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Search results 1 to 100 out of 130 for Shoc2

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
8036 | SHOC2
Type: gene
Organism: human
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Gene
100495610 | shoc2
Type: gene
Organism: frog, western clawed
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Gene
309548 | Shoc2
Type: gene
Organism: rat
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Gene
466200 | SHOC2
Type: gene
Organism: chimpanzee
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Gene
477819 | SHOC2
Type: gene
Organism: dog, domestic
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Gene
511417 | SHOC2
Type: gene
Organism: cattle
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Gene
555476 | shoc2
Type: gene
Organism: zebrafish
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Gene
695572 | SHOC2
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR027036 | SHOC2
Type: Family
Description: Leucine-rich repeat protein SHOC2 is a regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, it targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialised signaling complexes [, ]. In humans, defects in SHOC2 are the cause of Noonan syndrome-like disorder with loose anagen hair (NSLH) []. In Caenorhabditis elegans the homologue is known as Soc2 [].
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Gene
423894 | SHOC2
Type: gene
Organism: chicken
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Protein Coding Gene
MGI:1927197 | Shoc2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
19684605 | -
First Author: Cordeddu V
Year: 2009
Journal: Nat Genet
Title: Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hair.
Volume: 41
Issue: 9
Pages: 1022-6
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Publication
10783161 | -
First Author: Li W
Year: 2000
Journal: Genes Dev
Title: The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf.
Volume: 14
Issue: 8
Pages: 895-900
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Publication
16630891 | -
First Author: Rodriguez-Viciana P
Year: 2006
Journal: Mol Cell
Title: A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity.
Volume: 22
Issue: 2
Pages: 217-30
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Publication
9618511 | -
First Author: Selfors LM
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: soc-2 encodes a leucine-rich repeat protein implicated in fibroblast growth factor receptor signaling.
Volume: 95
Issue: 12
Pages: 6903-8
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Protein
G8DYY0
Organism: Mus musculus/domesticus
Length: 43  
Fragment?: true
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Protein
G8DYZ0
Organism: Mus musculus/domesticus
Length: 43  
Fragment?: true
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Protein
G8DYT3
Organism: Mus musculus/domesticus
Length: 43  
Fragment?: true
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Protein
G8DYY6
Organism: Mus musculus/domesticus
Length: 43  
Fragment?: true
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Protein
G8DYU5
Organism: Mus musculus/domesticus
Length: 43  
Fragment?: true
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Protein
A0A494BAG1
Organism: Mus musculus/domesticus
Length: 372  
Fragment?: true
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Protein
O88520
Organism: Mus musculus/domesticus
Length: 582  
Fragment?: false
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Protein
Q8R378
Organism: Mus musculus/domesticus
Length: 524  
Fragment?: false
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Publication
36543126 | J:332394
First Author: Tan M
Year: 2022
Journal: Cell Rep
Title: The Sag-Shoc2 axis regulates conversion of mPanINs to cystic lesions in Kras pancreatic tumor model.
Volume: 41
Issue: 12
Pages: 111837
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Publication
20549726 | J:161211
First Author: Yi J
Year: 2010
Journal: Dev Dyn
Title: Endothelial SUR-8 acts in an ERK-independent pathway during atrioventricular cushion development.
Volume: 239
Issue: 7
Pages: 2005-13
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Protein Coding Gene
MGP_CAROLIEiJ_G0023078 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0025252 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0025228 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0025197 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0025223 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0024983 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1927197 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0025666 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0024448 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0024963 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0025095 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0025056 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0025181 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0025089 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0025724 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0024196 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0024518 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0014566 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0023999 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
9674433 | J:48584
First Author: Sieburth DS
Year: 1998
Journal: Cell
Title: SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans.
Volume: 94
Issue: 1
Pages: 119-30
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GXD Expression
GXD Expression
   
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2024-03-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7614566
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_07
Specimen Label: euxassay_004370_07
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_08
Specimen Label: euxassay_004370_08
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_09
Specimen Label: euxassay_004370_09
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_13
Specimen Label: euxassay_004370_13
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_14
Specimen Label: euxassay_004370_14
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_15
Specimen Label: euxassay_004370_15
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_16
Specimen Label: euxassay_004370_16
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_17
Specimen Label: euxassay_004370_17
Detected: true
Specimen Num: 13
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GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_18
Specimen Label: euxassay_004370_18
Detected: true
Specimen Num: 14
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GXD Expression
GXD Expression
   
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2024-03-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7614566
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_02
Specimen Label: euxassay_004370_02
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_03
Specimen Label: euxassay_004370_03
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_04
Specimen Label: euxassay_004370_04
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_05
Specimen Label: euxassay_004370_05
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_06
Specimen Label: euxassay_004370_06
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_07
Specimen Label: euxassay_004370_07
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_08
Specimen Label: euxassay_004370_08
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_16
Specimen Label: euxassay_004370_16
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_17
Specimen Label: euxassay_004370_17
Detected: true
Specimen Num: 13
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GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_18
Specimen Label: euxassay_004370_18
Detected: true
Specimen Num: 14
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GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_19
Specimen Label: euxassay_004370_19
Detected: true
Specimen Num: 15
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GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_20
Specimen Label: euxassay_004370_20
Detected: true
Specimen Num: 16
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GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_21
Specimen Label: euxassay_004370_21
Detected: true
Specimen Num: 17
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GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_22
Specimen Label: euxassay_004370_22
Detected: true
Specimen Num: 18
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GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1756923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_03
Specimen Label: euxassay_004370_03
Detected: true
Specimen Num: 2
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•
GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1756923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_21
Specimen Label: euxassay_004370_21
Detected: true
Specimen Num: 17
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•
GXD Expression
GXD Expression
   
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2024-03-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280922
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7614566
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
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•
GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_06
Specimen Label: euxassay_004370_06
Detected: true
Specimen Num: 5
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•
GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_07
Specimen Label: euxassay_004370_07
Detected: true
Specimen Num: 6
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•
GXD Expression
GXD Expression
 
Probe: MGI:1817058
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828063
Age: embryonic day 14.5
Image: euxassay_004370_18
Specimen Label: euxassay_004370_18
Detected: true
Specimen Num: 14
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Publication
16682971 | J:109581
First Author: Clee SM
Year: 2006
Journal: Nat Genet
Title: Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus.
Volume: 38
Issue: 6
Pages: 688-93
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Publication
15597075 | J:98587
First Author: Hitzemann R
Year: 2004
Journal: Alcohol Clin Exp Res
Title: On the integration of alcohol-related quantitative trait loci and gene expression analyses.
Volume: 28
Issue: 10
Pages: 1437-48
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Publication
17276355 | J:129766
First Author: Sano M
Year: 2007
Journal: Cell Metab
Title: Ménage-à-trois 1 is critical for the transcriptional function of PPARgamma coactivator 1.
Volume: 5
Issue: 2
Pages: 129-42
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Publication
14621295 | J:86686
First Author: Okazaki N
Year: 2003
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 10
Issue: 4
Pages: 167-80
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Publication
10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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