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Search results 1 to 100 out of 448 for Sirt6

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Type Details Score
Gene
51548 | SIRT6
Type: gene
Organism: human
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Gene
299638 | Sirt6
Type: gene
Organism: rat
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Gene
737026 | SIRT6
Type: gene
Organism: chimpanzee
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Gene
485045 | SIRT6
Type: gene
Organism: dog, domestic
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Gene
535416 | SIRT6
Type: gene
Organism: cattle
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Gene
428332 | SIRT6
Type: gene
Organism: chicken
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Gene
415161 | sirt6
Type: gene
Organism: zebrafish
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Gene
714545 | SIRT6
Type: gene
Organism: macaque, rhesus
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Gene
394980 | sirt6
Type: gene
Organism: frog, western clawed
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Protein Coding Gene
MGI:1354161 | Sirt6
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
30530497 | J:274744
First Author: Chen L
Year: 2019
Journal: J Biol Chem
Title: Hepatocyte-specific Sirt6 deficiency impairs ketogenesis.
Volume: 294
Issue: 5
Pages: 1579-1589
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Publication
28644902 | J:247142
First Author: Okun E
Year: 2017
Journal: PLoS One
Title: Sirt6 alters adult hippocampal neurogenesis.
Volume: 12
Issue: 6
Pages: e0179681
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Publication
24896097 | J:229652
First Author: Silberman DM
Year: 2014
Journal: PLoS One
Title: SIRT6 is required for normal retinal function.
Volume: 9
Issue: 6
Pages: e98831
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Publication
36496445 | J:332151
First Author: Ji ML
Year: 2022
Journal: Nat Commun
Title: Sirt6 attenuates chondrocyte senescence and osteoarthritis progression.
Volume: 13
Issue: 1
Pages: 7658
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Publication
32915773 | J:298980
First Author: Wei H
Year: 2020
Journal: Aging (Albany NY)
Title: Sirt6 is required for spermatogenesis in mice.
Volume: 12
Issue: 17
Pages: 17099-17113
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Publication
26189760 | J:228148
 
First Author: Sugatani T
Year: 2015
Journal: Bone
Title: SIRT6 deficiency culminates in low-turnover osteopenia.
Volume: 81
Pages: 168-77
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Publication
35379817 | J:325747
First Author: Song MY
Year: 2022
Journal: Nat Commun
Title: Sirt6 reprograms myofibers to oxidative type through CREB-dependent Sox6 suppression.
Volume: 13
Issue: 1
Pages: 1808
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Publication
20829486 | J:163815
First Author: Kaidi A
Year: 2010
Journal: Science
Title: Human SIRT6 promotes DNA end resection through CtIP deacetylation.
Volume: 329
Issue: 5997
Pages: 1348-53
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Publication
21680843 | J:173531
First Author: Mao Z
Year: 2011
Journal: Science
Title: SIRT6 promotes DNA repair under stress by activating PARP1.
Volume: 332
Issue: 6036
Pages: 1443-6
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Publication
28406396 | J:326478
   
First Author: Zhang X
Year: 2017
Journal: Elife
Title: SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation.
Volume: 6
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Publication
22367546 | J:181684
First Author: Kanfi Y
Year: 2012
Journal: Nature
Title: The sirtuin SIRT6 regulates lifespan in male mice.
Volume: 483
Issue: 7388
Pages: 218-21
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Publication
37445896 | J:337834
 
First Author: Lee MJ
Year: 2023
Journal: Int J Mol Sci
Title: Sirt6 Activation Ameliorates Inflammatory Bone Loss in Ligature-Induced Periodontitis in Mice.
Volume: 24
Issue: 13
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Publication
20141841 | J:167957
First Author: Zhong L
Year: 2010
Journal: Cell
Title: The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha.
Volume: 140
Issue: 2
Pages: 280-93
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Publication
34050173 | J:341999
First Author: Roichman A
Year: 2021
Journal: Nat Commun
Title: Restoration of energy homeostasis by SIRT6 extends healthy lifespan.
Volume: 12
Issue: 1
Pages: 3208
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Publication
32580272 | J:305459
 
First Author: Xu K
Year: 2020
Journal: Cells
Title: Protective Effects of SIRT6 Overexpression against DSS-Induced Colitis in Mice.
Volume: 9
Issue: 6
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Publication
28723567 | J:249895
First Author: Yao L
Year: 2017
Journal: Cell Rep
Title: Cold-Inducible SIRT6 Regulates Thermogenesis of Brown and Beige Fat.
Volume: 20
Issue: 3
Pages: 641-654
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Publication
31851938 | J:288674
First Author: Naiman S
Year: 2019
Journal: Cell Rep
Title: SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα.
Volume: 29
Issue: 12
Pages: 4127-4143.e8
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Publication
30782483 | J:291806
First Author: Sun S
Year: 2019
Journal: Biochem Biophys Res Commun
Title: Sirt6 deacetylase activity regulates circadian rhythms via Per2.
Volume: 511
Issue: 2
Pages: 234-238
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Publication
27180906 | J:234471
First Author: Kugel S
Year: 2016
Journal: Cell
Title: SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b.
Volume: 165
Issue: 6
Pages: 1401-1415
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Publication
31399344 | J:278647
First Author: Etchegaray JP
Year: 2019
Journal: Mol Cell
Title: The Histone Deacetylase SIRT6 Restrains Transcription Elongation via Promoter-Proximal Pausing.
Volume: 75
Issue: 4
Pages: 683-699.e7
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Publication
20047575 | J:203899
First Author: Kanfi Y
Year: 2010
Journal: Aging Cell
Title: SIRT6 protects against pathological damage caused by diet-induced obesity.
Volume: 9
Issue: 2
Pages: 162-73
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Publication
15795229 | J:99908
First Author: Liszt G
Year: 2005
Journal: J Biol Chem
Title: Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase.
Volume: 280
Issue: 22
Pages: 21313-20
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Publication
30030453 | J:268716
First Author: Zhang D
Year: 2018
Journal: Sci Rep
Title: Evidence for excessive osteoclast activation in SIRT6 null mice.
Volume: 8
Issue: 1
Pages: 10992
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Publication
36356655 | J:334216
First Author: Liu X
Year: 2023
Journal: Exp Cell Res
Title: Sirt6 mediates antioxidative functions by increasing Nrf2 abundance.
Volume: 422
Issue: 1
Pages: 113409
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Publication
27189179 | J:254107
 
First Author: Park SJ
Year: 2016
Journal: Sci Rep
Title: Sirt6 cooperates with Blimp1 to positively regulate osteoclast differentiation.
Volume: 6
Pages: 26186
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Publication
29319170 | J:323786
First Author: Khan D
Year: 2018
Journal: J Cell Physiol
Title: SIRT6 deacetylase transcriptionally regulates glucose metabolism in heart.
Volume: 233
Issue: 7
Pages: 5478-5489
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Publication
24043303 | J:206096
First Author: Ronnebaum SM
Year: 2013
Journal: Mol Cell Biol
Title: The ubiquitin ligase CHIP prevents SirT6 degradation through noncanonical ubiquitination.
Volume: 33
Issue: 22
Pages: 4461-72
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Publication
32701506 | J:301821
 
First Author: Hao L
Year: 2020
Journal: JCI Insight
Title: ERRγ suppression by Sirt6 alleviates cholestatic liver injury and fibrosis.
Volume: 5
Issue: 17
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Publication
34077730 | J:324652
First Author: Khan D
Year: 2021
Journal: Cell Rep
Title: SIRT6 transcriptionally regulates fatty acid transport by suppressing PPARγ.
Volume: 35
Issue: 9
Pages: 109190
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Publication
31002797 | J:322389
First Author: Tian X
Year: 2019
Journal: Cell
Title: SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species.
Volume: 177
Issue: 3
Pages: 622-638.e22
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Publication
25320180 | J:217889
First Author: Ming M
Year: 2014
Journal: Cancer Res
Title: SIRT6 promotes COX-2 expression and acts as an oncogene in skin cancer.
Volume: 74
Issue: 20
Pages: 5925-33
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Publication
28329681 | J:250936
First Author: Chen W
Year: 2017
Journal: Cell Rep
Title: Sirt6 Promotes DNA End Joining in iPSCs Derived from Old Mice.
Volume: 18
Issue: 12
Pages: 2880-2892
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Publication
28351995 | J:315601
First Author: Huang W
Year: 2017
Journal: Aging (Albany NY)
Title: Sirt6 deficiency results in progression of glomerular injury in the kidney.
Volume: 9
Issue: 3
Pages: 1069-1083
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Publication
38288355 | J:344966
First Author: Wei Y
Year: 2024
Journal: iScience
Title: Sirt6 regulates the proliferation of neural precursor cells and cortical neurogenesis in mice.
Volume: 27
Issue: 2
Pages: 108706
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Publication
28860594 | J:255712
First Author: Zhang P
Year: 2017
Journal: Sci Rep
Title: SIRT6 promotes osteogenic differentiation of mesenchymal stem cells through BMP signaling.
Volume: 7
Issue: 1
Pages: 10229
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Publication
29555651 | J:322375
First Author: Ferrer CM
Year: 2018
Journal: Genes Dev
Title: An inactivating mutation in the histone deacetylase SIRT6 causes human perinatal lethality.
Volume: 32
Issue: 5-6
Pages: 373-388
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Publication
36653345 | J:332829
First Author: Smirnov D
Year: 2023
Journal: Cell Death Dis
Title: SIRT6 is a key regulator of mitochondrial function in the brain.
Volume: 14
Issue: 1
Pages: 35
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Publication
32278654 | J:305763
 
First Author: Tang Q
Year: 2020
Journal: Mol Metab
Title: Sirt6 in pro-opiomelanocortin neurons controls energy metabolism by modulating leptin signaling.
Volume: 37
Pages: 100994
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Publication
34425214 | J:312956
First Author: Zhu C
Year: 2021
Journal: Biochim Biophys Acta Mol Basis Dis
Title: SIRT6 controls hepatic lipogenesis by suppressing LXR, ChREBP, and SREBP1.
Volume: 1867
Issue: 12
Pages: 166249
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Publication
28355567 | J:250994
First Author: Chen Q
Year: 2017
Journal: Cell Rep
Title: SIRT6 Is Essential for Adipocyte Differentiation by Regulating Mitotic Clonal Expansion.
Volume: 18
Issue: 13
Pages: 3155-3166
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Publication
23217706 | J:219058
First Author: Sebastián C
Year: 2012
Journal: Cell
Title: The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism.
Volume: 151
Issue: 6
Pages: 1185-99
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Publication
25083875 | J:214604
First Author: Masri S
Year: 2014
Journal: Cell
Title: Partitioning circadian transcription by SIRT6 leads to segregated control of cellular metabolism.
Volume: 158
Issue: 3
Pages: 659-72
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Publication
24149372 | J:207785
 
First Author: Piao J
Year: 2013
Journal: Sci Rep
Title: Sirt6 regulates postnatal growth plate differentiation and proliferation via Ihh signaling.
Volume: 3
Pages: 3022
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Publication
28355287 | J:246291
First Author: Liao X
Year: 2017
Journal: PLoS One
Title: The Sirt6 gene: Does it play a role in tooth development?
Volume: 12
Issue: 3
Pages: e0174255
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Publication
25247314 | J:322377
 
First Author: Van Meter M
Year: 2014
Journal: Nat Commun
Title: SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age.
Volume: 5
Pages: 5011
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Publication
23911928 | J:202697
First Author: Toiber D
Year: 2013
Journal: Mol Cell
Title: SIRT6 recruits SNF2H to DNA break sites, preventing genomic instability through chromatin remodeling.
Volume: 51
Issue: 4
Pages: 454-68
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Publication
26362183 | J:232869
First Author: Ailixiding M
Year: 2015
Journal: Biochem Biophys Res Commun
Title: Pivotal role of Sirt6 in the crosstalk among ageing, metabolic syndrome and osteoarthritis.
Volume: 466
Issue: 3
Pages: 319-26
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Publication
27058938 | J:235192
First Author: Wang H
Year: 2016
Journal: Cell Stem Cell
Title: SIRT6 Controls Hematopoietic Stem Cell Homeostasis through Epigenetic Regulation of Wnt Signaling.
Volume: 18
Issue: 4
Pages: 495-507
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Publication
24013546 | J:211169
First Author: Jedrusik-Bode M
Year: 2013
Journal: J Cell Sci
Title: The sirtuin SIRT6 regulates stress granule formation in C. elegans and mammals.
Volume: 126
Issue: Pt 22
Pages: 5166-77
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Publication
23142079 | J:193985
First Author: Dominy JE Jr
Year: 2012
Journal: Mol Cell
Title: The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis.
Volume: 48
Issue: 6
Pages: 900-13
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Publication
28928419 | J:256527
First Author: Samant SA
Year: 2017
Journal: Sci Rep
Title: The histone deacetylase SIRT6 blocks myostatin expression and development of muscle atrophy.
Volume: 7
Issue: 1
Pages: 11877
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Publication
30514106 | J:286576
First Author: Sociali G
Year: 2019
Journal: FASEB J
Title: SIRT6 deacetylase activity regulates NAMPT activity and NAD(P)(H) pools in cancer cells.
Volume: 33
Issue: 3
Pages: 3704-3717
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Publication
23552949 | J:196437
First Author: Jiang H
Year: 2013
Journal: Nature
Title: SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine.
Volume: 496
Issue: 7443
Pages: 110-3
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Publication
28871079 | J:253685
First Author: Liu M
Year: 2017
Journal: Nat Commun
Title: Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling.
Volume: 8
Issue: 1
Pages: 413
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Publication
35506565 | J:344962
First Author: Xiang X
Year: 2022
Journal: FASEB J
Title: Impaired reciprocal regulation between SIRT6 and TGF-β signaling in fatty liver.
Volume: 36
Issue: 6
Pages: e22335
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Publication
28250020 | J:246935
First Author: Kuang J
Year: 2017
Journal: Diabetes
Title: Fat-Specific Sirt6 Ablation Sensitizes Mice to High-Fat Diet-Induced Obesity and Insulin Resistance by Inhibiting Lipolysis.
Volume: 66
Issue: 5
Pages: 1159-1171
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Publication
28765271 | J:257698
First Author: Cui X
Year: 2017
Journal: Am J Physiol Endocrinol Metab
Title: SIRT6 regulates metabolic homeostasis in skeletal muscle through activation of AMPK.
Volume: 313
Issue: 4
Pages: E493-E505
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Publication
35150745 | J:330260
First Author: Bresque M
Year: 2022
Journal: J Biol Chem
Title: SIRT6 stabilization and cytoplasmic localization in macrophages regulates acute and chronic inflammation in mice.
Volume: 298
Issue: 3
Pages: 101711
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Publication
38332150 | J:346094
First Author: Li L
Year: 2024
Journal: EMBO Rep
Title: Sirt6 ablation in the liver causes fatty liver that increases cancer risky by upregulating Serpina12.
Volume: 25
Issue: 3
Pages: 1361-1386
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Publication
30841754 | J:293845
First Author: Harlan BA
Year: 2019
Journal: FASEB J
Title: Enhanced SIRT6 activity abrogates the neurotoxic phenotype of astrocytes expressing ALS-linked mutant SOD1.
Volume: 33
Issue: 6
Pages: 7084-7091
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Publication
30189861 | J:324520
First Author: Kim H
Year: 2018
Journal: Mol Brain
Title: Elevated contextual fear memory by SIRT6 depletion in excitatory neurons of mouse forebrain.
Volume: 11
Issue: 1
Pages: 49
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Publication
29129519 | J:319290
 
First Author: Zhang S
Year: 2018
Journal: Free Radic Biol Med
Title: SIRT6 protects against hepatic ischemia/reperfusion injury by inhibiting apoptosis and autophagy related cell death.
Volume: 115
Pages: 18-30
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Publication
25009184 | J:212254
First Author: Zhang P
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion.
Volume: 111
Issue: 29
Pages: 10684-9
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Publication
19135889 | J:147591
First Author: Kawahara TL
Year: 2009
Journal: Cell
Title: SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span.
Volume: 136
Issue: 1
Pages: 62-74
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Publication
32239217 | J:288666
First Author: Peng L
Year: 2020
Journal: Nucleic Acids Res
Title: Deacetylase-independent function of SIRT6 couples GATA4 transcription factor and epigenetic activation against cardiomyocyte apoptosis.
Volume: 48
Issue: 9
Pages: 4992-5005
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Publication
30894089 | J:291846
First Author: Guo J
Year: 2019
Journal: Circ Res
Title: Endothelial SIRT6 Is Vital to Prevent Hypertension and Associated Cardiorenal Injury Through Targeting Nkx3.2-GATA5 Signaling.
Volume: 124
Issue: 10
Pages: 1448-1461
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Publication
31603194 | J:327409
First Author: Liberale L
Year: 2020
Journal: Eur Heart J
Title: Endothelial SIRT6 blunts stroke size and neurological deficit by preserving blood-brain barrier integrity: a translational study.
Volume: 41
Issue: 16
Pages: 1575-1587
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Publication
31216030 | J:322374
First Author: Rezazadeh S
Year: 2019
Journal: Nucleic Acids Res
Title: SIRT6 promotes transcription of a subset of NRF2 targets by mono-ADP-ribosylating BAF170.
Volume: 47
Issue: 15
Pages: 7914-7928
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Publication
25915124 | J:322365
First Author: Etchegaray JP
Year: 2015
Journal: Nat Cell Biol
Title: The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine.
Volume: 17
Issue: 5
Pages: 545-57
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Publication
23086477 | J:317186
First Author: Sundaresan NR
Year: 2012
Journal: Nat Med
Title: The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun.
Volume: 18
Issue: 11
Pages: 1643-50
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Publication
34493807 | J:314113
First Author: Wu D
Year: 2021
Journal: Exp Mol Med
Title: Loss of Sirt6 in adipocytes impairs the ability of adipose tissue to adapt to intermittent fasting.
Volume: 53
Issue: 9
Pages: 1298-1306
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Publication
31318577 | J:338782
First Author: Kanwal A
Year: 2019
Journal: FASEB J
Title: The nuclear and mitochondrial sirtuins, Sirt6 and Sirt3, regulate each other's activity and protect the heart from developing obesity-mediated diabetic cardiomyopathy.
Volume: 33
Issue: 10
Pages: 10872-10888
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Publication
20847051 | J:167023
First Author: Xiao C
Year: 2010
Journal: J Biol Chem
Title: SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice.
Volume: 285
Issue: 47
Pages: 36776-84
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Publication
32305562 | J:313610
First Author: Zhong X
Year: 2020
Journal: Cell Mol Gastroenterol Hepatol
Title: SIRT6 Protects Against Liver Fibrosis by Deacetylation and Suppression of SMAD3 in Hepatic Stellate Cells.
Volume: 10
Issue: 2
Pages: 341-364
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Publication
30912134 | J:290982
First Author: Tang C
Year: 2019
Journal: J Cell Physiol
Title: Sirt6 deletion in hepatocytes increases insulin sensitivity of female mice by enhancing ERα expression.
Volume: 234
Issue: 10
Pages: 18615-18625
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Publication
31372634 | J:279963
First Author: Ravi V
Year: 2019
Journal: Nucleic Acids Res
Title: SIRT6 transcriptionally regulates global protein synthesis through transcription factor Sp1 independent of its deacetylase activity.
Volume: 47
Issue: 17
Pages: 9115-9131
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Publication
34793336 | J:330102
 
First Author: Li W
Year: 2022
Journal: J Clin Invest
Title: SIRT6 protects vascular smooth muscle cells from osteogenic transdifferentiation via Runx2 in chronic kidney disease.
Volume: 132
Issue: 1
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Publication
35859073 | J:326813
First Author: Georgieva AM
Year: 2022
Journal: Nat Commun
Title: Inactivation of Sirt6 ameliorates muscular dystrophy in mdx mice by releasing suppression of utrophin expression.
Volume: 13
Issue: 1
Pages: 4184
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Publication
31972266 | J:288261
 
First Author: Arsiwala T
Year: 2020
Journal: J Mol Cell Cardiol
Title: Sirt6 deletion in bone marrow-derived cells increases atherosclerosis - Central role of macrophage scavenger receptor 1.
Volume: 139
Pages: 24-32
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Publication
32584788 | J:322373
First Author: Rezazadeh S
Year: 2020
Journal: Aging (Albany NY)
Title: SIRT6 mono-ADP ribosylates KDM2A to locally increase H3K36me2 at DNA damage sites to inhibit transcription and promote repair.
Volume: 12
Issue: 12
Pages: 11165-11184
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Publication
23086953 | J:192629
First Author: Bauer I
Year: 2012
Journal: J Biol Chem
Title: The NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses.
Volume: 287
Issue: 49
Pages: 40924-37
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Publication
36367517 | J:332028
 
First Author: Wang S
Year: 2022
Journal: J Mol Cell Cardiol
Title: Deletion of SIRT6 in vascular smooth muscle cells facilitates vascular calcification via suppression of DNA damage repair.
Volume: 173
Pages: 154-168
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Publication
31967391 | J:285888
First Author: Li Z
Year: 2020
Journal: Aging Cell
Title: A high-fat diet reverses metabolic disorders and premature aging by modulating insulin and IGF1 signaling in SIRT6 knockout mice.
Volume: 19
Issue: 3
Pages: e13104
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Publication
20816089 | J:166368
First Author: Kim HS
Year: 2010
Journal: Cell Metab
Title: Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis.
Volume: 12
Issue: 3
Pages: 224-36
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Publication
31295533 | J:299842
First Author: Kim HG
Year: 2019
Journal: J Hepatol
Title: The epigenetic regulator SIRT6 protects the liver from alcohol-induced tissue injury by reducing oxidative stress in mice.
Volume: 71
Issue: 5
Pages: 960-969
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Publication
27457971 | J:254113
 
First Author: Song MY
Year: 2016
Journal: Sci Rep
Title: Insulin secretion impairment in Sirt6 knockout pancreatic β cells is mediated by suppression of the FoxO1-Pdx1-Glut2 pathway.
Volume: 6
Pages: 30321
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Publication
23076146 | J:193418
First Author: Xiao C
Year: 2012
Journal: J Biol Chem
Title: Progression of chronic liver inflammation and fibrosis driven by activation of c-JUN signaling in Sirt6 mutant mice.
Volume: 287
Issue: 50
Pages: 41903-13
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Publication
27568560 | J:239021
First Author: Van Meter M
Year: 2016
Journal: Cell Rep
Title: JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks.
Volume: 16
Issue: 10
Pages: 2641-2650
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Publication
23974119 | J:203942
First Author: Tao R
Year: 2013
Journal: J Biol Chem
Title: FoxO3 transcription factor and Sirt6 deacetylase regulate low density lipoprotein (LDL)-cholesterol homeostasis via control of the proprotein convertase subtilisin/kexin type 9 (Pcsk9) gene expression.
Volume: 288
Issue: 41
Pages: 29252-9
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Publication
28385723 | J:271854
First Author: Xiong X
Year: 2017
Journal: J Endocrinol
Title: Fabp4-Cre-mediated Sirt6 deletion impairs adipose tissue function and metabolic homeostasis in mice.
Volume: 233
Issue: 3
Pages: 307-314
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