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Search results 1 to 76 out of 76 for Sh2b2

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Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
10603 | SH2B2
Type: gene
Organism: human
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Gene
100488327 | sh2b2
Type: gene
Organism: frog, western clawed
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Gene
114203 | Sh2b2
Type: gene
Organism: rat
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Gene
489820 | SH2B2
Type: gene
Organism: dog, domestic
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Gene
741557 | SH2B2
Type: gene
Organism: chimpanzee
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Gene
617840 | SH2B2
Type: gene
Organism: cattle
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Gene
100535524 | sh2b2
Type: gene
Organism: zebrafish
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Gene
714861 | SH2B2
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR030520 | SH2B2
Type: Family
Description: SH2B adapter protein 2 (SH2B2, also known as APS) belongs to the SH2B family of adapter proteins []. SH2B2 is involved in multiple signalling pathways, includingcytokine signalling and insulin receptor signalling [, ]. It also binds to Vav3, a member of the vav proto-oncogene family, and increases its activity [].SH2B family contains three members of adaptor proteins: SH2B1, 2 and 3 []. Typical SH2B proteins contain a SH2 (Src homology 2) and a PH (pleckstrin homology) domain. They serve as adaptors involved in signalling by the receptors for growth factors, such as insulin-like growth factor 1, platelet-derived growth factor and nerve growth factor [].
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Protein Coding Gene
MGI:1345171 | Sh2b2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
9989826 | J:113810
First Author: Yokouchi M
Year: 1999
Journal: Oncogene
Title: APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis.
Volume: 18
Issue: 3
Pages: 759-67
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Publication
24358267 | J:211139
First Author: Sheng L
Year: 2013
Journal: PLoS One
Title: Hepatic SH2B1 and SH2B2 regulate liver lipid metabolism and VLDL secretion in mice.
Volume: 8
Issue: 12
Pages: e83269
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Publication
12400014 | -
First Author: Yabana N
Year: 2002
Journal: Oncogene
Title: Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity.
Volume: 21
Issue: 50
Pages: 7720-9
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Protein
A0A0G2JDV1
Organism: Mus musculus/domesticus
Length: 44  
Fragment?: true
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Publication
11498022 | -
First Author: Ahmed Z
Year: 2001
Journal: Biochem Soc Trans
Title: Functional effects of APS and SH2-B on insulin receptor signalling.
Volume: 29
Issue: Pt 4
Pages: 529-34
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Publication
17140804 | -
First Author: Maures TJ
Year: 2007
Journal: Trends Endocrinol Metab
Title: SH2B1 (SH2-B) and JAK2: a multifunctional adaptor protein and kinase made for each other.
Volume: 18
Issue: 1
Pages: 38-45
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Protein
Q9JID9
Organism: Mus musculus/domesticus
Length: 621  
Fragment?: false
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Protein
A0A0G2JED4
Organism: Mus musculus/domesticus
Length: 420  
Fragment?: false
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Protein Coding Gene
MGP_CAROLIEiJ_G0027856 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0030205 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0030173 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0030106 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0030183 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0029899 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1345171 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0030636 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0029309 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0029869 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0030020 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0029975 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0030109 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0030007 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0030676 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0029022 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0029382 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0024439 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0028858 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
14993264 | J:88527
First Author: Iseki M
Year: 2004
Journal: Mol Cell Biol
Title: Increased numbers of B-1 cells and enhanced responses against TI-2 antigen in mice lacking APS, an adaptor molecule containing PH and SH2 domains.
Volume: 24
Issue: 6
Pages: 2243-50
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Publication
15809095 | J:97444
First Author: Iseki M
Year: 2005
Journal: Biochem Biophys Res Commun
Title: APS, an adaptor molecule containing PH and SH2 domains, has a negative regulatory role in B cell proliferation.
Volume: 330
Issue: 3
Pages: 1005-13
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GXD Expression
GXD Expression
     
Probe: MGI:3043059
Assay Type: RT-PCR
Annotation Date: 2004-06-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1620419
Stage: TS19
Assay Id: MGI:3043071
Age: embryonic day 11.5
Specimen Label: APS
Detected: true
Specimen Num: 2
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Publication
16455776 | J:108358
First Author: Li M
Year: 2006
Journal: Endocrinology
Title: Differential role of SH2-B and APS in regulating energy and glucose homeostasis.
Volume: 147
Issue: 5
Pages: 2163-70
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Publication
10196204 | J:54187
First Author: Moodie SA
Year: 1999
Journal: J Biol Chem
Title: Identification of the APS protein as a novel insulin receptor substrate.
Volume: 274
Issue: 16
Pages: 11186-93
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Publication
15946664 | J:100934
First Author: Barrès R
Year: 2005
Journal: Exp Cell Res
Title: The interaction between the adaptor protein APS and Enigma is involved in actin organisation.
Volume: 308
Issue: 2
Pages: 334-44
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Publication
14766215 | J:88311
First Author: Kubo-Akashi C
Year: 2004
Journal: Biochem Biophys Res Commun
Title: Roles of a conserved family of adaptor proteins, Lnk, SH2-B, and APS, for mast cell development, growth, and functions: APS-deficiency causes augmented degranulation and reduced actin assembly.
Volume: 315
Issue: 2
Pages: 356-62
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Publication
14578283 | J:86301
First Author: Minami A
Year: 2003
Journal: Diabetes
Title: Increased insulin sensitivity and hypoinsulinemia in APS knockout mice.
Volume: 52
Issue: 11
Pages: 2657-65
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Publication
11827956 | J:76351
First Author: Kong M
Year: 2002
Journal: J Biol Chem
Title: Interaction of fibroblast growth factor receptor 3 and the adapter protein SH2-B. A role in STAT5 activation.
Volume: 277
Issue: 18
Pages: 15962-70
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Publication
14612394 | J:89937
First Author: Nobuhisa I
Year: 2003
Journal: Mol Cell Biol
Title: Regulation of hematopoietic development in the aorta-gonad-mesonephros region mediated by Lnk adaptor protein.
Volume: 23
Issue: 23
Pages: 8486-94
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Publication
10872802 | J:62510
First Author: Iseki M
Year: 2000
Journal: Biochem Biophys Res Commun
Title: Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins.
Volume: 272
Issue: 1
Pages: 45-54
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Publication
18492766 | J:137608
First Author: Wu Y
Year: 2008
Journal: Am J Physiol Endocrinol Metab
Title: Wdnm1-like, a new adipokine with a role in MMP-2 activation.
Volume: 295
Issue: 1
Pages: E205-15
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Publication
- | J:157064
     
First Author: University of California, Davis
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the University of California, Davis
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Protein Domain
IPR035058 | SH2B2_SH2
Type: Domain
Description: This entry represents the SH2 domain of SH2B2.SH2B adapter protein 2 (SH2B2, also known as APS) belongs to the SH2B family of adapter proteins []. SH2B2 is involved in multiple signalling pathways, including cytokine signalling and insulin receptor signalling [, ]. It also binds to Vav3, a member of the vav proto-oncogene family, and increases its activity [].SH2B family contains three members of adaptor proteins: SH2B1, 2 and 3 []. Typical SH2B proteins contain a SH2 (Src homology 2) and a PH (pleckstrin homology) domain. They serve as adaptors involved in signalling by the receptors for growth factors, such as insulin-like growth factor 1, platelet-derived growth factor and nerve growth factor [].
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