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Search results 1 to 100 out of 141 for Sirt5

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0.039s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Du J
Year: 2011
Journal: Science
Title: Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase.
Volume: 334
Issue: 6057
Pages: 806-9
Publication  
First Author: Yu J
Year: 2013
Journal: Sci Rep
Title: Metabolic characterization of a Sirt5 deficient mouse model.
Volume: 3
Pages: 2806
Publication
First Author: Zhang R
Year: 2023
Journal: iScience
Title: Histone malonylation is regulated by SIRT5 and KAT2A.
Volume: 26
Issue: 3
Pages: 106193
Publication
First Author: Rardin MJ
Year: 2013
Journal: Cell Metab
Title: SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks.
Volume: 18
Issue: 6
Pages: 920-33
Publication
First Author: Nakamura Y
Year: 2012
Journal: FEBS Lett
Title: SIRT5 deacetylates and activates urate oxidase in liver mitochondria of mice.
Volume: 586
Issue: 23
Pages: 4076-81
Publication
First Author: Shuai L
Year: 2019
Journal: Diabetes
Title: SIRT5 Regulates Brown Adipocyte Differentiation and Browning of Subcutaneous White Adipose Tissue.
Volume: 68
Issue: 7
Pages: 1449-1461
Publication
First Author: Zhou L
Year: 2016
Journal: EMBO Rep
Title: SIRT5 promotes IDH2 desuccinylation and G6PD deglutarylation to enhance cellular antioxidant defense.
Volume: 17
Issue: 6
Pages: 811-22
Publication
First Author: Abril YLN
Year: 2021
Journal: Oncogene
Title: Pharmacological and genetic perturbation establish SIRT5 as a promising target in breast cancer.
Volume: 40
Issue: 9
Pages: 1644-1658
Publication  
First Author: Chen XF
Year: 2018
Journal: EMBO Rep
Title: SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer.
Volume: 19
Issue: 5
Publication
First Author: Nishida Y
Year: 2015
Journal: Mol Cell
Title: SIRT5 Regulates both Cytosolic and Mitochondrial Protein Malonylation with Glycolysis as a Major Target.
Volume: 59
Issue: 2
Pages: 321-32
Publication
First Author: Bentley NL
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Protein hypoacylation induced by Sirt5 overexpression has minimal metabolic effect in mice.
Volume: 503
Issue: 3
Pages: 1349-1355
Publication
First Author: Moon H
Year: 2019
Journal: Exp Dermatol
Title: Sirt5 is dispensable for BrafV600E -mediated cutaneous melanoma development and growth in vivo.
Volume: 28
Issue: 1
Pages: 83-85
Publication
First Author: Nakagawa T
Year: 2009
Journal: Cell
Title: SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle.
Volume: 137
Issue: 3
Pages: 560-70
Publication  
First Author: Koronowski KB
Year: 2018
Journal: Front Neurosci
Title: Metabolomics Based Identification of SIRT5 and Protein Kinase C Epsilon Regulated Pathways in Brain.
Volume: 12
Pages: 32
Publication
First Author: Sadhukhan S
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function.
Volume: 113
Issue: 16
Pages: 4320-5
Publication  
First Author: Du Y
Year: 2018
Journal: EBioMedicine
Title: SIRT5 deacylates metabolism-related proteins and attenuates hepatic steatosis in ob/ob mice.
Volume: 36
Pages: 347-357
Publication
First Author: Hu T
Year: 2021
Journal: Gastroenterology
Title: Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression.
Volume: 161
Issue: 5
Pages: 1584-1600
Publication
First Author: Wang F
Year: 2017
Journal: Cell Rep
Title: SIRT5 Desuccinylates and Activates Pyruvate Kinase M2 to Block Macrophage IL-1β Production and to Prevent DSS-Induced Colitis in Mice.
Volume: 19
Issue: 11
Pages: 2331-2344
Publication
First Author: Zhang Y
Year: 2017
Journal: J Biol Chem
Title: Lysine desuccinylase SIRT5 binds to cardiolipin and regulates the electron transport chain.
Volume: 292
Issue: 24
Pages: 10239-10249
Publication
First Author: Ogura M
Year: 2010
Journal: Biochem Biophys Res Commun
Title: Overexpression of SIRT5 confirms its involvement in deacetylation and activation of carbamoyl phosphate synthetase 1.
Volume: 393
Issue: 1
Pages: 73-8
Publication
First Author: Bhatt DP
Year: 2022
Journal: J Biol Chem
Title: Deglutarylation of glutaryl-CoA dehydrogenase by deacylating enzyme SIRT5 promotes lysine oxidation in mice.
Volume: 298
Issue: 4
Pages: 101723
Publication  
First Author: Heinonen T
Year: 2019
Journal: Front Immunol
Title: Impact of the Dual Deletion of the Mitochondrial Sirtuins SIRT3 and SIRT5 on Anti-microbial Host Defenses.
Volume: 10
Pages: 2341
Publication  
First Author: Li F
Year: 2016
Journal: Front Cell Neurosci
Title: SIRT5 Deficiency Enhances Susceptibility to Kainate-Induced Seizures and Exacerbates Hippocampal Neurodegeneration not through Mitochondrial Antioxidant Enzyme SOD2.
Volume: 10
Pages: 171
Publication  
First Author: Liu L
Year: 2015
Journal: Behav Brain Res
Title: Protective role of SIRT5 against motor deficit and dopaminergic degeneration in MPTP-induced mice model of Parkinson's disease.
Volume: 281
Pages: 215-21
Publication
First Author: Zhang Y
Year: 2015
Journal: PLoS One
Title: SIRT3 and SIRT5 regulate the enzyme activity and cardiolipin binding of very long-chain acyl-CoA dehydrogenase.
Volume: 10
Issue: 3
Pages: e0122297
Publication
First Author: Buler M
Year: 2014
Journal: FASEB J
Title: SIRT5 is under the control of PGC-1α and AMPK and is involved in regulation of mitochondrial energy metabolism.
Volume: 28
Issue: 7
Pages: 3225-37
Publication
First Author: Lin JB
Year: 2019
Journal: Sci Rep
Title: Combined SIRT3 and SIRT5 deletion is associated with inner retinal dysfunction in a mouse model of type 1 diabetes.
Volume: 9
Issue: 1
Pages: 3799
Publication  
First Author: Nandi SK
Year: 2019
Journal: Exp Eye Res
Title: The absence of SIRT3 and SIRT5 promotes the acetylation of lens proteins and improves the chaperone activity of α-crystallin in mouse lenses.
Volume: 182
Pages: 1-9
Publication
First Author: Mao J
Year: 2023
Journal: Exp Mol Med
Title: SIRT5-related desuccinylation modification of AIFM1 protects against compression-induced intervertebral disc degeneration by regulating mitochondrial homeostasis.
Volume: 55
Issue: 1
Pages: 253-268
Publication
First Author: Park J
Year: 2013
Journal: Mol Cell
Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.
Volume: 50
Issue: 6
Pages: 919-30
Publication  
First Author: Duan Q
Year: 2021
Journal: Front Cell Dev Biol
Title: Sirtuin 5 is Dispensable for CD8+ T Cell Effector and Memory Differentiation.
Volume: 9
Pages: 761193
Publication  
First Author: Heinonen T
Year: 2018
Journal: Front Immunol
Title: Sirtuin 5 Deficiency Does Not Compromise Innate Immune Responses to Bacterial Infections.
Volume: 9
Pages: 2675
Publication
First Author: Schlicker C
Year: 2008
Journal: J Mol Biol
Title: Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5.
Volume: 382
Issue: 3
Pages: 790-801
Publication
First Author: Hershberger KA
Year: 2017
Journal: J Biol Chem
Title: Sirtuin 5 is required for mouse survival in response to cardiac pressure overload.
Volume: 292
Issue: 48
Pages: 19767-19781
Publication
First Author: Guo AH
Year: 2022
Journal: Sci Rep
Title: Sirtuin 5 levels are limiting in preserving cardiac function and suppressing fibrosis in response to pressure overload.
Volume: 12
Issue: 1
Pages: 12258
Publication
First Author: Nakamura Y
Year: 2008
Journal: Biochem Biophys Res Commun
Title: Localization of mouse mitochondrial SIRT proteins: shift of SIRT3 to nucleus by co-expression with SIRT5.
Volume: 366
Issue: 1
Pages: 174-9
Publication
First Author: Chiba T
Year: 2019
Journal: J Am Soc Nephrol
Title: Sirtuin 5 Regulates Proximal Tubule Fatty Acid Oxidation to Protect against AKI.
Volume: 30
Issue: 12
Pages: 2384-2398
Publication
First Author: Tan M
Year: 2014
Journal: Cell Metab
Title: Lysine glutarylation is a protein posttranslational modification regulated by SIRT5.
Volume: 19
Issue: 4
Pages: 605-17
Publication
First Author: Wang G
Year: 2019
Journal: Mol Cell
Title: Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation.
Volume: 74
Issue: 4
Pages: 844-857.e7
Publication
First Author: Lin JB
Year: 2016
Journal: Cell Rep
Title: NAMPT-Mediated NAD(+) Biosynthesis Is Essential for Vision In Mice.
Volume: 17
Issue: 1
Pages: 69-85
Publication
First Author: Head PE
Year: 2022
Journal: Sci Transl Med
Title: Aberrant methylmalonylation underlies methylmalonic acidemia and is attenuated by an engineered sirtuin.
Volume: 14
Issue: 646
Pages: eabn4772
Publication
First Author: Fisher-Wellman KH
Year: 2019
Journal: Cell Rep
Title: Respiratory Phenomics across Multiple Models of Protein Hyperacylation in Cardiac Mitochondria Reveals a Marginal Impact on Bioenergetics.
Volume: 26
Issue: 6
Pages: 1557-1572.e8
Publication  
First Author: Boylston JA
Year: 2015
Journal: J Mol Cell Cardiol
Title: Characterization of the cardiac succinylome and its role in ischemia-reperfusion injury.
Volume: 88
Pages: 73-81
Publication
First Author: Goetzman ES
Year: 2020
Journal: Sci Rep
Title: Impaired mitochondrial medium-chain fatty acid oxidation drives periportal macrovesicular steatosis in sirtuin-5 knockout mice.
Volume: 10
Issue: 1
Pages: 18367
Publication
First Author: Hershberger KA
Year: 2018
Journal: J Biol Chem
Title: Ablation of Sirtuin5 in the postnatal mouse heart results in protein succinylation and normal survival in response to chronic pressure overload.
Volume: 293
Issue: 27
Pages: 10630-10645
Publication  
First Author: Morris-Blanco KC
Year: 2016
Journal: Sci Rep
Title: Protein Kinase C Epsilon Promotes Cerebral Ischemic Tolerance Via Modulation of Mitochondrial Sirt5.
Volume: 6
Pages: 29790
Publication
First Author: Zhang Y
Year: 2021
Journal: PLoS One
Title: The enzyme activity of mitochondrial trifunctional protein is not altered by lysine acetylation or lysine succinylation.
Volume: 16
Issue: 10
Pages: e0256619
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Peng C
Year: 2011
Journal: Mol Cell Proteomics
Title: The first identification of lysine malonylation substrates and its regulatory enzyme.
Volume: 10
Issue: 12
Pages: M111.012658
GXD Expression    
Probe: MGI:4833788
Assay Type: RT-PCR
Annotation Date: 2010-10-05
Strength: Present
Sex: Female
Emaps: EMAPS:3102528
Stage: TS28
Assay Id: MGI:4833808
Age: postnatal
Image: 1
Specimen Label: Egg
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:4833788
Assay Type: RT-PCR
Annotation Date: 2010-10-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360411
Stage: TS01
Assay Id: MGI:4833808
Age: embryonic day 0.5
Image: 1
Specimen Label: 1-cell
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:4833788
Assay Type: RT-PCR
Annotation Date: 2010-10-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360422
Stage: TS02
Assay Id: MGI:4833808
Age: embryonic day 1.0
Image: 1
Specimen Label: 2-cell
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:4833788
Assay Type: RT-PCR
Annotation Date: 2010-10-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360633
Stage: TS03
Assay Id: MGI:4833808
Age: embryonic day 2.0
Image: 1
Specimen Label: 4-8-cell
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:4833788
Assay Type: RT-PCR
Annotation Date: 2010-10-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360453
Stage: TS03
Assay Id: MGI:4833808
Age: embryonic day 3.0
Image: 1
Specimen Label: M
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:4833788
Assay Type: RT-PCR
Annotation Date: 2010-10-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:4833808
Age: embryonic day 3.5
Image: 1
Specimen Label: BL
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:4833794
Assay Type: RT-PCR
Annotation Date: 2010-10-05
Strength: Present
Sex: Female
Emaps: EMAPS:3102528
Stage: TS28
Assay Id: MGI:4833817
Age: postnatal
Image: 1
Specimen Label: Egg
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:4833794
Assay Type: RT-PCR
Annotation Date: 2010-10-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360422
Stage: TS02
Assay Id: MGI:4833817
Age: embryonic day 1.0
Image: 1
Specimen Label: 2-cell
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:4833794
Assay Type: RT-PCR
Annotation Date: 2010-10-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360453
Stage: TS03
Assay Id: MGI:4833817
Age: embryonic day 3.0
Image: 1
Specimen Label: M
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:4833794
Assay Type: RT-PCR
Annotation Date: 2010-10-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:4833817
Age: embryonic day 3.5
Image: 1
Specimen Label: BL
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:5614768
Assay Type: RT-PCR
Annotation Date: 2015-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1736222
Stage: TS22
Assay Id: MGI:5614774
Age: embryonic day 14.5
Specimen Label: E14.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:4844986
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1619815
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:4848761
Age: embryonic day 9.5
Specimen Label: Table S4 - E9.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:4844986
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1610517
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:4848761
Age: embryonic day 10.5
Specimen Label: Table S4 - E10.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4844986
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1638817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:4848761
Age: embryonic day 10.5
Note: Staining is present in the maxillary process.
Specimen Label: Table S4 - E10.5
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:4844986
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1619817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:4848761
Age: embryonic day 10.5
Specimen Label: Table S4 - E10.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4844986
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1680017
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:4848761
Age: embryonic day 10.5
Note: Staining is present in the olfactory placode.
Specimen Label: Table S4 - E10.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4844986
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1666917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:4848761
Age: embryonic day 10.5
Note: Staining is present in the otic pit.
Specimen Label: Table S4 - E10.5
Detected: true
Specimen Num: 2
Protein
Organism: Mus musculus/domesticus
Length: 188  
Fragment?: false
Publication
First Author: Scapoli L
Year: 2010
Journal: Hum Mutat
Title: Expression and association data strongly support JARID2 involvement in nonsyndromic cleft lip with or without cleft palate.
Volume: 31
Issue: 7
Pages: 794-800
Publication
First Author: Kawamura Y
Year: 2010
Journal: J Clin Invest
Title: Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest.
Volume: 120
Issue: 8
Pages: 2817-28
Publication
First Author: Lombard DB
Year: 2007
Journal: Mol Cell Biol
Title: Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.
Volume: 27
Issue: 24
Pages: 8807-14
Publication
First Author: Martin J
Year: 2016
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Nutritional stress exacerbates hepatic steatosis induced by deletion of the histidine nucleotide-binding (Hint2) mitochondrial protein.
Volume: 310
Issue: 7
Pages: G497-509
Publication
First Author: Witt O
Year: 2009
Journal: Cancer Lett
Title: HDAC family: What are the cancer relevant targets?
Volume: 277
Issue: 1
Pages: 8-21