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Search results 1 to 100 out of 1464 for Six2

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Type Details Score
Gene
Type: gene
Organism: Not Specified
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
GXD Expression  
Probe: MGI:2664237
Assay Type: RNA in situ
Annotation Date: 2003-07-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737519
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:2665166
Age: embryonic day 11.5
Image: M Six2
Specimen Label: M Six2
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:2664237
Assay Type: RNA in situ
Annotation Date: 2003-07-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737519
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:2665166
Age: embryonic day 11.5
Image: N Six2
Note: Expression in this mutant is the same as in wild-type embryos.
Specimen Label: N Six2
Detected: true
Specimen Num: 2
Publication
First Author: Kutejova E
Year: 2008
Journal: Development
Title: Six2 functions redundantly immediately downstream of Hoxa2.
Volume: 135
Issue: 8
Pages: 1463-70
GXD Expression
Probe: MGI:5750048
Assay Type: RNA in situ
Annotation Date: 2016-02-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1678117
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:5750052
Age: embryonic day 10.75
Image: S11 mouse hindlimb Six2
Note: Expression in mesenchyme of posterior distal limb bud.
Specimen Label: S11 mouse hindlimb Six2
Detected: true
Specimen Num: 16
GXD Expression
Probe: MGI:5750048
Assay Type: RNA in situ
Annotation Date: 2016-02-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640817
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:5750052
Age: embryonic day 10.75
Image: S11 mouse forelimb Six2
Note: Expression in mesenchyme of posterior distal limb bud.
Specimen Label: S11 mouse forelimb Six2
Detected: true
Specimen Num: 15
GXD Expression  
Probe: MGI:6469656
Assay Type: RNA in situ
Annotation Date: 2020-10-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609815
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:6469677
Age: embryonic day 9.5
Image: 1 E9.5 Six2
Specimen Label: 1 E9.5 Six2
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:23833
Assay Type: Northern blot
Annotation Date: 2001-08-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:2148795
Age: embryonic day 10.5
Image: 1
Specimen Label: Six2
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6436660
Assay Type: RT-PCR
Annotation Date: 2020-06-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3673015
Stage: TS15
Assay Id: MGI:6436695
Age: embryonic day 9.5
Image: 1
Specimen Label: Six2
Detected: true
Specimen Num: 1
Publication
First Author: Park JS
Year: 2012
Journal: Dev Cell
Title: Six2 and Wnt regulate self-renewal and commitment of nephron progenitors through shared gene regulatory networks.
Volume: 23
Issue: 3
Pages: 637-51
Publication
First Author: Self M
Year: 2009
Journal: Dev Biol
Title: Six2 activity is required for the formation of the mammalian pyloric sphincter.
Volume: 334
Issue: 2
Pages: 409-17
Publication
First Author: Kobayashi A
Year: 2008
Journal: Cell Stem Cell
Title: Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development.
Volume: 3
Issue: 2
Pages: 169-81
Publication
First Author: Self M
Year: 2006
Journal: EMBO J
Title: Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney.
Volume: 25
Issue: 21
Pages: 5214-28
Publication
First Author: Xu J
Year: 2014
Journal: Development
Title: Osr1 acts downstream of and interacts synergistically with Six2 to maintain nephron progenitor cells during kidney organogenesis.
Volume: 141
Issue: 7
Pages: 1442-52
Publication
First Author: Yallowitz AR
Year: 2009
Journal: Dev Biol
Title: Non-homeodomain regions of Hox proteins mediate activation versus repression of Six2 via a single enhancer site in vivo.
Volume: 335
Issue: 1
Pages: 156-65
Publication
First Author: Li C
Year: 2020
Journal: Genesis
Title: Generation and characterization of Six2 conditional mice.
Volume: 58
Issue: 7
Pages: e23365
Publication
First Author: He G
Year: 2010
Journal: Dev Biol
Title: Inactivation of Six2 in mouse identifies a novel genetic mechanism controlling development and growth of the cranial base.
Volume: 344
Issue: 2
Pages: 720-30
Publication
First Author: Sweat YY
Year: 2020
Journal: Dev Biol
Title: Six2 regulates Pax9 expression, palatogenesis and craniofacial bone formation.
Volume: 458
Issue: 2
Pages: 246-256
Publication
First Author: Kutejova E
Year: 2005
Journal: Development
Title: Hoxa2 downregulates Six2 in the neural crest-derived mesenchyme.
Volume: 132
Issue: 3
Pages: 469-78
Publication
First Author: Karner CM
Year: 2011
Journal: Development
Title: Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development.
Volume: 138
Issue: 7
Pages: 1247-57
Publication
First Author: Combes AN
Year: 2018
Journal: Kidney Int
Title: Haploinsufficiency for the Six2 gene increases nephron progenitor proliferation promoting branching and nephron number.
Volume: 93
Issue: 3
Pages: 589-598
Publication
First Author: Liu Z
Year: 2019
Journal: J Dent Res
Title: Crucial and Overlapping Roles of Six1 and Six2 in Craniofacial Development.
Volume: 98
Issue: 5
Pages: 572-579
Publication
First Author: Buller C
Year: 2001
Journal: Hum Mol Genet
Title: Molecular effects of Eya1 domain mutations causing organ defects in BOR syndrome.
Volume: 10
Issue: 24
Pages: 2775-81
Publication
First Author: Fogelgren B
Year: 2008
Journal: Dev Dyn
Title: Misexpression of Six2 is associated with heritable frontonasal dysplasia and renal hypoplasia in 3H1 Br mice.
Volume: 237
Issue: 7
Pages: 1767-79
Publication
First Author: lyu Z
Year: 2013
Journal: Biochem Biophys Res Commun
Title: MiR-181b targets Six2 and inhibits the proliferation of metanephric mesenchymal cells in vitro.
Volume: 440
Issue: 4
Pages: 495-501
Publication
First Author: Brodbeck S
Year: 2004
Journal: Mech Dev
Title: The transcription factor Six2 activates expression of the Gdnf gene as well as its own promoter.
Volume: 121
Issue: 10
Pages: 1211-22
Publication
First Author: Zhou P
Year: 2014
Journal: Mol Cell Biochem
Title: Down-regulated Six2 by knockdown of neurofibromin results in apoptosis of metanephric mesenchyme cells in vitro.
Volume: 390
Issue: 1-2
Pages: 205-13
Publication
First Author: Xu J
Year: 2014
Journal: Dev Cell
Title: Eya1 interacts with Six2 and Myc to regulate expansion of the nephron progenitor pool during nephrogenesis.
Volume: 31
Issue: 4
Pages: 434-47
Publication
First Author: Li J
Year: 2021
Journal: J Am Soc Nephrol
Title: Chromatin Remodelers Interact with Eya1 and Six2 to Target Enhancers to Control Nephron Progenitor Cell Maintenance.
Volume: 32
Issue: 11
Pages: 2815-2833
Publication  
First Author: Gu Y
Year: 2016
Journal: Int J Mol Sci
Title: Zeb1 Is a Potential Regulator of Six2 in the Proliferation, Apoptosis and Migration of Metanephric Mesenchyme Cells.
Volume: 17
Issue: 8
Publication  
First Author: Xu J
Year: 2022
Journal: Front Cell Dev Biol
Title: Six1 and Six2 of the Sine Oculis Homeobox Subfamily are Not Functionally Interchangeable in Mouse Nephron Formation.
Volume: 10
Pages: 815249
Publication
First Author: Yamamoto-Shiraishi Y
Year: 2013
Journal: Dev Biol
Title: Wnt and BMP signaling cooperate with Hox in the control of Six2 expression in limb tendon precursor.
Volume: 377
Issue: 2
Pages: 363-74
GXD Expression
Probe: MGI:6276025
Assay Type: Immunohistochemistry
Annotation Date: 2023-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2762122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7481327
Age: embryonic day 14.5
Image: 9B
Note: A significant loss of Six2 cells.
Specimen Label: 9B
Detected: true
Specimen Num: 16
GXD Expression
Probe: MGI:6276025
Assay Type: Immunohistochemistry
Annotation Date: 2023-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2762122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7481327
Age: embryonic day 14.5
Image: 9D
Note: A significant loss of Six2 cells.
Specimen Label: 9D
Detected: true
Specimen Num: 18
GXD Expression
Probe: MGI:6276025
Assay Type: Immunohistochemistry
Annotation Date: 2023-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2762122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7481327
Age: embryonic day 14.5
Image: 9F
Note: A significant loss of Six2 cells.
Specimen Label: 9F
Detected: true
Specimen Num: 20
Publication
First Author: Fogelgren B
Year: 2009
Journal: Am J Physiol Renal Physiol
Title: Deficiency in Six2 during prenatal development is associated with reduced nephron number, chronic renal failure, and hypertension in Br/+ adult mice.
Volume: 296
Issue: 5
Pages: F1166-78
Publication
First Author: Oliver G
Year: 1995
Journal: Development
Title: Homeobox genes and connective tissue patterning.
Volume: 121
Issue: 3
Pages: 693-705
Publication
First Author: Kawakami K
Year: 1996
Journal: FEBS Lett
Title: Identification and expression of six family genes in mouse retina.
Volume: 393
Issue: 2-3
Pages: 259-63
GXD Expression
Probe: MGI:6276025
Assay Type: Immunohistochemistry
Annotation Date: 2023-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2762127
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:7481327
Age: postnatal day 0
Image: 11C
Note: Six2 and GFP co-staining underscored the recovery of cap mesenchyme cells.
Specimen Label: 11C
Detected: true
Specimen Num: 23
GXD Expression  
Probe: MGI:3506051
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2772127
Stage: TS27
Assay Id: MGI:5539126
Age: postnatal day 4
Image: GUDMAP:14087
Note: No cap mesenchyme present at P4 therefore no Six2 expression in this structure within the nephrogenic zone at P4.
Specimen Label: GUDMAP:14087
Detected: false
Specimen Num: 9
Publication  
First Author: Okello DO
Year: 2017
Journal: Front Physiol
Title: Six2 Plays an Intrinsic Role in Regulating Proliferation of Mesenchymal Cells in the Developing Palate.
Volume: 8
Pages: 955
GXD Expression
Probe: MGI:6276025
Assay Type: Immunohistochemistry
Annotation Date: 2023-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2762122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7481327
Age: embryonic day 14.5
Image: 6B/D
Note: A significant loss of Six2 cells. The combined pHH3- and Six2-positive foci when normalized to Six2-positive cells revealed no change in mitotic rates between the wild-type control and mutant kidney.
Specimen Label: 6B/D
Detected: true
Specimen Num: 14
Publication
First Author: Ikeda K
Year: 2002
Journal: Mol Cell Biol
Title: Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein.
Volume: 22
Issue: 19
Pages: 6759-66
UniProt Feature
Begin: 1
Description: Homeobox protein SIX2
Type: chain
End: 296
Publication  
First Author: Tsujimoto H
Year: 2021
Journal: Biochem Biophys Res Commun
Title: Small molecule TCS21311 can replace BMP7 and facilitate cell proliferation in in vitro expansion culture of nephron progenitor cells.
Volume: 558
Pages: 231-238
Publication
First Author: Li Z
Year: 2016
Journal: Cell Stem Cell
Title: 3D Culture Supports Long-Term Expansion of Mouse and Human Nephrogenic Progenitors.
Volume: 19
Issue: 4
Pages: 516-529
Publication
First Author: O'Brien LL
Year: 2016
Journal: Development
Title: Differential regulation of mouse and human nephron progenitors by the Six family of transcriptional regulators.
Volume: 143
Issue: 4
Pages: 595-608
Publication
First Author: Chung E
Year: 2016
Journal: Development
Title: Notch signaling promotes nephrogenesis by downregulating Six2.
Volume: 143
Issue: 21
Pages: 3907-3913
Publication
First Author: Wang C
Year: 2013
Journal: PLoS One
Title: Embryonic origin and remodeling of the urinary and digestive outlets.
Volume: 8
Issue: 2
Pages: e55587
Publication
First Author: Denner DR
Year: 2013
Journal: Dev Biol
Title: Mi-2/NuRD is required in renal progenitor cells during embryonic kidney development.
Volume: 375
Issue: 2
Pages: 105-16
Publication
First Author: Zhou Z
Year: 2017
Journal: Cell Rep
Title: Temporally Distinct Six2-Positive Second Heart Field Progenitors Regulate Mammalian Heart Development and Disease.
Volume: 18
Issue: 4
Pages: 1019-1032
Publication
First Author: Cargill K
Year: 2019
Journal: J Am Soc Nephrol
Title: Von Hippel-Lindau Acts as a Metabolic Switch Controlling Nephron Progenitor Differentiation.
Volume: 30
Issue: 7
Pages: 1192-1205
Publication  
First Author: Liu H
Year: 2018
Journal: Development
Title: Histone deacetylases 1 and 2 regulate the transcriptional programs of nephron progenitors and renal vesicles.
Volume: 145
Issue: 10
Publication
First Author: O'Brien LL
Year: 2018
Journal: PLoS Genet
Title: Transcriptional regulatory control of mammalian nephron progenitors revealed by multi-factor cistromic analysis and genetic studies.
Volume: 14
Issue: 1
Pages: e1007181
Publication
First Author: Kiefer SM
Year: 2012
Journal: PLoS One
Title: Conditional expression of Wnt9b in Six2-positive cells disrupts stomach and kidney function.
Volume: 7
Issue: 8
Pages: e43098
Publication
First Author: Liu H
Year: 2020
Journal: J Biol Chem
Title: The polycomb proteins EZH1 and EZH2 co-regulate chromatin accessibility and nephron progenitor cell lifespan in mice.
Volume: 295
Issue: 33
Pages: 11542-11558
Publication
First Author: Kanda S
Year: 2014
Journal: J Am Soc Nephrol
Title: Sall1 maintains nephron progenitors and nascent nephrons by acting as both an activator and a repressor.
Volume: 25
Issue: 11
Pages: 2584-95
Publication
First Author: Wurmser M
Year: 2023
Journal: PLoS Genet
Title: Overlapping functions of SIX homeoproteins during embryonic myogenesis.
Volume: 19
Issue: 6
Pages: e1010781
Publication
First Author: Humphreys BD
Year: 2013
Journal: J Clin Invest
Title: Chronic epithelial kidney injury molecule-1 expression causes murine kidney fibrosis.
Volume: 123
Issue: 9
Pages: 4023-35
Publication
First Author: Guan N
Year: 2022
Journal: Kidney Int
Title: Disruption of mitochondrial complex III in cap mesenchyme but not in ureteric progenitors results in defective nephrogenesis associated with amino acid deficiency.
Volume: 102
Issue: 1
Pages: 108-120
Publication
First Author: Wainwright EN
Year: 2015
Journal: Dev Biol
Title: ROBO2 restricts the nephrogenic field and regulates Wolffian duct-nephrogenic cord separation.
Volume: 404
Issue: 2
Pages: 88-102
Publication
First Author: Gong KQ
Year: 2007
Journal: Mol Cell Biol
Title: A Hox-Eya-Pax complex regulates early kidney developmental gene expression.
Volume: 27
Issue: 21
Pages: 7661-8
Publication
First Author: Dolt KS
Year: 2013
Journal: PLoS One
Title: A universal vector for high-efficiency multi-fragment recombineering of BACs and knock-in constructs.
Volume: 8
Issue: 4
Pages: e62054
Publication
First Author: Mederacke M
Year: 2023
Journal: Cell Rep
Title: Geometric effects position renal vesicles during kidney development.
Volume: 42
Issue: 12
Pages: 113526
Publication
First Author: Jiang Q
Year: 2010
Journal: J Biochem
Title: Overexpression of Sall1 in vivo leads to reduced body weight without affecting kidney development.
Volume: 147
Issue: 3
Pages: 445-50
Publication
First Author: Fujimura S
Year: 2010
Journal: J Am Soc Nephrol
Title: Notch2 activation in the embryonic kidney depletes nephron progenitors.
Volume: 21
Issue: 5
Pages: 803-10
Publication  
First Author: Puri P
Year: 2016
Journal: Sci Rep
Title: Six2creFrs2α knockout mice are a novel model of renal cystogenesis.
Volume: 6
Pages: 36736
Publication
First Author: Yang Z
Year: 2013
Journal: Development
Title: De novo lumen formation and elongation in the developing nephron: a central role for afadin in apical polarity.
Volume: 140
Issue: 8
Pages: 1774-84
Publication
First Author: Somponpun SJ
Year: 2011
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Osmoregulatory defect in adult mice associated with deficient prenatal expression of six2.
Volume: 301
Issue: 3
Pages: R682-9
Publication  
First Author: Thiagarajan RD
Year: 2011
Journal: BMC Genomics
Title: Refining transcriptional programs in kidney development by integration of deep RNA-sequencing and array-based spatial profiling.
Volume: 12
Pages: 441
Publication
First Author: Lindström NO
Year: 2018
Journal: Dev Cell
Title: Progressive Recruitment of Mesenchymal Progenitors Reveals a Time-Dependent Process of Cell Fate Acquisition in Mouse and Human Nephrogenesis.
Volume: 45
Issue: 5
Pages: 651-660.e4
Publication
First Author: Umar M
Year: 2023
Journal: Genesis
Title: Characterizing expression pattern of Six2Cre during mouse craniofacial development.
Volume: 61
Issue: 5
Pages: e23516
Publication
First Author: Ransick A
Year: 2019
Journal: Dev Cell
Title: Single-Cell Profiling Reveals Sex, Lineage, and Regional Diversity in the Mouse Kidney.
Volume: 51
Issue: 3
Pages: 399-413.e7
Publication
First Author: Santagati F
Year: 2005
Journal: Development
Title: Temporal requirement of Hoxa2 in cranial neural crest skeletal morphogenesis.
Volume: 132
Issue: 22
Pages: 4927-36
Publication
First Author: Ohto H
Year: 1998
Journal: Int J Dev Biol
Title: Tissue and developmental distribution of Six family gene products.
Volume: 42
Issue: 2
Pages: 141-8
Publication
First Author: Kurtzeborn K
Year: 2022
Journal: BMC Biol
Title: Comparative whole-genome transcriptome analysis in renal cell populations reveals high tissue specificity of MAPK/ERK targets in embryonic kidney.
Volume: 20
Issue: 1
Pages: 112
Publication  
First Author: Marable SS
Year: 2018
Journal: JCI Insight
Title: Hnf4a deletion in the mouse kidney phenocopies Fanconi renotubular syndrome.
Volume: 3
Issue: 14
Publication
First Author: Wellik DM
Year: 2002
Journal: Genes Dev
Title: Hox11 paralogous genes are essential for metanephric kidney induction.
Volume: 16
Issue: 11
Pages: 1423-32
Publication
First Author: Dreyer SD
Year: 2004
Journal: Gene Expr Patterns
Title: Lmx1b expression during joint and tendon formation: localization and evaluation of potential downstream targets.
Volume: 4
Issue: 4
Pages: 397-405
Publication
First Author: Phua YL
Year: 2019
Journal: Am J Physiol Renal Physiol
Title: Loss of miR-17~92 results in dysregulation of Cftr in nephron progenitors.
Volume: 316
Issue: 5
Pages: F993-F1005
Publication
First Author: Kann M
Year: 2015
Journal: Development
Title: WT1 targets Gas1 to maintain nephron progenitor cells by modulating FGF signals.
Volume: 142
Issue: 7
Pages: 1254-66
Publication
First Author: Chen S
Year: 2015
Journal: Dev Cell
Title: Intrinsic Age-Dependent Changes and Cell-Cell Contacts Regulate Nephron Progenitor Lifespan.
Volume: 35
Issue: 1
Pages: 49-62
Publication
First Author: Liu J
Year: 2020
Journal: J Am Soc Nephrol
Title: Renoprotective and Immunomodulatory Effects of GDF15 following AKI Invoked by Ischemia-Reperfusion Injury.
Volume: 31
Issue: 4
Pages: 701-715
Publication
First Author: Elias BC
Year: 2015
Journal: J Cell Sci
Title: Cdc42 regulates epithelial cell polarity and cytoskeletal function during kidney tubule development.
Volume: 128
Issue: 23
Pages: 4293-305
Publication
First Author: Diniz F
Year: 2023
Journal: Nat Commun
Title: Acetyl-CoA is a key molecule for nephron progenitor cell pool maintenance.
Volume: 14
Issue: 1
Pages: 7733
Publication
First Author: Pan X
Year: 2015
Journal: Genesis
Title: A Cre-inducible fluorescent reporter for observing apical membrane dynamics.
Volume: 53
Issue: 3-4
Pages: 285-93
Publication
First Author: Rogg M
Year: 2021
Journal: J Am Soc Nephrol
Title: SRGAP1 Controls Small Rho GTPases To Regulate Podocyte Foot Process Maintenance.
Volume: 32
Issue: 3
Pages: 563-579
Publication
First Author: Saifudeen Z
Year: 2012
Journal: PLoS One
Title: A p53-Pax2 pathway in kidney development: implications for nephrogenesis.
Volume: 7
Issue: 9
Pages: e44869
Publication
First Author: Xu PX
Year: 2003
Journal: Development
Title: Six1 is required for the early organogenesis of mammalian kidney.
Volume: 130
Issue: 14
Pages: 3085-94
Publication
First Author: Gonçalves A
Year: 2011
Journal: PLoS One
Title: Genetic analysis reveals an unexpected role of BMP7 in initiation of ureteric bud outgrowth in mouse embryos.
Volume: 6
Issue: 4
Pages: e19370
Publication    
First Author: Munro DAD
Year: 2019
Journal: Elife
Title: Macrophages restrict the nephrogenic field and promote endothelial connections during kidney development.
Volume: 8