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Search results 1 to 27 out of 27 for Sept9

0.017s

Type

Details

Score

Protein Domain

IPR030645 | SEPT9

Type:

Family

Description:

Septin 9 (SEPT9) belongs to the septin family. It negatively regulates ubiquitin-dependent downregulation of epidermal growth factor receptor []. It has been linked to cancers [, ].Septins were first discovered in budding yeast as a major component of bud neck filaments during cell septation [, ]. Later, its homologues were identified in nearly all eukaryotes, including humans. They are all GTP-binding proteins that are involved in diverse cellular functions, including cell cycle progression, vesicle trafficking, cytokinesis, cell migration, membrane dynamics, and chromosome segregation [, ]. Similar to cytoskeleton components such as actins and tubulins, they can assemble into filaments and bundles. However, unlike actin filaments and microtubules, septin filaments are not polar, similarly to intermediate filaments []. The number of septin genes per organism is variable: S. cerevisiae has seven and humans have 13 (SEPT1-12 and SEPT14; SEPT13 is a pseudogene now called SEPT7P2) []. All septins can form heteromeric complexes, which associate to form higher-order structures, including filaments, rings and cage-like formations [, ].

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Protein

A8Y5D3

Organism:	Mus musculus/domesticus
Length:	74
Fragment?:	true

•

Protein

A2A6U5

Organism:	Mus musculus/domesticus
Length:	242
Fragment?:	true

•

Protein

A2A6U3

Organism:	Mus musculus/domesticus
Length:	565
Fragment?:	false

•

Protein

Q3TDR9

Organism:	Mus musculus/domesticus
Length:	334
Fragment?:	false

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Publication

25472714 | -

First Author:	Diesenberg K
Year:	2015
Journal:	J Cell Sci
Title:	SEPT9 negatively regulates ubiquitin-dependent downregulation of EGFR.
Volume:	128
Issue:	2
Pages:	397-407

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Protein

Q80UG5

Organism:	Mus musculus/domesticus
Length:	583
Fragment?:	false

•

Protein

A0A2R8VHB2

Organism:	Mus musculus/domesticus
Length:	75
Fragment?:	true

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Publication

4950437 | -

First Author:	Hartwell LH
Year:	1971
Journal:	Exp Cell Res
Title:	Genetic control of the cell division cycle in yeast. IV. Genes controlling bud emergence and cytokinesis.
Volume:	69
Issue:	2
Pages:	265-76

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Publication

773946 | -

First Author:	Byers B
Year:	1976
Journal:	J Cell Biol
Title:	A highly ordered ring of membrane-associated filaments in budding yeast.
Volume:	69
Issue:	3
Pages:	717-21

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Publication

22314400 | -

First Author:	Mostowy S
Year:	2012
Journal:	Nat Rev Mol Cell Biol
Title:	Septins: the fourth component of the cytoskeleton.
Volume:	13
Issue:	3
Pages:	183-94

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Publication

21990096 | -

First Author:	Hall PA
Year:	2012
Journal:	J Pathol
Title:	Mammalian septins: dynamic heteromers with roles in cellular morphogenesis and compartmentalization.
Volume:	226
Issue:	2
Pages:	287-99

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Publication

24469395 | -

First Author:	Zhai G
Year:	2014
Journal:	Mol Cell Biol
Title:	Sept6 is required for ciliogenesis in Kupffer's vesicle, the pronephros, and the neural tube during early embryonic development.
Volume:	34
Issue:	7
Pages:	1310-21

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Publication

25429690 | -

First Author:	Molnár B
Year:	2015
Journal:	Expert Rev Mol Diagn
Title:	Plasma methylated septin 9: a colorectal cancer screening marker.
Volume:	15
Issue:	2
Pages:	171-84

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Publication

24633736 | -

First Author:	Powrózek T
Year:	2014
Journal:	Med Oncol
Title:	Septin 9 promoter region methylation in free circulating DNA-potential role in noninvasive diagnosis of lung cancer: preliminary report.
Volume:	31
Issue:	4
Pages:	917

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Publication

17546647 | -

First Author:	Sudo K
Year:	2007
Journal:	Hum Mutat
Title:	SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling.
Volume:	28
Issue:	10
Pages:	1005-13

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Protein Coding Gene

MGI:1858222 | Septin9

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Protein

Q80UG5-2

Organism:	Mus musculus/domesticus
Length:	334
Fragment?:	false

•

Protein

Q80UG5-3

Organism:	Mus musculus/domesticus
Length:	576
Fragment?:	false

•

DO Term

DOID:10383 | amyotrophic neuralgia

•

Publication

23644740 | J:205027

First Author:	Lassen LB
Year:	2013
Journal:	Cell Tissue Res
Title:	Septin9 is involved in T-cell development and CD8+ T-cell homeostasis.
Volume:	352
Issue:	3
Pages:	695-705

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Publication

24344182 | J:208280

First Author:	Bai X
Year:	2013
Journal:	J Cell Biol
Title:	Novel septin 9 repeat motifs altered in neuralgic amyotrophy bind and bundle microtubules.
Volume:	203
Issue:	6
Pages:	895-905

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Publication

19196426 | J:266473

First Author:	Ito H
Year:	2009
Journal:	J Neurochem
Title:	Sept8 controls the binding of vesicle-associated membrane protein 2 to synaptophysin.
Volume:	108
Issue:	4
Pages:	867-80

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Publication

21824004 | J:205180

First Author:	Füchtbauer A
Year:	2011
Journal:	Biol Chem
Title:	Septin9 is involved in septin filament formation and cellular stability.
Volume:	392
Issue:	8-9
Pages:	769-77

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Publication

30158637 | J:278532

First Author:	Møller AMJ
Year:	2018
Journal:	Sci Rep
Title:	Septins are critical regulators of osteoclastic bone resorption.
Volume:	8
Issue:	1
Pages:	13016

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Publication

12727837 | J:95797

First Author:	Montagna C
Year:	2003
Journal:	Cancer Res
Title:	The Septin 9 (MSF) gene is amplified and overexpressed in mouse mammary gland adenocarcinomas and human breast cancer cell lines.
Volume:	63
Issue:	9
Pages:	2179-87

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Publication

27432399 | J:239705

First Author:	Wang Y
Year:	2016
Journal:	FASEB J
Title:	Critical role of bacterial isochorismatase in the autophagic process induced by Acinetobacter baumannii in mammalian cells.
Volume:	30
Issue:	10
Pages:	3563-3577

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