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Search results 1 to 100 out of 212 for Sharpin

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
81858 | SHARPIN
Type: gene
Organism: human
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Gene
81859 | Sharpin
Type: gene
Organism: rat
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Gene
475122 | SHARPIN
Type: gene
Organism: dog, domestic
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Gene
747207 | SHARPIN
Type: gene
Organism: chimpanzee
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Gene
512499 | SHARPIN
Type: gene
Organism: cattle
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Gene
793673 | sharpin
Type: gene
Organism: zebrafish
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Gene
713534 | SHARPIN
Type: gene
Organism: macaque, rhesus
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Gene
101751687 | SHARPIN
Type: gene
Organism: chicken
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Protein Coding Gene
MGI:1913331 | Sharpin
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
E0CZH2
Organism: Mus musculus/domesticus
Length: 157  
Fragment?: false
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Protein
Q91WA6
Organism: Mus musculus/domesticus
Length: 380  
Fragment?: false
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Protein
F6UHH8
Organism: Mus musculus/domesticus
Length: 83  
Fragment?: true
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Protein
Q91WA6-2
Organism: Mus musculus/domesticus
Length: 305  
Fragment?: false
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Publication
21455180 | J:170809
First Author: Tokunaga F
Year: 2011
Journal: Nature
Title: SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex.
Volume: 471
Issue: 7340
Pages: 633-6
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Publication
21455181 | J:170302
First Author: Ikeda F
Year: 2011
Journal: Nature
Title: SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis.
Volume: 471
Issue: 7340
Pages: 637-41
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Publication
17538631 | J:121810
First Author: Seymour RE
Year: 2007
Journal: Genes Immun
Title: Spontaneous mutations in the mouse Sharpin gene result in multiorgan inflammation, immune system dysregulation and dermatitis.
Volume: 8
Issue: 5
Pages: 416-21
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Publication
21455173 | J:170810
First Author: Gerlach B
Year: 2011
Journal: Nature
Title: Linear ubiquitination prevents inflammation and regulates immune signalling.
Volume: 471
Issue: 7340
Pages: 591-6
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Publication
24210817 | J:205531
First Author: Pouwels J
Year: 2013
Journal: Cell Rep
Title: SHARPIN regulates uropod detachment in migrating lymphocytes.
Volume: 5
Issue: 3
Pages: 619-28
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Publication
20811394 | J:182100
First Author: Liang Y
Year: 2011
Journal: J Invest Dermatol
Title: Inhibition of NF-κB signaling retards eosinophilic dermatitis in SHARPIN-deficient mice.
Volume: 131
Issue: 1
Pages: 141-9
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Publication
21829440 | J:176256
First Author: Liang Y
Year: 2011
Journal: PLoS One
Title: SHARPIN negatively associates with TRAF2-mediated NFκB activation.
Volume: 6
Issue: 7
Pages: e21696
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Publication
19650867 | J:244505
First Author: Renninger ML
Year: 2010
Journal: Exp Dermatol
Title: Anti-IL5 decreases the number of eosinophils but not the severity of dermatitis in Sharpin-deficient mice.
Volume: 19
Issue: 3
Pages: 252-8
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Publication
12753155 | J:103585
First Author: Daigo Y
Year: 2003
Journal: J Gastroenterol Hepatol
Title: Novel human and mouse genes encoding a shank-interacting protein and its upregulation in gastric fundus of W/WV mouse.
Volume: 18
Issue: 6
Pages: 712-8
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Publication
25443631 | J:269068
   
First Author: Kumari S
Year: 2014
Journal: Elife
Title: Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis.
Volume: 3
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Publication
26931177 | J:247266
First Author: Redecke V
Year: 2016
Journal: Immunology
Title: SHARPIN controls the development of regulatory T cells.
Volume: 148
Issue: 2
Pages: 216-26
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UniProt Feature
UniProt Feature
Begin: 1
Description: Sharpin
Type: chain
End: 380
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Publication
21947080 | J:180707
First Author: Rantala JK
Year: 2011
Journal: Nat Cell Biol
Title: SHARPIN is an endogenous inhibitor of β1-integrin activation.
Volume: 13
Issue: 11
Pages: 1315-24
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Publication
25637014 | J:296049
First Author: Gurung P
Year: 2015
Journal: J Immunol
Title: Cutting edge: SHARPIN is required for optimal NLRP3 inflammasome activation.
Volume: 194
Issue: 5
Pages: 2064-7
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Publication
32687504 | J:293252
First Author: Sundberg JP
Year: 2020
Journal: PLoS One
Title: Keratinocyte-specific deletion of SHARPIN induces atopic dermatitis-like inflammation in mice.
Volume: 15
Issue: 7
Pages: e0235295
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Publication
28094869 | J:272131
First Author: Potter CS
Year: 2017
Journal: Exp Dermatol
Title: Loss of FAS/FASL signalling does not reduce apoptosis in Sharpin null mice.
Volume: 26
Issue: 9
Pages: 820-822
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Publication
22253853 | J:184313
First Author: Sieber S
Year: 2012
Journal: PLoS One
Title: Sharpin contributes to TNFα dependent NFκB activation and anti-apoptotic signalling in hepatocytes.
Volume: 7
Issue: 1
Pages: e29993
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Publication
23424624 | J:197197
First Author: Seymour R
Year: 2013
Journal: PLoS One
Title: Loss of function of the mouse Sharpin gene results in Peyer's patch regression.
Volume: 8
Issue: 2
Pages: e55224
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Publication
22348129 | J:185326
First Author: Wang Z
Year: 2012
Journal: PLoS One
Title: SHARPIN is essential for cytokine production, NF-κB signaling, and induction of Th1 differentiation by dendritic cells.
Volume: 7
Issue: 2
Pages: e31809
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Publication
25484257 | J:218849
 
First Author: Li Y
Year: 2015
Journal: Neurosci Lett
Title: The alteration of SHARPIN expression in the mouse brainstem during herpes simplex virus 1-induced facial palsy.
Volume: 586
Pages: 50-4
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Publication
26829767 | J:259414
First Author: Park Y
Year: 2016
Journal: Nat Immunol
Title: SHARPIN controls regulatory T cells by negatively modulating the T cell antigen receptor complex.
Volume: 17
Issue: 3
Pages: 286-96
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Publication
27974362 | J:240189
First Author: Peuhu E
Year: 2017
Journal: EMBO J
Title: SHARPIN regulates collagen architecture and ductal outgrowth in the developing mouse mammary gland.
Volume: 36
Issue: 2
Pages: 165-182
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Publication
26968342 | J:231908
First Author: Nastase MV
Year: 2016
Journal: Am J Pathol
Title: An Essential Role for SHARPIN in the Regulation of Caspase 1 Activity in Sepsis.
Volume: 186
Issue: 5
Pages: 1206-20
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Publication
25524971 | J:333590
First Author: McGowan HW
Year: 2014
Journal: J Musculoskelet Neuronal Interact
Title: Sharpin is a key regulator of skeletal homeostasis in a TNF-dependent manner.
Volume: 14
Issue: 4
Pages: 454-63
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Publication
29694895 | J:270829
First Author: Fujita H
Year: 2018
Journal: Cell Rep
Title: Cooperative Domain Formation by Homologous Motifs in HOIL-1L and SHARPIN Plays A Crucial Role in LUBAC Stabilization.
Volume: 23
Issue: 4
Pages: 1192-1204
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Publication
26976635 | J:236193
First Author: Shimizu S
Year: 2016
Journal: Mol Cell Biol
Title: Differential Involvement of the Npl4 Zinc Finger Domains of SHARPIN and HOIL-1L in Linear Ubiquitin Chain Assembly Complex-Mediated Cell Death Protection.
Volume: 36
Issue: 10
Pages: 1569-83
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Publication
24465642 | J:225167
First Author: Potter CS
Year: 2014
Journal: PLoS One
Title: Chronic proliferative dermatitis in Sharpin null mice: development of an autoinflammatory disease in the absence of B and T lymphocytes and IL4/IL13 signaling.
Volume: 9
Issue: 1
Pages: e85666
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Publication
20956555 | J:187563
First Author: Landgraf K
Year: 2010
Journal: Mol Cell Biol
Title: Sipl1 and Rbck1 are novel Eya1-binding proteins with a role in craniofacial development.
Volume: 30
Issue: 24
Pages: 5764-75
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Gene
569903 | shrprbck1r
Type: gene
Organism: zebrafish
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Publication
21069580 | -
First Author: Xia T
Year: 2011
Journal: Endocrine
Title: Loss-of-function of SHARPIN causes an osteopenic phenotype in mice.
Volume: 39
Issue: 2
Pages: 104-12
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Publication
30850498 | J:293466
First Author: Siitonen R
Year: 2019
Journal: J Nucl Med
Title: 68Ga-DOTA-E[c(RGDfK)]2 PET Imaging of SHARPIN-Regulated Integrin Activity in Mice.
Volume: 60
Issue: 10
Pages: 1380-1387
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Publication
32393887 | J:291215
First Author: Fuseya Y
Year: 2020
Journal: Nat Cell Biol
Title: The HOIL-1L ligase modulates immune signalling and cell death via monoubiquitination of LUBAC.
Volume: 22
Issue: 6
Pages: 663-673
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Publication
32122970 | J:286834
First Author: Douglas T
Year: 2020
Journal: J Biol Chem
Title: Cross-regulation between LUBAC and caspase-1 modulates cell death and inflammation.
Volume: 295
Issue: 16
Pages: 5216-5228
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Publication
27892465 | J:295919
 
First Author: Gurung P
Year: 2016
Journal: Sci Rep
Title: Distinct role of IL-1β in instigating disease in Sharpincpdm mice.
Volume: 6
Pages: 36634
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Publication
34755089 | J:319466
First Author: Gomez-Diaz C
Year: 2021
Journal: iScience
Title: The ubiquitin ligase HOIL-1L regulates immune responses by interacting with linear ubiquitin chains.
Volume: 24
Issue: 11
Pages: 103241
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Publication
35675765 | J:340344
First Author: Anderton H
Year: 2022
Journal: Cell Rep
Title: Langerhans cells are an essential cellular intermediary in chronic dermatitis.
Volume: 39
Issue: 10
Pages: 110922
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Publication
31462647 | J:279330
First Author: Sasaki K
Year: 2019
Journal: Nat Commun
Title: Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death.
Volume: 10
Issue: 1
Pages: 3878
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Publication
33215740 | J:300149
   
First Author: Fennell LM
Year: 2020
Journal: EMBO J
Title: Site-specific ubiquitination of the E3 ligase HOIP regulates apoptosis and immune signaling.
Pages: e103303
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Publication
31985117 | J:298113
First Author: Webster JD
Year: 2020
Journal: J Leukoc Biol
Title: RIP1 kinase activity is critical for skin inflammation but not for viral propagation.
Volume: 107
Issue: 6
Pages: 941-952
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Publication
34887354 | J:335160
 
First Author: Ang RL
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Immune dysregulation in SHARPIN-deficient mice is dependent on CYLD-mediated cell death.
Volume: 118
Issue: 50
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Publication
29040328 | J:247289
First Author: Peuhu E
Year: 2017
Journal: PLoS One
Title: Integrin beta 1 inhibition alleviates the chronic hyperproliferative dermatitis phenotype of SHARPIN-deficient mice.
Volume: 12
Issue: 10
Pages: e0186628
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Protein Coding Gene
MGP_CAROLIEiJ_G0019922 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0021986 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0021944 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0021927 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0021953 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0021725 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1913331 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0022393 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0021244 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0021692 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0021817 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0021798 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0021888 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0021822 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0022413 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0020985 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0021296 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0019932 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0020825 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
8362989 | J:14539
First Author: HogenEsch H
Year: 1993
Journal: Am J Pathol
Title: A spontaneous mutation characterized by chronic proliferative dermatitis in C57BL mice.
Volume: 143
Issue: 3
Pages: 972-82
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Publication
8738473 | J:33147
First Author: Gallardo Torres HI
Year: 1995
Journal: Pathobiology
Title: Chronic proliferative dermatitis in mice: neutrophil-endothelium interactions and the role of adhesion molecules.
Volume: 63
Issue: 6
Pages: 341-7
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Publication
11241277 | J:68121
First Author: HogenEsch H
Year: 2001
Journal: Eur J Immunol
Title: Increased expression of type 2 cytokines in chronic proliferative dermatitis (cpdm) mutant mice and resolution of inflammation following treatment with IL-12.
Volume: 31
Issue: 3
Pages: 734-42
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Publication
8774148 | J:31745
First Author: Gijbels MJ
Year: 1996
Journal: Am J Pathol
Title: Pathogenesis of skin lesions in mice with chronic proliferative dermatitis (cpdm/cpdm).
Volume: 148
Issue: 3
Pages: 941-50
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Publication
10201907 | J:53575
First Author: HogenEsch H
Year: 1999
Journal: J Immunol
Title: Absence of Peyer's patches and abnormal lymphoid architecture in chronic proliferative dermatitis (cpdm/cpdm) mice.
Volume: 162
Issue: 7
Pages: 3890-6
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Publication
7490470 | J:30497
First Author: Gijbels MJ
Year: 1995
Journal: J Invest Dermatol
Title: Maintenance of donor phenotype after full-thickness skin transplantation from mice with chronic proliferative dermatitis (cpdm/cpdm) to C57BL/Ka and nude mice and vice versa.
Volume: 105
Issue: 6
Pages: 769-73
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Publication
29698466 | J:262056
First Author: Franco J
Year: 2018
Journal: PLoS One
Title: Profiling of epidermal lipids in a mouse model of dermatitis: Identification of potential biomarkers.
Volume: 13
Issue: 4
Pages: e0196595
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Publication
- | J:68129
 
First Author: Sundberg JP
Year: 2000
Journal: J Exp Anim Sci
Title: The chronic proliferative dermatitis mouse mutation (cpdm): mapping of the mutant gene locus.
Volume: 41
Pages: 101-8
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Publication
7792947 | J:27806
First Author: Gijbels MJ
Year: 1995
Journal: Ultrastruct Pathol
Title: Ultrastructure of epidermis of mice with chronic proliferative dermatitis.
Volume: 19
Issue: 2
Pages: 107-11
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Publication
30655516 | J:270249
First Author: Wu M
Year: 2019
Journal: Nat Commun
Title: LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores.
Volume: 10
Issue: 1
Pages: 273
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Publication
27794420 | J:356848
First Author: HogenEsch H
Year: 2016
Journal: Exp Mol Pathol
Title: Angiogenesis in the skin of SHARPIN-deficient mice with chronic proliferative dermatitis.
Volume: 101
Issue: 3
Pages: 303-307
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Publication
24634492 | J:210010
First Author: Tamiya H
Year: 2014
Journal: J Immunol
Title: IFN-γ or IFN-α ameliorates chronic proliferative dermatitis by inducing expression of linear ubiquitin chain assembly complex.
Volume: 192
Issue: 8
Pages: 3793-804
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Publication
16274458 | J:116833
First Author: Renninger ML
Year: 2005
Journal: Exp Dermatol
Title: Increased expression of chemokines in the skin of chronic proliferative dermatitis mutant mice.
Volume: 14
Issue: 12
Pages: 906-13
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Publication
10201915 | J:53573
First Author: Zhou X
Year: 1999
Journal: J Immunol
Title: Increased generation of CD8+ T cell clones in p53 mutant mice.
Volume: 162
Issue: 7
Pages: 3957-60
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GXD Expression
GXD Expression
     
Probe: MGI:7567653
Assay Type: RT-PCR
Annotation Date: 2023-12-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1624721
Stage: TS21
Assay Id: MGI:7567664
Age: embryonic day 13.5
Specimen Label: gut
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:7567653
Assay Type: RT-PCR
Annotation Date: 2023-12-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185821
Stage: TS21
Assay Id: MGI:7567664
Age: embryonic day 13.5
Specimen Label: head
Detected: true
Specimen Num: 2
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•
GXD Expression
GXD Expression
     
Probe: MGI:7567653
Assay Type: RT-PCR
Annotation Date: 2023-12-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610521
Stage: TS21
Assay Id: MGI:7567664
Age: embryonic day 13.5
Specimen Label: heart
Detected: true
Specimen Num: 3
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•
•
GXD Expression
GXD Expression
     
Probe: MGI:7567653
Assay Type: RT-PCR
Annotation Date: 2023-12-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737321
Stage: TS21
Assay Id: MGI:7567664
Age: embryonic day 13.5
Specimen Label: kidney
Detected: true
Specimen Num: 4
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•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7567653
Assay Type: RT-PCR
Annotation Date: 2023-12-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640521
Stage: TS21
Assay Id: MGI:7567664
Age: embryonic day 13.5
Specimen Label: limb
Detected: true
Specimen Num: 5
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•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7567653
Assay Type: RT-PCR
Annotation Date: 2023-12-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672821
Stage: TS21
Assay Id: MGI:7567664
Age: embryonic day 13.5
Specimen Label: lung
Detected: true
Specimen Num: 6
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•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7567653
Assay Type: RT-PCR
Annotation Date: 2023-12-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1674421
Stage: TS21
Assay Id: MGI:7567664
Age: embryonic day 13.5
Specimen Label: mesonephros
Detected: true
Specimen Num: 7
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•
•
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•
GXD Expression
GXD Expression
     
Probe: MGI:7567653
Assay Type: RT-PCR
Annotation Date: 2023-12-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1647021
Stage: TS21
Assay Id: MGI:7567664
Age: embryonic day 13.5
Specimen Label: neural tube
Detected: true
Specimen Num: 8
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•
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•
GXD Expression
GXD Expression
     
Probe: MGI:7567653
Assay Type: RT-PCR
Annotation Date: 2023-12-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1647021
Stage: TS21
Assay Id: MGI:7567664
Age: embryonic day 13.5
Specimen Label: stomach
Detected: true
Specimen Num: 9
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•
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•
GXD Expression
GXD Expression
     
Probe: MGI:7567653
Assay Type: RT-PCR
Annotation Date: 2023-12-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1624721
Stage: TS21
Assay Id: MGI:7567669
Age: embryonic day 13.5
Specimen Label: gut
Detected: true
Specimen Num: 1
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•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7567653
Assay Type: RT-PCR
Annotation Date: 2023-12-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185821
Stage: TS21
Assay Id: MGI:7567669
Age: embryonic day 13.5
Specimen Label: head
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7567653
Assay Type: RT-PCR
Annotation Date: 2023-12-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610521
Stage: TS21
Assay Id: MGI:7567669
Age: embryonic day 13.5
Specimen Label: heart
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7567653
Assay Type: RT-PCR
Annotation Date: 2023-12-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737321
Stage: TS21
Assay Id: MGI:7567669
Age: embryonic day 13.5
Specimen Label: kidney
Detected: true
Specimen Num: 4
•
•
•
•
•




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