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Search results 1 to 100 out of 323 for Shc1

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Saccharomyces cerevisiae
Gene
Type: gene
Organism: Danio rerio
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication  
First Author: Ahn R
Year: 2017
Journal: Nat Commun
Title: The Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression.
Volume: 8
Pages: 14638
Publication
First Author: Trampont P
Year: 2006
Journal: Mol Cell Biol
Title: ShcA mediates the dominant pathway to extracellular signal-regulated kinase activation during early thymic development.
Volume: 26
Issue: 23
Pages: 9035-44
Publication
First Author: McFarland KN
Year: 2006
Journal: J Neurosci
Title: Neural-specific inactivation of ShcA results in increased embryonic neural progenitor apoptosis and microencephaly.
Volume: 26
Issue: 30
Pages: 7885-97
Publication
First Author: Ursini-Siegel J
Year: 2012
Journal: Oncogene
Title: The ShcA SH2 domain engages a 14-3-3/PI3'K signaling complex and promotes breast cancer cell survival.
Volume: 31
Issue: 48
Pages: 5038-44
Publication
First Author: Ahn R
Year: 2013
Journal: Cancer Res
Title: The ShcA PTB domain functions as a biological sensor of phosphotyrosine signaling during breast cancer progression.
Volume: 73
Issue: 14
Pages: 4521-32
Publication
First Author: Ponti G
Year: 2010
Journal: Neuroscience
Title: Neural-specific inactivation of ShcA functions results in anatomical disorganization of subventricular zone neural stem cell niche in the adult brain.
Volume: 168
Issue: 1
Pages: 314-22
Publication
First Author: Zhang L
Year: 2002
Journal: Nat Immunol
Title: A nonredundant role for the adapter protein Shc in thymic T cell development.
Volume: 3
Issue: 8
Pages: 749-55
Publication
First Author: Trampont PC
Year: 2015
Journal: Mol Cell Biol
Title: ShcA regulates thymocyte proliferation through specific transcription factors and a c-Abl-dependent signaling axis.
Volume: 35
Issue: 8
Pages: 1462-76
Publication
First Author: Zheng Y
Year: 2013
Journal: Nature
Title: Temporal regulation of EGF signalling networks by the scaffold protein Shc1.
Volume: 499
Issue: 7457
Pages: 166-71
Publication
First Author: Soliman MA
Year: 2014
Journal: Sci Signal
Title: The adaptor protein p66Shc inhibits mTOR-dependent anabolic metabolism.
Volume: 7
Issue: 313
Pages: ra17
Publication
First Author: Pelicci G
Year: 1992
Journal: Cell
Title: A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction.
Volume: 70
Issue: 1
Pages: 93-104
Publication
First Author: Giles AJ
Year: 2009
Journal: J Immunol
Title: The adaptor protein Shc plays a key role during early B cell development.
Volume: 183
Issue: 9
Pages: 5468-76
Publication
First Author: Miyamoto Y
Year: 2005
Journal: J Neurosci
Title: Hippocampal synaptic modulation by the phosphotyrosine adapter protein ShcC/N-Shc via interaction with the NMDA receptor.
Volume: 25
Issue: 7
Pages: 1826-35
Publication
First Author: Buckley MW
Year: 2014
Journal: PLoS One
Title: Unexpected phenotype of mice lacking Shcbp1, a protein induced during T cell proliferation.
Volume: 9
Issue: 8
Pages: e105576
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Napoli C
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet.
Volume: 100
Issue: 4
Pages: 2112-6
Publication
First Author: Sweet DT
Year: 2012
Journal: Blood
Title: The adaptor protein Shc integrates growth factor and ECM signaling during postnatal angiogenesis.
Volume: 119
Issue: 8
Pages: 1946-55
Publication
First Author: Migliaccio E
Year: 1999
Journal: Nature
Title: The p66shc adaptor protein controls oxidative stress response and life span in mammals.
Volume: 402
Issue: 6759
Pages: 309-13
Publication
First Author: Ciciliot S
Year: 2018
Journal: FASEB J
Title: Interplay between gut microbiota and p66Shc affects obesity-associated insulin resistance.
Volume: 32
Issue: 7
Pages: 4004-4015
Publication
First Author: Natalicchio A
Year: 2015
Journal: Diabetologia
Title: The p66(Shc) redox adaptor protein is induced by saturated fatty acids and mediates lipotoxicity-induced apoptosis in pancreatic beta cells.
Volume: 58
Issue: 6
Pages: 1260-71
Publication
First Author: Tomilov AA
Year: 2011
Journal: Aging Cell
Title: The Shc locus regulates insulin signaling and adiposity in mammals.
Volume: 10
Issue: 1
Pages: 55-65
Publication
First Author: Berry A
Year: 2008
Journal: Exp Gerontol
Title: Deletion of the lifespan determinant p66(Shc) improves performance in a spatial memory task, decreases levels of oxidative stress markers in the hippocampus and increases levels of the neurotrophin BDNF in adult mice.
Volume: 43
Issue: 3
Pages: 200-8
Publication
First Author: Stern JH
Year: 2012
Journal: PLoS One
Title: The influence of shc proteins and aging on whole body energy expenditure and substrate utilization in mice.
Volume: 7
Issue: 11
Pages: e48790
Publication
First Author: Rota M
Year: 2006
Journal: Circ Res
Title: Diabetes promotes cardiac stem cell aging and heart failure, which are prevented by deletion of the p66shc gene.
Volume: 99
Issue: 1
Pages: 42-52
Publication
First Author: Zaccagnini G
Year: 2004
Journal: Circulation
Title: p66ShcA modulates tissue response to hindlimb ischemia.
Volume: 109
Issue: 23
Pages: 2917-23
Publication
First Author: Finetti F
Year: 2008
Journal: Blood
Title: The proapoptotic and antimitogenic protein p66SHC acts as a negative regulator of lymphocyte activation and autoimmunity.
Volume: 111
Issue: 10
Pages: 5017-27
Publication
First Author: Berry A
Year: 2007
Journal: Exp Gerontol
Title: Deletion of the life span determinant p66Shc prevents age-dependent increases in emotionality and pain sensitivity in mice.
Volume: 42
Issue: 1-2
Pages: 37-45
Publication
First Author: Giorgio M
Year: 2012
Journal: Aging Cell
Title: The p66Shc knocked out mice are short lived under natural condition.
Volume: 11
Issue: 1
Pages: 162-8
Publication
First Author: Lunghi B
Year: 2015
Journal: PLoS One
Title: Smoking p66Shc knocked out mice develop respiratory bronchiolitis with fibrosis but not emphysema.
Volume: 10
Issue: 3
Pages: e0119797
Publication
First Author: Menini S
Year: 2006
Journal: Diabetes
Title: Deletion of p66Shc longevity gene protects against experimental diabetic glomerulopathy by preventing diabetes-induced oxidative stress.
Volume: 55
Issue: 6
Pages: 1642-50
Publication
First Author: Lithgow GJ
Year: 2000
Journal: Bioessays
Title: The real Dorian Gray mouse.
Volume: 22
Issue: 5
Pages: 410-3
Publication
First Author: Camici GG
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Genetic deletion of p66(Shc) adaptor protein prevents hyperglycemia-induced endothelial dysfunction and oxidative stress.
Volume: 104
Issue: 12
Pages: 5217-22
Publication
First Author: Fadini GP
Year: 2010
Journal: Diabetes
Title: The redox enzyme p66Shc contributes to diabetes and ischemia-induced delay in cutaneous wound healing.
Volume: 59
Issue: 9
Pages: 2306-14
Publication
First Author: Carpi A
Year: 2009
Journal: Biochim Biophys Acta
Title: The cardioprotective effects elicited by p66(Shc) ablation demonstrate the crucial role of mitochondrial ROS formation in ischemia/reperfusion injury.
Volume: 1787
Issue: 7
Pages: 774-80
Publication
First Author: Patrussi L
Year: 2019
Journal: Haematologica
Title: p66Shc deficiency in the Eμ-TCL1 mouse model of chronic lymphocytic leukemia enhances leukemogenesis by altering the chemokine receptor landscape.
Volume: 104
Issue: 10
Pages: 2040-2052
Publication
First Author: Naldini A
Year: 2010
Journal: J Leukoc Biol
Title: The adaptor protein p66Shc is a positive regulator in the angiogenic response induced by hypoxic T cells.
Volume: 87
Issue: 3
Pages: 365-9
Publication
First Author: Gong J
Year: 2012
Journal: FASEB J
Title: Two protein kinase C isoforms, δ and ε, regulate energy homeostasis in mitochondria by transmitting opposing signals to the pyruvate dehydrogenase complex.
Volume: 26
Issue: 8
Pages: 3537-49
Publication
First Author: Granatiero V
Year: 2017
Journal: Sci Rep
Title: Role of p66shc in skeletal muscle function.
Volume: 7
Issue: 1
Pages: 6283
Publication
First Author: Berniakovich I
Year: 2008
Journal: J Biol Chem
Title: p66Shc-generated oxidative signal promotes fat accumulation.
Volume: 283
Issue: 49
Pages: 34283-93
Publication
First Author: Capitani N
Year: 2010
Journal: Blood
Title: Impaired expression of p66Shc, a novel regulator of B-cell survival, in chronic lymphocytic leukemia.
Volume: 115
Issue: 18
Pages: 3726-36
Publication
First Author: Tomilov A
Year: 2014
Journal: Aging Cell
Title: Shc depletion stimulates brown fat activity in vivo and in vitro.
Volume: 13
Issue: 6
Pages: 1049-58
Publication
First Author: Magenta A
Year: 2011
Journal: Cell Death Differ
Title: miR-200c is upregulated by oxidative stress and induces endothelial cell apoptosis and senescence via ZEB1 inhibition.
Volume: 18
Issue: 10
Pages: 1628-39
Publication
First Author: Ulivieri C
Year: 2011
Journal: J Immunol
Title: p66Shc is a negative regulator of FcεRI-dependent signaling in mast cells.
Volume: 186
Issue: 9
Pages: 5095-106
Publication
First Author: Graiani G
Year: 2005
Journal: Hypertension
Title: Genetic deletion of the p66Shc adaptor protein protects from angiotensin II-induced myocardial damage.
Volume: 46
Issue: 2
Pages: 433-40
Publication
First Author: Capitani N
Year: 2012
Journal: Blood
Title: S1P1 expression is controlled by the pro-oxidant activity of p66Shc and is impaired in B-CLL patients with unfavorable prognosis.
Volume: 120
Issue: 22
Pages: 4391-9
Publication
First Author: Berry A
Year: 2010
Journal: Exp Gerontol
Title: Greater resistance to inflammation at adulthood could contribute to extended life span of p66(Shc-/-) mice.
Volume: 45
Issue: 5
Pages: 343-50
Publication
First Author: Hagopian K
Year: 2015
Journal: PLoS One
Title: Key glycolytic enzyme activities of skeletal muscle are decreased under fed and fasted states in mice with knocked down levels of Shc proteins.
Volume: 10
Issue: 4
Pages: e0124204
Publication
First Author: Masi G
Year: 2014
Journal: J Leukoc Biol
Title: p66Shc regulates vesicle-mediated secretion in mast cells by affecting F-actin dynamics.
Volume: 95
Issue: 2
Pages: 285-92
Publication
First Author: Koch OR
Year: 2008
Journal: Lab Invest
Title: Role of the life span determinant P66(shcA) in ethanol-induced liver damage.
Volume: 88
Issue: 7
Pages: 750-60
Publication
First Author: Zaccagnini G
Year: 2007
Journal: J Biol Chem
Title: p66(ShcA) and oxidative stress modulate myogenic differentiation and skeletal muscle regeneration after hind limb ischemia.
Volume: 282
Issue: 43
Pages: 31453-9
Publication
First Author: Sweet DT
Year: 2013
Journal: Circ Res
Title: Endothelial Shc regulates arteriogenesis through dual control of arterial specification and inflammation via the notch and nuclear factor-κ-light-chain-enhancer of activated B-cell pathways.
Volume: 113
Issue: 1
Pages: 32-39
Publication
First Author: Ursini-Siegel J
Year: 2010
Journal: Cancer Res
Title: Receptor tyrosine kinase signaling favors a protumorigenic state in breast cancer cells by inhibiting the adaptive immune response.
Volume: 70
Issue: 20
Pages: 7776-87
Publication
First Author: Pesaresi MG
Year: 2011
Journal: Hum Mol Genet
Title: Mitochondrial redox signalling by p66Shc mediates ALS-like disease through Rac1 inactivation.
Volume: 20
Issue: 21
Pages: 4196-208
Publication
First Author: Salhan D
Year: 2012
Journal: Am J Physiol Renal Physiol
Title: HIV gene expression deactivates redox-sensitive stress response program in mouse tubular cells both in vitro and in vivo.
Volume: 302
Issue: 1
Pages: F129-40
Publication
First Author: Giorgio M
Year: 2016
Journal: Aging Cell
Title: P66SHC deletion improves fertility and progeric phenotype of late-generation TERC-deficient mice but not their short lifespan.
Volume: 15
Issue: 3
Pages: 446-54
Publication
First Author: Gertz M
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Activation of the lifespan regulator p66Shc through reversible disulfide bond formation.
Volume: 105
Issue: 15
Pages: 5705-9
Publication
First Author: Migliaccio E
Year: 1997
Journal: EMBO J
Title: Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway.
Volume: 16
Issue: 4
Pages: 706-16
Publication
First Author: Okada S
Year: 1997
Journal: J Biol Chem
Title: The 66-kDa Shc isoform is a negative regulator of the epidermal growth factor-stimulated mitogen-activated protein kinase pathway.
Volume: 272
Issue: 44
Pages: 28042-9
Publication
First Author: Khanday FA
Year: 2006
Journal: J Cell Biol
Title: Sos-mediated activation of rac1 by p66shc.
Volume: 172
Issue: 6
Pages: 817-22
Publication
First Author: Borg JP
Year: 1996
Journal: Mol Cell Biol
Title: The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein.
Volume: 16
Issue: 11
Pages: 6229-41
Publication
First Author: Liu Y
Year: 2008
Journal: J Cell Biol
Title: Shc coordinates signals from intercellular junctions and integrins to regulate flow-induced inflammation.
Volume: 182
Issue: 1
Pages: 185-96
Publication
First Author: Kasuno K
Year: 2007
Journal: Cell Death Differ
Title: Antagonism of p66shc by melanoma inhibitory activity.
Volume: 14
Issue: 8
Pages: 1414-21
Publication
First Author: Lebiedzinska M
Year: 2009
Journal: Arch Biochem Biophys
Title: Age-related changes in levels of p66Shc and serine 36-phosphorylated p66Shc in organs and mouse tissues.
Volume: 486
Issue: 1
Pages: 73-80
Publication
First Author: Papadimou E
Year: 2009
Journal: Mol Cell Neurosci
Title: p66(ShcA) adaptor molecule accelerates ES cell neural induction.
Volume: 41
Issue: 1
Pages: 74-84
Publication
First Author: Kumar A
Year: 2009
Journal: FASEB J
Title: Transcriptional repression of Kruppel like factor-2 by the adaptor protein p66shc.
Volume: 23
Issue: 12
Pages: 4344-52
Publication
First Author: Xiao D
Year: 2010
Journal: Cancer Res
Title: p66Shc is indispensable for phenethyl isothiocyanate-induced apoptosis in human prostate cancer cells.
Volume: 70
Issue: 8
Pages: 3150-8
Publication
First Author: Haga S
Year: 2010
Journal: Lab Invest
Title: p66(Shc) has a pivotal function in impaired liver regeneration in aged mice by a redox-dependent mechanism.
Volume: 90
Issue: 12
Pages: 1718-26
Publication  
First Author: Frijhoff J
Year: 2014
Journal: Free Radic Biol Med
Title: The mitochondrial reactive oxygen species regulator p66Shc controls PDGF-induced signaling and migration through protein tyrosine phosphatase oxidation.
Volume: 68
Pages: 268-77
Publication
First Author: Kumar S
Year: 2014
Journal: Biochem Biophys Res Commun
Title: P66Shc mediates increased platelet activation and aggregation in hypercholesterolemia.
Volume: 449
Issue: 4
Pages: 496-501
Publication
First Author: Minami Y
Year: 2018
Journal: Sci Rep
Title: p66Shc Signaling Mediates Diabetes-Related Cognitive Decline.
Volume: 8
Issue: 1
Pages: 3213
Publication
First Author: Im YK
Year: 2018
Journal: Cancer Res
Title: Interplay between ShcA Signaling and PGC-1α Triggers Targetable Metabolic Vulnerabilities in Breast Cancer.
Volume: 78
Issue: 17
Pages: 4826-4838
Publication
First Author: Baldassini WA
Year: 2017
Journal: Cell Biochem Funct
Title: The influence of Shc proteins and high-fat diet on energy metabolism of mice.
Volume: 35
Issue: 8
Pages: 527-537
GXD Expression    
Probe: MGI:4944253
Assay Type: RT-PCR
Annotation Date: 2011-04-12
Strength: Present
Sex: Female
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:4946246
Age: postnatal adult
Image: 1
Detected: true
Specimen Num: 10
GXD Expression    
Probe: MGI:4944253
Assay Type: RT-PCR
Annotation Date: 2011-04-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610522
Stage: TS22
Assay Id: MGI:4946246
Age: embryonic day 14.5
Image: 1
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:4944253
Assay Type: RT-PCR
Annotation Date: 2011-04-12
Strength: Present
Sex: Female
Emaps: EMAPS:3557728
Stage: TS28
Assay Id: MGI:4946246
Age: postnatal adult
Image: 1
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:4944253
Assay Type: RT-PCR
Annotation Date: 2011-04-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3557722
Stage: TS22
Assay Id: MGI:4946246
Age: embryonic day 14.5
Image: 1
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6159703
Assay Type: Western blot
Annotation Date: 2018-06-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6159733
Age: postnatal week 10
Image: 1
Detected: true
Specimen Num: 6