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Search results 1 to 100 out of 784 for Ski

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Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
6497 | SKI
Type: gene
Organism: human
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Gene
313757 | Ski
Type: gene
Organism: rat
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Gene
457216 | SKI
Type: gene
Organism: chimpanzee
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Gene
506127 | SKI
Type: gene
Organism: cattle
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Gene
428181 | SKI
Type: gene
Organism: chicken
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Gene
697890 | SKI
Type: gene
Organism: macaque, rhesus
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Gene
100486949 | ski
Type: gene
Organism: frog, western clawed
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Gene
489610 | SKI
Type: gene
Organism: dog, domestic
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Protein Domain
IPR028760 | Ski
Type: Family
Description: Ski is involved in oncogenic transformation and enhancement of muscle differentiation by blocking TGF-beta signaling [, ]. Ski binds directly to the Smad3/4 complex and negatively regulates TGF-beta signaling [, , ]. It plays a role in terminal differentiation of skeletal muscle cells, but not in the determination of cells to the myogenic lineage []. Ski is a component of the histone deacetylase complex (HDAC) complex and is required for the transcriptional repression mediated by this complex []. This entry includes v-ski (viral oncogene ski) from the avian Sloan-Kettering retroviruses and its homologue from animals, c-ski []. c-ski can promote cancer progression and is highly expressed in some of solid cancers including leukemia, melanoma, colorectal cancer, gastric cancer and pancreatic cancer []. However, it can also act as a tumour suppressor in some cases [].
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Protein Coding Gene
MGI:98310 | Ski
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
7659522 | J:28293
First Author: Engert JC
Year: 1995
Journal: Nucleic Acids Res
Title: Activation of a muscle-specific enhancer by the Ski proto-oncogene.
Volume: 23
Issue: 15
Pages: 2988-94
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Publication
10049357 | J:53313
First Author: Nomura T
Year: 1999
Journal: Genes Dev
Title: Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor.
Volume: 13
Issue: 4
Pages: 412-23
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GXD Expression
GXD Expression
 
Probe: MGI:3624773
Assay Type: RNA in situ
Annotation Date: 2006-06-20
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1640619
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:3624802
Age: embryonic day 11.5
Image: Ski E11.5
Specimen Label: Ski E11.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:3624773
Assay Type: RNA in situ
Annotation Date: 2006-06-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3265120
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:3624802
Age: embryonic day 12.5
Image: Ski E12.5
Specimen Label: Ski E12.5
Detected: true
Specimen Num: 2
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Protein
Q99KU4
Organism: Mus musculus/domesticus
Length: 104  
Fragment?: true
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Protein
Q8K0R3
Organism: Mus musculus/domesticus
Length: 324  
Fragment?: true
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Publication
19049980 | -
First Author: Takahata M
Year: 2009
Journal: J Biol Chem
Title: SKI and MEL1 cooperate to inhibit transforming growth factor-beta signal in gastric cancer cells.
Volume: 284
Issue: 5
Pages: 3334-44
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Protein
Q60698
Organism: Mus musculus/domesticus
Length: 725  
Fragment?: false
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Protein
Q6NV61
Organism: Mus musculus/domesticus
Length: 675  
Fragment?: false
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Protein
B1AUF2
Organism: Mus musculus/domesticus
Length: 675  
Fragment?: false
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Protein
B1AUF1
Organism: Mus musculus/domesticus
Length: 727  
Fragment?: false
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Publication
16200078 | J:102645
First Author: Arndt S
Year: 2005
Journal: Lab Invest
Title: Cloning and functional characterization of a new Ski homolog, Fussel-18, specifically expressed in neuronal tissues.
Volume: 85
Issue: 11
Pages: 1330-41
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Publication
12874272 | -
First Author: Harada J
Year: 2003
Journal: J Biol Chem
Title: Requirement of the co-repressor homeodomain-interacting protein kinase 2 for ski-mediated inhibition of bone morphogenetic protein-induced transcriptional activation.
Volume: 278
Issue: 40
Pages: 38998-9005
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Publication
10575014 | -
First Author: Akiyoshi S
Year: 1999
Journal: J Biol Chem
Title: c-Ski acts as a transcriptional co-repressor in transforming growth factor-beta signaling through interaction with smads.
Volume: 274
Issue: 49
Pages: 35269-77
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Publication
1870207 | -
First Author: Colmenares C
Year: 1991
Journal: J Virol
Title: Activation of the c-ski oncogene by overexpression.
Volume: 65
Issue: 9
Pages: 4929-35
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Publication
11278756 | -
First Author: Leong GM
Year: 2001
Journal: J Biol Chem
Title: Ski-interacting protein interacts with Smad proteins to augment transforming growth factor-beta-dependent transcription.
Volume: 276
Issue: 21
Pages: 18243-8
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Publication
24011664 | -
First Author: Wang L
Year: 2013
Journal: Mol Oncol
Title: c-Ski activates cancer-associated fibroblasts to regulate breast cancer cell invasion.
Volume: 7
Issue: 6
Pages: 1116-28
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Publication
11731796 | J:75396
First Author: Colmenares C
Year: 2002
Journal: Nat Genet
Title: Loss of the SKI proto-oncogene in individuals affected with 1p36 deletion syndrome is predicted by strain-dependent defects in Ski-/- mice.
Volume: 30
Issue: 1
Pages: 106-9
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Publication
17003410 | J:116273
First Author: McGannon P
Year: 2006
Journal: Invest Ophthalmol Vis Sci
Title: Ocular abnormalities in mice lacking the Ski proto-oncogene.
Volume: 47
Issue: 10
Pages: 4231-7
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Publication
8573720 | J:29515
First Author: Namciu S
Year: 1995
Journal: Dev Dyn
Title: Enhanced expression of mouse c-ski accompanies terminal skeletal muscle differentiation in vivo and in vitro.
Volume: 204
Issue: 3
Pages: 291-300
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Publication
12435627 | J:80205
First Author: Dai P
Year: 2002
Journal: Genes Dev
Title: Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3.
Volume: 16
Issue: 22
Pages: 2843-8
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Publication
15312649 | J:96530
First Author: Atanasoski S
Year: 2004
Journal: Neuron
Title: The protooncogene Ski controls Schwann cell proliferation and myelination.
Volume: 43
Issue: 4
Pages: 499-511
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Publication
21600873 | J:174083
First Author: Mosquera J
Year: 2011
Journal: Biochem Biophys Res Commun
Title: Identification of Ski as a target for Aurora A kinase.
Volume: 409
Issue: 3
Pages: 539-43
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Publication
2762147 | J:9932
First Author: Nomura N
Year: 1989
Journal: Nucleic Acids Res
Title: Isolation of human cDNA clones of ski and the ski-related gene, sno.
Volume: 17
Issue: 14
Pages: 5489-500
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Publication
8770548 | J:30418
First Author: Lana DP
Year: 1996
Journal: Dev Dyn
Title: Selective expression of a ski transgene affects IIb fast muscles and skeletal structure.
Volume: 205
Issue: 1
Pages: 13-23
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Publication
9284043 | J:42573
First Author: Berk M
Year: 1997
Journal: Genes Dev
Title: Mice lacking the ski proto-oncogene have defects in neurulation, craniofacial, patterning, and skeletal muscle development.
Volume: 11
Issue: 16
Pages: 2029-39
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Publication
11441023 | J:159081
First Author: Kokura K
Year: 2001
Journal: J Biol Chem
Title: The Ski protein family is required for MeCP2-mediated transcriptional repression.
Volume: 276
Issue: 36
Pages: 34115-21
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Protein
Q9CTE9
Organism: Mus musculus/domesticus
Length: 124  
Fragment?: true
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Gene
6498 | SKIL
Type: gene
Organism: human
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Publication
19341714 | J:148346
First Author: Zhao HL
Year: 2009
Journal: Biochem Biophys Res Commun
Title: The Ski protein can inhibit ligand induced RARalpha and HDAC3 degradation in the retinoic acid signaling pathway.
Volume: 383
Issue: 1
Pages: 119-24
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Publication
12034730 | J:78254
First Author: Pessah M
Year: 2002
Journal: J Biol Chem
Title: c-Jun associates with the oncoprotein Ski and suppresses Smad2 transcriptional activity.
Volume: 277
Issue: 32
Pages: 29094-100
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Publication
22334647 | J:182157
First Author: Baranek C
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Protooncogene Ski cooperates with the chromatin-remodeling factor Satb2 in specifying callosal neurons.
Volume: 109
Issue: 9
Pages: 3546-51
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Publication
19008232 | J:147237
First Author: Zhang H
Year: 2009
Journal: J Biol Chem
Title: Ski regulates muscle terminal differentiation by transcriptional activation of Myog in a complex with Six1 and Eya3.
Volume: 284
Issue: 5
Pages: 2867-79
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Publication
18950738 | J:146021
First Author: Yuzawa H
Year: 2009
Journal: Bone
Title: Arkadia represses the expression of myoblast differentiation markers through degradation of Ski and the Ski-bound Smad complex in C2C12 myoblasts.
Volume: 44
Issue: 1
Pages: 53-60
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GXD Expression
GXD Expression
Probe: MGI:6473150
Assay Type: Immunohistochemistry
Annotation Date: 2020-11-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1914226
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:6473217
Age: embryonic day 18.5
Image: 6D Smad2
Note: There was no obvious change in Ski expression levels in prehypertrophic and hypertrophic chondrocytes in the mutant compared with control.
Specimen Label: 6D Smad2
Detected: true
Specimen Num: 2
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Publication
12419246 | -
First Author: Wu JW
Year: 2002
Journal: Cell
Title: Structural mechanism of Smad4 recognition by the nuclear oncoprotein Ski: insights on Ski-mediated repression of TGF-beta signaling.
Volume: 111
Issue: 3
Pages: 357-67
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Publication
11781823 | J:73349
First Author: Shinagawa T
Year: 2001
Journal: Oncogene
Title: Increased susceptibility to tumorigenesis of ski-deficient heterozygous mice.
Volume: 20
Issue: 56
Pages: 8100-8
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GXD Expression
GXD Expression
Probe: MGI:6473150
Assay Type: Immunohistochemistry
Annotation Date: 2020-11-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1914226
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:6473217
Age: embryonic day 18.5
Image: 6D Smad3<-/->
Note: There was no obvious change in Ski expression levels in prehypertrophic and hypertrophic chondrocytes in the mutant compared with control. However, expression was increased in the proliferative zone.
Specimen Label: 6D Smad3<-/->
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:6473150
Assay Type: Immunohistochemistry
Annotation Date: 2020-11-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1914226
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:6473217
Age: embryonic day 18.5
Image: 6D Smad2;Smad3<-/->
Note: There was no obvious change in Ski expression levels in prehypertrophic and hypertrophic chondrocytes in the double mutant compared with control. However, expression was increased in the proliferative zone.
Specimen Label: 6D Smad2;Smad3<-/->
Detected: true
Specimen Num: 4
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Publication
17292623 | J:123207
First Author: Arndt S
Year: 2007
Journal: Mol Cell Neurosci
Title: Fussel-15, a novel Ski/Sno homolog protein, antagonizes BMP signaling.
Volume: 34
Issue: 4
Pages: 603-11
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Publication
7894074 | J:21947
First Author: Lyons GE
Year: 1994
Journal: Dev Dyn
Title: Protooncogene c-ski is expressed in both proliferating and postmitotic neuronal populations.
Volume: 201
Issue: 4
Pages: 354-65
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Gene
390598 | SKOR1
Type: gene
Organism: human
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Gene
652991 | SKOR2
Type: gene
Organism: human
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Publication
9207045 | J:41760
First Author: Pearson-White S
Year: 1997
Journal: Nucleic Acids Res
Title: Proto-oncogene Sno expression, alternative isoforms and immediate early serum response.
Volume: 25
Issue: 14
Pages: 2930-7
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Publication
12782652 | J:83742
First Author: Shinagawa T
Year: 2003
Journal: Genes Dev
Title: Generation of Ski-knockdown mice by expressing a long double-strand RNA from an RNA polymerase II promoter.
Volume: 17
Issue: 11
Pages: 1340-5
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Protein Coding Gene
MGP_CAROLIEiJ_G0026885 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0029209 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0029174 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0029122 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0029190 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0028911 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_98310 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0029639 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0028324 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0028873 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0029022 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0028986 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0029112 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0029013 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0029671 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0028044 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0028404 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0029233 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0027878 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
15375607 | J:97747
First Author: Carbó N
Year: 2004
Journal: Int J Mol Med
Title: Effect of c-ski overexpression on the development of cachexia in mice bearing the Lewis lung carcinoma.
Volume: 14
Issue: 4
Pages: 719-23
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Publication
7823166 | J:22278
First Author: Leferovich JM
Year: 1995
Journal: J Neurosci
Title: Regulation of c-ski transgene expression in developing and mature mice.
Volume: 15
Issue: 1 Pt 2
Pages: 596-603
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GXD Expression
GXD Expression
   
Probe: MGI:3624938
Assay Type: Western blot
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:3624939
Age: embryonic day 12.5
Image: S1
Specimen Label: E12.5
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:7610288
Assay Type: RNA in situ
Annotation Date: 2024-03-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7614817
Age: embryonic day 14.5
Specimen Label: 4D E14.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7610288
Assay Type: RNA in situ
Annotation Date: 2024-03-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716124
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:7614817
Age: embryonic day 16.5
Specimen Label: 4D E16.5
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:7610288
Assay Type: RNA in situ
Annotation Date: 2024-03-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619817
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:7614817
Age: embryonic day 10.5
Note: Expression is in the periocular neural crest cells and cornea.
Specimen Label: 4D E10.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:7610288
Assay Type: RNA in situ
Annotation Date: 2024-03-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619822
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:7614817
Age: embryonic day 14.5
Note: Expression is in ths periocular neural crest cells.
Specimen Label: 4D E14.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:7610288
Assay Type: RNA in situ
Annotation Date: 2024-03-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619824
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:7614817
Age: embryonic day 16.5
Note: Expression is in ths periocular neural crest cells.
Specimen Label: 4D E16.5
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:6473150
Assay Type: Immunohistochemistry
Annotation Date: 2020-11-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1914226
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:6473217
Age: embryonic day 18.5
Image: 6D Smad2
Note: Expression was detected in the nucleus in prehypertrophic and hypertrophic zones.
Specimen Label: 6D Smad2
Detected: true
Specimen Num: 1
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Publication
- | J:69444
   
First Author: Strausberg R
Year: 2001
Journal: GenBank Submission
Title: Mus musculus, clone MGC: 8300, mRNA, complete cds
Pages: BC004088
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Publication
22371338 | J:184368
First Author: Mukhopadhyay P
Year: 2012
Journal: Birth Defects Res A Clin Mol Teratol
Title: Strain-specific modifier genes governing craniofacial phenotypes.
Volume: 94
Issue: 3
Pages: 162-75
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Publication
7662963 | J:28741
First Author: Pearson-White S
Year: 1995
Journal: Blood
Title: The ski/sno protooncogene family in hematopoietic development.
Volume: 86
Issue: 6
Pages: 2146-55
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Publication
23610558 | J:198828
First Author: Kelly CE
Year: 2013
Journal: PLoS Biol
Title: Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension.
Volume: 11
Issue: 4
Pages: e1001538
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Publication
24728352 | J:259947
First Author: Hauri-Hohl M
Year: 2014
Journal: Nat Immunol
Title: A regulatory role for TGF-β signaling in the establishment and function of the thymic medulla.
Volume: 15
Issue: 6
Pages: 554-61
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Publication
12016514 | J:76559
First Author: Ernest S
Year: 2002
Journal: Mamm Genome
Title: Genetic and molecular control of folate-homocysteine metabolism in mutant mice.
Volume: 13
Issue: 5
Pages: 259-67
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Publication
29072299 | J:283183
First Author: Zhang S
Year: 2017
Journal: Nature
Title: Reversing SKI-SMAD4-mediated suppression is essential for TH17 cell differentiation.
Volume: 551
Issue: 7678
Pages: 105-109
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Publication
17352741 | J:127114
First Author: Kobayashi N
Year: 2007
Journal: Genes Cells
Title: c-Ski activates MyoD in the nucleus of myoblastic cells through suppression of histone deacetylases.
Volume: 12
Issue: 3
Pages: 375-85
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Publication
27741240 | J:236232
First Author: Wang W
Year: 2016
Journal: PLoS Genet
Title: Smad2 and Smad3 Regulate Chondrocyte Proliferation and Differentiation in the Growth Plate.
Volume: 12
Issue: 10
Pages: e1006352
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Publication
8199413 | J:17311
First Author: Mock BA
Year: 1994
Journal: Mamm Genome
Title: The gene for mouse p58cdc2L1 (Cdc2l1) protein kinase maps to distal mouse chromosome 4.
Volume: 5
Issue: 3
Pages: 191-2
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Publication
17168649 | J:125213
First Author: Tesseur I
Year: 2006
Journal: Curr Alzheimer Res
Title: A role for TGF-beta signaling in neurodegeneration: evidence from genetically engineered models.
Volume: 3
Issue: 5
Pages: 505-13
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Publication
21937600 | J:178818
First Author: Wang B
Year: 2011
Journal: Development
Title: Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development.
Volume: 138
Issue: 20
Pages: 4487-97
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Publication
7774930 | J:23228
First Author: Autieri MV
Year: 1995
Journal: Genomics
Title: Genomic organization and genetic mapping of the neuroimmune gene I2rf5 to mouse chromosome 4.
Volume: 25
Issue: 1
Pages: 282-4
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Publication
23024056 | J:190946
First Author: Cabrera RM
Year: 2012
Journal: Birth Defects Res A Clin Mol Teratol
Title: Transcriptional analyses of two mouse models of spina bifida.
Volume: 94
Issue: 10
Pages: 782-9
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Publication
8405064 | J:15289
First Author: Goodwin RG
Year: 1993
Journal: Eur J Immunol
Title: Molecular cloning of a ligand for the inducible T cell gene 4-1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor.
Volume: 23
Issue: 10
Pages: 2631-41
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Publication
26814051 | J:230652
 
First Author: Harb K
Year: 2016
Journal: Elife
Title: Area-specific development of distinct projection neuron subclasses is regulated by postnatal epigenetic modifications.
Volume: 5
Pages: e09531
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Publication
1645445 | J:11207
First Author: Goodwin RG
Year: 1991
Journal: Mol Cell Biol
Title: Molecular cloning and expression of the type 1 and type 2 murine receptors for tumor necrosis factor.
Volume: 11
Issue: 6
Pages: 3020-6
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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