Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
SH2B adapter protein 1 (SH2B1) belongs to the SH2B family of adapter proteins []. It promotes insulin expression and glucose metabolism in beta-cells in mice []. It is also involved in brain-derived neurotrophic factor-induced neurite outgrowth [].SH2B family contains three members of adaptor proteins: SH2B1, 2 and 3 []. Typical SH2B proteins contain a SH2 (Src homology 2) and a PH (pleckstrin homology) domain. They serve as adaptors involved in signalling by the receptors for growth factors, such as insulin-like growth factor 1, platelet-derived growth factor and nerve growth factor []. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen Z |
Year: |
2014 |
Journal: |
Mol Endocrinol |
Title: |
SH2B1 in β-cells promotes insulin expression and glucose metabolism in mice. |
Volume: |
28 |
Issue: |
5 |
Pages: |
696-705 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ren D |
Year: |
2007 |
Journal: |
J Clin Invest |
Title: |
Neuronal SH2B1 is essential for controlling energy and glucose homeostasis. |
Volume: |
117 |
Issue: |
2 |
Pages: |
397-406 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jiang L |
Year: |
2020 |
Journal: |
Nat Commun |
Title: |
Leptin receptor-expressing neuron Sh2b1 supports sympathetic nervous system and protects against obesity and metabolic disease. |
Volume: |
11 |
Issue: |
1 |
Pages: |
1517 |
|
•
•
•
•
•
|
Publication |
First Author: |
Flores A |
Year: |
2019 |
Journal: |
Diabetes |
Title: |
Crucial Role of the SH2B1 PH Domain for the Control of Energy Balance. |
Volume: |
68 |
Issue: |
11 |
Pages: |
2049-2062 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jiang L |
Year: |
2018 |
Journal: |
FASEB J |
Title: |
Neural deletion of Sh2b1 results in brain growth retardation and reactive aggression. |
Volume: |
32 |
Issue: |
4 |
Pages: |
1830-1840 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen Z |
Year: |
2014 |
Journal: |
Diabetes |
Title: |
SH2B1 in β-cells regulates glucose metabolism by promoting β-cell survival and islet expansion. |
Volume: |
63 |
Issue: |
2 |
Pages: |
585-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Han X |
Year: |
2022 |
Journal: |
Redox Biol |
Title: |
Neuronal SH2B1 attenuates apoptosis in an MPTP mouse model of Parkinson's disease via promoting PLIN4 degradation. |
Volume: |
52 |
|
Pages: |
102308 |
|
•
•
•
•
•
|
Publication |
First Author: |
Argetsinger LS |
Year: |
2023 |
Journal: |
Endocrinology |
Title: |
Role of the Beta and Gamma Isoforms of the Adapter Protein SH2B1 in Regulating Energy Balance. |
Volume: |
164 |
Issue: |
5 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Cote JL |
Year: |
2021 |
Journal: |
Diabetes |
Title: |
Deletion of the Brain-Specific α and δ Isoforms of Adapter Protein SH2B1 Protects Mice From Obesity. |
Volume: |
70 |
Issue: |
2 |
Pages: |
400-414 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu G |
Year: |
2015 |
Journal: |
Cardiovasc Res |
Title: |
SH2B1 is critical for the regulation of cardiac remodelling in response to pressure overload. |
Volume: |
107 |
Issue: |
2 |
Pages: |
203-15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Maures TJ |
Year: |
2007 |
Journal: |
Trends Endocrinol Metab |
Title: |
SH2B1 (SH2-B) and JAK2: a multifunctional adaptor protein and kinase made for each other. |
Volume: |
18 |
Issue: |
1 |
Pages: |
38-45 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shih CH |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
New function of the adaptor protein SH2B1 in brain-derived neurotrophic factor-induced neurite outgrowth. |
Volume: |
8 |
Issue: |
11 |
Pages: |
e79619 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sheng L |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Hepatic SH2B1 and SH2B2 regulate liver lipid metabolism and VLDL secretion in mice. |
Volume: |
8 |
Issue: |
12 |
Pages: |
e83269 |
|
•
•
•
•
•
|
Publication |
First Author: |
Morris DL |
Year: |
2009 |
Journal: |
Diabetes |
Title: |
SH2B1 enhances insulin sensitivity by both stimulating the insulin receptor and inhibiting tyrosine dephosphorylation of insulin receptor substrate proteins. |
Volume: |
58 |
Issue: |
9 |
Pages: |
2039-47 |
|
•
•
•
•
•
|
Publication |
First Author: |
Morris DL |
Year: |
2010 |
Journal: |
Endocrinology |
Title: |
Critical role of the Src homology 2 (SH2) domain of neuronal SH2B1 in the regulation of body weight and glucose homeostasis in mice. |
Volume: |
151 |
Issue: |
8 |
Pages: |
3643-51 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
756
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
306
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
73
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Ahmed Z |
Year: |
2001 |
Journal: |
Biochem Soc Trans |
Title: |
Functional effects of APS and SH2-B on insulin receptor signalling. |
Volume: |
29 |
Issue: |
Pt 4 |
Pages: |
529-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Song W |
Year: |
2010 |
Journal: |
Cell Metab |
Title: |
SH2B regulation of growth, metabolism, and longevity in both insects and mammals. |
Volume: |
11 |
Issue: |
5 |
Pages: |
427-37 |
|
•
•
•
•
•
|
Publication |
First Author: |
Blandino-Rosano M |
Year: |
2016 |
Journal: |
Diabetes |
Title: |
4E-BP2/SH2B1/IRS2 Are Part of a Novel Feedback Loop That Controls β-Cell Mass. |
Volume: |
65 |
Issue: |
8 |
Pages: |
2235-48 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Riedel H |
Year: |
1997 |
Journal: |
J Biochem |
Title: |
PSM, an insulin-dependent, pro-rich, PH, SH2 domain containing partner of the insulin receptor. |
Volume: |
122 |
Issue: |
6 |
Pages: |
1105-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang J |
Year: |
1998 |
Journal: |
J Biol Chem |
Title: |
Insulin-like growth factor-I receptor and insulin receptor association with a Src homology-2 domain-containing putative adapter. |
Volume: |
273 |
Issue: |
6 |
Pages: |
3136-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ren D |
Year: |
2005 |
Journal: |
Cell Metab |
Title: |
Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice. |
Volume: |
2 |
Issue: |
2 |
Pages: |
95-104 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ohtsuka S |
Year: |
2002 |
Journal: |
Mol Cell Biol |
Title: |
SH2-B is required for both male and female reproduction. |
Volume: |
22 |
Issue: |
9 |
Pages: |
3066-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yoshiga D |
Year: |
2007 |
Journal: |
Mol Endocrinol |
Title: |
Adaptor protein SH2-B linking receptor-tyrosine kinase and Akt promotes adipocyte differentiation by regulating peroxisome proliferator-activated receptor gamma messenger ribonucleic acid levels. |
Volume: |
21 |
Issue: |
5 |
Pages: |
1120-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Duan C |
Year: |
2004 |
Journal: |
Mol Cell Biol |
Title: |
Disruption of the SH2-B gene causes age-dependent insulin resistance and glucose intolerance. |
Volume: |
24 |
Issue: |
17 |
Pages: |
7435-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Diakonova M |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
SH2-Bbeta is a Rac-binding protein that regulates cell motility. |
Volume: |
277 |
Issue: |
12 |
Pages: |
10669-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chua S Jr |
Year: |
2010 |
Journal: |
Endocrinology |
Title: |
SH2B1--the adaptor protein that could. |
Volume: |
151 |
Issue: |
9 |
Pages: |
4100-2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3043060 |
Assay Type: |
RT-PCR |
Annotation Date: |
2004-06-18 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1620419 |
|
Stage: |
TS19 |
Assay Id: |
MGI:3043072 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
SH2-B |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li M |
Year: |
2006 |
Journal: |
Endocrinology |
Title: |
Differential role of SH2-B and APS in regulating energy and glucose homeostasis. |
Volume: |
147 |
Issue: |
5 |
Pages: |
2163-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Diakonova M |
Year: |
2007 |
Journal: |
Infect Immun |
Title: |
Adapter protein SH2-Bbeta stimulates actin-based motility of Listeria monocytogenes in a vasodilator-stimulated phosphoprotein (VASP)-dependent fashion. |
Volume: |
75 |
Issue: |
7 |
Pages: |
3581-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hu J |
Year: |
2006 |
Journal: |
J Mol Biol |
Title: |
Structural basis for phosphotyrosine recognition by the Src homology-2 domains of the adapter proteins SH2-B and APS. |
Volume: |
361 |
Issue: |
1 |
Pages: |
69-79 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kurzer JH |
Year: |
2004 |
Journal: |
Mol Cell Biol |
Title: |
Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta. |
Volume: |
24 |
Issue: |
10 |
Pages: |
4557-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nelms K |
Year: |
1999 |
Journal: |
Mamm Genome |
Title: |
Alternative splicing, gene localization, and binding of SH2-B to the insulin receptor kinase domain. |
Volume: |
10 |
Issue: |
12 |
Pages: |
1160-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Franquinho F |
Year: |
2017 |
Journal: |
Cereb Cortex |
Title: |
The Dyslexia-susceptibility Protein KIAA0319 Inhibits Axon Growth Through Smad2 Signaling. |
Volume: |
27 |
Issue: |
3 |
Pages: |
1732-1747 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kubo-Akashi C |
Year: |
2004 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Roles of a conserved family of adaptor proteins, Lnk, SH2-B, and APS, for mast cell development, growth, and functions: APS-deficiency causes augmented degranulation and reduced actin assembly. |
Volume: |
315 |
Issue: |
2 |
Pages: |
356-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kong M |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
Interaction of fibroblast growth factor receptor 3 and the adapter protein SH2-B. A role in STAT5 activation. |
Volume: |
277 |
Issue: |
18 |
Pages: |
15962-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nobuhisa I |
Year: |
2003 |
Journal: |
Mol Cell Biol |
Title: |
Regulation of hematopoietic development in the aorta-gonad-mesonephros region mediated by Lnk adaptor protein. |
Volume: |
23 |
Issue: |
23 |
Pages: |
8486-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Riedel H |
Year: |
2000 |
Journal: |
Oncogene |
Title: |
PSM, a mediator of PDGF-BB-, IGF-I-, and insulin-stimulated mitogenesis. |
Volume: |
19 |
Issue: |
1 |
Pages: |
39-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jiang W |
Year: |
2005 |
Journal: |
Mol Cell Biol |
Title: |
IRIP, a new ischemia/reperfusion-inducible protein that participates in the regulation of transporter activity. |
Volume: |
25 |
Issue: |
15 |
Pages: |
6496-508 |
|
•
•
•
•
•
|
Publication |
First Author: |
Masuhara M |
Year: |
2000 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Molecular cloning of murine STAP-1, the stem-cell-specific adaptor protein containing PH and SH2 domains. |
Volume: |
268 |
Issue: |
3 |
Pages: |
697-703 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Backcross DNA Panel Mapping Resource |
Year: |
1999 |
Journal: |
Database Release |
Title: |
JAX BSS Panel Mapping Data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI and IMPC |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Lennon G |
Year: |
1999 |
Journal: |
Database Download |
Title: |
WashU-HHMI Mouse EST Project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2001 |
|
Title: |
Gene Ontology Annotation by the MGI Curatorial Staff |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2000 |
|
Title: |
Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Gaudet P |
Year: |
2011 |
Journal: |
Brief Bioinform |
Title: |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. |
Volume: |
12 |
Issue: |
5 |
Pages: |
449-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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Publication |
First Author: |
Li Z |
Year: |
2007 |
Journal: |
Mol Endocrinol |
Title: |
SH2B1 enhances leptin signaling by both Janus kinase 2 Tyr813 phosphorylation-dependent and -independent mechanisms. |
Volume: |
21 |
Issue: |
9 |
Pages: |
2270-81 |
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Publication |
First Author: |
Chen KW |
Year: |
2017 |
Journal: |
Biochim Biophys Acta |
Title: |
SH2B1 modulates chromatin state and MyoD occupancy to enhance expressions of myogenic genes. |
Volume: |
1860 |
Issue: |
2 |
Pages: |
270-281 |
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