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Search results 1 to 100 out of 104 for Sh2b1

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0.036s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Protein Domain
Type: Family
Description: SH2B adapter protein 1 (SH2B1) belongs to the SH2B family of adapter proteins []. It promotes insulin expression and glucose metabolism in beta-cells in mice []. It is also involved in brain-derived neurotrophic factor-induced neurite outgrowth [].SH2B family contains three members of adaptor proteins: SH2B1, 2 and 3 []. Typical SH2B proteins contain a SH2 (Src homology 2) and a PH (pleckstrin homology) domain. They serve as adaptors involved in signalling by the receptors for growth factors, such as insulin-like growth factor 1, platelet-derived growth factor and nerve growth factor [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Chen Z
Year: 2014
Journal: Mol Endocrinol
Title: SH2B1 in β-cells promotes insulin expression and glucose metabolism in mice.
Volume: 28
Issue: 5
Pages: 696-705
Publication
First Author: Ren D
Year: 2007
Journal: J Clin Invest
Title: Neuronal SH2B1 is essential for controlling energy and glucose homeostasis.
Volume: 117
Issue: 2
Pages: 397-406
Publication
First Author: Jiang L
Year: 2020
Journal: Nat Commun
Title: Leptin receptor-expressing neuron Sh2b1 supports sympathetic nervous system and protects against obesity and metabolic disease.
Volume: 11
Issue: 1
Pages: 1517
Publication
First Author: Flores A
Year: 2019
Journal: Diabetes
Title: Crucial Role of the SH2B1 PH Domain for the Control of Energy Balance.
Volume: 68
Issue: 11
Pages: 2049-2062
Publication
First Author: Jiang L
Year: 2018
Journal: FASEB J
Title: Neural deletion of Sh2b1 results in brain growth retardation and reactive aggression.
Volume: 32
Issue: 4
Pages: 1830-1840
Publication
First Author: Chen Z
Year: 2014
Journal: Diabetes
Title: SH2B1 in β-cells regulates glucose metabolism by promoting β-cell survival and islet expansion.
Volume: 63
Issue: 2
Pages: 585-95
Publication  
First Author: Han X
Year: 2022
Journal: Redox Biol
Title: Neuronal SH2B1 attenuates apoptosis in an MPTP mouse model of Parkinson's disease via promoting PLIN4 degradation.
Volume: 52
Pages: 102308
Publication  
First Author: Argetsinger LS
Year: 2023
Journal: Endocrinology
Title: Role of the Beta and Gamma Isoforms of the Adapter Protein SH2B1 in Regulating Energy Balance.
Volume: 164
Issue: 5
Publication
First Author: Cote JL
Year: 2021
Journal: Diabetes
Title: Deletion of the Brain-Specific α and δ Isoforms of Adapter Protein SH2B1 Protects Mice From Obesity.
Volume: 70
Issue: 2
Pages: 400-414
Publication
First Author: Wu G
Year: 2015
Journal: Cardiovasc Res
Title: SH2B1 is critical for the regulation of cardiac remodelling in response to pressure overload.
Volume: 107
Issue: 2
Pages: 203-15
Publication
First Author: Maures TJ
Year: 2007
Journal: Trends Endocrinol Metab
Title: SH2B1 (SH2-B) and JAK2: a multifunctional adaptor protein and kinase made for each other.
Volume: 18
Issue: 1
Pages: 38-45
Publication
First Author: Shih CH
Year: 2013
Journal: PLoS One
Title: New function of the adaptor protein SH2B1 in brain-derived neurotrophic factor-induced neurite outgrowth.
Volume: 8
Issue: 11
Pages: e79619
Publication
First Author: Sheng L
Year: 2013
Journal: PLoS One
Title: Hepatic SH2B1 and SH2B2 regulate liver lipid metabolism and VLDL secretion in mice.
Volume: 8
Issue: 12
Pages: e83269
Publication
First Author: Morris DL
Year: 2009
Journal: Diabetes
Title: SH2B1 enhances insulin sensitivity by both stimulating the insulin receptor and inhibiting tyrosine dephosphorylation of insulin receptor substrate proteins.
Volume: 58
Issue: 9
Pages: 2039-47
Publication
First Author: Morris DL
Year: 2010
Journal: Endocrinology
Title: Critical role of the Src homology 2 (SH2) domain of neuronal SH2B1 in the regulation of body weight and glucose homeostasis in mice.
Volume: 151
Issue: 8
Pages: 3643-51
Protein
Organism: Mus musculus/domesticus
Length: 756  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 306  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 73  
Fragment?: true
Publication
First Author: Ahmed Z
Year: 2001
Journal: Biochem Soc Trans
Title: Functional effects of APS and SH2-B on insulin receptor signalling.
Volume: 29
Issue: Pt 4
Pages: 529-34
Publication
First Author: Song W
Year: 2010
Journal: Cell Metab
Title: SH2B regulation of growth, metabolism, and longevity in both insects and mammals.
Volume: 11
Issue: 5
Pages: 427-37
Publication
First Author: Blandino-Rosano M
Year: 2016
Journal: Diabetes
Title: 4E-BP2/SH2B1/IRS2 Are Part of a Novel Feedback Loop That Controls β-Cell Mass.
Volume: 65
Issue: 8
Pages: 2235-48
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Riedel H
Year: 1997
Journal: J Biochem
Title: PSM, an insulin-dependent, pro-rich, PH, SH2 domain containing partner of the insulin receptor.
Volume: 122
Issue: 6
Pages: 1105-13
Publication
First Author: Wang J
Year: 1998
Journal: J Biol Chem
Title: Insulin-like growth factor-I receptor and insulin receptor association with a Src homology-2 domain-containing putative adapter.
Volume: 273
Issue: 6
Pages: 3136-9
Publication
First Author: Ren D
Year: 2005
Journal: Cell Metab
Title: Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice.
Volume: 2
Issue: 2
Pages: 95-104
Publication
First Author: Ohtsuka S
Year: 2002
Journal: Mol Cell Biol
Title: SH2-B is required for both male and female reproduction.
Volume: 22
Issue: 9
Pages: 3066-77
Publication
First Author: Yoshiga D
Year: 2007
Journal: Mol Endocrinol
Title: Adaptor protein SH2-B linking receptor-tyrosine kinase and Akt promotes adipocyte differentiation by regulating peroxisome proliferator-activated receptor gamma messenger ribonucleic acid levels.
Volume: 21
Issue: 5
Pages: 1120-31
Publication
First Author: Duan C
Year: 2004
Journal: Mol Cell Biol
Title: Disruption of the SH2-B gene causes age-dependent insulin resistance and glucose intolerance.
Volume: 24
Issue: 17
Pages: 7435-43
Publication
First Author: Diakonova M
Year: 2002
Journal: J Biol Chem
Title: SH2-Bbeta is a Rac-binding protein that regulates cell motility.
Volume: 277
Issue: 12
Pages: 10669-77
Publication
First Author: Chua S Jr
Year: 2010
Journal: Endocrinology
Title: SH2B1--the adaptor protein that could.
Volume: 151
Issue: 9
Pages: 4100-2
GXD Expression      
Probe: MGI:3043060
Assay Type: RT-PCR
Annotation Date: 2004-06-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1620419
Stage: TS19
Assay Id: MGI:3043072
Age: embryonic day 11.5
Specimen Label: SH2-B
Detected: true
Specimen Num: 3
Publication
First Author: Li M
Year: 2006
Journal: Endocrinology
Title: Differential role of SH2-B and APS in regulating energy and glucose homeostasis.
Volume: 147
Issue: 5
Pages: 2163-70
Publication
First Author: Diakonova M
Year: 2007
Journal: Infect Immun
Title: Adapter protein SH2-Bbeta stimulates actin-based motility of Listeria monocytogenes in a vasodilator-stimulated phosphoprotein (VASP)-dependent fashion.
Volume: 75
Issue: 7
Pages: 3581-93
Publication
First Author: Hu J
Year: 2006
Journal: J Mol Biol
Title: Structural basis for phosphotyrosine recognition by the Src homology-2 domains of the adapter proteins SH2-B and APS.
Volume: 361
Issue: 1
Pages: 69-79
Publication
First Author: Kurzer JH
Year: 2004
Journal: Mol Cell Biol
Title: Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta.
Volume: 24
Issue: 10
Pages: 4557-70
Publication
First Author: Nelms K
Year: 1999
Journal: Mamm Genome
Title: Alternative splicing, gene localization, and binding of SH2-B to the insulin receptor kinase domain.
Volume: 10
Issue: 12
Pages: 1160-7
Publication
First Author: Franquinho F
Year: 2017
Journal: Cereb Cortex
Title: The Dyslexia-susceptibility Protein KIAA0319 Inhibits Axon Growth Through Smad2 Signaling.
Volume: 27
Issue: 3
Pages: 1732-1747
Publication
First Author: Kubo-Akashi C
Year: 2004
Journal: Biochem Biophys Res Commun
Title: Roles of a conserved family of adaptor proteins, Lnk, SH2-B, and APS, for mast cell development, growth, and functions: APS-deficiency causes augmented degranulation and reduced actin assembly.
Volume: 315
Issue: 2
Pages: 356-62
Publication
First Author: Kong M
Year: 2002
Journal: J Biol Chem
Title: Interaction of fibroblast growth factor receptor 3 and the adapter protein SH2-B. A role in STAT5 activation.
Volume: 277
Issue: 18
Pages: 15962-70
Publication
First Author: Nobuhisa I
Year: 2003
Journal: Mol Cell Biol
Title: Regulation of hematopoietic development in the aorta-gonad-mesonephros region mediated by Lnk adaptor protein.
Volume: 23
Issue: 23
Pages: 8486-94
Publication
First Author: Riedel H
Year: 2000
Journal: Oncogene
Title: PSM, a mediator of PDGF-BB-, IGF-I-, and insulin-stimulated mitogenesis.
Volume: 19
Issue: 1
Pages: 39-50
Publication
First Author: Jiang W
Year: 2005
Journal: Mol Cell Biol
Title: IRIP, a new ischemia/reperfusion-inducible protein that participates in the regulation of transporter activity.
Volume: 25
Issue: 15
Pages: 6496-508
Publication
First Author: Masuhara M
Year: 2000
Journal: Biochem Biophys Res Commun
Title: Molecular cloning of murine STAP-1, the stem-cell-specific adaptor protein containing PH and SH2 domains.
Volume: 268
Issue: 3
Pages: 697-703
Publication      
First Author: The Jackson Laboratory Backcross DNA Panel Mapping Resource
Year: 1999
Journal: Database Release
Title: JAX BSS Panel Mapping Data
Publication      
First Author: MGI and IMPC
Year: 2017
Journal: MGI Direct Data Submission
Title: MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication
First Author: Li Z
Year: 2007
Journal: Mol Endocrinol
Title: SH2B1 enhances leptin signaling by both Janus kinase 2 Tyr813 phosphorylation-dependent and -independent mechanisms.
Volume: 21
Issue: 9
Pages: 2270-81
Publication
First Author: Chen KW
Year: 2017
Journal: Biochim Biophys Acta
Title: SH2B1 modulates chromatin state and MyoD occupancy to enhance expressions of myogenic genes.
Volume: 1860
Issue: 2
Pages: 270-281