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Search results 1 to 100 out of 722 for Sim1

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Saccharomyces cerevisiae
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Kohno D
Year: 2014
Journal: J Neurosci
Title: Dnmt3a in Sim1 neurons is necessary for normal energy homeostasis.
Volume: 34
Issue: 46
Pages: 15288-96
Publication
First Author: Semple E
Year: 2018
Journal: Endocrinology
Title: Sim1 Neurons Are Sufficient for MC4R-Mediated Sexual Function in Male Mice.
Volume: 159
Issue: 1
Pages: 439-449
Publication
First Author: Xi D
Year: 2012
Journal: PLoS One
Title: Ablation of Sim1 neurons causes obesity through hyperphagia and reduced energy expenditure.
Volume: 7
Issue: 4
Pages: e36453
Publication
First Author: Xi D
Year: 2013
Journal: PLoS One
Title: Paraventricular nucleus Sim1 neuron ablation mediated obesity is resistant to high fat diet.
Volume: 8
Issue: 11
Pages: e81087
Publication
First Author: Blacklaws J
Year: 2015
Journal: Dev Neurobiol
Title: Sim1 is required for the migration and axonal projections of V3 interneurons in the developing mouse spinal cord.
Volume: 75
Issue: 9
Pages: 1003-17
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Cardinal P
Year: 2015
Journal: Endocrinology
Title: Cannabinoid type 1 (CB1) receptors on Sim1-expressing neurons regulate energy expenditure in male mice.
Volume: 156
Issue: 2
Pages: 411-8
Publication
First Author: Xu Y
Year: 2010
Journal: J Neurosci
Title: A serotonin and melanocortin circuit mediates D-fenfluramine anorexia.
Volume: 30
Issue: 44
Pages: 14630-4
Publication
First Author: Fyffe SL
Year: 2008
Journal: Neuron
Title: Deletion of Mecp2 in Sim1-expressing neurons reveals a critical role for MeCP2 in feeding behavior, aggression, and the response to stress.
Volume: 59
Issue: 6
Pages: 947-58
Publication
First Author: Balthasar N
Year: 2005
Journal: Cell
Title: Divergence of melanocortin pathways in the control of food intake and energy expenditure.
Volume: 123
Issue: 3
Pages: 493-505
Publication
First Author: Borowska J
Year: 2013
Journal: J Neurosci
Title: Functional subpopulations of V3 interneurons in the mature mouse spinal cord.
Volume: 33
Issue: 47
Pages: 18553-65
Publication  
First Author: Magown P
Year: 2015
Journal: Nat Commun
Title: Direct optical activation of skeletal muscle fibres efficiently controls muscle contraction and attenuates denervation atrophy.
Volume: 6
Pages: 8506
Publication
First Author: Zhang Y
Year: 2008
Journal: Neuron
Title: V3 spinal neurons establish a robust and balanced locomotor rhythm during walking.
Volume: 60
Issue: 1
Pages: 84-96
Publication
First Author: Chopek JW
Year: 2018
Journal: Cell Rep
Title: Sub-populations of Spinal V3 Interneurons Form Focal Modules of Layered Pre-motor Microcircuits.
Volume: 25
Issue: 1
Pages: 146-156.e3
Publication    
First Author: Sternfeld MJ
Year: 2017
Journal: Elife
Title: Speed and segmentation control mechanisms characterized in rhythmically-active circuits created from spinal neurons produced from genetically-tagged embryonic stem cells.
Volume: 6
Publication
First Author: Amin ND
Year: 2015
Journal: Science
Title: Loss of motoneuron-specific microRNA-218 causes systemic neuromuscular failure.
Volume: 350
Issue: 6267
Pages: 1525-9
Publication
First Author: Pivetta C
Year: 2014
Journal: Cell
Title: Motor-circuit communication matrix from spinal cord to brainstem neurons revealed by developmental origin.
Volume: 156
Issue: 3
Pages: 537-48
Publication
First Author: Ruder L
Year: 2016
Journal: Neuron
Title: Long-Distance Descending Spinal Neurons Ensure Quadrupedal Locomotor Stability.
Volume: 92
Issue: 5
Pages: 1063-1078
Publication
First Author: Xu Y
Year: 2013
Journal: Cell Metab
Title: Glutamate mediates the function of melanocortin receptor 4 on Sim1 neurons in body weight regulation.
Volume: 18
Issue: 6
Pages: 860-70
Publication
First Author: Wu J
Year: 2017
Journal: Nat Commun
Title: A V0 core neuronal circuit for inspiration.
Volume: 8
Issue: 1
Pages: 544
Publication
First Author: Petracca YL
Year: 2016
Journal: Development
Title: The late and dual origin of cerebrospinal fluid-contacting neurons in the mouse spinal cord.
Volume: 143
Issue: 5
Pages: 880-91
Publication  
First Author: Soylu-Kucharz R
Year: 2016
Journal: Sci Rep
Title: Metabolic and behavioral effects of mutant huntingtin deletion in Sim1 neurons in the BACHD mouse model of Huntington's disease.
Volume: 6
Pages: 28322
Publication
First Author: Ghosal S
Year: 2017
Journal: J Neurosci
Title: Disruption of Glucagon-Like Peptide 1 Signaling in Sim1 Neurons Reduces Physiological and Behavioral Reactivity to Acute and Chronic Stress.
Volume: 37
Issue: 1
Pages: 184-193
Publication
First Author: Kublaoui BM
Year: 2008
Journal: Mol Endocrinol
Title: Oxytocin deficiency mediates hyperphagic obesity of Sim1 haploinsufficient mice.
Volume: 22
Issue: 7
Pages: 1723-34
Publication
First Author: Coumailleau P
Year: 2009
Journal: Int J Dev Biol
Title: Sim1 and Sim2 expression during chick and mouse limb development.
Volume: 53
Issue: 1
Pages: 149-57
Publication
First Author: Tolson KP
Year: 2010
Journal: J Neurosci
Title: Postnatal Sim1 deficiency causes hyperphagic obesity and reduced Mc4r and oxytocin expression.
Volume: 30
Issue: 10
Pages: 3803-12
Publication
First Author: Tolson KP
Year: 2014
Journal: Endocrinology
Title: Inducible neuronal inactivation of Sim1 in adult mice causes hyperphagic obesity.
Volume: 155
Issue: 7
Pages: 2436-44
Publication
First Author: Kublaoui BM
Year: 2006
Journal: Mol Endocrinol
Title: Sim1 haploinsufficiency impairs melanocortin-mediated anorexia and activation of paraventricular nucleus neurons.
Volume: 20
Issue: 10
Pages: 2483-92
Publication
First Author: Xu C
Year: 2007
Journal: Mol Endocrinol
Title: Allocation of paraventricular and supraoptic neurons requires Sim1 function: a role for a Sim1 downstream gene PlexinC1.
Volume: 21
Issue: 5
Pages: 1234-45
Publication
First Author: Chrast R
Year: 1997
Journal: Genome Res
Title: Cloning of two human homologs of the Drosophila single-minded gene SIM1 on chromosome 6q and SIM2 on 21q within the Down syndrome chromosomal region.
Volume: 7
Issue: 6
Pages: 615-24
Publication
First Author: Michaud JL
Year: 2001
Journal: Hum Mol Genet
Title: Sim1 haploinsufficiency causes hyperphagia, obesity and reduction of the paraventricular nucleus of the hypothalamus.
Volume: 10
Issue: 14
Pages: 1465-73
Publication
First Author: Holder JL Jr
Year: 2004
Journal: Am J Physiol Endocrinol Metab
Title: Sim1 gene dosage modulates the homeostatic feeding response to increased dietary fat in mice.
Volume: 287
Issue: 1
Pages: E105-13
Publication
First Author: Marion JF
Year: 2005
Journal: Development
Title: Sim1 and Sim2 are required for the correct targeting of mammillary body axons.
Volume: 132
Issue: 24
Pages: 5527-37
GXD Expression
Probe: MGI:4442797
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1690619
Pattern: Non-Uniform
Stage: TS19
Assay Id: MGI:4450888
Age: embryonic day 11.5
Image: Sim1 - E11.5
Note: Staining is strong in the MZ of the dorsal thalamus, prethalamus, dorsal POA, PVH nucleus, AVH & mam zone. Staining is either absent or ubiquitous in the MZ of the ventral POA, anterior & posterior ID, VMH & ARH nuclei, premam & supramam zones & TT.
Detected: true
Specimen Num: 8
GXD Expression  
Probe: MGI:4442797
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1690819
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:4450888
Age: embryonic day 11.5
Image: Sim1 - E11.5
Note: Staining is either absent or ubiquitous in the ventricular zone of the dorsal thalamus, the prethalamus, dorsal and ventral POAs, the PVH, VMH and ARH nuclei, the AVH, the anterior and posterior IDs, the premam, mam and supramam zones and the TT.
Specimen Num: 8
GXD Expression  
Probe: MGI:4442797
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1691119
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:4450888
Age: embryonic day 11.5
Image: Sim1 - E11.5
Note: Staining is either absent or ubiquitous in the postmitotic neurons in the intermediate zone and cortical plate of the cerebral cortex and in the mantle zone of the ganglionic eminences.
Specimen Num: 8
GXD Expression  
Probe: MGI:4442797
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1691319
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:4450888
Age: embryonic day 11.5
Image: Sim1 - E11.5
Note: Staining is either absent or ubiquitous in the ventricular zone of the cerebral cortex and the ganglionic eminences.
Specimen Num: 8
GXD Expression  
Probe: MGI:4442797
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:3271220
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:4450888
Age: embryonic day 12.5
Image: Sim1 - E12.5
Note: Staining is either absent or ubiquitous in the postmitotic neurons in the intermediate zone of the cerebral cortex.
Specimen Num: 9
GXD Expression  
Probe: MGI:4442797
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1754720
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:4450888
Age: embryonic day 12.5
Image: Sim1 - E12.5
Note: Staining is either absent or ubiquitous in the ventricular zone of the cerebral cortex.
Specimen Num: 9
GXD Expression  
Probe: MGI:4442797
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:3271120
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:4450888
Age: embryonic day 12.5
Image: Sim1 - E12.5
Note: Staining is either absent or ubiquitous in the postmitotic neurons in the cortical plate of the cerebral cortex.
Specimen Num: 9
GXD Expression
Probe: MGI:4442797
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3271820
Pattern: Non-Uniform
Stage: TS20
Assay Id: MGI:4450888
Age: embryonic day 12.5
Image: Sim1 - E12.5
Note: There is strong staining in the mantle zone of the mam zone. Staining is either absent or ubiquitous in the mantle zone of the premam and supramam zones and the TT.
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:4442797
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:3271020
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:4450888
Age: embryonic day 12.5
Image: Sim1 - E12.5
Note: Staining is either absent or ubiquitous in the ventricular zone of the premam, mam and supramam zones and the TT.
Specimen Num: 9
GXD Expression  
Probe: MGI:4442797
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:3266520
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:4450888
Age: embryonic day 12.5
Image: Sim1 - E12.5
Note: Staining is either absent or ubiquitous in the ventricular and mantle zones of the ganglionic eminences.
Specimen Num: 9
GXD Expression
Probe: MGI:4442797
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1753720
Pattern: Non-Uniform
Stage: TS20
Assay Id: MGI:4450888
Age: embryonic day 12.5
Image: Sim1 - E12.5
Note: There is strong staining in the mantle zone of the dorsal POA, PVH nucleus and the AVH. Staining is either absent or ubiquitous in the mantle zone of the ventral POA, the VMH and ARH nuclei and anterior and posterior IDs.
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:4442797
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1753920
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:4450888
Age: embryonic day 12.5
Image: Sim1 - E12.5
Note: Staining is either absent or ubiquitous in the ventricular zone of the dorsal and ventral POAs, the PVH, VMH and ARH nuclei, the AVH and anterior and posterior IDs.
Specimen Num: 9
GXD Expression
Probe: MGI:4442797
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1754120
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:4450888
Age: embryonic day 12.5
Image: Sim1 - E12.5
Note: There is strong staining in the mantle zone of the dorsal thalamus and prethalamus.
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:4442797
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1754320
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:4450888
Age: embryonic day 12.5
Image: Sim1 - E12.5
Note: Staining is either absent or ubiquitous in the ventricular zone of the dorsal thalamus and prethalamus.
Specimen Num: 9
GXD Expression  
Probe: MGI:4442797
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:3271222
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4450888
Age: embryonic day 14.5
Image: Sim1 - E14.5
Note: Staining is either absent or ubiquitous in the postmitotic neurons in the intermediate zone of the cerebral cortex.
Specimen Num: 10
GXD Expression  
Probe: MGI:4442797
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4450888
Age: embryonic day 14.5
Image: Sim1 - E14.5
Note: Staining is either absent or ubiquitous in the ventricular zone of the cerebral cortex.
Specimen Num: 10
GXD Expression  
Probe: MGI:4442797
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:3271122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4450888
Age: embryonic day 14.5
Image: Sim1 - E14.5
Note: Staining is either absent or ubiquitous in the postmitotic neurons in the cortical plate of the cerebral cortex.
Specimen Num: 10
GXD Expression
Probe: MGI:4442797
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3271822
Pattern: Non-Uniform
Stage: TS22
Assay Id: MGI:4450888
Age: embryonic day 14.5
Image: Sim1 - E14.5
Note: There is strong staining in the mantle zone of the mam zone. Staining is either absent or ubiquitous in the mantle zone of the premam and supramam zones and the TT.
Detected: true
Specimen Num: 10
GXD Expression  
Probe: MGI:4442797
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:3271022
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4450888
Age: embryonic day 14.5
Image: Sim1 - E14.5
Note: Staining is either absent or ubiquitous in the ventricular zone of the premam, mam and supramam zones and the TT.
Specimen Num: 10
GXD Expression  
Probe: MGI:4442797
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:3266522
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4450888
Age: embryonic day 14.5
Image: Sim1 - E14.5
Note: Staining is either absent or ubiquitous in the ventricular and mantle zones of the ganglionic eminences.
Specimen Num: 10
GXD Expression
Probe: MGI:4442797
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1753722
Pattern: Non-Uniform
Stage: TS22
Assay Id: MGI:4450888
Age: embryonic day 14.5
Image: Sim1 - E14.5
Note: There is strong staining in the mantle zone of the dorsal POA, PVH nucleus and the AVH. Staining is either absent or ubiquitous in the mantle zone of the ventral POA, the VMH and ARH nuclei and anterior and posterior IDs.
Detected: true
Specimen Num: 10
GXD Expression  
Probe: MGI:4442797
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1753922
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4450888
Age: embryonic day 14.5
Image: Sim1 - E14.5
Note: Staining is either absent or ubiquitous in the ventricular zone of the dorsal and ventral POAs, the PVH, VMH and ARH nuclei, the AVH and anterior and posterior IDs.
Specimen Num: 10
GXD Expression
Probe: MGI:4442797
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1754122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4450888
Age: embryonic day 14.5
Image: Sim1 - E14.5
Note: There is strong staining in the mantle zone of the dorsal thalamus and prethalamus.
Detected: true
Specimen Num: 10
GXD Expression  
Probe: MGI:4442797
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1754322
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4450888
Age: embryonic day 14.5
Image: Sim1 - E14.5
Note: Staining is either absent or ubiquitous in the ventricular zone of the dorsal thalamus and prethalamus.
Specimen Num: 10
GXD Expression  
Probe: MGI:4442797
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:3271224
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:4450888
Age: embryonic day 16.5
Image: Sim1 - E16.5
Note: Staining is either absent or ubiquitous in the postmitotic neurons in the intermediate zone of the cerebral cortex.
Specimen Num: 11
GXD Expression  
Probe: MGI:4442797
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1754724
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:4450888
Age: embryonic day 16.5
Image: Sim1 - E16.5
Note: Staining is either absent or ubiquitous in the ventricular zone of the cerebral cortex.
Specimen Num: 11
GXD Expression  
Probe: MGI:4442797
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:3271124
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:4450888
Age: embryonic day 16.5
Image: Sim1 - E16.5
Note: Staining is either absent or ubiquitous in the postmitotic neurons in the cortical plate of the cerebral cortex.
Specimen Num: 11
GXD Expression  
Probe: MGI:4442797
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:3271824
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:4450888
Age: embryonic day 16.5
Image: Sim1 - E16.5
Note: Staining is either absent or ubiquitous in the mantle zone of the premam, mam and supramam zones.
Specimen Num: 11
GXD Expression  
Probe: MGI:4442797
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:3271024
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:4450888
Age: embryonic day 16.5
Image: Sim1 - E16.5
Note: Staining is either absent or ubiquitous in the ventricular zone of the premam, mam and supramam zones.
Specimen Num: 11
GXD Expression  
Probe: MGI:4442797
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:3266524
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:4450888
Age: embryonic day 16.5
Image: Sim1 - E16.5
Note: Staining is either absent or ubiquitous in the ventricular and mantle zones of the ganglionic eminences.
Specimen Num: 11
GXD Expression
Probe: MGI:4442797
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1753724
Pattern: Non-Uniform
Stage: TS24
Assay Id: MGI:4450888
Age: embryonic day 16.5
Image: Sim1 - E16.5
Note: There is strong staining in the mantle zone of the dorsal POA, the PVH nucleus, the AVH and the PH. Staining is either absent or ubiquitous in the mantle zone of the ventral POA, the DAH and the SCH, DMH, VMH and ARH nuclei.
Detected: true
Specimen Num: 11
GXD Expression  
Probe: MGI:4442797
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1753924
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:4450888
Age: embryonic day 16.5
Image: Sim1 - E16.5
Note: Staining is either absent or ubiquitous in the ventricular zone of the dorsal and ventral POAs, the PVH, SCH, DMH, VMH and ARH nuclei, the AVH, the DAH and the PH.
Specimen Num: 11
GXD Expression  
Probe: MGI:4442797
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1754124
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:4450888
Age: embryonic day 16.5
Image: Sim1 - E16.5
Note: Staining is either absent or ubiquitous in the mantle zone of the dorsal thalamus and prethalamus.
Specimen Num: 11
GXD Expression  
Probe: MGI:4442797
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1754324
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:4450888
Age: embryonic day 16.5
Image: Sim1 - E16.5
Note: Staining is either absent or ubiquitous in the ventricular zone of the dorsal thalamus and prethalamus.
Specimen Num: 11
Publication
First Author: Michaud JL
Year: 2000
Journal: Mech Dev
Title: ARNT2 acts as the dimerization partner of SIM1 for the development of the hypothalamus.
Volume: 90
Issue: 2
Pages: 253-61
Publication
First Author: Goshu E
Year: 2002
Journal: Mol Cell Biol
Title: Sim2 mutants have developmental defects not overlapping with those of Sim1 mutants.
Volume: 22
Issue: 12
Pages: 4147-57
Publication
First Author: Osterberg N
Year: 2011
Journal: PLoS One
Title: Sim1 is a novel regulator in the differentiation of mouse dorsal raphe serotonergic neurons.
Volume: 6
Issue: 4
Pages: e19239
Publication
First Author: Duplan SM
Year: 2009
Journal: Eur J Neurosci
Title: Impact of Sim1 gene dosage on the development of the paraventricular and supraoptic nuclei of the hypothalamus.
Volume: 30
Issue: 12
Pages: 2239-49
Allele
Name: transgene insertion 1, Bradford B Lowell
Allele Type: Transgenic
Attribute String: Recombinase
Publication categories: ProxyCollection
Allele
Name: transgene insertion 2, Bradford B Lowell
Allele Type: Transgenic
Attribute String: Recombinase
Publication categories: ProxyCollection
Gene
Type: gene
Organism: Saccharomyces cerevisiae
Strain
Attribute String: congenic, mutant strain, transgenic
Strain
Attribute String: mutant stock, transgenic
Allele
Name: transgene insertion, Bradford B Lowell
Allele Type: Transgenic
Attribute String: Recombinase
Publication categories: ProxyCollection
Publication
First Author: Zhang R
Year: 2017
Journal: Mol Psychiatry
Title: Loss of hypothalamic corticotropin-releasing hormone markedly reduces anxiety behaviors in mice.
Volume: 22
Issue: 5
Pages: 733-744
Publication
First Author: Xu P
Year: 2015
Journal: J Clin Invest
Title: Estrogen receptor-α in medial amygdala neurons regulates body weight.
Volume: 125
Issue: 7
Pages: 2861-76
Publication  
First Author: Dubreucq S
Year: 2012
Journal: Neuroscience
Title: Cannabinoid type 1 receptors located on single-minded 1-expressing neurons control emotional behaviors.
Volume: 204
Pages: 230-44
Publication
First Author: Solomon MB
Year: 2015
Journal: Endocrinology
Title: Neuroendocrine Function After Hypothalamic Depletion of Glucocorticoid Receptors in Male and Female Mice.
Volume: 156
Issue: 8
Pages: 2843-53
Genotype
Symbol: Nr3c1/Nr3c1<+> Tg(Sim1-cre)1Lowl/?
Background: involves: 129 * C57BL/6 * FVB
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Col1a1/Col1a1 Tg(Sim1-cre)1Lowl/?
Background: involves: 129S4/SvJae * C57BL/6 * FVB
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Mrap2/Mrap2 Tg(Sim1-cre)1Lowl/?
Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Mc4r/Mc4r Tg(Sim1-cre)1Lowl/?
Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Rai1/Rai1 Tg(Sim1-cre)1Lowl/?
Background: either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Rai1/Rai1<+> Tg(Sim1-cre)1Lowl/?
Background: either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Crh/Crh Tg(Sim1-cre)1Lowl/?
Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Nr3c1/Nr3c1 Tg(Sim1-cre)1Lowl/?
Background: involves: 129 * C57BL/6 * FVB
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Akirin2/Akirin2<+> Tg(Sim1-cre)1Lowl/?
Background: involves: 129X1/SvJ * FVB
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Akirin2/Akirin2 Tg(Sim1-cre)1Lowl/?
Background: involves: 129X1/SvJ * FVB
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Singha AK
Year: 2019
Journal: Endocrinology
Title: Glucose-Lowering by Leptin in the Absence of Insulin Does Not Fully Rely on the Central Melanocortin System in Male Mice.
Volume: 160
Issue: 3
Pages: 651-663
Publication
First Author: Chiappini F
Year: 2011
Journal: J Biol Chem
Title: Lack of cAMP-response element-binding protein 1 in the hypothalamus causes obesity.
Volume: 286
Issue: 10
Pages: 8094-105
Publication
First Author: Samuelsson AS
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Central role for melanocortin-4 receptors in offspring hypertension arising from maternal obesity.
Volume: 113
Issue: 43
Pages: 12298-12303
Publication
First Author: Biancardi VC
Year: 2016
Journal: Am J Physiol Heart Circ Physiol
Title: Cross talk between AT1 receptors and Toll-like receptor 4 in microglia contributes to angiotensin II-derived ROS production in the hypothalamic paraventricular nucleus.
Volume: 310
Issue: 3
Pages: H404-15
Publication
First Author: de Kloet AD
Year: 2013
Journal: J Neurosci
Title: Angiotensin type 1a receptors in the paraventricular nucleus of the hypothalamus protect against diet-induced obesity.
Volume: 33
Issue: 11
Pages: 4825-33