Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
Not Specified |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6198677 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-09-19 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1614413 |
Pattern: |
Regionally restricted |
Stage: |
TS13 |
Assay Id: |
MGI:6198685 |
Age: |
embryonic day 8.25 |
Image: |
1G Six3 |
Note: |
Expression predominant in prospective pituitary/hypothalamic axis and ventral forebrain. |
Specimen Label: |
1G Six3 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6198677 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-09-19 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:3598913 |
|
Stage: |
TS13 |
Assay Id: |
MGI:6198685 |
Age: |
embryonic day 8.25 |
Image: |
1G Six3 |
Note: |
Expression nearly absent in region of anterior retina corresponding to presumptive retina field. |
Specimen Label: |
1G Six3 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Publication |
First Author: |
Lavado A |
Year: |
2011 |
Journal: |
Development |
Title: |
Six3 is required for ependymal cell maturation. |
Volume: |
138 |
Issue: |
24 |
Pages: |
5291-300 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6502085 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2021-01-27 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1667216 |
Pattern: |
Regionally restricted |
Stage: |
TS16 |
Assay Id: |
MGI:6502093 |
Age: |
embryonic day 10.0 |
Image: |
S3 Prep1+/+ Six3 |
Note: |
Expression in presumptive lens ectoderm. |
Specimen Label: |
S3 Prep1+/+ Six3 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6479758 |
Assay Type: |
RNA in situ |
Annotation Date: |
2020-12-17 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1691015 |
Pattern: |
Not Specified |
Stage: |
TS15 |
Assay Id: |
MGI:6479817 |
Age: |
embryonic day 9.5 |
Image: |
2b Six3 OG/OG weak |
Note: |
Authors report telencephalon developed normally. |
Specimen Label: |
2b Six3 OG/OG weak |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6502085 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2021-01-27 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1667216 |
Pattern: |
Regionally restricted |
Stage: |
TS16 |
Assay Id: |
MGI:6502093 |
Age: |
embryonic day 10.0 |
Image: |
S3 Prep1i/- Six3 |
|
Specimen Label: |
S3 Prep1i/- Six3 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6479758 |
Assay Type: |
RNA in situ |
Annotation Date: |
2020-12-17 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1691015 |
Pattern: |
Not Specified |
Stage: |
TS15 |
Assay Id: |
MGI:6479817 |
Age: |
embryonic day 9.5 |
Image: |
2b Six3 +/OG |
|
Specimen Label: |
2b Six3 +/OG |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6479758 |
Assay Type: |
RNA in situ |
Annotation Date: |
2020-12-17 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1691015 |
Pattern: |
Not Specified |
Stage: |
TS15 |
Assay Id: |
MGI:6479817 |
Age: |
embryonic day 9.5 |
Image: |
2b Six3 OG/OG strong |
Note: |
Authors report telencephalon developed normally. |
Specimen Label: |
2b Six3 OG/OG strong |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carl M |
Year: |
2002 |
Journal: |
Development |
Title: |
Six3 inactivation reveals its essential role for the formation and patterning of the vertebrate eye. |
Volume: |
129 |
Issue: |
17 |
Pages: |
4057-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Appolloni I |
Year: |
2008 |
Journal: |
Cereb Cortex |
Title: |
Six3 controls the neural progenitor status in the murine CNS. |
Volume: |
18 |
Issue: |
3 |
Pages: |
553-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu W |
Year: |
2006 |
Journal: |
EMBO J |
Title: |
Six3 activation of Pax6 expression is essential for mammalian lens induction and specification. |
Volume: |
25 |
Issue: |
22 |
Pages: |
5383-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Geng X |
Year: |
2008 |
Journal: |
Dev Cell |
Title: |
Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly. |
Volume: |
15 |
Issue: |
2 |
Pages: |
236-47 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lavado A |
Year: |
2008 |
Journal: |
Development |
Title: |
Six3 inactivation causes progressive caudalization and aberrant patterning of the mammalian diencephalon. |
Volume: |
135 |
Issue: |
3 |
Pages: |
441-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lengler J |
Year: |
2001 |
Journal: |
Nucleic Acids Res |
Title: |
Antagonistic action of Six3 and Prox1 at the gamma-crystallin promoter. |
Volume: |
29 |
Issue: |
2 |
Pages: |
515-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lagutin O |
Year: |
2001 |
Journal: |
Dev Dyn |
Title: |
Six3 promotes the formation of ectopic optic vesicle-like structures in mouse embryos. |
Volume: |
221 |
Issue: |
3 |
Pages: |
342-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee B |
Year: |
2013 |
Journal: |
Dev Biol |
Title: |
Genomic code for Sox2 binding uncovers its regulatory role in Six3 activation in the forebrain. |
Volume: |
381 |
Issue: |
2 |
Pages: |
491-501 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lagutin OV |
Year: |
2003 |
Journal: |
Genes Dev |
Title: |
Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development. |
Volume: |
17 |
Issue: |
3 |
Pages: |
368-79 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gaston-Massuet C |
Year: |
2008 |
Journal: |
Dev Biol |
Title: |
Genetic interaction between the homeobox transcription factors HESX1 and SIX3 is required for normal pituitary development. |
Volume: |
324 |
Issue: |
2 |
Pages: |
322-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Abe Y |
Year: |
2009 |
Journal: |
Hum Mutat |
Title: |
EYA4, deleted in a case with middle interhemispheric variant of holoprosencephaly, interacts with SIX3 both physically and functionally. |
Volume: |
30 |
Issue: |
10 |
Pages: |
E946-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Goudreau G |
Year: |
2002 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype. |
Volume: |
99 |
Issue: |
13 |
Pages: |
8719-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Manavathi B |
Year: |
2007 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Repression of Six3 by a corepressor regulates rhodopsin expression. |
Volume: |
104 |
Issue: |
32 |
Pages: |
13128-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kumar R |
Year: |
2010 |
Journal: |
Cancer Res |
Title: |
Metastasis-associated protein 1 and its short form variant stimulates Wnt1 transcription through promoting its derepression from Six3 corepressor. |
Volume: |
70 |
Issue: |
16 |
Pages: |
6649-58 |
|
•
•
•
•
•
|
Publication |
First Author: |
Geng X |
Year: |
2016 |
Journal: |
Development |
Title: |
Six3 dosage mediates the pathogenesis of holoprosencephaly. |
Volume: |
143 |
Issue: |
23 |
Pages: |
4462-4473 |
|
•
•
•
•
•
|
Publication |
First Author: |
Geng X |
Year: |
2007 |
Journal: |
Gene Expr Patterns |
Title: |
Expression of Six3 Opposite Strand (Six3OS) during mouse embryonic development. |
Volume: |
7 |
Issue: |
3 |
Pages: |
252-7 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2014-01-27 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603913 |
Pattern: |
Not Specified |
Stage: |
TS13 |
Assay Id: |
MGI:5532320 |
Age: |
embryonic day 8.5 |
Image: |
4D Six3 left |
|
Specimen Label: |
4D Six3 left |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2014-01-27 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603913 |
Pattern: |
Not Specified |
Stage: |
TS13 |
Assay Id: |
MGI:5532320 |
Age: |
embryonic day 8.5 |
Image: |
4D Six3 right |
|
Specimen Label: |
4D Six3 right |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7464584 |
Assay Type: |
RNA in situ |
Annotation Date: |
2023-04-21 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603911 |
|
Stage: |
TS11 |
Assay Id: |
MGI:7464825 |
Age: |
embryonic day 7.5 |
|
|
Specimen Label: |
4 Six3 E7.5 -/- |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7464584 |
Assay Type: |
RNA in situ |
Annotation Date: |
2023-04-21 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603913 |
|
Stage: |
TS13 |
Assay Id: |
MGI:7464825 |
Age: |
embryonic day 8.5 |
|
|
Specimen Label: |
4 Six3 E8.5 -/- |
Detected: |
false |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7464584 |
Assay Type: |
RNA in situ |
Annotation Date: |
2023-04-21 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1608911 |
Pattern: |
Regionally restricted |
Stage: |
TS11 |
Assay Id: |
MGI:7464825 |
Age: |
embryonic day 7.5 |
|
Note: |
Expression in prospective forebrain. |
Specimen Label: |
4 Six3 E7.5 WT |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Granadino B |
Year: |
1999 |
Journal: |
Genomics |
Title: |
Genomic cloning, structure, expression pattern, and chromosomal location of the human SIX3 gene. |
Volume: |
55 |
Issue: |
1 |
Pages: |
100-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jeong Y |
Year: |
2008 |
Journal: |
Nat Genet |
Title: |
Regulation of a remote Shh forebrain enhancer by the Six3 homeoprotein. |
Volume: |
40 |
Issue: |
11 |
Pages: |
1348-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lavalle SN |
Year: |
2022 |
Journal: |
Mol Cell Endocrinol |
Title: |
Deletion of the homeodomain gene Six3 from kisspeptin neurons causes subfertility in female mice. |
Volume: |
546 |
|
Pages: |
111577 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xie H |
Year: |
2015 |
Journal: |
Mol Endocrinol |
Title: |
Homeodomain Proteins SIX3 and SIX6 Regulate Gonadotrope-specific Genes During Pituitary Development. |
Volume: |
29 |
Issue: |
6 |
Pages: |
842-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rapicavoli NA |
Year: |
2011 |
Journal: |
Neural Dev |
Title: |
The long noncoding RNA Six3OS acts in trans to regulate retinal development by modulating Six3 activity. |
Volume: |
6 |
|
Pages: |
32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bando H |
Year: |
2023 |
Journal: |
Hum Mol Genet |
Title: |
Heterozygous variants in SIX3 and POU1F1 cause pituitary hormone deficiency in mouse and man. |
Volume: |
32 |
Issue: |
3 |
Pages: |
367-385 |
|
•
•
•
•
•
|
Publication |
First Author: |
Takata N |
Year: |
2017 |
Journal: |
Cell Rep |
Title: |
An Eye Organoid Approach Identifies Six3 Suppression of R-spondin 2 as a Critical Step in Mouse Neuroretina Differentiation. |
Volume: |
21 |
Issue: |
6 |
Pages: |
1534-1549 |
|
•
•
•
•
•
|
Publication |
First Author: |
Meadows JD |
Year: |
2022 |
Journal: |
Mol Metab |
Title: |
Deletion of Six3 in post-proliferative neurons produces weakened SCN circadian output, improved metabolic function, and dwarfism in male mice. |
Volume: |
57 |
|
Pages: |
101431 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hoffmann HM |
Year: |
2021 |
Journal: |
J Neurosci Res |
Title: |
The transcription factors SIX3 and VAX1 are required for suprachiasmatic nucleus circadian output and fertility in female mice. |
Volume: |
99 |
Issue: |
10 |
Pages: |
2625-2645 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pandolfi EC |
Year: |
2018 |
Journal: |
Mol Neurobiol |
Title: |
Haploinsufficiency of SIX3 Abolishes Male Reproductive Behavior Through Disrupted Olfactory Development, and Impairs Female Fertility Through Disrupted GnRH Neuron Migration. |
Volume: |
55 |
Issue: |
11 |
Pages: |
8709-8727 |
|
•
•
•
•
•
|
Publication |
First Author: |
Diacou R |
Year: |
2018 |
Journal: |
Cell Rep |
Title: |
Six3 and Six6 Are Jointly Required for the Maintenance of Multipotent Retinal Progenitors through Both Positive and Negative Regulation. |
Volume: |
25 |
Issue: |
9 |
Pages: |
2510-2523.e4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu W |
Year: |
2010 |
Journal: |
J Clin Invest |
Title: |
Neuroretina specification in mouse embryos requires Six3-mediated suppression of Wnt8b in the anterior neural plate. |
Volume: |
120 |
Issue: |
10 |
Pages: |
3568-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu W |
Year: |
2017 |
Journal: |
Dev Biol |
Title: |
Six3 in a small population of progenitors at E8.5 is required for neuroretinal specification via regulating cell signaling and survival in mice. |
Volume: |
428 |
Issue: |
1 |
Pages: |
164-175 |
|
•
•
•
•
•
|
Publication |
First Author: |
Oliver G |
Year: |
1995 |
Journal: |
Development |
Title: |
Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development. |
Volume: |
121 |
Issue: |
12 |
Pages: |
4045-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Takata N |
Year: |
2016 |
Journal: |
In Vitro Cell Dev Biol Anim |
Title: |
IGF-2/IGF-1R signaling has distinct effects on Sox1, Irx3, and Six3 expressions during ES cell derived-neuroectoderm development in vitro. |
Volume: |
52 |
Issue: |
5 |
Pages: |
607-15 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6183330 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689419 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:6191306 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Table S2 - E11.5 - Six3 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6183330 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689421 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:6191306 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
Table S2 - E13.5 - Six3 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6183330 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689424 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:6191306 |
Age: |
embryonic day 15.5 |
|
|
Specimen Label: |
Table S2 - E15.5 - Six3 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6183330 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689426 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6191306 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
Table S2 - E18.5 - Six3 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6183330 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6191306 |
Age: |
postnatal day 4 |
|
|
Specimen Label: |
Table S2 - P4 - Six3 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6183330 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6191306 |
Age: |
postnatal day 14 |
|
|
Specimen Label: |
Table S2 - P14 - Six3 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6183330 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6191306 |
Age: |
postnatal day 28 |
|
|
Specimen Label: |
Table S2 - P28 - Six3 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Grimm C |
Year: |
1998 |
Journal: |
Dev Genet |
Title: |
Aphakia (ak), a mouse mutation affecting early eye development: fine mapping, consideration of candidate genes and altered Pax6 and Six3 gene expression pattern. |
Volume: |
23 |
Issue: |
4 |
Pages: |
299-316 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1315062 |
Assay Type: |
RNA in situ |
Annotation Date: |
1998-12-17 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1609512 |
Pattern: |
Regionally restricted |
Stage: |
TS12 |
Assay Id: |
MGI:1315073 |
Age: |
embryonic day 8.0 |
Image: |
7B |
Note: |
Six3 is expressed in the anterior neural plate. |
Specimen Label: |
7B |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawakami K |
Year: |
1996 |
Journal: |
FEBS Lett |
Title: |
Identification and expression of six family genes in mouse retina. |
Volume: |
393 |
Issue: |
2-3 |
Pages: |
259-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Purcell P |
Year: |
2005 |
Journal: |
Gene Expr Patterns |
Title: |
Pax6-dependence of Six3, Eya1 and Dach1 expression during lens and nasal placode induction. |
Volume: |
6 |
Issue: |
1 |
Pages: |
110-8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1315062 |
Assay Type: |
RNA in situ |
Annotation Date: |
1998-12-17 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1619813 |
Pattern: |
Regionally restricted |
Stage: |
TS13 |
Assay Id: |
MGI:1315073 |
Age: |
embryonic day 8.0 |
Image: |
7C |
Note: |
Six3 is normally expressed in the ventral diencephalon and optic vesicles. |
Specimen Label: |
7C |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1315062 |
Assay Type: |
RNA in situ |
Annotation Date: |
1999-02-02 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1607311 |
|
Stage: |
TS11 |
Assay Id: |
MGI:1328441 |
Age: |
embryonic day 7.5-7.75 |
Image: |
6F |
Note: |
Six3 was used as a marker for rostral neural ectoderm in these mutant embryos. |
Specimen Label: |
6F |
Detected: |
false |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1315062 |
Assay Type: |
RNA in situ |
Annotation Date: |
1998-12-17 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1614413 |
Pattern: |
Regionally restricted |
Stage: |
TS13 |
Assay Id: |
MGI:1315073 |
Age: |
embryonic day 8.0 |
Image: |
7C |
Note: |
Six3 is normally expressed in the ventral diencephalon and optic vesicles. |
Specimen Label: |
7C |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1289468 |
Assay Type: |
RNA in situ |
Annotation Date: |
1998-10-07 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1616415 |
Pattern: |
Regionally restricted |
Stage: |
TS15 |
Assay Id: |
MGI:1289474 |
Age: |
embryonic day 9.5 |
Image: |
4G |
Note: |
Six3 is expressed in the most anterior aspect of the developing neural tube. |
Specimen Label: |
4G |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1315062 |
Assay Type: |
RNA in situ |
Annotation Date: |
1998-12-17 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1608911 |
Pattern: |
Not Specified |
Stage: |
TS11 |
Assay Id: |
MGI:1315073 |
Age: |
embryonic day 7.75 |
Image: |
2A |
Note: |
Six3 is expressed in the presumptive forebrain region in wild-type embryos. |
Specimen Label: |
2A |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhu CC |
Year: |
2002 |
Journal: |
Development |
Title: |
Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors. |
Volume: |
129 |
Issue: |
12 |
Pages: |
2835-49 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xu Z |
Year: |
2018 |
Journal: |
Development |
Title: |
SP8 and SP9 coordinately promote D2-type medium spiny neuron production by activating Six3 expression. |
Volume: |
145 |
Issue: |
14 |
|
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
1 |
Description: |
Homeobox protein SIX3 |
Type: |
chain |
End: |
333 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee B |
Year: |
2017 |
Journal: |
Genesis |
Title: |
Identification of a conserved cis-regulatory element controlling mid-diencephalic expression of mouse Six3. |
Volume: |
55 |
Issue: |
3 |
|
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
347
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhou X |
Year: |
2000 |
Journal: |
Mech Dev |
Title: |
Cloning and expression of xSix3, the Xenopus homologue of murine Six3. |
Volume: |
91 |
Issue: |
1-2 |
Pages: |
327-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liao GY |
Year: |
2008 |
Journal: |
Genesis |
Title: |
Cre recombinase-mediated gene deletion in layer 4 of murine sensory cortical areas. |
Volume: |
46 |
Issue: |
6 |
Pages: |
289-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Furuta Y |
Year: |
2000 |
Journal: |
Genesis |
Title: |
Retina- and ventral forebrain-specific Cre recombinase activity in transgenic mice. |
Volume: |
26 |
Issue: |
2 |
Pages: |
130-2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang L |
Year: |
2021 |
Journal: |
Cell Death Dis |
Title: |
Transcriptional profiling reveals the transcription factor networks regulating the survival of striatal neurons. |
Volume: |
12 |
Issue: |
3 |
Pages: |
262 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ferran JL |
Year: |
2008 |
Journal: |
Brain Res Bull |
Title: |
Early pretectal gene expression pattern shows a conserved anteroposterior tripartition in mouse and chicken. |
Volume: |
75 |
Issue: |
2-4 |
Pages: |
295-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Newman EA |
Year: |
2018 |
Journal: |
Dev Biol |
Title: |
Foxd1 is required for terminal differentiation of anterior hypothalamic neuronal subtypes. |
Volume: |
439 |
Issue: |
2 |
Pages: |
102-111 |
|
•
•
•
•
•
|
Publication |
First Author: |
Su Z |
Year: |
2022 |
Journal: |
Development |
Title: |
Dlx1/2-dependent expression of Meis2 promotes neuronal fate determination in the mammalian striatum. |
Volume: |
149 |
Issue: |
4 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Jean D |
Year: |
1999 |
Journal: |
Mech Dev |
Title: |
Six6 (Optx2) is a novel murine Six3-related homeobox gene that demarcates the presumptive pituitary/hypothalamic axis and the ventral optic stalk. |
Volume: |
84 |
Issue: |
1-2 |
Pages: |
31-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Graw J |
Year: |
2005 |
Journal: |
Invest Ophthalmol Vis Sci |
Title: |
Three novel Pax6 alleles in the mouse leading to the same small-eye phenotype caused by different consequences at target promoters. |
Volume: |
46 |
Issue: |
12 |
Pages: |
4671-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tétreault N |
Year: |
2009 |
Journal: |
Dev Biol |
Title: |
The LIM homeobox transcription factor Lhx2 is required to specify the retina field and synergistically cooperates with Pax6 for Six6 trans-activation. |
Volume: |
327 |
Issue: |
2 |
Pages: |
541-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Martinez-Barbera JP |
Year: |
2000 |
Journal: |
Dev Biol |
Title: |
The homeobox gene Hesx1 is required in the anterior neural ectoderm for normal forebrain formation. |
Volume: |
223 |
Issue: |
2 |
Pages: |
422-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Martinez-Morales JR |
Year: |
2001 |
Journal: |
Development |
Title: |
Otx genes are required for tissue specification in the developing eye. |
Volume: |
128 |
Issue: |
11 |
Pages: |
2019-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang W |
Year: |
2000 |
Journal: |
Dev Biol |
Title: |
The murine Otp homeobox gene plays an essential role in the specification of neuronal cell lineages in the developing hypothalamus. |
Volume: |
227 |
Issue: |
2 |
Pages: |
432-49 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wolf L |
Year: |
2013 |
Journal: |
Nucleic Acids Res |
Title: |
Histone posttranslational modifications and cell fate determination: lens induction requires the lysine acetyltransferases CBP and p300. |
Volume: |
41 |
Issue: |
22 |
Pages: |
10199-214 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yamada R |
Year: |
2003 |
Journal: |
Development |
Title: |
Cell-autonomous involvement of Mab21l1 is essential for lens placode development. |
Volume: |
130 |
Issue: |
9 |
Pages: |
1759-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
O'Brien LL |
Year: |
2018 |
Journal: |
PLoS Genet |
Title: |
Transcriptional regulatory control of mammalian nephron progenitors revealed by multi-factor cistromic analysis and genetic studies. |
Volume: |
14 |
Issue: |
1 |
Pages: |
e1007181 |
|
•
•
•
•
•
|
Publication |
First Author: |
VanDunk C |
Year: |
2011 |
Journal: |
J Neurosci |
Title: |
Development, maturation, and necessity of transcription factors in the mouse suprachiasmatic nucleus. |
Volume: |
31 |
Issue: |
17 |
Pages: |
6457-67 |
|
•
•
•
•
•
|
Publication |
First Author: |
Burns CJ |
Year: |
2008 |
Journal: |
Dev Dyn |
Title: |
Investigation of Frizzled-5 during embryonic neural development in mouse. |
Volume: |
237 |
Issue: |
6 |
Pages: |
1614-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dixit R |
Year: |
2014 |
Journal: |
Gene Expr Patterns |
Title: |
Gene expression is dynamically regulated in retinal progenitor cells prior to and during overt cellular differentiation. |
Volume: |
14 |
Issue: |
1 |
Pages: |
42-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Del Bene F |
Year: |
2004 |
Journal: |
Nature |
Title: |
Direct interaction of geminin and Six3 in eye development. |
Volume: |
427 |
Issue: |
6976 |
Pages: |
745-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fiore L |
Year: |
2020 |
Journal: |
Dev Biol |
Title: |
Optic vesicle morphogenesis requires primary cilia. |
Volume: |
462 |
Issue: |
2 |
Pages: |
119-128 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lu F |
Year: |
2013 |
Journal: |
J Neurosci |
Title: |
Rax is a selector gene for mediobasal hypothalamic cell types. |
Volume: |
33 |
Issue: |
1 |
Pages: |
259-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cai Z |
Year: |
2013 |
Journal: |
Development |
Title: |
Deficient FGF signaling causes optic nerve dysgenesis and ocular coloboma. |
Volume: |
140 |
Issue: |
13 |
Pages: |
2711-23 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|