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Search results 1 to 89 out of 89 for Siglech

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Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
361584 | Siglech
Type: gene
Organism: rat
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Protein Coding Gene
MGI:2443256 | Siglech
Type: protein_coding_gene
Organism: mouse, laboratory
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GXD Expression
GXD Expression
Probe: MGI:7488356
Assay Type: Immunohistochemistry
Annotation Date: 2023-06-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3819020
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:7488360
Age: embryonic day 12.5
Image: S1G E12.5 SiglecH
Note: Almost all P2ry12-expressing cells were positive for Siglech expression.
Specimen Label: S1G E12.5 SiglecH
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:7488356
Assay Type: Immunohistochemistry
Annotation Date: 2023-06-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3819021
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:7488360
Age: embryonic day 13.5
Image: S1G E13.5 SiglecH
Note: Almost all P2ry12-expressing cells were positive for Siglech expression.
Specimen Label: S1G E13.5 SiglecH
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:7488356
Assay Type: Immunohistochemistry
Annotation Date: 2023-06-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3819022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:7488360
Age: embryonic day 14.5
Image: S1G E14.5 SiglecH
Note: Almost all P2ry12-expressing cells were positive for Siglech expression.
Specimen Label: S1G E14.5 SiglecH
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:7488356
Assay Type: Immunohistochemistry
Annotation Date: 2023-06-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3819023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:7488360
Age: embryonic day 15.5
Image: S1G E15.5 SiglecH
Note: Almost all P2ry12-expressing cells were positive for Siglech expression.
Specimen Label: S1G E15.5 SiglecH
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:7488356
Assay Type: Immunohistochemistry
Annotation Date: 2023-06-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3819024
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:7488360
Age: embryonic day 16.5
Image: S1G E16.5 SiglecH
Note: Almost all P2ry12-expressing cells were positive for Siglech expression.
Specimen Label: S1G E16.5 SiglecH
Detected: true
Specimen Num: 5
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Publication
24683186 | J:209974
First Author: Swiecki M
Year: 2014
Journal: J Immunol
Title: Cell depletion in mice that express diphtheria toxin receptor under the control of SiglecH encompasses more than plasmacytoid dendritic cells.
Volume: 192
Issue: 9
Pages: 4409-16
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Publication
36928414 | J:337732
First Author: Valente M
Year: 2023
Journal: Nat Immunol
Title: Novel mouse models based on intersectional genetics to identify and characterize plasmacytoid dendritic cells.
Volume: 24
Issue: 4
Pages: 714-728
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Publication
28836308 | J:253079
First Author: Konishi H
Year: 2017
Journal: Glia
Title: Siglec-H is a microglia-specific marker that discriminates microglia from CNS-associated macrophages and CNS-infiltrating monocytes.
Volume: 65
Issue: 12
Pages: 1927-1943
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Publication
30131424 | J:267220
 
First Author: Tomasello E
Year: 2018
Journal: EMBO J
Title: Molecular dissection of plasmacytoid dendritic cell activation in vivo during a viral infection.
Volume: 37
Issue: 19
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Protein Coding Gene
MGP_CAROLIEiJ_G0029802 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0032311 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0032290 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0032226 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0032302 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0032015 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2443256 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0032795 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0031344 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0031980 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0032137 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0032091 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0032218 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0032128 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0032812 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0031064 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0031462 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0013027 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0030905 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:94077
     
First Author: Mutant Mouse Regional Resource Centers
Year: 2004
Journal: Unpublished
Title: Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC)
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
35921817 | J:330795
First Author: Wang X
Year: 2022
Journal: Cell Metab
Title: CD24-Siglec axis is an innate immune checkpoint against metaflammation and metabolic disorder.
Volume: 34
Issue: 8
Pages: 1088-1103.e6
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Publication
23118208 | J:217719
First Author: Orr SL
Year: 2013
Journal: Glycobiology
Title: A phenotype survey of 36 mutant mouse strains with gene-targeted defects in glycosyltransferases or glycan-binding proteins.
Volume: 23
Issue: 3
Pages: 363-80
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Publication
31264967 | J:282050
First Author: Koda Y
Year: 2019
Journal: J Clin Invest
Title: Plasmacytoid dendritic cells protect against immune-mediated acute liver injury via IL-35.
Volume: 129
Issue: 8
Pages: 3201-3213
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Publication
24086137 | J:214874
First Author: Puttur F
Year: 2013
Journal: PLoS Pathog
Title: Absence of Siglec-H in MCMV infection elevates interferon alpha production but does not enhance viral clearance.
Volume: 9
Issue: 9
Pages: e1003648
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Publication
27377589 | J:236472
First Author: Schmitt H
Year: 2016
Journal: J Exp Med
Title: Siglec-H protects from virus-triggered severe systemic autoimmunity.
Volume: 213
Issue: 8
Pages: 1627-44
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Publication
22177923 | J:179283
First Author: Takagi H
Year: 2011
Journal: Immunity
Title: Plasmacytoid dendritic cells are crucial for the initiation of inflammation and T cell immunity in vivo.
Volume: 35
Issue: 6
Pages: 958-71
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Publication
34157360 | J:310641
     
First Author: Li C
Year: 2021
Journal: Neurosci Res
Title: A mouse model of microglia-specific ablation in the embryonic central nervous system.
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Publication
27075414 | J:275853
 
First Author: Takagi H
Year: 2016
Journal: Sci Rep
Title: Plasmacytoid dendritic cells orchestrate TLR7-mediated innate and adaptive immunity for the initiation of autoimmune inflammation.
Volume: 6
Pages: 24477
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Publication
32959911 | J:297442
First Author: Konishi H
Year: 2020
Journal: EMBO J
Title: Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction.
Volume: 39
Issue: 22
Pages: e104464
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Publication
21130004 | J:166504
First Author: Swiecki M
Year: 2010
Journal: Immunity
Title: Plasmacytoid dendritic cell ablation impacts early interferon responses and antiviral NK and CD8(+) T cell accrual.
Volume: 33
Issue: 6
Pages: 955-66
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Publication
22084408 | J:178613
First Author: Swiecki M
Year: 2011
Journal: J Exp Med
Title: Type I interferon negatively controls plasmacytoid dendritic cell numbers in vivo.
Volume: 208
Issue: 12
Pages: 2367-74
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Publication
36753421 | J:333946
First Author: Hattori Y
Year: 2023
Journal: Cell Rep
Title: CD206(+) macrophages transventricularly infiltrate the early embryonic cerebral wall to differentiate into microglia.
Volume: 42
Issue: 2
Pages: 112092
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Publication
24591644 | J:207383
First Author: Ippolito GC
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Dendritic cell fate is determined by BCL11A.
Volume: 111
Issue: 11
Pages: E998-1006
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Publication
16280085 | J:103338
 
First Author: Stefan M
Year: 2005
Journal: BMC Genomics
Title: Genetic mapping of putative Chrna7 and Luzp2 neuronal transcriptional enhancers due to impact of a transgene-insertion and 6.8 Mb deletion in a mouse model of Prader-Willi and Angelman syndromes.
Volume: 6
Pages: 157
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
16397130 | J:132557
First Author: Zhang J
Year: 2006
Journal: Blood
Title: Characterization of Siglec-H as a novel endocytic receptor expressed on murine plasmacytoid dendritic cell precursors.
Volume: 107
Issue: 9
Pages: 3600-8
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Publication
16293595 | J:129371
First Author: Blasius AL
Year: 2006
Journal: Blood
Title: Siglec-H is an IPC-specific receptor that modulates type I IFN secretion through DAP12.
Volume: 107
Issue: 6
Pages: 2474-6
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Publication
22732587 | J:189788
First Author: Piva L
Year: 2012
Journal: J Immunol
Title: Cutting edge: Clec9A+ dendritic cells mediate the development of experimental cerebral malaria.
Volume: 189
Issue: 3
Pages: 1128-32
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Publication
23633299 | J:198565
First Author: Kopatz J
Year: 2013
Journal: Glia
Title: Siglec-h on activated microglia for recognition and engulfment of glioma cells.
Volume: 61
Issue: 7
Pages: 1122-33
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Publication
34497606 | J:312879
 
First Author: Szumilas N
Year: 2021
Journal: Front Immunol
Title: Siglec-H-Deficient Mice Show Enhanced Type I IFN Responses, but Do Not Develop Autoimmunity After Influenza or LCMV Infections.
Volume: 12
Pages: 698420
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GXD Expression
GXD Expression
   
Probe: MGI:6199180
Assay Type: RT-PCR
Annotation Date: 2018-09-24
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684625
Stage: TS25
Assay Id: MGI:6199186
Age: embryonic day 17.0
Image: S1
Specimen Label: -/-
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6199180
Assay Type: RT-PCR
Annotation Date: 2018-09-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684625
Stage: TS25
Assay Id: MGI:6199186
Age: embryonic day 17.0
Image: S1
Specimen Label: +/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6199180
Assay Type: RT-PCR
Annotation Date: 2018-09-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684625
Stage: TS25
Assay Id: MGI:6199186
Age: embryonic day 17.0
Image: S1
Specimen Label: +/-
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6199180
Assay Type: RT-PCR
Annotation Date: 2018-09-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684625
Stage: TS25
Assay Id: MGI:6199186
Age: embryonic day 17.0
Image: S1
Specimen Label: +/+
Detected: true
Specimen Num: 4
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Protein
B7ZMQ5
Organism: Mus musculus/domesticus
Length: 216  
Fragment?: false
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Protein
B7ZMQ6
Organism: Mus musculus/domesticus
Length: 332  
Fragment?: false
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Protein
Q4QQK7
Organism: Mus musculus/domesticus
Length: 309  
Fragment?: false
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Allele
Siglech<em1Smoc> | MGI:7292321
Name: sialic acid binding Ig-like lectin H; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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GXD Expression
GXD Expression
Probe: MGI:7488353
Assay Type: Immunohistochemistry
Annotation Date: 2023-06-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3819021
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:7488357
Age: embryonic day 13.5
Image: S1G E13.5 P2RY12
Note: Almost all P2ry12-expressing cells were positive for Siglech expression.
Specimen Label: S1G E13.5 P2RY12
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
Probe: MGI:7488353
Assay Type: Immunohistochemistry
Annotation Date: 2023-06-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3819022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:7488357
Age: embryonic day 14.5
Image: S1G E14.5 P2RY12
Note: Almost all P2ry12-expressing cells were positive for Siglech expression.
Specimen Label: S1G E14.5 P2RY12
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
Probe: MGI:7488353
Assay Type: Immunohistochemistry
Annotation Date: 2023-06-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3819023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:7488357
Age: embryonic day 15.5
Image: S1G E15.5 P2RY12
Note: Almost all P2ry12-expressing cells were positive for Siglech expression.
Specimen Label: S1G E15.5 P2RY12
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
Probe: MGI:7488353
Assay Type: Immunohistochemistry
Annotation Date: 2023-06-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3819024
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:7488357
Age: embryonic day 16.5
Image: S1G E16.5 P2RY12
Note: Almost all P2ry12-expressing cells were positive for Siglech expression.
Specimen Label: S1G E16.5 P2RY12
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
Probe: MGI:7488353
Assay Type: Immunohistochemistry
Annotation Date: 2023-06-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3819020
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:7488357
Age: embryonic day 12.5
Image: S1G E12.5 P2RY12
Note: Almost all P2ry12-expressing cells were positive for Siglech expression.
Specimen Label: S1G E12.5 P2RY12
Detected: true
Specimen Num: 7
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Allele
Siglech<tm1.1(icre)Ciphe> | MGI:6357988
Name: sialic acid binding Ig-like lectin H; targeted mutation 1.1, Centre d'ImmunoPhenomique
Allele Type: Targeted
Attribute String: Recombinase
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Publication
29925996 | J:282415
First Author: Rodrigues PF
Year: 2018
Journal: Nat Immunol
Title: Distinct progenitor lineages contribute to the heterogeneity of plasmacytoid dendritic cells.
Volume: 19
Issue: 7
Pages: 711-722
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Siglech/Siglech<+>
Background: involves: C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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