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Search results 1 to 100 out of 1679 for Six3

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Type Details Score
Gene
key_980094 | Six3
Type: gene
Organism: Not Specified
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Gene
6496 | SIX3
Type: gene
Organism: human
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Gene
100493798 | six3
Type: gene
Organism: frog, western clawed
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Gene
78974 | Six3
Type: gene
Organism: rat
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Gene
481356 | SIX3
Type: gene
Organism: dog, domestic
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Gene
470367 | SIX3
Type: gene
Organism: chimpanzee
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Gene
616756 | SIX3
Type: gene
Organism: cattle
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Gene
378786 | SIX3
Type: gene
Organism: chicken
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Gene
717027 | SIX3
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:102764 | Six3
Type: protein_coding_gene
Organism: mouse, laboratory
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GXD Expression
GXD Expression
Probe: MGI:6198677
Assay Type: RNA in situ
Annotation Date: 2018-09-19
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1614413
Pattern: Regionally restricted
Stage: TS13
Assay Id: MGI:6198685
Age: embryonic day 8.25
Image: 1G Six3
Note: Expression predominant in prospective pituitary/hypothalamic axis and ventral forebrain.
Specimen Label: 1G Six3
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:6198677
Assay Type: RNA in situ
Annotation Date: 2018-09-19
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3598913
Stage: TS13
Assay Id: MGI:6198685
Age: embryonic day 8.25
Image: 1G Six3
Note: Expression nearly absent in region of anterior retina corresponding to presumptive retina field.
Specimen Label: 1G Six3
Detected: false
Specimen Num: 1
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Gene
100506108 | SIX3-AS1
Type: gene
Organism: human
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Publication
22071110 | J:178674
First Author: Lavado A
Year: 2011
Journal: Development
Title: Six3 is required for ependymal cell maturation.
Volume: 138
Issue: 24
Pages: 5291-300
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GXD Expression
GXD Expression
Probe: MGI:6502085
Assay Type: Immunohistochemistry
Annotation Date: 2021-01-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1667216
Pattern: Regionally restricted
Stage: TS16
Assay Id: MGI:6502093
Age: embryonic day 10.0
Image: S3 Prep1+/+ Six3
Note: Expression in presumptive lens ectoderm.
Specimen Label: S3 Prep1+/+ Six3
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:6502085
Assay Type: Immunohistochemistry
Annotation Date: 2021-01-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1667216
Pattern: Regionally restricted
Stage: TS16
Assay Id: MGI:6502093
Age: embryonic day 10.0
Image: S3 Prep1i/- Six3
Specimen Label: S3 Prep1i/- Six3
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:7717796
Assay Type: RNA in situ
Annotation Date: 2024-09-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1753620
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:7717798
Age: embryonic day 12.5
Image: 1E E12.5 Six3
Note: Expression in basal hypothalamic region in Pomc-expressing neurons throughout development and adulthood.
Specimen Label: 1E E12.5 Six3
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:7717796
Assay Type: RNA in situ
Annotation Date: 2024-09-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1753622
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:7717798
Age: embryonic day 14.5
Image: S1 E14.5 Six3
Note: Expression in basal hypothalamic region in Pomc-expressing neurons throughout development and adulthood.
Specimen Label: S1 E14.5 Six3
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:7717796
Assay Type: RNA in situ
Annotation Date: 2024-09-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1753624
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:7717798
Age: embryonic day 16.5
Image: 1E E16.5 Six3
Note: Expression in basal hypothalamic region in Pomc-expressing neurons throughout development and adulthood.
Specimen Label: 1E E16.5 Six3
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:7717796
Assay Type: RNA in situ
Annotation Date: 2024-09-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1753628
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:7717798
Age: postnatal adult
Image: S1 E18.5 Six3
Note: Expression in basal hypothalamic region in Pomc-expressing neurons throughout development and adulthood.
Specimen Label: S1 E18.5 Six3
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:6479758
Assay Type: RNA in situ
Annotation Date: 2020-12-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691015
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:6479817
Age: embryonic day 9.5
Image: 2b Six3 +/OG
Specimen Label: 2b Six3 +/OG
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:6479758
Assay Type: RNA in situ
Annotation Date: 2020-12-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691015
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:6479817
Age: embryonic day 9.5
Image: 2b Six3 OG/OG weak
Note: Authors report telencephalon developed normally.
Specimen Label: 2b Six3 OG/OG weak
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:6479758
Assay Type: RNA in situ
Annotation Date: 2020-12-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691015
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:6479817
Age: embryonic day 9.5
Image: 2b Six3 OG/OG strong
Note: Authors report telencephalon developed normally.
Specimen Label: 2b Six3 OG/OG strong
Detected: true
Specimen Num: 3
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Publication
12163408 | J:212815
First Author: Carl M
Year: 2002
Journal: Development
Title: Six3 inactivation reveals its essential role for the formation and patterning of the vertebrate eye.
Volume: 129
Issue: 17
Pages: 4057-63
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Publication
17576749 | J:212804
First Author: Appolloni I
Year: 2008
Journal: Cereb Cortex
Title: Six3 controls the neural progenitor status in the murine CNS.
Volume: 18
Issue: 3
Pages: 553-62
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Publication
17066077 | J:116102
First Author: Liu W
Year: 2006
Journal: EMBO J
Title: Six3 activation of Pax6 expression is essential for mammalian lens induction and specification.
Volume: 25
Issue: 22
Pages: 5383-95
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Publication
18694563 | J:140315
First Author: Geng X
Year: 2008
Journal: Dev Cell
Title: Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly.
Volume: 15
Issue: 2
Pages: 236-47
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Publication
18094027 | J:130851
First Author: Lavado A
Year: 2008
Journal: Development
Title: Six3 inactivation causes progressive caudalization and aberrant patterning of the mammalian diencephalon.
Volume: 135
Issue: 3
Pages: 441-50
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Publication
11139622 | J:67049
First Author: Lengler J
Year: 2001
Journal: Nucleic Acids Res
Title: Antagonistic action of Six3 and Prox1 at the gamma-crystallin promoter.
Volume: 29
Issue: 2
Pages: 515-26
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Publication
11458394 | J:70282
First Author: Lagutin O
Year: 2001
Journal: Dev Dyn
Title: Six3 promotes the formation of ectopic optic vesicle-like structures in mouse embryos.
Volume: 221
Issue: 3
Pages: 342-9
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Publication
23792023 | J:200777
First Author: Lee B
Year: 2013
Journal: Dev Biol
Title: Genomic code for Sox2 binding uncovers its regulatory role in Six3 activation in the forebrain.
Volume: 381
Issue: 2
Pages: 491-501
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Publication
12569128 | J:81797
First Author: Lagutin OV
Year: 2003
Journal: Genes Dev
Title: Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development.
Volume: 17
Issue: 3
Pages: 368-79
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Publication
18775421 | J:142425
First Author: Gaston-Massuet C
Year: 2008
Journal: Dev Biol
Title: Genetic interaction between the homeobox transcription factors HESX1 and SIX3 is required for normal pituitary development.
Volume: 324
Issue: 2
Pages: 322-33
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Publication
19606496 | J:212800
First Author: Abe Y
Year: 2009
Journal: Hum Mutat
Title: EYA4, deleted in a case with middle interhemispheric variant of holoprosencephaly, interacts with SIX3 both physically and functionally.
Volume: 30
Issue: 10
Pages: E946-55
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Publication
12072567 | J:77351
First Author: Goudreau G
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype.
Volume: 99
Issue: 13
Pages: 8719-24
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Publication
17666527 | J:123470
First Author: Manavathi B
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Repression of Six3 by a corepressor regulates rhodopsin expression.
Volume: 104
Issue: 32
Pages: 13128-33
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Publication
20682799 | J:162763
First Author: Kumar R
Year: 2010
Journal: Cancer Res
Title: Metastasis-associated protein 1 and its short form variant stimulates Wnt1 transcription through promoting its derepression from Six3 corepressor.
Volume: 70
Issue: 16
Pages: 6649-58
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Publication
27770010 | J:240473
First Author: Geng X
Year: 2016
Journal: Development
Title: Six3 dosage mediates the pathogenesis of holoprosencephaly.
Volume: 143
Issue: 23
Pages: 4462-4473
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Publication
17084678 | J:116113
First Author: Geng X
Year: 2007
Journal: Gene Expr Patterns
Title: Expression of Six3 Opposite Strand (Six3OS) during mouse embryonic development.
Volume: 7
Issue: 3
Pages: 252-7
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GXD Expression
GXD Expression
     
Probe: MGI:7464584
Assay Type: RNA in situ
Annotation Date: 2023-04-21
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:7464825
Age: embryonic day 7.5
Specimen Label: 4 Six3 E7.5 -/-
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:7464584
Assay Type: RNA in situ
Annotation Date: 2023-04-21
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:7464825
Age: embryonic day 8.5
Specimen Label: 4 Six3 E8.5 -/-
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:7464584
Assay Type: RNA in situ
Annotation Date: 2023-04-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608911
Pattern: Regionally restricted
Stage: TS11
Assay Id: MGI:7464825
Age: embryonic day 7.5
Note: Expression in prospective forebrain.
Specimen Label: 4 Six3 E7.5 WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2014-01-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:5532320
Age: embryonic day 8.5
Image: 4D Six3 left
Specimen Label: 4D Six3 left
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2014-01-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:5532320
Age: embryonic day 8.5
Image: 4D Six3 right
Specimen Label: 4D Six3 right
Detected: true
Specimen Num: 6
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Publication
9889003 | J:52921
First Author: Granadino B
Year: 1999
Journal: Genomics
Title: Genomic cloning, structure, expression pattern, and chromosomal location of the human SIX3 gene.
Volume: 55
Issue: 1
Pages: 100-5
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Publication
18836447 | J:186828
First Author: Jeong Y
Year: 2008
Journal: Nat Genet
Title: Regulation of a remote Shh forebrain enhancer by the Six3 homeoprotein.
Volume: 40
Issue: 11
Pages: 1348-53
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Publication
35121076 | J:332723
 
First Author: Lavalle SN
Year: 2022
Journal: Mol Cell Endocrinol
Title: Deletion of the homeodomain gene Six3 from kisspeptin neurons causes subfertility in female mice.
Volume: 546
Pages: 111577
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Publication
25915183 | J:232657
First Author: Xie H
Year: 2015
Journal: Mol Endocrinol
Title: Homeodomain Proteins SIX3 and SIX6 Regulate Gonadotrope-specific Genes During Pituitary Development.
Volume: 29
Issue: 6
Pages: 842-55
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Publication
21936910 | J:177132
 
First Author: Rapicavoli NA
Year: 2011
Journal: Neural Dev
Title: The long noncoding RNA Six3OS acts in trans to regulate retinal development by modulating Six3 activity.
Volume: 6
Pages: 32
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Publication
34014554 | J:350099
First Author: Song X
Year: 2021
Journal: Neurosci Bull
Title: Homeobox Gene Six3 is Required for the Differentiation of D2-Type Medium Spiny Neurons.
Volume: 37
Issue: 7
Pages: 985-998
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Publication
35951005 | J:334460
First Author: Bando H
Year: 2023
Journal: Hum Mol Genet
Title: Heterozygous variants in SIX3 and POU1F1 cause pituitary hormone deficiency in mouse and man.
Volume: 32
Issue: 3
Pages: 367-385
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Publication
29117559 | J:255241
First Author: Takata N
Year: 2017
Journal: Cell Rep
Title: An Eye Organoid Approach Identifies Six3 Suppression of R-spondin 2 as a Critical Step in Mouse Neuroretina Differentiation.
Volume: 21
Issue: 6
Pages: 1534-1549
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Publication
34212416 | J:317193
First Author: Hoffmann HM
Year: 2021
Journal: J Neurosci Res
Title: The transcription factors SIX3 and VAX1 are required for suprachiasmatic nucleus circadian output and fertility in female mice.
Volume: 99
Issue: 10
Pages: 2625-2645
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Publication
34974160 | J:321850
 
First Author: Meadows JD
Year: 2022
Journal: Mol Metab
Title: Deletion of Six3 in post-proliferative neurons produces weakened SCN circadian output, improved metabolic function, and dwarfism in male mice.
Volume: 57
Pages: 101431
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Publication
29589282 | J:307582
First Author: Pandolfi EC
Year: 2018
Journal: Mol Neurobiol
Title: Haploinsufficiency of SIX3 Abolishes Male Reproductive Behavior Through Disrupted Olfactory Development, and Impairs Female Fertility Through Disrupted GnRH Neuron Migration.
Volume: 55
Issue: 11
Pages: 8709-8727
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Publication
30485816 | J:271140
First Author: Diacou R
Year: 2018
Journal: Cell Rep
Title: Six3 and Six6 Are Jointly Required for the Maintenance of Multipotent Retinal Progenitors through Both Positive and Negative Regulation.
Volume: 25
Issue: 9
Pages: 2510-2523.e4
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Publication
20890044 | J:165328
First Author: Liu W
Year: 2010
Journal: J Clin Invest
Title: Neuroretina specification in mouse embryos requires Six3-mediated suppression of Wnt8b in the anterior neural plate.
Volume: 120
Issue: 10
Pages: 3568-77
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Publication
8575305 | J:30342
First Author: Oliver G
Year: 1995
Journal: Development
Title: Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development.
Volume: 121
Issue: 12
Pages: 4045-55
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Publication
28579317 | J:246467
First Author: Liu W
Year: 2017
Journal: Dev Biol
Title: Six3 in a small population of progenitors at E8.5 is required for neuroretinal specification via regulating cell signaling and survival in mice.
Volume: 428
Issue: 1
Pages: 164-175
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Publication
26956358 | J:231972
First Author: Takata N
Year: 2016
Journal: In Vitro Cell Dev Biol Anim
Title: IGF-2/IGF-1R signaling has distinct effects on Sox1, Irx3, and Six3 expressions during ES cell derived-neuroectoderm development in vitro.
Volume: 52
Issue: 5
Pages: 607-15
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GXD Expression
GXD Expression
   
Probe: MGI:6183330
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6191306
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Six3
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6183330
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6191306
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Six3
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6183330
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6191306
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Six3
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6183330
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191306
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Six3
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6183330
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191306
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Six3
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
   
Probe: MGI:6183330
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6191306
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Six3
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6183330
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191306
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Six3
Detected: true
Specimen Num: 6
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Publication
39446806 | J:357477
First Author: Ferrena A
Year: 2024
Journal: PLoS One
Title: Six3 and Six6 jointly control diverse target genes in multiple cell populations over developmental trajectories of mouse embryonic retinal progenitor cells.
Volume: 19
Issue: 10
Pages: e0308839
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Publication
9883582 | J:51693
First Author: Grimm C
Year: 1998
Journal: Dev Genet
Title: Aphakia (ak), a mouse mutation affecting early eye development: fine mapping, consideration of candidate genes and altered Pax6 and Six3 gene expression pattern.
Volume: 23
Issue: 4
Pages: 299-316
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Publication
39025297 | J:353361
 
First Author: Yu H
Year: 2024
Journal: Mol Metab
Title: The homeodomain transcription factor Six3 regulates hypothalamic Pomc expression and its absence from POMC neurons induces hyperphagia and mild obesity in male mice.
Volume: 87
Pages: 101993
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GXD Expression
GXD Expression
Probe: MGI:1315062
Assay Type: RNA in situ
Annotation Date: 1998-12-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609512
Pattern: Regionally restricted
Stage: TS12
Assay Id: MGI:1315073
Age: embryonic day 8.0
Image: 7B
Note: Six3 is expressed in the anterior neural plate.
Specimen Label: 7B
Detected: true
Specimen Num: 3
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Publication
8814301 | J:35368
First Author: Kawakami K
Year: 1996
Journal: FEBS Lett
Title: Identification and expression of six family genes in mouse retina.
Volume: 393
Issue: 2-3
Pages: 259-63
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Publication
16024294 | J:103131
First Author: Purcell P
Year: 2005
Journal: Gene Expr Patterns
Title: Pax6-dependence of Six3, Eya1 and Dach1 expression during lens and nasal placode induction.
Volume: 6
Issue: 1
Pages: 110-8
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GXD Expression
GXD Expression
Probe: MGI:1315062
Assay Type: RNA in situ
Annotation Date: 1998-12-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619813
Pattern: Regionally restricted
Stage: TS13
Assay Id: MGI:1315073
Age: embryonic day 8.0
Image: 7C
Note: Six3 is normally expressed in the ventral diencephalon and optic vesicles.
Specimen Label: 7C
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:3506052
Assay Type: RNA in situ
Annotation Date: 2024-06-26
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1753626
Stage: TS26
Assay Id: MGI:7660839
Age: embryonic day 18.5
Image: 8A Six3;Nestin-cre<+>
Note: This mutant sample showed complete bilateral loss of Six3 in the ventral anterior hypothalamus.
Specimen Label: 8A Six3;Nestin-cre<+>
Detected: false
Specimen Num: 33
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GXD Expression
GXD Expression
Probe: MGI:3506052
Assay Type: RNA in situ
Annotation Date: 2024-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3541923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:7660839
Age: embryonic day 15.5
Image: 8C Six3;Nestin-cre<+> No loss
Note: A mutant with no loss of Six3 retained expression in the early suprachiasmatic nucleus.
Specimen Label: 8C Six3;Nestin-cre<+> No loss
Detected: true
Specimen Num: 39
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GXD Expression
GXD Expression
 
Probe: MGI:1315062
Assay Type: RNA in situ
Annotation Date: 1999-02-02
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1607311
Stage: TS11
Assay Id: MGI:1328441
Age: embryonic day 7.5-7.75
Image: 6F
Note: Six3 was used as a marker for rostral neural ectoderm in these mutant embryos.
Specimen Label: 6F
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:1315062
Assay Type: RNA in situ
Annotation Date: 1998-12-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608911
Pattern: Not Specified
Stage: TS11
Assay Id: MGI:1315073
Age: embryonic day 7.75
Image: 2A
Note: Six3 is expressed in the presumptive forebrain region in wild-type embryos.
Specimen Label: 2A
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:3506052
Assay Type: RNA in situ
Annotation Date: 2024-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3541923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:7660839
Age: embryonic day 15.5
Image: 8C Six3;Nestin-cre<+> Partial loss
Note: Expression was detected in the early suprachiasmatic nucleus unilaterally in mice displaying partial Six3 deletion.
Specimen Label: 8C Six3;Nestin-cre<+> Partial loss
Detected: true
Specimen Num: 38
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GXD Expression
GXD Expression
Probe: MGI:1315062
Assay Type: RNA in situ
Annotation Date: 1998-12-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1614413
Pattern: Regionally restricted
Stage: TS13
Assay Id: MGI:1315073
Age: embryonic day 8.0
Image: 7C
Note: Six3 is normally expressed in the ventral diencephalon and optic vesicles.
Specimen Label: 7C
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:1289468
Assay Type: RNA in situ
Annotation Date: 1998-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616415
Pattern: Regionally restricted
Stage: TS15
Assay Id: MGI:1289474
Age: embryonic day 9.5
Image: 4G
Note: Six3 is expressed in the most anterior aspect of the developing neural tube.
Specimen Label: 4G
Detected: true
Specimen Num: 1
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Publication
12050133 | J:77680
First Author: Zhu CC
Year: 2002
Journal: Development
Title: Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors.
Volume: 129
Issue: 12
Pages: 2835-49
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Publication
29967281 | J:264125
 
First Author: Xu Z
Year: 2018
Journal: Development
Title: SP8 and SP9 coordinately promote D2-type medium spiny neuron production by activating Six3 expression.
Volume: 145
Issue: 14
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GXD Expression
GXD Expression
Probe: MGI:3506052
Assay Type: RNA in situ
Annotation Date: 2024-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691019
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:7660839
Age: embryonic day 11.5
Image: 6D E11.5 Rostral 1
Note: At E11.5, Six3 was restricted to more ventral regions of the early telencephalon/diencephalon but remained expressed within the developing hypothalamus and pituitary.
Specimen Label: 6D E11.5 Rostral 1
Detected: true
Specimen Num: 22
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GXD Expression
GXD Expression
Probe: MGI:3506052
Assay Type: RNA in situ
Annotation Date: 2024-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691019
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:7660839
Age: embryonic day 11.5
Image: 6D E11.5 2
Note: At E11.5, Six3 was restricted to more ventral regions of the early telencephalon/diencephalon but remained expressed within the developing hypothalamus and pituitary.
Specimen Label: 6D E11.5 2
Detected: true
Specimen Num: 23
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GXD Expression
GXD Expression
Probe: MGI:3506052
Assay Type: RNA in situ
Annotation Date: 2024-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691019
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:7660839
Age: embryonic day 11.5
Image: 6D E11.5 3
Note: At E11.5, Six3 was restricted to more ventral regions of the early telencephalon/diencephalon but remained expressed within the developing hypothalamus and pituitary.
Specimen Label: 6D E11.5 3
Detected: true
Specimen Num: 24
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GXD Expression
GXD Expression
Probe: MGI:3506052
Assay Type: RNA in situ
Annotation Date: 2024-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691019
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:7660839
Age: embryonic day 11.5
Image: 6D E11.5 4
Note: At E11.5, Six3 was restricted to more ventral regions of the early telencephalon/diencephalon but remained expressed within the developing hypothalamus and pituitary.
Specimen Label: 6D E11.5 4
Detected: true
Specimen Num: 25
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•
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GXD Expression
GXD Expression
Probe: MGI:3506052
Assay Type: RNA in situ
Annotation Date: 2024-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691019
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:7660839
Age: embryonic day 11.5
Image: 6D E11.5 Caudal 5
Note: At E11.5, Six3 was restricted to more ventral regions of the early telencephalon/diencephalon but remained expressed within the developing hypothalamus and pituitary.
Specimen Label: 6D E11.5 Caudal 5
Detected: true
Specimen Num: 26
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GXD Expression
GXD Expression
Probe: MGI:3506052
Assay Type: RNA in situ
Annotation Date: 2024-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689619
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:7660839
Age: embryonic day 11.5
Image: 6D E11.5 Rostral 1
Note: At E11.5, Six3 was restricted to more ventral regions of the early telencephalon/diencephalon but remained expressed within the developing hypothalamus and pituitary.
Specimen Label: 6D E11.5 Rostral 1
Detected: true
Specimen Num: 22
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GXD Expression
GXD Expression
Probe: MGI:3506052
Assay Type: RNA in situ
Annotation Date: 2024-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689619
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:7660839
Age: embryonic day 11.5
Image: 6D E11.5 2
Note: At E11.5, Six3 was restricted to more ventral regions of the early telencephalon/diencephalon but remained expressed within the developing hypothalamus and pituitary.
Specimen Label: 6D E11.5 2
Detected: true
Specimen Num: 23
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GXD Expression
GXD Expression
Probe: MGI:3506052
Assay Type: RNA in situ
Annotation Date: 2024-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689619
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:7660839
Age: embryonic day 11.5
Image: 6D E11.5 3
Note: At E11.5, Six3 was restricted to more ventral regions of the early telencephalon/diencephalon but remained expressed within the developing hypothalamus and pituitary.
Specimen Label: 6D E11.5 3
Detected: true
Specimen Num: 24
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•
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GXD Expression
GXD Expression
Probe: MGI:3506052
Assay Type: RNA in situ
Annotation Date: 2024-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689619
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:7660839
Age: embryonic day 11.5
Image: 6D E11.5 4
Note: At E11.5, Six3 was restricted to more ventral regions of the early telencephalon/diencephalon but remained expressed within the developing hypothalamus and pituitary.
Specimen Label: 6D E11.5 4
Detected: true
Specimen Num: 25
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•
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GXD Expression
GXD Expression
Probe: MGI:3506052
Assay Type: RNA in situ
Annotation Date: 2024-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689619
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:7660839
Age: embryonic day 11.5
Image: 6D E11.5 Caudal 5
Note: At E11.5, Six3 was restricted to more ventral regions of the early telencephalon/diencephalon but remained expressed within the developing hypothalamus and pituitary.
Specimen Label: 6D E11.5 Caudal 5
Detected: true
Specimen Num: 26
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UniProt Feature
UniProt Feature
Begin: 1
Description: Homeobox protein SIX3
Type: chain
End: 333
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Publication
28093895 | J:240033
 
First Author: Lee B
Year: 2017
Journal: Genesis
Title: Identification of a conserved cis-regulatory element controlling mid-diencephalic expression of mouse Six3.
Volume: 55
Issue: 3
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Protein
Q52KB8
Organism: Mus musculus/domesticus
Length: 347  
Fragment?: false
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Publication
10704858 | J:61353
First Author: Zhou X
Year: 2000
Journal: Mech Dev
Title: Cloning and expression of xSix3, the Xenopus homologue of murine Six3.
Volume: 91
Issue: 1-2
Pages: 327-30
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Publication
18543315 | J:137218
First Author: Liao GY
Year: 2008
Journal: Genesis
Title: Cre recombinase-mediated gene deletion in layer 4 of murine sensory cortical areas.
Volume: 46
Issue: 6
Pages: 289-93
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Publication
10686607 | J:69312
First Author: Furuta Y
Year: 2000
Journal: Genesis
Title: Retina- and ventral forebrain-specific Cre recombinase activity in transgenic mice.
Volume: 26
Issue: 2
Pages: 130-2
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•
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Publication
33712552 | J:306377
First Author: Yang L
Year: 2021
Journal: Cell Death Dis
Title: Transcriptional profiling reveals the transcription factor networks regulating the survival of striatal neurons.
Volume: 12
Issue: 3
Pages: 262
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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