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Search results 1 to 100 out of 130 for Slc12a6

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
9990 | SLC12A6
Type: gene
Organism: human
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Gene
780031 | slc12a6
Type: gene
Organism: frog, western clawed
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Gene
691209 | Slc12a6
Type: gene
Organism: rat
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Gene
478239 | SLC12A6
Type: gene
Organism: dog, domestic
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Gene
750207 | SLC12A6
Type: gene
Organism: chimpanzee
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Gene
521217 | SLC12A6
Type: gene
Organism: cattle
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Gene
100330290 | slc12a6
Type: gene
Organism: zebrafish
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Gene
697536 | SLC12A6
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:2135960 | Slc12a6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q6P6P5
Organism: Mus musculus/domesticus
Length: 1106  
Fragment?: false
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Publication
18343091 | J:136097
First Author: Jiao Y
Year: 2008
Journal: Genomics
Title: A deletion mutation in Slc12a6 is associated with neuromuscular disease in gaxp mice.
Volume: 91
Issue: 5
Pages: 407-14
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Publication
12368912 | J:79870
First Author: Howard HC
Year: 2002
Journal: Nat Genet
Title: The K-Cl cotransporter KCC3 is mutant in a severe peripheral neuropathy associated with agenesis of the corpus callosum.
Volume: 32
Issue: 3
Pages: 384-92
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Publication
20549748 | J:167273
First Author: Sun YT
Year: 2010
Journal: Glia
Title: Deficiency of electroneutral K+-Cl- cotransporter 3 causes a disruption in impulse propagation along peripheral nerves.
Volume: 58
Issue: 13
Pages: 1544-52
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Publication
16048901 | J:175181
First Author: Mercado A
Year: 2005
Journal: Am J Physiol Renal Physiol
Title: NH2-terminal heterogeneity in the KCC3 K+-Cl- cotransporter.
Volume: 289
Issue: 6
Pages: F1246-61
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Publication
25116249 | J:217087
 
First Author: Ding J
Year: 2014
Journal: Behav Brain Res
Title: Deletion of KCC3 in parvalbumin neurons leads to locomotor deficit in a conditional mouse model of peripheral neuropathy associated with agenesis of the corpus callosum.
Volume: 274
Pages: 128-36
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Publication
22423107 | J:183239
First Author: Shekarabi M
Year: 2012
Journal: J Neurosci
Title: Loss of neuronal potassium/chloride cotransporter 3 (KCC3) is responsible for the degenerative phenotype in a conditional mouse model of hereditary motor and sensory neuropathy associated with agenesis of the corpus callosum.
Volume: 32
Issue: 11
Pages: 3865-76
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Protein Coding Gene
MGP_CAROLIEiJ_G0024088 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0026287 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0026248 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0026227 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0026261 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0026006 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2135960 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0026708 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0025469 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0025983 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0026122 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0026084 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0026223 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0026103 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0026763 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0025205 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0025538 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0025531 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0025004 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
11246162 | J:76182
First Author: Pearson MM
Year: 2001
Journal: Neuroscience
Title: Localization of the K(+)-Cl(-) cotransporter, KCC3, in the central and peripheral nervous systems: expression in the choroid plexus, large neurons and white matter tracts.
Volume: 103
Issue: 2
Pages: 481-91
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Publication
27568057 | J:238231
 
First Author: Sun YT
Year: 2016
Journal: Neuroscience
Title: KCC3 deficiency-induced disruption of paranodal loops and impairment of axonal excitability in the peripheral nervous system.
Volume: 335
Pages: 91-102
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Publication
22526882 | J:200061
First Author: Sun YT
Year: 2012
Journal: J Physiol
Title: K⁺-Cl⁻ cotransport mediates the bactericidal activity of neutrophils by regulating NADPH oxidase activation.
Volume: 590
Issue: 14
Pages: 3231-43
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Publication
22609694 | J:203167
First Author: Lucas O
Year: 2012
Journal: Mol Cell Neurosci
Title: KCC3-dependent chloride extrusion in adult sensory neurons.
Volume: 50
Issue: 3-4
Pages: 211-20
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Publication
17659877 | J:134838
First Author: Byun N
Year: 2007
Journal: Neurobiol Dis
Title: Axonal and periaxonal swelling precede peripheral neurodegeneration in KCC3 knockout mice.
Volume: 28
Issue: 1
Pages: 39-51
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Publication
32506846 | J:358274
First Author: Flores B
Year: 2020
Journal: Cell Physiol Biochem
Title: Osmotic Response of Dorsal Root Ganglion Neurons Expressing Wild-Type and Mutant KCC3 Transporters.
Volume: 54
Issue: 4
Pages: 577-590
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Publication
35874803 | J:327440
 
First Author: Ferdaus MZ
Year: 2022
Journal: Front Cell Dev Biol
Title: KCC3a, a Strong Candidate Pathway for K+ Loss in Alkalemia.
Volume: 10
Pages: 931326
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Publication
- | J:82451
     
First Author: Harris BS
Year: 2003
Journal: MGI Direct Data Submission
Title: Giant axonopathy(gaxp), a new spontaneous neuromuscular mutation on Chromosome 2 in the mouse. Mouse Mutant Resources Web Site, The Jackson Laboratory, Bar Harbor, Maine
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Publication
16424367 | J:118876
First Author: Rust MB
Year: 2006
Journal: Circ Res
Title: Neurogenic mechanisms contribute to hypertension in mice with disruption of the K-Cl cotransporter KCC3.
Volume: 98
Issue: 4
Pages: 549-56
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Publication
27166674 | J:248818
First Author: Garneau AP
Year: 2016
Journal: PLoS One
Title: Ablation of Potassium-Chloride Cotransporter Type 3 (Kcc3) in Mouse Causes Multiple Cardiovascular Defects and Isosmotic Polyuria.
Volume: 11
Issue: 5
Pages: e0154398
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Publication
27485015 | J:259728
First Author: Kahle KT
Year: 2016
Journal: Sci Signal
Title: Peripheral motor neuropathy is associated with defective kinase regulation of the KCC3 cotransporter.
Volume: 9
Issue: 439
Pages: ra77
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Publication
31649201 | J:335671
First Author: Liu S
Year: 2019
Journal: Science
Title: Cryo-EM structures of the human cation-chloride cotransporter KCC1.
Volume: 366
Issue: 6464
Pages: 505-508
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Publication
23593405 | J:200577
First Author: Ding J
Year: 2013
Journal: PLoS One
Title: A trafficking-deficient mutant of KCC3 reveals dominant-negative effects on K-Cl cotransport function.
Volume: 8
Issue: 4
Pages: e61112
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Publication
33596149 | J:316799
First Author: Flores B
Year: 2021
Journal: Am J Physiol Cell Physiol
Title: Temporal manipulation of KCC3 expression in juvenile or adult mice suggests irreversible developmental deficit in hereditary motor sensory neuropathy with agenesis of the corpus callosum.
Volume: 320
Issue: 5
Pages: C722-C730
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GXD Expression
GXD Expression
 
Probe: MGI:4425538
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1760623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828096
Age: embryonic day 14.5
Image: euxassay_016520_10
Specimen Label: euxassay_016520_10
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4425538
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1760623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828096
Age: embryonic day 14.5
Image: euxassay_016520_11
Specimen Label: euxassay_016520_11
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4425538
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1760623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828096
Age: embryonic day 14.5
Image: euxassay_016520_12
Specimen Label: euxassay_016520_12
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:4425538
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1760623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828096
Age: embryonic day 14.5
Image: euxassay_016520_13
Specimen Label: euxassay_016520_13
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:4425538
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1760623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828096
Age: embryonic day 14.5
Image: euxassay_016520_14
Specimen Label: euxassay_016520_14
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:4425538
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1760623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828096
Age: embryonic day 14.5
Image: euxassay_016520_15
Specimen Label: euxassay_016520_15
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:4425538
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1760623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828096
Age: embryonic day 14.5
Image: euxassay_016520_16
Specimen Label: euxassay_016520_16
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:4425538
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1760623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828096
Age: embryonic day 14.5
Image: euxassay_016520_18
Specimen Label: euxassay_016520_18
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
 
Probe: MGI:4425538
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1760623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828096
Age: embryonic day 14.5
Image: euxassay_016520_19
Specimen Label: euxassay_016520_19
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
   
Probe: MGI:7529683
Assay Type: RNA in situ
Annotation Date: 2023-09-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1666720
Pattern: Diffuse
Stage: TS20
Assay Id: MGI:7529691
Age: embryonic day 12.5
Specimen Label: 2C
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4425538
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828096
Age: embryonic day 14.5
Image: euxassay_016520_10
Specimen Label: euxassay_016520_10
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4425538
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828096
Age: embryonic day 14.5
Image: euxassay_016520_11
Specimen Label: euxassay_016520_11
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4425538
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828096
Age: embryonic day 14.5
Image: euxassay_016520_12
Specimen Label: euxassay_016520_12
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:4425538
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828096
Age: embryonic day 14.5
Image: euxassay_016520_17
Specimen Label: euxassay_016520_17
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
 
Probe: MGI:4425538
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828096
Age: embryonic day 14.5
Image: euxassay_016520_18
Specimen Label: euxassay_016520_18
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
 
Probe: MGI:4425538
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828096
Age: embryonic day 14.5
Image: euxassay_016520_19
Specimen Label: euxassay_016520_19
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
 
Probe: MGI:4425538
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828096
Age: embryonic day 14.5
Image: euxassay_016520_20
Specimen Label: euxassay_016520_20
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
 
Probe: MGI:4425538
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828096
Age: embryonic day 14.5
Image: euxassay_016520_21
Specimen Label: euxassay_016520_21
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
Probe: MGI:6435197
Assay Type: Immunohistochemistry
Annotation Date: 2020-06-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3579828
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6436289
Age: postnatal day 21
Image: 5I
Note: Expression was detected in type I, III and V fibrocytes.
Specimen Label: 5I
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4425538
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1761223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828096
Age: embryonic day 14.5
Image: euxassay_016520_13
Specimen Label: euxassay_016520_13
Detected: true
Specimen Num: 4
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•
GXD Expression
GXD Expression
   
Probe: MGI:7529683
Assay Type: RNA in situ
Annotation Date: 2023-09-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757720
Pattern: Diffuse
Stage: TS20
Assay Id: MGI:7529691
Age: embryonic day 12.5
Specimen Label: 2C
Detected: true
Specimen Num: 1
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•
GXD Expression
GXD Expression
 
Probe: MGI:7529683
Assay Type: RNA in situ
Annotation Date: 2023-09-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757726
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:7529691
Age: embryonic day 18.5
Note: Decreased expression compared with that of E12.5.
Specimen Label: 2H
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:7529683
Assay Type: RNA in situ
Annotation Date: 2023-09-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757726
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:7529691
Age: embryonic day 18.5
Note: Similar as in the wild-type.
Specimen Label: not shown
Detected: true
Specimen Num: 3
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Publication
10347194 | J:55435
First Author: Mount DB
Year: 1999
Journal: J Biol Chem
Title: Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family.
Volume: 274
Issue: 23
Pages: 16355-62
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Publication
17510708 | J:122087
First Author: Rust MB
Year: 2007
Journal: J Clin Invest
Title: Disruption of erythroid K-Cl cotransporters alters erythrocyte volume and partially rescues erythrocyte dehydration in SAD mice.
Volume: 117
Issue: 6
Pages: 1708-17
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Publication
18566107 | J:138272
First Author: Salin-Cantegrel A
Year: 2008
Journal: Hum Mol Genet
Title: HMSN/ACC truncation mutations disrupt brain-type creatine kinase-dependant activation of K+/Cl- co-transporter 3.
Volume: 17
Issue: 17
Pages: 2703-11
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Publication
34858138 | J:315133
 
First Author: Lim WM
Year: 2021
Journal: Front Mol Neurosci
Title: WNK3 Maintains the GABAergic Inhibitory Tone, Synaptic Excitation and Neuronal Excitability via Regulation of KCC2 Cotransporter in Mature Neurons.
Volume: 14
Pages: 762142
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Publication
31352162 | J:291471
 
First Author: Shmukler BE
Year: 2019
Journal: Blood Cells Mol Dis
Title: Combined genetic disruption of K-Cl cotransporters and Gardos channel KCNN4 rescues erythrocyte dehydration in the SAD mouse model of sickle cell disease.
Volume: 79
Pages: 102346
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Publication
35274823 | J:322288
First Author: Shmukler BE
Year: 2022
Journal: Physiol Rep
Title: Erythroid-specific inactivation of Slc12a6/Kcc3 by EpoR promoter-driven Cre expression reduces K-Cl cotransport activity in mouse erythrocytes.
Volume: 10
Issue: 5
Pages: e15186
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Publication
21733850 | J:176623
First Author: Pan D
Year: 2011
Journal: J Biol Chem
Title: K-Cl cotransporter gene expression during human and murine erythroid differentiation.
Volume: 286
Issue: 35
Pages: 30492-503
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Publication
24089410 | J:202948
First Author: Melo Z
Year: 2013
Journal: Am J Physiol Renal Physiol
Title: Molecular evidence for a role for K(+)-Cl(-) cotransporters in the kidney.
Volume: 305
Issue: 10
Pages: F1402-11
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Publication
22252133 | J:181930
First Author: Seja P
Year: 2012
Journal: EMBO J
Title: Raising cytosolic Cl- in cerebellar granule cells affects their excitability and vestibulo-ocular learning.
Volume: 31
Issue: 5
Pages: 1217-30
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Publication
12386165 | J:80982
First Author: Piechotta K
Year: 2002
Journal: J Biol Chem
Title: Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1).
Volume: 277
Issue: 52
Pages: 50812-9
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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