|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 93 out of 93 for Skap1

0.033s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
8631 | SKAP1
Type: gene
Organism: human
•
•
•
•
•
Gene
506769 | SKAP1
Type: gene
Organism: cattle
•
•
•
•
•
Gene
563784 | skap1
Type: gene
Organism: zebrafish
•
•
•
•
•
Gene
697043 | SKAP1
Type: gene
Organism: macaque, rhesus
•
•
•
•
•
Gene
101752206 | SKAP1
Type: gene
Organism: chicken
•
•
•
•
•
Gene
448448 | skap1
Type: gene
Organism: frog, western clawed
•
•
•
•
•
Gene
286975 | Skap1
Type: gene
Organism: rat
•
•
•
•
•
Gene
480543 | SKAP1
Type: gene
Organism: dog, domestic
•
•
•
•
•
Gene
468432 | SKAP1
Type: gene
Organism: chimpanzee
•
•
•
•
•
Protein Coding Gene
MGI:1925723 | Skap1
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Gene
105371807 | SKAP1-AS2
Type: gene
Organism: human
•
•
•
•
•
Gene
110806289 | SKAP1-AS1
Type: gene
Organism: human
•
•
•
•
•
Publication
17403904 | J:122332
First Author: Ménasché G
Year: 2007
Journal: Mol Cell Biol
Title: RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activation.
Volume: 27
Issue: 11
Pages: 4070-81
•
•
•
•
•
Publication
20346707 | J:160767
First Author: Raab M
Year: 2010
Journal: Immunity
Title: T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes.
Volume: 32
Issue: 4
Pages: 541-56
•
•
•
•
•
Publication
26905930 | J:319147
 
First Author: Lim D
Year: 2016
Journal: Immunol Lett
Title: Non-cleavable talin rescues defect in the T-cell conjugation of T-cells deficient in the immune adaptor SKAP1.
Volume: 172
Pages: 40-6
•
•
•
•
•
Protein Coding Gene
MGP_CAROLIEiJ_G0017033 | -
Type: protein_coding_gene
Organism: Mus caroli
•
•
•
•
•
Protein Coding Gene
MGP_129S1SvImJ_G0019010 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_AJ_G0018978 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_AKRJ_G0018948 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_BALBcJ_G0018951 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_C3HHeJ_G0018765 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI_C57BL6J_1925723 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_C57BL6NJ_G0019403 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_CASTEiJ_G0018318 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_CBAJ_G0018736 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_DBA2J_G0018844 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_FVBNJ_G0018833 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_LPJ_G0018914 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_NODShiLtJ_G0018860 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_NZOHlLtJ_G0019443 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_PWKPhJ_G0018090 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_WSBEiJ_G0018368 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_PahariEiJ_G0018163 | -
Type: protein_coding_gene
Organism: Mus pahari
•
•
•
•
•
Protein Coding Gene
MGP_SPRETEiJ_G0017879 | -
Type: protein_coding_gene
Organism: Mus spretus
•
•
•
•
•
Publication
18320039 | J:133130
First Author: Schneider H
Year: 2008
Journal: PLoS One
Title: Adaptor SKAP-55 binds p21 activating exchange factor RasGRP1 and negatively regulates the p21-ERK pathway in T-cells.
Volume: 3
Issue: 3
Pages: e1718
•
•
•
•
•
Publication
15939789 | J:99208
First Author: Jo EK
Year: 2005
Journal: J Exp Med
Title: An essential role for SKAP-55 in LFA-1 clustering on T cells that cannot be substituted by SKAP-55R.
Volume: 201
Issue: 11
Pages: 1733-9
•
•
•
•
•
Publication
21525391 | J:173181
First Author: Burbach BJ
Year: 2011
Journal: J Immunol
Title: The pleckstrin homology domain in the SKAP55 adapter protein defines the ability of the adapter protein ADAP to regulate integrin function and NF-kappaB activation.
Volume: 186
Issue: 11
Pages: 6227-37
•
•
•
•
•
Publication
17646386 | J:126545
First Author: Wang H
Year: 2007
Journal: Mol Cell Biol
Title: Functional defects of SKAP-55-deficient T cells identify a regulatory role for the adaptor in LFA-1 adhesion.
Volume: 27
Issue: 19
Pages: 6863-75
•
•
•
•
•
Publication
20824186 | J:165021
 
First Author: Königsberger S
Year: 2010
Journal: PLoS One
Title: HPK1 associates with SKAP-HOM to negatively regulate Rap1-mediated B-lymphocyte adhesion.
Volume: 5
Issue: 9
•
•
•
•
•
Publication
23897807 | J:203536
First Author: Ayoub E
Year: 2013
Journal: J Biol Chem
Title: Regulation of the Src kinase-associated phosphoprotein 55 homologue by the protein tyrosine phosphatase PTP-PEST in the control of cell motility.
Volume: 288
Issue: 36
Pages: 25739-48
•
•
•
•
•
Publication
25851535 | J:233407
First Author: Li C
Year: 2015
Journal: EMBO Mol Med
Title: ADAP and SKAP55 deficiency suppresses PD-1 expression in CD8+ cytotoxic T lymphocytes for enhanced anti-tumor immunotherapy.
Volume: 7
Issue: 6
Pages: 754-69
•
•
•
•
•
Publication
23793062 | J:205441
First Author: Liang Y
Year: 2013
Journal: Nat Immunol
Title: The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells.
Volume: 14
Issue: 8
Pages: 858-66
•
•
•
•
•
Publication
17062627 | J:137511
First Author: Lin Q
Year: 2006
Journal: Nucleic Acids Res
Title: Mutagenesis of diploid mammalian genes by gene entrapment.
Volume: 34
Issue: 20
Pages: e139
•
•
•
•
•
Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
•
•
•
•
•
Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
•
•
•
•
•
Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
•
•
•
•
•
Publication
- | J:155856
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
•
•
•
•
•
Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
•
•
•
•
•
Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
•
•
•
•
•
Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
•
•
•
•
•
Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
•
•
•
•
•
Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
•
•
•
•
•
Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
•
•
•
•
•
Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
•
•
•
•
•
Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
•
•
•
•
•
Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
•
•
•
•
•
Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
•
•
•
•
•
Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
•
•
•
•
•
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
•
•
•
•
•
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
•
•
•
•
•
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
•
•
•
•
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
•
•
•
•
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
•
•
•
•
•
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
•
•
•
•
•
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
•
•
•
•
•
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
•
•
•
•
•
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
•
•
•
•
•
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
•
•
•
•
•
Protein
B7ZWB3
Organism: Mus musculus/domesticus
Length: 339  
Fragment?: false
•
•
•
•
•
Protein
B2RWZ1
Organism: Mus musculus/domesticus
Length: 339  
Fragment?: false
•
•
•
•
•
Publication
17658605 | -
First Author: Kosco KA
Year: 2008
Journal: Mol Immunol
Title: SKAP55 modulates T cell antigen receptor-induced activation of the Ras-Erk-AP1 pathway by binding RasGRP1.
Volume: 45
Issue: 2
Pages: 510-22
•
•
•
•
•
Publication
18760924 | -
First Author: Wang H
Year: 2008
Journal: Trends Cell Biol
Title: SKAP-55, SKAP-55-related and ADAP adaptors modulate integrin-mediated immune-cell adhesion.
Volume: 18
Issue: 10
Pages: 486-93
•
•
•
•
•
Publication
9232446 | -
First Author: Schraven B
Year: 1997
Journal: Immunol Lett
Title: Molecular analysis of the fyn-complex: cloning of SKAP55 and SLAP-130, two novel adaptor proteins which associate with fyn and may participate in the regulation of T cell receptor-mediated signaling.
Volume: 57
Issue: 1-3
Pages: 165-9
•
•
•
•
•
Publication
16461356 | -
First Author: Duke-Cohan JS
Year: 2006
Journal: J Biol Chem
Title: Regulation and function of SKAP-55 non-canonical motif binding to the SH3c domain of adhesion and degranulation-promoting adaptor protein.
Volume: 281
Issue: 19
Pages: 13743-50
•
•
•
•
•
Publication
10856234 | -
First Author: Kang H
Year: 2000
Journal: EMBO J
Title: SH3 domain recognition of a proline-independent tyrosine-based RKxxYxxY motif in immune cell adaptor SKAP55.
Volume: 19
Issue: 12
Pages: 2889-99
•
•
•
•
•
Protein Domain
IPR035765 | SKAP1_SH3
Type: Domain
Description: SKAP1 (also known as SKAP55) is an immune cell-specific adaptor protein that plays an important role in T-cell adhesion, migration, and integrin clustering. It is expressed exclusively in T-lymphocytes, mast cells, and macrophages []. Binding partners include ADAP (adhesion and degranulation-promoting adaptor protein), Fyn, Riam, RapL, and RasGRP [, , ]. It contains a pleckstrin homology (PH) domain, a C-terminal SH3 domain, and several tyrosine phosphorylation sites. The SH3 domain of SKAP1 is necessary for its ability to regulate T-cell conjugation with antigen-presenting cells and the formation of LFA-1 clusters. SKAP1 binds primarily to a proline-rich region of ADAP through its SH3 domain; its degradation is regulated by ADAP. A secondary interaction occurs via the ADAP SH3 domain and the RKxxYxxY motif in SKAP1 [, ].This entry represents the SH3 domain of SKAP1.
•
•
•
•
•
Publication
19026786 | J:142190
First Author: Swanson KD
Year: 2008
Journal: Mol Cell
Title: The Skap-hom dimerization and PH domains comprise a 3'-phosphoinositide-gated molecular switch.
Volume: 32
Issue: 4
Pages: 564-75
•
•
•
•
•
Protein
Q3V3C6
Organism: Mus musculus/domesticus
Length: 165  
Fragment?: false
•
•
•
•
•
Protein
B1AQX1
Organism: Mus musculus/domesticus
Length: 165  
Fragment?: false
•
•
•
•
•
Protein
B1AQX5
Organism: Mus musculus/domesticus
Length: 126  
Fragment?: false
•
•
•
•
•
Protein
Q3U5H2
Organism: Mus musculus/domesticus
Length: 78  
Fragment?: false
•
•
•
•
•
Publication
28052935 | -
 
First Author: Witte A
Year: 2017
Journal: Mol Cell Biol
Title: D120 and K152 within the PH Domain of T Cell Adapter SKAP55 Regulate Plasma Membrane Targeting of SKAP55 and LFA-1 Affinity Modulation in Human T Lymphocytes.
Volume: 37
Issue: 7
•
•
•
•
•
Publication
28183734 | J:241223
First Author: Boras M
Year: 2017
Journal: J Exp Med
Title: Skap2 is required for β2 integrin-mediated neutrophil recruitment and functions.
Volume: 214
Issue: 3
Pages: 851-874
•
•
•
•
•
Protein Domain
IPR037781 | SKAP_fam
Type: Family
Description: This entry represents the SKAP (Src kinase-associated phosphoprotein) family, whose members include SKAP1 and SKAP2. They are adaptor proteins that have been implicated in cell adhesion through their association to integrins and cytoplasmic actin []. They contain an N-terminal coiled-coil conformation, a central PH domain and a C-terminal SH3 domain [].SKAP1 (also known as SKAP55) is required for microcluster persistence and movement, junctional stabilization, and integrin-independent adhesion via the T cell receptor (TCR). It interacts with RAPL and RIAM via its N-termianl dimerization (DM) domain. The K152 and D120 within the PH domain of SKAP55 regulate plasma membrane targeting and TCR-mediated activation of LFA-1 (lymphocyte function-associated antigen 1) [].SKAP2 (also known as RA70) is required for beta2 integrin-mediated neutrophil recruitment and functions [].
•
•
•
•
•
Publication
24523237 | J:210761
First Author: Kasirer-Friede A
Year: 2014
Journal: Blood
Title: ADAP interactions with talin and kindlin promote platelet integrin αIIbβ3 activation and stable fibrinogen binding.
Volume: 123
Issue: 20
Pages: 3156-65
•
•
•
•
•
Publication
27170314 | J:237311
First Author: Cindric Vranesic A
Year: 2016
Journal: Hum Mol Genet
Title: Characterization of SKAP/kinastrin isoforms: the N-terminus defines tissue specificity and Pontin binding.
Volume: 25
Issue: 13
Pages: 2838-2852
•
•
•
•
•
Publication
25455592 | J:319083
First Author: Thaker YR
Year: 2015
Journal: Immunol Lett
Title: TCR and CD28 activate the transcription factor NF-κB in T-cells via distinct adaptor signaling complexes.
Volume: 163
Issue: 1
Pages: 113-9
•
•
•
•
•
Protein
Q3UUV5
Organism: Mus musculus/domesticus
Length: 355  
Fragment?: false
•
•
•
•
•
Protein
Q3V3I1
Organism: Mus musculus/domesticus
Length: 178  
Fragment?: false
•
•
•
•
•
Protein
Q3UND0
Organism: Mus musculus/domesticus
Length: 358  
Fragment?: false
•
•
•
•
•
Protein
A0A0N4SVW8
Organism: Mus musculus/domesticus
Length: 126  
Fragment?: true
•
•
•
•
•
Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom