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Search results 1 to 100 out of 111 for Sik2

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0.022s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Drosophila melanogaster
Gene
Type: gene
Organism: Rattus norvegicus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Horike N
Year: 2003
Journal: J Biol Chem
Title: Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2.
Volume: 278
Issue: 20
Pages: 18440-7
Publication
First Author: Horike N
Year: 2010
Journal: Pigment Cell Melanoma Res
Title: Downregulation of SIK2 expression promotes the melanogenic program in mice.
Volume: 23
Issue: 6
Pages: 809-19
Publication
First Author: Park J
Year: 2014
Journal: Diabetes
Title: SIK2 is critical in the regulation of lipid homeostasis and adipogenesis in vivo.
Volume: 63
Issue: 11
Pages: 3659-73
Publication
First Author: Park M
Year: 2020
Journal: Sci Rep
Title: Loss of the conserved PKA sites of SIK1 and SIK2 increases sleep need.
Volume: 10
Issue: 1
Pages: 8676
Publication
First Author: Darling NJ
Year: 2017
Journal: Biochem J
Title: Inhibition of SIK2 and SIK3 during differentiation enhances the anti-inflammatory phenotype of macrophages.
Volume: 474
Issue: 4
Pages: 521-537
Publication
First Author: Katoh Y
Year: 2006
Journal: FEBS J
Title: Silencing the constitutive active transcription factor CREB by the LKB1-SIK signaling cascade.
Volume: 273
Issue: 12
Pages: 2730-48
Publication
First Author: Popov S
Year: 2014
Journal: PLoS One
Title: Lack of salt-inducible kinase 2 (SIK2) prevents the development of cardiac hypertrophy in response to chronic high-salt intake.
Volume: 9
Issue: 4
Pages: e95771
Publication
First Author: Wei T
Year: 2019
Journal: Cell Death Dis
Title: Sirtuin 3-mediated pyruvate dehydrogenase activity determines brown adipocytes phenotype under high-salt conditions.
Volume: 10
Issue: 8
Pages: 614
Publication
First Author: Nakatsu Y
Year: 2017
Journal: J Biol Chem
Title: The prolyl isomerase Pin1 increases β-cell proliferation and enhances insulin secretion.
Volume: 292
Issue: 28
Pages: 11886-11895
Publication
First Author: Sakamaki J
Year: 2014
Journal: Nat Cell Biol
Title: Role of the SIK2-p35-PJA2 complex in pancreatic β-cell functional compensation.
Volume: 16
Issue: 3
Pages: 234-44
Publication  
First Author: Armouti M
Year: 2020
Journal: Endocrinology
Title: Salt-inducible Kinases Are Critical Determinants of Female Fertility.
Volume: 161
Issue: 7
Publication  
First Author: Patel K
Year: 2014
Journal: Nat Commun
Title: The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver.
Volume: 5
Pages: 4535
Publication
First Author: Paulo E
Year: 2018
Journal: Sci Rep
Title: Sympathetic inputs regulate adaptive thermogenesis in brown adipose tissue through cAMP-Salt inducible kinase axis.
Volume: 8
Issue: 1
Pages: 11001
Publication
First Author: Bricambert J
Year: 2010
Journal: J Clin Invest
Title: Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice.
Volume: 120
Issue: 12
Pages: 4316-31
Publication
First Author: Muraoka M
Year: 2009
Journal: Am J Physiol Endocrinol Metab
Title: Involvement of SIK2/TORC2 signaling cascade in the regulation of insulin-induced PGC-1alpha and UCP-1 gene expression in brown adipocytes.
Volume: 296
Issue: 6
Pages: E1430-9
Publication    
First Author: Darling NJ
Year: 2021
Journal: J Biol Chem
Title: Salt-inducible kinases are required for the IL-33-dependent secretion of cytokines and chemokines in mast cells.
Pages: 100428
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Nishimori S
Year: 2019
Journal: J Clin Invest
Title: Salt-inducible kinases dictate parathyroid hormone 1 receptor action in bone development and remodeling.
Volume: 129
Issue: 12
Pages: 5187-5203
Publication
First Author: Lin C
Year: 2017
Journal: PLoS One
Title: Adiposity QTL Adip20 decomposes into at least four loci when dissected using congenic strains.
Volume: 12
Issue: 12
Pages: e0188972
Publication
First Author: Sanosaka M
Year: 2015
Journal: Immunology
Title: Salt-inducible kinase 3 deficiency exacerbates lipopolysaccharide-induced endotoxin shock accompanied by increased levels of pro-inflammatory molecules in mice.
Volume: 145
Issue: 2
Pages: 268-78
Publication
First Author: Kim MJ
Year: 2015
Journal: Diabetes
Title: Salt-Inducible Kinase 1 Terminates cAMP Signaling by an Evolutionarily Conserved Negative-Feedback Loop in β-Cells.
Volume: 64
Issue: 9
Pages: 3189-202
Publication
First Author: Clark K
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages.
Volume: 109
Issue: 42
Pages: 16986-91
Publication  
First Author: Wein MN
Year: 2016
Journal: Nat Commun
Title: SIKs control osteocyte responses to parathyroid hormone.
Volume: 7
Pages: 13176
Publication
First Author: Kuwako KI
Year: 2018
Journal: Cell Rep
Title: The LKB1-SIK Pathway Controls Dendrite Self-Avoidance in Purkinje Cells.
Volume: 24
Issue: 11
Pages: 2808-2818.e4
Publication
First Author: Patra KC
Year: 2018
Journal: Nat Cell Biol
Title: Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism.
Volume: 20
Issue: 7
Pages: 811-822
Publication
First Author: Trivedi CM
Year: 2010
Journal: Dev Cell
Title: Hopx and Hdac2 interact to modulate Gata4 acetylation and embryonic cardiac myocyte proliferation.
Volume: 19
Issue: 3
Pages: 450-9
Publication      
First Author: MGI and IMPC
Year: 2017
Journal: MGI Direct Data Submission
Title: MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication          
First Author: MGD Nomenclature Committee
Year: 1995
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Protein
Organism: Mus musculus
Length: 931  
Fragment?: false
UniProt Feature
Begin: 1
Description: Serine/threonine-protein kinase SIK2
Type: chain
End: 931
UniProt Feature
Begin: 162
Description: Phosphoserine; by SIK2
Type: modified residue
End: 162
UniProt Feature
Begin: 789
Description: Phosphoserine; by AMPK and SIK2
Type: modified residue
End: 789
UniProt Feature
Begin: 171
Description: Phosphoserine; by AMPK, MARK2, SIK1 and SIK2
Type: modified residue
End: 171
Publication
First Author: Ahmed AA
Year: 2010
Journal: Cancer Cell
Title: SIK2 is a centrosome kinase required for bipolar mitotic spindle formation that provides a potential target for therapy in ovarian cancer.
Volume: 18
Issue: 2
Pages: 109-21
Publication
First Author: Sonntag T
Year: 2018
Journal: FEBS J
Title: 14-3-3 proteins mediate inhibitory effects of cAMP on salt-inducible kinases (SIKs).
Volume: 285
Issue: 3
Pages: 467-480
Publication
First Author: Jaitovich A
Year: 2010
Journal: Biochim Biophys Acta
Title: Intracellular sodium sensing: SIK1 network, hormone action and high blood pressure.
Volume: 1802
Issue: 12
Pages: 1140-9
Publication
First Author: Takemori H
Year: 2003
Journal: J Steroid Biochem Mol Biol
Title: Salt-inducible kinase-mediated regulation of steroidogenesis at the early stage of ACTH-stimulation.
Volume: 85
Issue: 2-5
Pages: 397-400
Publication
First Author: Uebi T
Year: 2012
Journal: PLoS One
Title: Involvement of SIK3 in glucose and lipid homeostasis in mice.
Volume: 7
Issue: 5
Pages: e37803
Publication
First Author: Katoh Y
Year: 2004
Journal: Mol Cell Endocrinol
Title: Salt-inducible kinase (SIK) isoforms: their involvement in steroidogenesis and adipogenesis.
Volume: 217
Issue: 1-2
Pages: 109-12
Publication
First Author: Hietakangas V
Year: 2008
Journal: Cell Metab
Title: TORCing up metabolic control in the brain.
Volume: 7
Issue: 5
Pages: 357-8
Protein Domain
Type: Domain
Description: SIKsare serine/threonine kinasse that are part of a complex network that regulates Na,K-ATPase to maintain sodium homeostasis and blood pressure []. Vertebrates contain three forms of SIKs (SIK1-3) from three distinct genes, which display tissue-specific effects. SIK1, also called SNF1LK, controls steroidogenic enzyme production in adrenocortical cells []. In the brain, both SIK1 and SIK2 regulate energy metabolism []. SIK2, also called QIK or SNF1LK2, is involved in the regulation of gluconeogenesis in the liver and lipogenesis in adipose tissues, where it phosphorylates the insulin receptor substrate-1 []. In the liver, SIK3 (also called QSK) regulates cholesterol and bile acid metabolism []. In addition, SIK2 plays an important role in the initiation of mitosis and regulates the localization of C-Nap1, a centrosome linker protein [].
Publication
First Author: Katoh M
Year: 2003
Journal: Int J Oncol
Title: Identification and characterization of human KIAA1391 and mouse Kiaa1391 genes encoding novel RhoGAP family proteins with RA domain and ANXL repeats.
Volume: 23
Issue: 5
Pages: 1471-6
Publication
First Author: Dentin R
Year: 2007
Journal: Nature
Title: Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2.
Volume: 449
Issue: 7160
Pages: 366-9
Publication
First Author: Ricarte FR
Year: 2018
Journal: J Biol Chem
Title: Parathyroid hormone(1-34) and its analogs differentially modulate osteoblastic Rankl expression via PKA/SIK2/SIK3 and PP1/PP2A-CRTC3 signaling.
Volume: 293
Issue: 52
Pages: 20200-20213
Publication
First Author: Kim MK
Year: 2019
Journal: Cell Death Dis
Title: Salt-inducible kinase 1 regulates bone anabolism via the CRTC1-CREB-Id1 axis.
Volume: 10
Issue: 11
Pages: 826
Publication  
First Author: Nishimori S
Year: 2021
Journal: Bone
Title: PTHrP targets salt-inducible kinases, HDAC4 and HDAC5, to repress chondrocyte hypertrophy in the growth plate.
Volume: 142
Pages: 115709
Publication
First Author: Darling NJ
Year: 2021
Journal: Biochem J
Title: Nuts and bolts of the salt-inducible kinases (SIKs).
Volume: 478
Issue: 7
Pages: 1377-1397
Publication
First Author: Katoh Y
Year: 2004
Journal: Eur J Biochem
Title: Salt-inducible kinase-1 represses cAMP response element-binding protein activity both in the nucleus and in the cytoplasm.
Volume: 271
Issue: 21
Pages: 4307-19
Publication
First Author: Stephenson A
Year: 2004
Journal: Genomics
Title: snf1lk encodes a protein kinase that may function in cell cycle regulation.
Volume: 83
Issue: 6
Pages: 1105-15
Protein Domain
Type: Family
Description: Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].This entry represents the salt-inducible protein kinases, SIK1 and SIK2, which are serine/threonine-protein kinases. SIK1 is involved in a variety of processes, such as cell cycle regulation, gluconeogenesis and lipogenesis regulation and muscle growth [, , ]. SIK2 phosphorylates insulin receptor substrate-1 (IRS1) in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction, and may have a role in the development of insulin resistance in diabetes [].
Publication
First Author: Lombardi MS
Year: 2017
Journal: PLoS One
Title: Salt-inducible kinases (SIK) inhibition reduces RANKL-induced osteoclastogenesis.
Volume: 12
Issue: 10
Pages: e0185426
Publication
First Author: Koo SH
Year: 2005
Journal: Nature
Title: The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism.
Volume: 437
Issue: 7062
Pages: 1109-11
Protein
Organism: Mus musculus
Length: 779  
Fragment?: false
Protein
Organism: Mus musculus
Length: 927  
Fragment?: false
Protein
Organism: Mus musculus
Length: 931  
Fragment?: false