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Search results 1 to 100 out of 130 for Shoc2

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Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
8036 | SHOC2
Type: gene
Organism: human
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Gene
100495610 | shoc2
Type: gene
Organism: frog, western clawed
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Gene
477819 | SHOC2
Type: gene
Organism: dog, domestic
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Gene
511417 | SHOC2
Type: gene
Organism: cattle
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Gene
555476 | shoc2
Type: gene
Organism: zebrafish
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Gene
695572 | SHOC2
Type: gene
Organism: macaque, rhesus
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Gene
309548 | Shoc2
Type: gene
Organism: rat
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Gene
423894 | SHOC2
Type: gene
Organism: chicken
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Gene
466200 | SHOC2
Type: gene
Organism: chimpanzee
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Protein Domain
IPR027036 | SHOC2
Type: Family
Description: Leucine-rich repeat protein SHOC2 is a regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, it targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialised signaling complexes [, ]. In humans, defects in SHOC2 are the cause of Noonan syndrome-like disorder with loose anagen hair (NSLH) []. In Caenorhabditis elegans the homologue is known as Soc2 [].
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Protein Coding Gene
MGI:1927197 | Shoc2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
19684605 | -
First Author: Cordeddu V
Year: 2009
Journal: Nat Genet
Title: Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hair.
Volume: 41
Issue: 9
Pages: 1022-6
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Publication
10783161 | -
First Author: Li W
Year: 2000
Journal: Genes Dev
Title: The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf.
Volume: 14
Issue: 8
Pages: 895-900
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Publication
16630891 | -
First Author: Rodriguez-Viciana P
Year: 2006
Journal: Mol Cell
Title: A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity.
Volume: 22
Issue: 2
Pages: 217-30
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Publication
9618511 | -
First Author: Selfors LM
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: soc-2 encodes a leucine-rich repeat protein implicated in fibroblast growth factor receptor signaling.
Volume: 95
Issue: 12
Pages: 6903-8
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Protein
G8DYY0
Organism: Mus musculus/domesticus
Length: 43  
Fragment?: true
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Protein
G8DYZ0
Organism: Mus musculus/domesticus
Length: 43  
Fragment?: true
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Protein
G8DYT3
Organism: Mus musculus/domesticus
Length: 43  
Fragment?: true
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Protein
G8DYY6
Organism: Mus musculus/domesticus
Length: 43  
Fragment?: true
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Protein
G8DYU5
Organism: Mus musculus/domesticus
Length: 43  
Fragment?: true
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Protein
O88520
Organism: Mus musculus/domesticus
Length: 582  
Fragment?: false
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Protein
Q8R378
Organism: Mus musculus/domesticus
Length: 524  
Fragment?: false
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Protein
A0A494BAG1
Organism: Mus musculus/domesticus
Length: 372  
Fragment?: true
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Publication
36543126 | J:332394
First Author: Tan M
Year: 2022
Journal: Cell Rep
Title: The Sag-Shoc2 axis regulates conversion of mPanINs to cystic lesions in Kras pancreatic tumor model.
Volume: 41
Issue: 12
Pages: 111837
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Publication
20549726 | J:161211
First Author: Yi J
Year: 2010
Journal: Dev Dyn
Title: Endothelial SUR-8 acts in an ERK-independent pathway during atrioventricular cushion development.
Volume: 239
Issue: 7
Pages: 2005-13
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Protein Coding Gene
MGP_CAROLIEiJ_G0023078 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0025252 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0025228 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0025197 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0025223 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0024983 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1927197 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0025666 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0024448 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0024963 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0025095 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0025056 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0025181 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0025089 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0025724 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0024196 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0024518 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0014566 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0023999 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
9674433 | J:48584
First Author: Sieburth DS
Year: 1998
Journal: Cell
Title: SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans.
Volume: 94
Issue: 1
Pages: 119-30
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GXD Expression
GXD Expression
   
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2024-03-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7614566
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_07
Specimen Label: euxassay_004370_07
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_08
Specimen Label: euxassay_004370_08
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_09
Specimen Label: euxassay_004370_09
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_13
Specimen Label: euxassay_004370_13
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_14
Specimen Label: euxassay_004370_14
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_15
Specimen Label: euxassay_004370_15
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_16
Specimen Label: euxassay_004370_16
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_17
Specimen Label: euxassay_004370_17
Detected: true
Specimen Num: 13
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GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_18
Specimen Label: euxassay_004370_18
Detected: true
Specimen Num: 14
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GXD Expression
GXD Expression
   
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2024-03-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7614566
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_02
Specimen Label: euxassay_004370_02
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_03
Specimen Label: euxassay_004370_03
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_04
Specimen Label: euxassay_004370_04
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_05
Specimen Label: euxassay_004370_05
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_06
Specimen Label: euxassay_004370_06
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_07
Specimen Label: euxassay_004370_07
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_08
Specimen Label: euxassay_004370_08
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_16
Specimen Label: euxassay_004370_16
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_17
Specimen Label: euxassay_004370_17
Detected: true
Specimen Num: 13
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GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_18
Specimen Label: euxassay_004370_18
Detected: true
Specimen Num: 14
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GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_19
Specimen Label: euxassay_004370_19
Detected: true
Specimen Num: 15
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GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_20
Specimen Label: euxassay_004370_20
Detected: true
Specimen Num: 16
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GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_21
Specimen Label: euxassay_004370_21
Detected: true
Specimen Num: 17
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GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_22
Specimen Label: euxassay_004370_22
Detected: true
Specimen Num: 18
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GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1756923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_03
Specimen Label: euxassay_004370_03
Detected: true
Specimen Num: 2
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•
GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1756923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_21
Specimen Label: euxassay_004370_21
Detected: true
Specimen Num: 17
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•
GXD Expression
GXD Expression
   
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2024-03-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280922
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7614566
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
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•
GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_06
Specimen Label: euxassay_004370_06
Detected: true
Specimen Num: 5
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•
GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_07
Specimen Label: euxassay_004370_07
Detected: true
Specimen Num: 6
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•
GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_18
Specimen Label: euxassay_004370_18
Detected: true
Specimen Num: 14
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Publication
16682971 | J:109581
First Author: Clee SM
Year: 2006
Journal: Nat Genet
Title: Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus.
Volume: 38
Issue: 6
Pages: 688-93
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Publication
15597075 | J:98587
First Author: Hitzemann R
Year: 2004
Journal: Alcohol Clin Exp Res
Title: On the integration of alcohol-related quantitative trait loci and gene expression analyses.
Volume: 28
Issue: 10
Pages: 1437-48
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Publication
17276355 | J:129766
First Author: Sano M
Year: 2007
Journal: Cell Metab
Title: Ménage-à-trois 1 is critical for the transcriptional function of PPARgamma coactivator 1.
Volume: 5
Issue: 2
Pages: 129-42
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Publication
14621295 | J:86686
First Author: Okazaki N
Year: 2003
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 10
Issue: 4
Pages: 167-80
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Publication
10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
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