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Search results 1 to 93 out of 93 for Ska1

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Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
220134 | SKA1
Type: gene
Organism: human
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Gene
507703 | SKA1
Type: gene
Organism: cattle
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Gene
436865 | ska1
Type: gene
Organism: zebrafish
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Gene
700712 | SKA1
Type: gene
Organism: macaque, rhesus
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Gene
100144953 | ska1
Type: gene
Organism: frog, western clawed
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Gene
107049906 | SKA1
Type: gene
Organism: chicken
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Gene
291441 | Ska1
Type: gene
Organism: rat
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Gene
491691 | SKA1
Type: gene
Organism: dog, domestic
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Gene
455420 | SKA1
Type: gene
Organism: chimpanzee
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Protein Domain
IPR009829 | SKA1
Type: Family
Description: Spindle and kinetochore-associated protein 1 (SKA1) is a component of the SKA1 complex (consists of Ska1, Ska2, and Ska3/Rama1), a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation []. It is required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint []. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerisation-coupled manner. SKA1 contains a microtubule-binding domain that interacts with tubulins using multiple contact sites that allow the Ska complex to bind microtubules in multiple modes [].
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Protein Coding Gene
MGI:1913718 | Ska1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
17093495 | -
First Author: Hanisch A
Year: 2006
Journal: EMBO J
Title: Timely anaphase onset requires a novel spindle and kinetochore complex comprising Ska1 and Ska2.
Volume: 25
Issue: 23
Pages: 5504-15
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Publication
24827423 | J:214753
First Author: Li J
Year: 2014
Journal: J Pathol
Title: SKA1 over-expression promotes centriole over-duplication, centrosome amplification and prostate tumourigenesis.
Volume: 234
Issue: 2
Pages: 178-89
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Protein
Q9CPV1
Organism: Mus musculus/domesticus
Length: 254  
Fragment?: false
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Protein
A0A0R4J0M5
Organism: Mus musculus/domesticus
Length: 254  
Fragment?: false
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Publication
24413531 | -
 
First Author: Abad MA
Year: 2014
Journal: Nat Commun
Title: Structural basis for microtubule recognition by the human kinetochore Ska complex.
Volume: 5
Pages: 2964
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Publication
22483620 | -
First Author: Jeyaprakash AA
Year: 2012
Journal: Mol Cell
Title: Structural and functional organization of the Ska complex, a key component of the kinetochore-microtubule interface.
Volume: 46
Issue: 3
Pages: 274-86
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Protein
A0A494BA00
Organism: Mus musculus/domesticus
Length: 78  
Fragment?: false
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Publication
23085020 | -
First Author: Schmidt JC
Year: 2012
Journal: Dev Cell
Title: The kinetochore-bound Ska1 complex tracks depolymerizing microtubules and binds to curved protofilaments.
Volume: 23
Issue: 5
Pages: 968-80
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Protein Coding Gene
MGP_CAROLIEiJ_G0022398 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0024554 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0024521 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0024492 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0024521 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0024289 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1913718 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0024967 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0023762 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0024258 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0024388 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0024354 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0024472 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0024384 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0025015 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0023506 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0023825 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0019126 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0023311 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
 
Probe: MGI:5000926
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:1737921
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:5541484
Age: embryonic day 13.5
Image: GUDMAP:11059
Specimen Label: GUDMAP:11059
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:5000926
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:1737321
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:5541484
Age: embryonic day 13.5
Image: GUDMAP:11058
Specimen Label: GUDMAP:11058
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:5000926
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:1736621
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:5541484
Age: embryonic day 13.5
Image: GUDMAP:11058
Specimen Label: GUDMAP:11058
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:5000926
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:1736621
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:5541484
Age: embryonic day 13.5
Image: GUDMAP:11059
Specimen Label: GUDMAP:11059
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:5000926
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:1795021
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:5541484
Age: embryonic day 13.5
Image: GUDMAP:11058
Specimen Label: GUDMAP:11058
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:5000926
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:1795021
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:5541484
Age: embryonic day 13.5
Image: GUDMAP:11059
Specimen Label: GUDMAP:11059
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:5000926
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2890921
Stage: TS21
Assay Id: MGI:5541484
Age: embryonic day 13.5
Image: GUDMAP:11060
Specimen Label: GUDMAP:11060
Detected: false
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:5000926
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:1796821
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:5541484
Age: embryonic day 13.5
Image: GUDMAP:11057
Specimen Label: GUDMAP:11057
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:5000926
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2909821
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:5541484
Age: embryonic day 13.5
Image: GUDMAP:11057
Specimen Label: GUDMAP:11057
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:5000926
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Ambiguous
Sex: Male
Emaps: EMAPS:2913821
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:5541484
Age: embryonic day 13.5
Image: GUDMAP:11057
Note: uncertain expression
Specimen Label: GUDMAP:11057
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:5000926
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:1797221
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:5541484
Age: embryonic day 13.5
Image: GUDMAP:11057
Specimen Label: GUDMAP:11057
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:5000926
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Ambiguous
Sex: Male
Emaps: EMAPS:1797321
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:5541484
Age: embryonic day 13.5
Image: GUDMAP:11057
Note: uncertain expression
Specimen Label: GUDMAP:11057
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:5000926
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:3087021
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:5541484
Age: embryonic day 13.5
Image: GUDMAP:11059
Specimen Label: GUDMAP:11059
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:5000926
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:1796221
Stage: TS21
Assay Id: MGI:5541484
Age: embryonic day 13.5
Image: GUDMAP:11060
Specimen Label: GUDMAP:11060
Detected: false
Specimen Num: 4
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Publication
21633384 | J:320274
First Author: Lampert F
Year: 2011
Journal: Nat Rev Mol Cell Biol
Title: A blueprint for kinetochores - new insights into the molecular mechanics of cell division.
Volume: 12
Issue: 7
Pages: 407-12
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Publication
33798452 | J:314103
First Author: Ulmke PA
Year: 2021
Journal: Stem Cell Reports
Title: Molecular Profiling Reveals Involvement of ESCO2 in Intermediate Progenitor Cell Maintenance in the Developing Mouse Cortex.
Volume: 16
Issue: 4
Pages: 968-984
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GO Term
GO:0170027 | SKA complex
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Protein Domain
IPR042031 | SKA1-MBD
Type: Homologous_superfamily
Description: Spindle and kinetochore-associated protein 1 (SKA1) is a component of the SKA1 complex (consists of Ska1, Ska2, and Ska3/Rama1), a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation []. It is required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint []. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerisation-coupled manner. SKA1 contains a microtubule-binding domain that interacts with tubulins using multiple contact sites that allow the Ska complex to bind microtubules in multiple modes [].This superfamily corresponds to the microtubule binding domain (MBD) in SKA1, spindle and kinetochore associated protein 1. Its structure is a variation of the winged helix domain which, in addition of the three helix-bundle and anti-parallel β-sheets found in canonical winged-helix domains, it contains an extended helix (alphaB) as part of three helix bundle and an additional helix (alphaC) inserted between alphaB and betaA [].
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Publication
19289083 | -
First Author: Welburn JP
Year: 2009
Journal: Dev Cell
Title: The human kinetochore Ska1 complex facilitates microtubule depolymerization-coupled motility.
Volume: 16
Issue: 3
Pages: 374-85
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Heritable Phenotypic Marker
MGI:2671517 | skax1
Type: heritable_phenotypic_marker
Organism: mouse, laboratory
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Protein Domain
IPR026762 | Ska2
Type: Family
Description: Spindle and kinetochore-associated protein 2 (Ska2) is a component of the SKA1 complex (consists of Ska1, Ska2, and Ska3/Rama1), a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation []. It is required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint []. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerisation-coupled manner. In the complex, it is required for SKA1 localisation [].
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Protein Domain
IPR042091 | Ska2_N
Type: Domain
Description: Spindle and kinetochore-associated protein 2 (Ska2) is a component of the SKA1 complex (consists of Ska1, Ska2, and Ska3/Rama1), a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation []. It is required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint []. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerisation-coupled manner. In the complex, it is required for SKA1 localisation [].This entry represents the N-terminal domain of Ska2.
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Protein
Q9CR46
Organism: Mus musculus/domesticus
Length: 120  
Fragment?: false
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Publication
9423873 | J:44849
First Author: Nordstrand A
Year: 1998
Journal: Infect Immun
Title: Streptokinase as a mediator of acute post-streptococcal glomerulonephritis in an experimental mouse model.
Volume: 66
Issue: 1
Pages: 315-21
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Publication
18583474 | J:138293
First Author: Rice L
Year: 2008
Journal: J Endocrinol
Title: Identification and functional analysis of SKA2 interaction with the glucocorticoid receptor.
Volume: 198
Issue: 3
Pages: 499-509
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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