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Search results 1 to 100 out of 266 for Setd1a

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Protein Domain
Type: Family
Description: In animals, histone-lysine N-methyltransferase SETD1A () is a histone methyltransferase that produces mono-, di-, and trimethylated histone H3 at 'Lys-4. However, if 'Lys-9' residue is already methylated, 'Lys-4' will not be. The 'Lys-4' methylation is a tag for epigenetic transcriptional activation [, ]. The SET1 complex contains either SETD1A or SETD1B.The SET1 complex is a methyltransferase that that produces trimethylated histone H3 at Lys(4). It is composed of at least the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30 []. In yeast there is only one SET1 complex, but in mammals there are additional H3K4 methylases [].
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 70  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 849  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 458  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 316  
Fragment?: true
Publication
First Author: Yu X
Year: 2019
Journal: Neurosci Bull
Title: De Novo and Inherited SETD1A Variants in Early-onset Epilepsy.
Volume: 35
Issue: 6
Pages: 1045-1057
Protein
Organism: Mus musculus/domesticus
Length: 247  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 196  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 1716  
Fragment?: false
Publication
First Author: Bledau AS
Year: 2014
Journal: Development
Title: The H3K4 methyltransferase Setd1a is first required at the epiblast stage, whereas Setd1b becomes essential after gastrulation.
Volume: 141
Issue: 5
Pages: 1022-35
Publication
First Author: Lee JH
Year: 2005
Journal: J Biol Chem
Title: CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex.
Volume: 280
Issue: 50
Pages: 41725-31
Publication
First Author: Arndt K
Year: 2018
Journal: Blood
Title: SETD1A protects HSCs from activation-induced functional decline in vivo.
Volume: 131
Issue: 12
Pages: 1311-1324
Publication
First Author: Chen R
Year: 2022
Journal: Sci Adv
Title: Cell type-specific mechanism of Setd1a heterozygosity in schizophrenia pathogenesis.
Volume: 8
Issue: 9
Pages: eabm1077
Publication
First Author: Lee JH
Year: 2007
Journal: J Biol Chem
Title: Identification and characterization of the human Set1B histone H3-Lys4 methyltransferase complex.
Volume: 282
Issue: 18
Pages: 13419-28
Publication
First Author: Wu M
Year: 2008
Journal: Mol Cell Biol
Title: Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS.
Volume: 28
Issue: 24
Pages: 7337-44
Protein
Organism: Mus musculus/domesticus
Length: 1173  
Fragment?: true
Publication
First Author: Hoshii T
Year: 2018
Journal: Cell
Title: A Non-catalytic Function of SETD1A Regulates Cyclin K and the DNA Damage Response.
Volume: 172
Issue: 5
Pages: 1007-1021.e17
Publication
First Author: Nagahama K
Year: 2020
Journal: Cell Rep
Title: Setd1a Insufficiency in Mice Attenuates Excitatory Synaptic Function and Recapitulates Schizophrenia-Related Behavioral Abnormalities.
Volume: 32
Issue: 11
Pages: 108126
Publication
First Author: Tusi BK
Year: 2015
Journal: FASEB J
Title: Setd1a regulates progenitor B-cell-to-precursor B-cell development through histone H3 lysine 4 trimethylation and Ig heavy-chain rearrangement.
Volume: 29
Issue: 4
Pages: 1505-15
Publication
First Author: Clifton NE
Year: 2022
Journal: Hum Mol Genet
Title: Developmental disruption to the cortical transcriptome and synaptosome in a model of SETD1A loss-of-function.
Volume: 31
Issue: 18
Pages: 3095-3106
Publication
First Author: Tate CM
Year: 2010
Journal: FEBS J
Title: CXXC finger protein 1 restricts the Setd1A histone H3K4 methyltransferase complex to euchromatin.
Volume: 277
Issue: 1
Pages: 210-23
Publication
First Author: Li Y
Year: 2016
Journal: Nucleic Acids Res
Title: Setd1a and NURF mediate chromatin dynamics and gene regulation during erythroid lineage commitment and differentiation.
Volume: 44
Issue: 15
Pages: 7173-88
Publication
First Author: Qiao H
Year: 2018
Journal: Cell Rep
Title: Nap1l1 Controls Embryonic Neural Progenitor Cell Proliferation and Differentiation in the Developing Brain.
Volume: 22
Issue: 9
Pages: 2279-2293
Publication
First Author: Cenik BK
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: A synthetic lethality screen reveals ING5 as a genetic dependency of catalytically dead Set1A/COMPASS in mouse embryonic stem cells.
Volume: 119
Issue: 19
Pages: e2118385119
Publication
First Author: Rabadan MA
Year: 2022
Journal: Nat Commun
Title: An in vitro model of neuronal ensembles.
Volume: 13
Issue: 1
Pages: 3340
Publication
First Author: Obi-Nagata K
Year: 2023
Journal: Sci Adv
Title: Distorted neurocomputation by a small number of extra-large spines in psychiatric disorders.
Volume: 9
Issue: 23
Pages: eade5973
Publication
First Author: Mukai J
Year: 2019
Journal: Neuron
Title: Recapitulation and Reversal of Schizophrenia-Related Phenotypes in Setd1a-Deficient Mice.
Volume: 104
Issue: 3
Pages: 471-487.e12
Publication
First Author: Greulich F
Year: 2021
Journal: Cell Rep
Title: The glucocorticoid receptor recruits the COMPASS complex to regulate inflammatory transcription at macrophage enhancers.
Volume: 34
Issue: 6
Pages: 108742
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Kutsuwada K
Year: 1999
Journal: Biochim Biophys Acta
Title: Cloning and characterization of 5'-flanking region of mouse non-selective cation channel 1.
Volume: 1444
Issue: 1
Pages: 92-100
GXD Expression      
Probe: MGI:4947231
Assay Type: RT-PCR
Annotation Date: 2011-04-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360411
Stage: TS01
Assay Id: MGI:4947249
Age: embryonic day 0.5
Specimen Label: 1-cell zyote
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:4947231
Assay Type: RT-PCR
Annotation Date: 2011-04-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360422
Stage: TS02
Assay Id: MGI:4947249
Age: embryonic day 1.0
Specimen Label: 2-cell embryo
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:4947231
Assay Type: RT-PCR
Annotation Date: 2011-04-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360433
Stage: TS03
Assay Id: MGI:4947249
Age: embryonic day 2.0
Specimen Label: 4-cell embryo
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:4947231
Assay Type: RT-PCR
Annotation Date: 2011-04-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:4947249
Age: embryonic day 3.5
Specimen Label: blastocyte embryo
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:4947231
Assay Type: RT-PCR
Annotation Date: 2011-04-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360453
Stage: TS03
Assay Id: MGI:4947249
Age: embryonic day 3.0
Specimen Label: morula embryo
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6469544
Assay Type: RT-PCR
Annotation Date: 2020-10-27
Strength: Present
Sex: Female
Emaps: EMAPS:3102528
Stage: TS28
Assay Id: MGI:6469556
Age: postnatal
Image: 2
Specimen Label: oocyte
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6469544
Assay Type: RT-PCR
Annotation Date: 2020-10-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360411
Stage: TS01
Assay Id: MGI:6469556
Age: embryonic day 0.5
Image: 2
Specimen Label: 1 cell
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6469544
Assay Type: RT-PCR
Annotation Date: 2020-10-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360422
Stage: TS02
Assay Id: MGI:6469556
Age: embryonic day 1.0
Image: 2
Specimen Label: 2 cell
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6469544
Assay Type: RT-PCR
Annotation Date: 2020-10-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360433
Stage: TS03
Assay Id: MGI:6469556
Age: embryonic day 2.0
Image: 2
Specimen Label: 4 cell
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6469544
Assay Type: RT-PCR
Annotation Date: 2020-10-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360443
Stage: TS03
Assay Id: MGI:6469556
Age: embryonic day 2.5
Image: 2
Specimen Label: 8 cell
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6469544
Assay Type: RT-PCR
Annotation Date: 2020-10-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360453
Stage: TS03
Assay Id: MGI:6469556
Age: embryonic day 3.0
Image: 2
Specimen Label: morula
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6469544
Assay Type: RT-PCR
Annotation Date: 2020-10-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:6469556
Age: embryonic day 3.5
Image: 2
Specimen Label: blastocyst
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:6469544
Assay Type: RT-PCR
Annotation Date: 2020-10-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360465
Stage: TS05
Assay Id: MGI:6469556
Age: embryonic day 4.5
Image: 2
Specimen Label: E4.5
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:6469544
Assay Type: RT-PCR
Annotation Date: 2020-10-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360407
Stage: TS07
Assay Id: MGI:6469556
Age: embryonic day 5.5
Image: 2
Specimen Label: E5.5
Detected: true
Specimen Num: 9
GXD Expression    
Probe: MGI:6469544
Assay Type: RT-PCR
Annotation Date: 2020-10-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360409
Stage: TS09
Assay Id: MGI:6469556
Age: embryonic day 6.5
Image: 2
Specimen Label: E6.5
Detected: true
Specimen Num: 10
GXD Expression    
Probe: MGI:6469544
Assay Type: RT-PCR
Annotation Date: 2020-10-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3604011
Stage: TS11
Assay Id: MGI:6469556
Age: embryonic day 7.5
Image: 2
Specimen Label: E7.5
Detected: true
Specimen Num: 11
GXD Expression    
Probe: MGI:6469544
Assay Type: RT-PCR
Annotation Date: 2020-10-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3604013
Stage: TS13
Assay Id: MGI:6469556
Age: embryonic day 8.5
Image: 2
Specimen Label: E8.5
Detected: true
Specimen Num: 12
GXD Expression    
Probe: MGI:6469544
Assay Type: RT-PCR
Annotation Date: 2020-10-27
Strength: Present
Sex: Female
Emaps: EMAPS:3102528
Stage: TS28
Assay Id: MGI:6469560
Age: postnatal
Image: 3
Specimen Label: Oo-F/+
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6469544
Assay Type: RT-PCR
Annotation Date: 2020-10-27
Strength: Present
Sex: Female
Emaps: EMAPS:3102528
Stage: TS28
Assay Id: MGI:6469560
Age: postnatal
Image: 3
Specimen Label: OoF/F
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6469544
Assay Type: RT-PCR
Annotation Date: 2020-10-27
Strength: Present
Sex: Female
Emaps: EMAPS:3102528
Stage: TS28
Assay Id: MGI:6469560
Age: postnatal
Image: 3
Specimen Label: Oo-wt
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5310241
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3516422
Stage: TS22
Assay Id: MGI:5423565
Age: embryonic day 14.5
Specimen Label: EH1298; Specimen C2563
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310241
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1716122
Stage: TS22
Assay Id: MGI:5423565
Age: embryonic day 14.5
Specimen Label: EH1298; Specimen C2563
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310241
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1691622
Stage: TS22
Assay Id: MGI:5423565
Age: embryonic day 14.5
Specimen Label: EH1298; Specimen C2563
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310241
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1760622
Stage: TS22
Assay Id: MGI:5423565
Age: embryonic day 14.5
Specimen Label: EH1298; Specimen C2563
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310241
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1737322
Stage: TS22
Assay Id: MGI:5423565
Age: embryonic day 14.5
Specimen Label: EH1298; Specimen C2563
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310241
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3284222
Stage: TS22
Assay Id: MGI:5423565
Age: embryonic day 14.5
Specimen Label: EH1298; Specimen C2563
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:5310241
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1666522
Pattern: Ubiquitous
Stage: TS22
Assay Id: MGI:5423565
Age: embryonic day 14.5
Image: EH1298; Specimen C2563
Specimen Label: EH1298; Specimen C2563
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5310241
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1619822
Stage: TS22
Assay Id: MGI:5423565
Age: embryonic day 14.5
Specimen Label: EH1298; Specimen C2563
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5310241
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754922
Stage: TS22
Assay Id: MGI:5423565
Age: embryonic day 14.5
Note: Expression was not detected in the corpus striatum (lateral ganglionic eminence).
Specimen Label: EH1298; Specimen C2563
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310241
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1697422
Stage: TS22
Assay Id: MGI:5423565
Age: embryonic day 14.5
Specimen Label: EH1298; Specimen C2563
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5310241
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3276322
Stage: TS22
Assay Id: MGI:5423565
Age: embryonic day 14.5
Note: Expression was not detected in the face/soft tissues.
Specimen Label: EH1298; Specimen C2563
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310241
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1783822
Stage: TS22
Assay Id: MGI:5423565
Age: embryonic day 14.5
Specimen Label: EH1298; Specimen C2563
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:5310241
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1665922
Pattern: Ubiquitous
Stage: TS22
Assay Id: MGI:5423565
Age: embryonic day 14.5
Image: EH1298; Specimen C2563
Specimen Label: EH1298; Specimen C2563
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5310241
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1706822
Stage: TS22
Assay Id: MGI:5423565
Age: embryonic day 14.5
Specimen Label: EH1298; Specimen C2563
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310241
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1674822
Stage: TS22
Assay Id: MGI:5423565
Age: embryonic day 14.5
Specimen Label: EH1298; Specimen C2563
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310241
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1670622
Stage: TS22
Assay Id: MGI:5423565
Age: embryonic day 14.5
Specimen Label: EH1298; Specimen C2563
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310241
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1738222
Stage: TS22
Assay Id: MGI:5423565
Age: embryonic day 14.5
Specimen Label: EH1298; Specimen C2563
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310241
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1654222
Stage: TS22
Assay Id: MGI:5423565
Age: embryonic day 14.5
Specimen Label: EH1298; Specimen C2563
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310241
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1777922
Stage: TS22
Assay Id: MGI:5423565
Age: embryonic day 14.5
Specimen Label: EH1298; Specimen C2563
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310241
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684922
Stage: TS22
Assay Id: MGI:5423565
Age: embryonic day 14.5
Specimen Label: EH1298; Specimen C2563
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5787616
Assay Type: Immunohistochemistry
Annotation Date: 2016-08-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160414
Pattern: Not Specified
Stage: TS04
Assay Id: MGI:5787620
Age: embryonic day 3.5
Specimen Label: S7 SET1A
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5787616
Assay Type: Immunohistochemistry
Annotation Date: 2016-08-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160414
Pattern: Not Specified
Stage: TS04
Assay Id: MGI:5787620
Age: embryonic day 3.5
Specimen Label: 7C SET1A +/+ +/-
Detected: true
Specimen Num: 2