

•

Protein

A0A338P755

Organism:	Mus musculus/domesticus
Length:	126
Fragment?:	true

•

Publication

10321247 | -

First Author:	Beites CL
Year:	1999
Journal:	Nat Neurosci
Title:	The septin CDCrel-1 binds syntaxin and inhibits exocytosis.
Volume:	2
Issue:	5
Pages:	434-9

•

Publication

16767699 | -

First Author:	Bläser S
Year:	2006
Journal:	J Pathol
Title:	Human endothelial cell septins: SEPT11 is an interaction partner of SEPT5.
Volume:	210
Issue:	1
Pages:	103-10

•

Protein

A0A338P6R8

Organism:	Mus musculus/domesticus
Length:	365
Fragment?:	false

•

Publication

773946 | -

First Author:	Byers B
Year:	1976
Journal:	J Cell Biol
Title:	A highly ordered ring of membrane-associated filaments in budding yeast.
Volume:	69
Issue:	3
Pages:	717-21

•

Publication

22314400 | -

First Author:	Mostowy S
Year:	2012
Journal:	Nat Rev Mol Cell Biol
Title:	Septins: the fourth component of the cytoskeleton.
Volume:	13
Issue:	3
Pages:	183-94

•

Publication

21990096 | -

First Author:	Hall PA
Year:	2012
Journal:	J Pathol
Title:	Mammalian septins: dynamic heteromers with roles in cellular morphogenesis and compartmentalization.
Volume:	226
Issue:	2
Pages:	287-99

•

Publication

24469395 | -

First Author:	Zhai G
Year:	2014
Journal:	Mol Cell Biol
Title:	Sept6 is required for ciliogenesis in Kupffer's vesicle, the pronephros, and the neural tube during early embryonic development.
Volume:	34
Issue:	7
Pages:	1310-21

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Publication

4950437 | -

First Author:	Hartwell LH
Year:	1971
Journal:	Exp Cell Res
Title:	Genetic control of the cell division cycle in yeast. IV. Genes controlling bud emergence and cytokinesis.
Volume:	69
Issue:	2
Pages:	265-76

•

Publication

19240081 | J:147200

First Author:	Suzuki G
Year:	2009
Journal:	Hum Mol Genet
Title:	Sept5 deficiency exerts pleiotropic influence on affective behaviors and cognitive functions in mice.
Volume:	18
Issue:	9
Pages:	1652-60

•

Publication

22589251 | J:185360

First Author:	Harper KM
Year:	2012
Journal:	Hum Mol Genet
Title:	Alterations of social interaction through genetic and environmental manipulation of the 22q11.2 gene Sept5 in the mouse brain.
Volume:	21
Issue:	15
Pages:	3489-99

•

Publication

17564677 | J:122593

First Author:	Fujishima K
Year:	2007
Journal:	J Neurochem
Title:	Targeted disruption of Sept3, a heteromeric assembly partner of Sept5 and Sept7 in axons, has no effect on developing CNS neurons.
Volume:	102
Issue:	1
Pages:	77-92

•

Interaction Experiment

Amin ND (2008)

Description:

Cyclin-dependent kinase 5 phosphorylation of human septin SEPT5 (hCDCrel-1) modulates exocytosis.

•

Protein Coding Gene

MGI:1195461 | Septin5

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Allele

Septin5<tm1Bld> | MGI:3640090

Name:	septin 5; targeted mutation 1, Antonio Baldini
Allele Type:	Targeted
Attribute String:	Null/knockout

•

Strain

MGI:4834617 | B6.129S7-Septin5<tm1Bld>/Cnrm

Attribute String:

targeted mutation, mutant strain, congenic

•

Genotype

Symbol:	Septin5/Septin5<+>
Background:	B6.Cg-Tyr Septin5
Zygosity:	ht
Has Mutant Allele:	true

•

Genotype

Symbol:	Septin5/Septin5
Background:	involves: 129S7/SvEvBrd
Zygosity:	hm
Has Mutant Allele:	true

•

Allele

Del(16Es2el-Sept5)3Bld | MGI:3640126

Name:	deletion, Chr 16, Antonio Baldini 3
Allele Type:	Targeted
Attribute String:	Null/knockout

•

Strain

MGI:4834609 | B6.129S7-Del(16Es2el-Sept5)3Bld/Cnrm

Attribute String:

congenic, mutant strain, targeted mutation, chromosome aberration, deletion

•

Allele

Dp(16Dgcr14-Sept5)3Bld | MGI:3640122

Name:	duplication, Chr 16, Antonio Baldini 3
Allele Type:	Targeted
Attribute String:	Null/knockout

•

Strain

MGI:5002712 | B6;129S7-Dp(16Dgcr14-Sept5)3Bld/Cnrm

Attribute String:

targeted mutation, mutant stock, duplication

•

Genotype

Symbol:	Del(16Es2el-Sept5)3Bld/+
Background:	B6.Cg-Tyr Del(16Es2el-Sept5)3Bld
Zygosity:	ht
Has Mutant Allele:	true

•

Genotype

Symbol:	Del(16Es2el-Sept5)3Bld/+
Background:	involves: 129S7/SvEvBrd
Zygosity:	ht
Has Mutant Allele:	true

•

Strain

MGI:3713862 | B6.Cg-Tyr<c-Brd> Septin5<tm1Bld>

Attribute String:

congenic, mutant strain, spontaneous mutation, targeted mutation

•

Genotype

Symbol:	Del(16Es2el-Sept5)3Bld/+ Del(16Es2el-Ufd1l)217Bld/+
Background:	involves: 129S7/SvEvBrd
Zygosity:	cx
Has Mutant Allele:	true

•

Genotype

Symbol:	Dp(16Dgcr14-Sept5)3Bld/? Del(16Es2el-Ufd1l)217Bld/?
Background:	involves: 129S7/SvEvBrd
Zygosity:	cx
Has Mutant Allele:	true

•

Publication

15213102 | J:93756

First Author:	Kato K
Year:	2004
Journal:	Blood
Title:	Genetic deletion of mouse platelet glycoprotein Ibbeta produces a Bernard-Soulier phenotype with increased alpha-granule size.
Volume:	104
Issue:	8
Pages:	2339-44

•

Publication

18809578 | J:142823

First Author:	Tsang CW
Year:	2008
Journal:	Mol Cell Biol
Title:	Superfluous role of mammalian septins 3 and 5 in neuronal development and synaptic transmission.
Volume:	28
Issue:	23
Pages:	7012-29

•

Publication

22575789 | J:186260

First Author:	Yoshida A
Year:	2012
Journal:	Hear Res
Title:	Localization of septin proteins in the mouse cochlea.
Volume:	289
Issue:	1-2
Pages:	40-51

•

Publication

15355307 | J:116266

First Author:	Beites CL
Year:	2005
Journal:	Biochem J
Title:	The septin Sept5/CDCrel-1 competes with alpha-SNAP for binding to the SNARE complex.
Volume:	385
Issue:	Pt 2
Pages:	347-53

•

Strain

MGI:3692529 | B6.Cg-Tyr<c-Brd> Del(16Es2el-Sept5)3Bld

Attribute String:

targeted mutation, mutant strain, congenic, deletion, chromosome aberration

•

Publication

11242049 | J:67409

First Author:	Lindsay EA
Year:	2001
Journal:	Nature
Title:	Tbx1 haploinsufficieny in the DiGeorge syndrome region causes aortic arch defects in mice.
Volume:	410
Issue:	6824
Pages:	97-101

•

Publication

16684884 | J:110101

First Author:	Paylor R
Year:	2006
Journal:	Proc Natl Acad Sci U S A
Title:	Tbx1 haploinsufficiency is linked to behavioral disorders in mice and humans: implications for 22q11 deletion syndrome.
Volume:	103
Issue:	20
Pages:	7729-34

•

Publication

21821099 | J:184660

First Author:	Kvajo M
Year:	2012
Journal:	Neuroscience
Title:	Avoiding mouse traps in schizophrenia genetics: lessons and promises from current and emerging mouse models.
Volume:	211

Pages:	136-64

•

Publication

15489334 | -

First Author:	Gerhard DS
Year:	2004
Journal:	Genome Res
Title:	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume:	14
Issue:	10B
Pages:	2121-7

•

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