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Search results 1 to 100 out of 530 for Six6

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0.037s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Protein Domain
Type: Family
Description: SIX6 is a homeodomain transcription factor involved in development of the mammalian neuroendocrine system. It also regulates transcription of gonadotrope-specific genes as gonadotrope cells differentiate []. It has been linked to glaucoma [, ].The human SIX protein family consists of six members (SIX1-SIX6), all of which contain two protein domains: a DNA binding homeobox domain and a SIX domain, which binds downstream effector molecules. They are thought to be transcription factors required for proper eye development [].
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Xie H
Year: 2015
Journal: Mol Endocrinol
Title: Homeodomain Proteins SIX3 and SIX6 Regulate Gonadotrope-specific Genes During Pituitary Development.
Volume: 29
Issue: 6
Pages: 842-55
Protein
Organism: Mus musculus/domesticus
Length: 246  
Fragment?: false
Publication
First Author: Cheng CY
Year: 2014
Journal: Invest Ophthalmol Vis Sci
Title: Association of common SIX6 polymorphisms with peripapillary retinal nerve fiber layer thickness: the Singapore Chinese Eye Study.
Volume: 56
Issue: 1
Pages: 478-83
Publication
First Author: Carnes MU
Year: 2014
Journal: PLoS Genet
Title: Discovery and functional annotation of SIX6 variants in primary open-angle glaucoma.
Volume: 10
Issue: 5
Pages: e1004372
Publication
First Author: Jean D
Year: 1999
Journal: Mech Dev
Title: Six6 (Optx2) is a novel murine Six3-related homeobox gene that demarcates the presumptive pituitary/hypothalamic axis and the ventral optic stalk.
Volume: 84
Issue: 1-2
Pages: 31-40
Protein
Organism: Mus musculus/domesticus
Length: 246  
Fragment?: false
Publication
First Author: Alfano G
Year: 2005
Journal: Hum Mol Genet
Title: Natural antisense transcripts associated with genes involved in eye development.
Volume: 14
Issue: 7
Pages: 913-23
Publication
First Author: Toy J
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: The optx2 homeobox gene is expressed in early precursors of the eye and activates retina-specific genes.
Volume: 95
Issue: 18
Pages: 10643-8
Publication
First Author: López-Ríos J
Year: 1999
Journal: Mech Dev
Title: Six9 (Optx2), a new member of the six gene family of transcription factors, is expressed at early stages of vertebrate ocular and pituitary development.
Volume: 83
Issue: 1-2
Pages: 155-9
Publication
First Author: Skowronska-Krawczyk D
Year: 2015
Journal: Mol Cell
Title: P16INK4a Upregulation Mediated by SIX6 Defines Retinal Ganglion Cell Pathogenesis in Glaucoma.
Volume: 59
Issue: 6
Pages: 931-40
Publication
First Author: Pandolfi EC
Year: 2019
Journal: Endocrinology
Title: Deletion of the Homeodomain Protein Six6 From GnRH Neurons Decreases GnRH Gene Expression, Resulting in Infertility.
Volume: 160
Issue: 9
Pages: 2151-2164
Publication
First Author: Lee B
Year: 2012
Journal: Dev Biol
Title: Direct transcriptional regulation of Six6 is controlled by SoxB1 binding to a remote forebrain enhancer.
Volume: 366
Issue: 2
Pages: 393-403
Publication
First Author: Pandolfi EC
Year: 2020
Journal: Mol Neurobiol
Title: The Homeodomain Transcription Factors Vax1 and Six6 Are Required for SCN Development and Function.
Volume: 57
Issue: 2
Pages: 1217-1232
Publication
First Author: Diacou R
Year: 2018
Journal: Cell Rep
Title: Six3 and Six6 Are Jointly Required for the Maintenance of Multipotent Retinal Progenitors through Both Positive and Negative Regulation.
Volume: 25
Issue: 9
Pages: 2510-2523.e4
GXD Expression    
Probe: MGI:6183334
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6191309
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Six6
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6183334
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6191309
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Six6
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6183334
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6191309
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Six6
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6183334
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6191309
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Six6
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6183334
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191309
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Six6
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6183334
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191309
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Six6
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6183334
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191309
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Six6
Detected: true
Specimen Num: 7
Publication
First Author: Tétreault N
Year: 2009
Journal: Dev Biol
Title: The LIM homeobox transcription factor Lhx2 is required to specify the retina field and synergistically cooperates with Pax6 for Six6 trans-activation.
Volume: 327
Issue: 2
Pages: 541-50
Protein
Organism: Mus musculus/domesticus
Length: 574  
Fragment?: false
Publication
First Author: Zhu CC
Year: 2002
Journal: Development
Title: Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors.
Volume: 129
Issue: 12
Pages: 2835-49
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: frog, western clawed
Publication
First Author: Clark DD
Year: 2013
Journal: J Biol Rhythms
Title: Aberrant development of the suprachiasmatic nucleus and circadian rhythms in mice lacking the homeodomain protein Six6.
Volume: 28
Issue: 1
Pages: 15-25
Publication
First Author: Li X
Year: 2002
Journal: Science
Title: Tissue-specific regulation of retinal and pituitary precursor cell proliferation.
Volume: 297
Issue: 5584
Pages: 1180-3
Publication
First Author: Jeong Y
Year: 2008
Journal: Nat Genet
Title: Regulation of a remote Shh forebrain enhancer by the Six3 homeoprotein.
Volume: 40
Issue: 11
Pages: 1348-53
Publication
First Author: Larder R
Year: 2011
Journal: J Neurosci
Title: Hypothalamic dysregulation and infertility in mice lacking the homeodomain protein Six6.
Volume: 31
Issue: 2
Pages: 426-38
UniProt Feature
Begin: 1
Description: Homeobox protein SIX6
Type: chain
End: 246
Publication
First Author: Bharti K
Year: 2012
Journal: PLoS Genet
Title: A regulatory loop involving PAX6, MITF, and WNT signaling controls retinal pigment epithelium development.
Volume: 8
Issue: 7
Pages: e1002757
Publication
First Author: Goldsmith S
Year: 2016
Journal: Development
Title: SOX2 is sequentially required for progenitor proliferation and lineage specification in the developing pituitary.
Volume: 143
Issue: 13
Pages: 2376-88
Publication
First Author: Brinkmeier ML
Year: 2007
Journal: Dev Biol
Title: TCF4 deficiency expands ventral diencephalon signaling and increases induction of pituitary progenitors.
Volume: 311
Issue: 2
Pages: 396-407
Protein
Organism: Mus musculus/domesticus
Length: 143  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 575  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 107  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 71  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 574  
Fragment?: false
Protein Domain
Type: Family
Description: Protein SIX6OS1 (Six6 opposite strand transcript 1) may be involved in eye development through regulation of the SIX6 transcription factor [].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Toy J
Year: 1999
Journal: Mech Dev
Title: Expression of the optx2 homeobox gene during mouse development.
Volume: 83
Issue: 1-2
Pages: 183-6
GXD Expression    
Probe: MGI:5545776
Assay Type: RT-PCR
Annotation Date: 2014-02-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1691627
Stage: TS27
Assay Id: MGI:5545777
Age: postnatal day 0
Image: 1
Specimen Label: RhoEn
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5545776
Assay Type: RT-PCR
Annotation Date: 2014-02-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1691628
Stage: TS28
Assay Id: MGI:5545779
Age: postnatal adult
Image: 1
Specimen Label: RhoEn
Detected: false
Specimen Num: 1
GXD Expression        
Probe: MGI:4358984
Assay Type: RT-PCR
Annotation Date: 2009-09-24
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:4359017
Age: postnatal adult
Specimen Label: Ki
Specimen Num: 6
GXD Expression      
Probe: MGI:6452593
Assay Type: RT-PCR
Annotation Date: 2020-09-02
Strength: Absent
Sex: Female
Emaps: EMAPS:1775926
Stage: TS26
Assay Id: MGI:6452594
Age: embryonic day 18.5
Specimen Label: WT
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:6452593
Assay Type: RT-PCR
Annotation Date: 2020-09-02
Strength: Absent
Sex: Female
Emaps: EMAPS:1775926
Stage: TS26
Assay Id: MGI:6452594
Age: embryonic day 18.5
Specimen Label: Het
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:6452593
Assay Type: RT-PCR
Annotation Date: 2020-09-02
Strength: Absent
Sex: Female
Emaps: EMAPS:1775926
Stage: TS26
Assay Id: MGI:6452594
Age: embryonic day 18.5
Specimen Label: KO
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:5426818
Assay Type: Northern blot
Annotation Date: 2012-07-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619819
Stage: TS19
Assay Id: MGI:5426821
Age: embryonic day 11.5
Image: 1
Specimen Label: None
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5545776
Assay Type: RT-PCR
Annotation Date: 2014-02-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754927
Stage: TS27
Assay Id: MGI:5545777
Age: postnatal day 0
Image: 1
Specimen Label: Str
Detected: false
Specimen Num: 11
GXD Expression    
Probe: MGI:5545776
Assay Type: RT-PCR
Annotation Date: 2014-02-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754928
Stage: TS28
Assay Id: MGI:5545779
Age: postnatal adult
Image: 1
Specimen Label: Str
Detected: false
Specimen Num: 11
GXD Expression    
Probe: MGI:5545776
Assay Type: RT-PCR
Annotation Date: 2014-02-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1697427
Stage: TS27
Assay Id: MGI:5545777
Age: postnatal day 0
Image: 1
Specimen Label: MB
Detected: false
Specimen Num: 10
GXD Expression    
Probe: MGI:5545776
Assay Type: RT-PCR
Annotation Date: 2014-02-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1697428
Stage: TS28
Assay Id: MGI:5545779
Age: postnatal adult
Image: 1
Specimen Label: MB
Detected: false
Specimen Num: 10
GXD Expression      
Probe: MGI:4358984
Assay Type: RT-PCR
Annotation Date: 2009-09-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Stage: TS28
Assay Id: MGI:4359017
Age: postnatal adult
Specimen Label: Re
Detected: true
Specimen Num: 9
GXD Expression    
Probe: MGI:5545776
Assay Type: RT-PCR
Annotation Date: 2014-02-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716827
Stage: TS27
Assay Id: MGI:5545777
Age: postnatal day 0
Image: 1
Specimen Label: RN
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:5545776
Assay Type: RT-PCR
Annotation Date: 2014-02-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Stage: TS28
Assay Id: MGI:5545779
Age: postnatal adult
Image: 1
Specimen Label: RN
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:5911716
Assay Type: RT-PCR
Annotation Date: 2017-10-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1859021
Stage: TS21
Assay Id: MGI:5911717
Age: embryonic day 13.5
Image: 3
Specimen Label: e13.5 nr
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:5545776
Assay Type: RT-PCR
Annotation Date: 2014-02-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1753627
Stage: TS27
Assay Id: MGI:5545777
Age: postnatal day 0
Image: 1
Specimen Label: Hyth
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:5545776
Assay Type: RT-PCR
Annotation Date: 2014-02-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1753628
Stage: TS28
Assay Id: MGI:5545779
Age: postnatal adult
Image: 1
Specimen Label: Hyth
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:5545776
Assay Type: RT-PCR
Annotation Date: 2014-02-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1778727
Stage: TS27
Assay Id: MGI:5545777
Age: postnatal day 0
Image: 1
Specimen Label: Cerb
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:5545776
Assay Type: RT-PCR
Annotation Date: 2014-02-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:5545779
Age: postnatal adult
Image: 1
Specimen Label: Cerb
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:5545776
Assay Type: RT-PCR
Annotation Date: 2014-02-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754427
Stage: TS27
Assay Id: MGI:5545777
Age: postnatal day 0
Image: 1
Specimen Label: Cx
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:5545776
Assay Type: RT-PCR
Annotation Date: 2014-02-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:5545779
Age: postnatal adult
Image: 1
Specimen Label: Cx
Detected: false
Specimen Num: 3
GXD Expression        
Probe: MGI:4358984
Assay Type: RT-PCR
Annotation Date: 2009-09-24
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:4359017
Age: postnatal adult
Specimen Label: Lu
Specimen Num: 4
GXD Expression      
Probe: MGI:6752575
Assay Type: RT-PCR
Annotation Date: 2021-08-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691020
Stage: TS20
Assay Id: MGI:6753226
Age: embryonic day 12.5
Specimen Label: PA1
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6752575
Assay Type: RT-PCR
Annotation Date: 2021-08-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691020
Stage: TS20
Assay Id: MGI:6753228
Age: embryonic day 12.5
Specimen Label: PA2
Detected: true
Specimen Num: 1
GXD Expression        
Probe: MGI:4358984
Assay Type: RT-PCR
Annotation Date: 2009-09-24
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:4359017
Age: postnatal adult
Specimen Label: SM
Specimen Num: 8
GXD Expression    
Probe: MGI:5545776
Assay Type: RT-PCR
Annotation Date: 2014-02-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3284527
Stage: TS27
Assay Id: MGI:5545777
Age: postnatal day 0
Image: 1
Specimen Label: Hp
Detected: false
Specimen Num: 8
GXD Expression    
Probe: MGI:5545776
Assay Type: RT-PCR
Annotation Date: 2014-02-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3284528
Stage: TS28
Assay Id: MGI:5545779
Age: postnatal adult
Image: 1
Specimen Label: Hp
Detected: false
Specimen Num: 8
GXD Expression        
Probe: MGI:4358984
Assay Type: RT-PCR
Annotation Date: 2009-09-24
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:4359017
Age: postnatal adult
Specimen Label: He
Specimen Num: 3
GXD Expression    
Probe: MGI:6474190
Assay Type: RT-PCR
Annotation Date: 2020-11-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:6474198
Age: embryonic day 11.5
Image: 8
Specimen Label: +/+
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6474190
Assay Type: RT-PCR
Annotation Date: 2020-11-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:6474198
Age: embryonic day 11.5
Image: 8
Specimen Label: -/-
Detected: true
Specimen Num: 3