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Search results 1 to 100 out of 395 for Serpinh1

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0.036s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Protein Domain
Type: Family
Description: Colligin 1 (also known as SERPINH1; MEROPS identifier I04.035) is a chaperone exclusive for collagen folding in the ER. Mutations in the gene cause a severe form of osteogenesis imperfecta, a connective tissue disease characterised by bone fragility and increased risk of fractures in dogs []. The serpin does not inhibit serine peptidases, unlike most serpins, but has been shown to inhibit the lysosomal cysteine endopeptidase cathepsin L [].This entry represents the full sequence of serprin H1.
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
GXD Expression      
Probe: MGI:4354529
Assay Type: RNA in situ
Annotation Date: 2009-08-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3270422
Stage: TS22
Assay Id: MGI:4354916
Age: embryonic day 14.5
Specimen Label: Table S5 - Serpinh1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:4354529
Assay Type: RNA in situ
Annotation Date: 2009-08-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3271122
Stage: TS22
Assay Id: MGI:4354916
Age: embryonic day 14.5
Note: There is no expression in either the upper or lower cortical plate.
Specimen Label: Table S5 - Serpinh1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:4354529
Assay Type: RNA in situ
Annotation Date: 2009-08-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4354916
Age: embryonic day 14.5
Specimen Label: Table S5 - Serpinh1
Detected: true
Specimen Num: 1
Protein
Organism: Mus musculus/domesticus
Length: 417  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 417  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 417  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 203  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 115  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 417  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 417  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 417  
Fragment?: false
Publication
First Author: Lindert U
Year: 2015
Journal: J Biol Chem
Title: Molecular Consequences of the SERPINH1/HSP47 Mutation in the Dachshund Natural Model of Osteogenesis Imperfecta.
Volume: 290
Issue: 29
Pages: 17679-89
Publication
First Author: Siavash H
Year: 2002
Journal: Connect Tissue Res
Title: Inhibition of cysteine proteinases by autolytic digestion is mediated by CBP2/Hsp47.
Volume: 43
Issue: 4
Pages: 589-94
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Takechi H
Year: 1992
Journal: Eur J Biochem
Title: Molecular cloning of a mouse 47-kDa heat-shock protein (HSP47), a collagen-binding stress protein, and its expression during the differentiation of F9 teratocarcinoma cells.
Volume: 206
Issue: 2
Pages: 323-9
Publication
First Author: Wang SY
Year: 1990
Journal: J Biol Chem
Title: A retinoic acid-inducible mRNA from F9 teratocarcinoma cells encodes a novel protease inhibitor homologue.
Volume: 265
Issue: 26
Pages: 15818-22
Publication
First Author: Wang SY
Year: 1992
Journal: J Biol Chem
Title: Structure of the gene and its retinoic acid-regulatory region for murine J6 serpin. An F9 teratocarcinoma cell retinoic acid-inducible protein.
Volume: 267
Issue: 22
Pages: 15362-6
Publication
First Author: Hosokawa N
Year: 1993
Journal: Gene
Title: Structure of the gene encoding the mouse 47-kDa heat-shock protein (HSP47).
Volume: 126
Issue: 2
Pages: 187-93
Publication
First Author: Ishida Y
Year: 2006
Journal: Mol Biol Cell
Title: Type I collagen in Hsp47-null cells is aggregated in endoplasmic reticulum and deficient in N-propeptide processing and fibrillogenesis.
Volume: 17
Issue: 5
Pages: 2346-55
Publication
First Author: Sepulveda D
Year: 2018
Journal: Mol Cell
Title: Interactome Screening Identifies the ER Luminal Chaperone Hsp47 as a Regulator of the Unfolded Protein Response Transducer IRE1α.
Volume: 69
Issue: 2
Pages: 238-252.e7
Publication
First Author: Thienel M
Year: 2023
Journal: Science
Title: Immobility-associated thromboprotection is conserved across mammalian species from bear to human.
Volume: 380
Issue: 6641
Pages: 178-187
Publication
First Author: Kawasaki K
Year: 2015
Journal: J Biol Chem
Title: Deletion of the collagen-specific molecular chaperone Hsp47 causes endoplasmic reticulum stress-mediated apoptosis of hepatic stellate cells.
Volume: 290
Issue: 6
Pages: 3639-46
Publication
First Author: Clarke EP
Year: 1992
Journal: Biochim Biophys Acta
Title: Cloning of a human collagen-binding protein, and its homology with rat gp46, chick hsp47 and mouse J6 proteins.
Volume: 1129
Issue: 2
Pages: 246-8
Publication
First Author: Shroff B
Year: 1993
Journal: Connect Tissue Res
Title: Hsp 47 is localized to regions of type I collagen production in developing murine femurs and molars.
Volume: 29
Issue: 4
Pages: 273-86
Publication
First Author: Henle KJ
Year: 1994
Journal: Exp Cell Res
Title: Heat shock glycoprotein GP50: product of the retinoic acid-inducible J6 gene.
Volume: 210
Issue: 2
Pages: 185-91
Publication
First Author: Sauk JJ
Year: 1994
Journal: J Biol Chem
Title: Hsp47 and the translation-translocation machinery cooperate in the production of alpha 1(I) chains of type I procollagen.
Volume: 269
Issue: 6
Pages: 3941-6
Publication
First Author: Ikegawa S
Year: 1995
Journal: Cytogenet Cell Genet
Title: Isolation, characterization and chromosomal assignment of human colligin-2 gene (CBP2).
Volume: 71
Issue: 2
Pages: 182-6
Publication
First Author: Nagata K
Year: 1996
Journal: Trends Biochem Sci
Title: Hsp47: a collagen-specific molecular chaperone.
Volume: 21
Issue: 1
Pages: 22-6
Publication
First Author: Matsuoka Y
Year: 2004
Journal: Mol Biol Cell
Title: Insufficient folding of type IV collagen and formation of abnormal basement membrane-like structure in embryoid bodies derived from Hsp47-null embryonic stem cells.
Volume: 15
Issue: 10
Pages: 4467-75
Publication
First Author: Koide T
Year: 2006
Journal: J Biol Chem
Title: Specific recognition of the collagen triple helix by chaperone HSP47: minimal structural requirement and spatial molecular orientation.
Volume: 281
Issue: 6
Pages: 3432-8
Publication
First Author: Koide T
Year: 2006
Journal: J Biol Chem
Title: Specific recognition of the collagen triple helix by chaperone HSP47. II. The HSP47-binding structural motif in collagens and related proteins.
Volume: 281
Issue: 16
Pages: 11177-85
Publication
First Author: Wong MM
Year: 2014
Journal: PLoS One
Title: Over-expression of HSP47 augments mouse embryonic stem cell smooth muscle differentiation and chemotaxis.
Volume: 9
Issue: 1
Pages: e86118
Publication
First Author: Yamakawa T
Year: 2018
Journal: Blood
Title: Vitamin A-coupled liposomes containing siRNA against HSP47 ameliorate skin fibrosis in chronic graft-versus-host disease.
Volume: 131
Issue: 13
Pages: 1476-1485
GXD Expression      
Probe: MGI:3040414
Assay Type: Northern blot
Annotation Date: 2004-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619821
Stage: TS21
Assay Id: MGI:3040423
Age: embryonic day 13.5
Specimen Label: embryonic stage 4
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3040414
Assay Type: Northern blot
Annotation Date: 2004-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619822
Stage: TS22
Assay Id: MGI:3040423
Age: embryonic day 14.5
Specimen Label: embryonic stage 5
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3040414
Assay Type: Northern blot
Annotation Date: 2004-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619824
Stage: TS24
Assay Id: MGI:3040423
Age: embryonic day 16.5
Specimen Label: embryonic stage 6
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3040414
Assay Type: Northern blot
Annotation Date: 2004-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619826
Stage: TS26
Assay Id: MGI:3040423
Age: embryonic day 18.5
Specimen Label: embryonic stage 7
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3040414
Assay Type: Northern blot
Annotation Date: 2004-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619827
Stage: TS27
Assay Id: MGI:3040423
Age: postnatal day 3
Specimen Label: post-natal day 3
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3040414
Assay Type: Northern blot
Annotation Date: 2004-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:3040423
Age: postnatal day 5
Specimen Label: post-natal day 5
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3040414
Assay Type: Northern blot
Annotation Date: 2004-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:3040423
Age: postnatal day 7
Specimen Label: post-natal day 7
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:3040414
Assay Type: Northern blot
Annotation Date: 2004-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:3040423
Age: postnatal day 14
Specimen Label: post-natal day 14
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:3040414
Assay Type: Northern blot
Annotation Date: 2004-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:3040423
Age: postnatal day 21
Specimen Label: post-natal day 21
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:3040421
Assay Type: Western blot
Annotation Date: 2004-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619821
Stage: TS21
Assay Id: MGI:3040429
Age: embryonic day 13.5
Specimen Label: embryonic stage 4
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3040421
Assay Type: Western blot
Annotation Date: 2004-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619822
Stage: TS22
Assay Id: MGI:3040429
Age: embryonic day 14.5
Specimen Label: embryonic stage 5
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3040421
Assay Type: Western blot
Annotation Date: 2004-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619824
Stage: TS24
Assay Id: MGI:3040429
Age: embryonic day 16.5
Specimen Label: embryonic stage 6
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3040421
Assay Type: Western blot
Annotation Date: 2004-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619826
Stage: TS26
Assay Id: MGI:3040429
Age: embryonic day 18.5
Specimen Label: embryonic stage 7
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3040421
Assay Type: Western blot
Annotation Date: 2004-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619827
Stage: TS27
Assay Id: MGI:3040429
Age: postnatal day 3
Specimen Label: post-natal day 3
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3040421
Assay Type: Western blot
Annotation Date: 2004-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:3040429
Age: postnatal day 5
Specimen Label: post-natal day 5
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3040421
Assay Type: Western blot
Annotation Date: 2004-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:3040429
Age: postnatal day 7
Specimen Label: post-natal day 7
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:3040421
Assay Type: Western blot
Annotation Date: 2004-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:3040429
Age: postnatal day 14
Specimen Label: post-natal day 14
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:3040421
Assay Type: Western blot
Annotation Date: 2004-05-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:3040429
Age: postnatal day 21
Specimen Label: post-natal day 21
Detected: false
Specimen Num: 9
GXD Expression    
Probe: MGI:3695576
Assay Type: Western blot
Annotation Date: 2007-02-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:3695707
Age: embryonic day 8.5
Image: 5
Specimen Label: +/+
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3695576
Assay Type: Western blot
Annotation Date: 2007-02-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:3695707
Age: embryonic day 8.5
Image: 5
Specimen Label: -/-
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3695576
Assay Type: Western blot
Annotation Date: 2007-02-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:3695707
Age: embryonic day 9.5
Image: 5
Specimen Label: +/+
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:3695576
Assay Type: Western blot
Annotation Date: 2007-02-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:3695707
Age: embryonic day 9.5
Image: 5
Specimen Label: -/-
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:3695576
Assay Type: Western blot
Annotation Date: 2007-02-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:3695707
Age: embryonic day 10.5
Image: 5
Specimen Label: +/+
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:3695576
Assay Type: Western blot
Annotation Date: 2007-02-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:3695707
Age: embryonic day 10.5
Image: 5
Specimen Label: -/-
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:3695576
Assay Type: Western blot
Annotation Date: 2007-02-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:3695707
Age: embryonic day 11.5
Image: 5
Specimen Label: +/+
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:3695576
Assay Type: Western blot
Annotation Date: 2007-02-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:3695707
Age: embryonic day 11.5
Image: 5
Specimen Label: -/-
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:7451355
Assay Type: Western blot
Annotation Date: 2023-04-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:7451358
Age: embryonic day 10.5
Specimen Label: 5
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:7451355
Assay Type: Western blot
Annotation Date: 2023-04-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:7451358
Age: embryonic day 14.5
Specimen Label: 6
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:7451355
Assay Type: Western blot
Annotation Date: 2023-04-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603926
Stage: TS26
Assay Id: MGI:7451358
Age: embryonic day 18.5
Specimen Label: 7
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:7469822
Assay Type: RT-PCR
Annotation Date: 2023-05-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3287428
Stage: TS28
Assay Id: MGI:7470771
Age: postnatal
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7469822
Assay Type: RT-PCR
Annotation Date: 2023-05-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3287428
Stage: TS28
Assay Id: MGI:7470771
Age: postnatal
Specimen Label: -/-
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:7703416
Assay Type: RT-PCR
Annotation Date: 2024-07-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1674819
Stage: TS19
Assay Id: MGI:7703425
Age: embryonic day 11.5
Specimen Label: E11.5
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7703416
Assay Type: RT-PCR
Annotation Date: 2024-07-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1674820
Stage: TS20
Assay Id: MGI:7703425
Age: embryonic day 12.5
Specimen Label: E12.5
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:7703416
Assay Type: RT-PCR
Annotation Date: 2024-07-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1674822
Stage: TS22
Assay Id: MGI:7703425
Age: embryonic day 14.5
Specimen Label: E14.5
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:7798805
Assay Type: Western blot
Annotation Date: 2025-01-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1768126
Stage: TS26
Assay Id: MGI:7840302
Age: embryonic day 18.5
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7798805
Assay Type: Western blot
Annotation Date: 2025-01-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1768126
Stage: TS26
Assay Id: MGI:7840302
Age: embryonic day 18.5
Specimen Label: Plod2
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:7798805
Assay Type: Western blot
Annotation Date: 2025-01-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1768126
Stage: TS26
Assay Id: MGI:7840302
Age: embryonic day 18.5
Specimen Label: Plod2
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:7798805
Assay Type: Western blot
Annotation Date: 2025-01-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1768126
Stage: TS26
Assay Id: MGI:7840296
Age: embryonic day 18.5
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7798805
Assay Type: Western blot
Annotation Date: 2025-01-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1768126
Stage: TS26
Assay Id: MGI:7840296
Age: embryonic day 18.5
Specimen Label: Plod2
Detected: true
Specimen Num: 2