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Search results 1 to 100 out of 447 for Slc12a3

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0.038s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Domain
Type: Family
Description: Solute carrier family 12 member 3 (Slc12a3) is also known as Tsc (thiazide-sensitive Na-Cl co-transporter). Tsc is a large integral membraneprotein (~1000 amino acids) that mediates the coupled transport of Na+andCl-in an electrically silent manner. In the mammalian kidney, it is thedominant mechanism mediating Cl-absorption in the early distal tubule, andhere it is the target of the widely-used thiazide class of diuretic drugs.It is also known to be present in the urinary bladder of the winterflounder (Pseudopleuronectes americanus), from where the gene encoding it was initially cloned [].Hydrophobicity analysis predicts the Na-Cl co-transporter to have 12transmembrane (TM) domains and comparisons with other cloned ionco-transporters reveals that a superfamily of electroneutral cation-chlorideco-transporters exists, which includes the K-Cl co-transporters ()and the Na-K-Cl co-transporters (). All share a similar predictedmembrane topology in a central hydrophobic domain, together withhydrophilic N- and C-termini that are likely cytoplasmic [].Mutations in the thiazide-sensitive Na-Cl co-transporter have beenfound that give rise to Gitelman's variant of Bartter's syndrome,an inherited kidney disease characterised by hypokalaemic alkalosis [].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Trepiccione F
Year: 2016
Journal: Am J Physiol Renal Physiol
Title: A fate-mapping approach reveals the composite origin of the connecting tubule and alerts on "single-cell"-specific KO model of the distal nephron.
Volume: 311
Issue: 5
Pages: F901-F906
Publication      
First Author: McMahon A
Year: 2010
Journal: Unpublished
Title: Summary of mouse strains characterized by GUDMAP consortium.
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Allele
Name: solute carrier family 12, member 3; endonuclease-mediated mutation 1, Andrew P McMahon
Allele Type: Endonuclease-mediated
Attribute String: Inducible, Recombinase
Publication categories: ProxyCollection
Allele
Name: solute carrier family 12, member 3; targeted mutation 1, Juliette Hadchouel
Allele Type: Targeted
Attribute String: Recombinase
Publication categories: ProxyCollection
Strain
Attribute String: mutant strain, coisogenic, endonuclease-mediated mutation
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Slc12a3/Slc12a3<+>
Background: involves: 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
Protein
Organism: Mus musculus
Length: 1002  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1001  
Fragment?: false
Protein
Organism: Mus musculus
Length: 956  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1002  
Fragment?: false
Protein
Organism: Mus musculus
Length: 130  
Fragment?: true
Publication
First Author: Gamba G
Year: 1993
Journal: Proc Natl Acad Sci U S A
Title: Primary structure and functional expression of a cDNA encoding the thiazide-sensitive, electroneutral sodium-chloride cotransporter.
Volume: 90
Issue: 7
Pages: 2749-53
Publication
First Author: Mount DB
Year: 1998
Journal: J Exp Biol
Title: The electroneutral cation-chloride cotransporters.
Volume: 201
Issue: Pt 14
Pages: 2091-102
Publication
First Author: Simon DB
Year: 1996
Journal: Nat Genet
Title: Gitelman's variant of Bartter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter.
Volume: 12
Issue: 1
Pages: 24-30
Allele
Name: solute carrier family 12, member 3; targeted mutation 1, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Inducible, Recombinase, Reporter
Publication categories: ProxyCollection
Strain
Attribute String: targeted mutation, mutant strain, coisogenic
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Kunchaparty S
Year: 1999
Journal: Am J Physiol
Title: Defective processing and expression of thiazide-sensitive Na-Cl cotransporter as a cause of Gitelman's syndrome.
Volume: 277
Issue: 4 Pt 2
Pages: F643-9
Publication
First Author: Schultheis PJ
Year: 1998
Journal: J Biol Chem
Title: Phenotype resembling Gitelman's syndrome in mice lacking the apical Na+-Cl- cotransporter of the distal convoluted tubule.
Volume: 273
Issue: 44
Pages: 29150-5
Publication
First Author: Morris RG
Year: 2006
Journal: Am J Physiol Renal Physiol
Title: Hypokalemia in a mouse model of Gitelman's syndrome.
Volume: 290
Issue: 6
Pages: F1416-20
Publication
First Author: Pathare G
Year: 2018
Journal: Sci Rep
Title: Elevated FGF23 Levels in Mice Lacking the Thiazide-Sensitive NaCl cotransporter (NCC).
Volume: 8
Issue: 1
Pages: 3590
Publication
First Author: Nicolet-Barousse L
Year: 2005
Journal: J Bone Miner Res
Title: Inactivation of the Na-Cl co-transporter (NCC) gene is associated with high BMD through both renal and bone mechanisms: analysis of patients with Gitelman syndrome and Ncc null mice.
Volume: 20
Issue: 5
Pages: 799-808
Publication
First Author: Sinke AP
Year: 2014
Journal: Am J Physiol Renal Physiol
Title: Hydrochlorothiazide attenuates lithium-induced nephrogenic diabetes insipidus independently of the sodium-chloride cotransporter.
Volume: 306
Issue: 5
Pages: F525-33
Publication
First Author: Hoorn EJ
Year: 2011
Journal: Nat Med
Title: The calcineurin inhibitor tacrolimus activates the renal sodium chloride cotransporter to cause hypertension.
Volume: 17
Issue: 10
Pages: 1304-9
Publication
First Author: Loffing J
Year: 2004
Journal: J Am Soc Nephrol
Title: Altered renal distal tubule structure and renal Na(+) and Ca(2+) handling in a mouse model for Gitelman's syndrome.
Volume: 15
Issue: 9
Pages: 2276-88
Publication
First Author: Needham PG
Year: 2011
Journal: J Biol Chem
Title: The thiazide-sensitive NaCl cotransporter is targeted for chaperone-dependent endoplasmic reticulum-associated degradation.
Volume: 286
Issue: 51
Pages: 43611-21
Publication
First Author: Ko B
Year: 2012
Journal: Am J Physiol Renal Physiol
Title: A new model of the distal convoluted tubule.
Volume: 303
Issue: 5
Pages: F700-10
Publication
First Author: Wu G
Year: 2013
Journal: FEBS Lett
Title: Disease-causing mutations in KLHL3 impair its effect on WNK4 degradation.
Volume: 587
Issue: 12
Pages: 1717-22
GXD Expression      
Probe: MGI:5473385
Assay Type: Western blot
Annotation Date: 2013-04-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5475518
Age: postnatal
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:5473385
Assay Type: Western blot
Annotation Date: 2013-04-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5475518
Age: postnatal
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:5473385
Assay Type: Western blot
Annotation Date: 2013-04-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5475518
Age: postnatal
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:5473385
Assay Type: Western blot
Annotation Date: 2013-04-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5475518
Age: postnatal
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:5473385
Assay Type: Western blot
Annotation Date: 2013-04-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5475518
Age: postnatal
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:5473385
Assay Type: Western blot
Annotation Date: 2013-04-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5475518
Age: postnatal
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:5473385
Assay Type: Western blot
Annotation Date: 2013-04-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5475518
Age: postnatal
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:5473385
Assay Type: Western blot
Annotation Date: 2013-04-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5475518
Age: postnatal
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:5473385
Assay Type: Western blot
Annotation Date: 2013-04-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5475518
Age: postnatal
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5472007
Assay Type: Western blot
Annotation Date: 2013-04-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5473282
Age: postnatal
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:5472007
Assay Type: Western blot
Annotation Date: 2013-04-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5473282
Age: postnatal
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:5472007
Assay Type: Western blot
Annotation Date: 2013-04-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5473282
Age: postnatal
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:5472007
Assay Type: Western blot
Annotation Date: 2013-04-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5473282
Age: postnatal
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:5472007
Assay Type: Western blot
Annotation Date: 2013-04-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5473282
Age: postnatal
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:5472007
Assay Type: Western blot
Annotation Date: 2013-04-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5473282
Age: postnatal
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:5472007
Assay Type: Western blot
Annotation Date: 2013-04-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5473282
Age: postnatal
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:5472007
Assay Type: Western blot
Annotation Date: 2013-04-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5473282
Age: postnatal
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:5472007
Assay Type: Western blot
Annotation Date: 2013-04-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5473282
Age: postnatal
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5309808
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876922
Stage: TS22
Assay Id: MGI:5423134
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5298987
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876922
Stage: TS22
Assay Id: MGI:5422751
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309808
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1753622
Stage: TS22
Assay Id: MGI:5423134
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5298987
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1753622
Stage: TS22
Assay Id: MGI:5422751
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309808
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610522
Stage: TS22
Assay Id: MGI:5423134
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5298987
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610522
Stage: TS22
Assay Id: MGI:5422751
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309808
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3274322
Stage: TS22
Assay Id: MGI:5423134
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5298987
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3274322
Stage: TS22
Assay Id: MGI:5422751
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309808
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1672722
Stage: TS22
Assay Id: MGI:5423134
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5298987
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1672722
Stage: TS22
Assay Id: MGI:5422751
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5298987
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2768126
Stage: TS26
Assay Id: MGI:5542972
Age: embryonic day 17.5
Image: GUDMAP:14470
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5298987
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2813628
Stage: TS28
Assay Id: MGI:5542972
Age: postnatal day 84
Image: GUDMAP:14471
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:5309808
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1647022
Stage: TS22
Assay Id: MGI:5423134
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5298987
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1647022
Stage: TS22
Assay Id: MGI:5422751
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309808
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684622
Stage: TS22
Assay Id: MGI:5423134
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5298987
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684622
Stage: TS22
Assay Id: MGI:5422751
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5309808
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3272922
Stage: TS22
Assay Id: MGI:5423134
Age: embryonic day 14.5
Note: Expression was not detected in the skeleton (limbs, shoulder, hip).
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5298987
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3272922
Stage: TS22
Assay Id: MGI:5422751
Age: embryonic day 14.5
Note: Expression was not detected in the skeleton (limbs, shoulder, hip).
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5298987
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2836428
Stage: TS28
Assay Id: MGI:5542972
Age: postnatal day 84
Image: GUDMAP:14471
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:5309808
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1781522
Stage: TS22
Assay Id: MGI:5423134
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5298987
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1781522
Stage: TS22
Assay Id: MGI:5422751
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:4849491
Assay Type: RNA in situ
Annotation Date: 2010-12-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2852727
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:4849490
Age: postnatal day 1
Image: 4M
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4849491
Assay Type: RNA in situ
Annotation Date: 2010-12-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2852723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:4849490
Age: embryonic day 15.5
Image: 4E
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5309808
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3276322
Stage: TS22
Assay Id: MGI:5423134
Age: embryonic day 14.5
Note: Expression was not detected in the face/soft tissues.
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5298987
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3276322
Stage: TS22
Assay Id: MGI:5422751
Age: embryonic day 14.5
Note: Expression was not detected in the face/soft tissues.
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5298987
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:1867628
Stage: TS28
Assay Id: MGI:5542972
Age: postnatal day 84
Image: GUDMAP:14471
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:5298987
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1867626
Stage: TS26
Assay Id: MGI:5542972
Age: embryonic day 17.5
Image: GUDMAP:14470
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309808
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1619422
Stage: TS22
Assay Id: MGI:5423134
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5298987
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1619422
Stage: TS22
Assay Id: MGI:5422751
Age: embryonic day 14.5
Detected: false
Specimen Num: 1