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Search results 1 to 100 out of 316 for Slc23a2

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0.068s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Domain
Type: Family
Description: In mammals, L-ascorbic acid (vitamin C) enters cells via Na+-dependent transporters SVCT1 (solute carrier family 23 member 1, SLC23A1) and SVCT2 (solute carrier family 23 member 1, SLC23A2). Both proteins are predicted to contain 12 potential transmembrane (TM) domains with N- and C-termini on the cytoplasmic side of the membrane. Both isoforms have Na+:ascorbic acid stoichiometry of 2:1. SVCT2 may exhibit a higher affinity for ascorbic acid than SVCT1, but with a lower maximum velocity. SVCT1 is present in epithelial tissues, whereas SVCT2 is present in most tissues with the exception of lung and skeletal muscle []. SVCT1 is involved in whole-body homeostasis of vitamin C, while SVCT2 protects metabolicallyactive cells against oxidative stress [].This entry represents SVCT2 (SLC23A2).
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Publication  
First Author: Cao B
Year: 2023
Journal: Neuroscience
Title: Construction of a Brain-specific SLC23A2 Gene Knockout Mice Model.
Volume: 524
Pages: 137-148
Publication
First Author: Eck PK
Year: 2017
Journal: Biochem Cell Biol
Title: Temporo-spacial microanatomical distribution of the murine sodium-dependent ascorbic acid transporters Slc23a1 and Slc23a2 in the kidney throughout development.
Volume: 95
Issue: 3
Pages: 421-427
Protein
Organism: Mus musculus/domesticus
Length: 648  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 214  
Fragment?: true
Publication
First Author: Liang WJ
Year: 2001
Journal: Mol Membr Biol
Title: Vitamin C transport systems of mammalian cells.
Volume: 18
Issue: 1
Pages: 87-95
Publication
First Author: Savini I
Year: 2008
Journal: Amino Acids
Title: SVCT1 and SVCT2: key proteins for vitamin C uptake.
Volume: 34
Issue: 3
Pages: 347-55
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Gispert S
Year: 2000
Journal: DNA Res
Title: Cloning and genomic organization of the mouse gene slc23a1 encoding a vitamin C transporter.
Volume: 7
Issue: 6
Pages: 339-45
Publication
First Author: Salazar K
Year: 2014
Journal: J Neurochem
Title: SVCT2 transporter expression is post-natally induced in cortical neurons and its function is regulated by its short isoform.
Volume: 130
Issue: 5
Pages: 693-706
Publication
First Author: Röhr D
Year: 2017
Journal: Glia
Title: Sodium-dependent Vitamin C transporter 2 deficiency impairs myelination and remyelination after injury: Roles of collagen and demethylation.
Volume: 65
Issue: 7
Pages: 1186-1200
Publication
First Author: Boyer JC
Year: 2005
Journal: Biochem Biophys Res Commun
Title: Polarized localization of vitamin C transporters, SVCT1 and SVCT2, in epithelial cells.
Volume: 334
Issue: 1
Pages: 150-6
Publication
First Author: Babaev VR
Year: 2011
Journal: Free Radic Biol Med
Title: Selective macrophage ascorbate deficiency suppresses early atherosclerosis.
Volume: 50
Issue: 1
Pages: 27-36
Publication
First Author: Bornstein SR
Year: 2003
Journal: FASEB J
Title: Impaired adrenal catecholamine system function in mice with deficiency of the ascorbic acid transporter (SVCT2).
Volume: 17
Issue: 13
Pages: 1928-30
Publication
First Author: Gess B
Year: 2011
Journal: J Neurosci
Title: Sodium-dependent vitamin C transporter 2 deficiency causes hypomyelination and extracellular matrix defects in the peripheral nervous system.
Volume: 31
Issue: 47
Pages: 17180-92
Publication
First Author: Harrison FE
Year: 2010
Journal: Free Radic Biol Med
Title: Low vitamin C and increased oxidative stress and cell death in mice that lack the sodium-dependent vitamin C transporter SVCT2.
Volume: 49
Issue: 5
Pages: 821-9
Publication
First Author: Daruwala R
Year: 1999
Journal: FEBS Lett
Title: Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2.
Volume: 460
Issue: 3
Pages: 480-4
Publication
First Author: Rajan DP
Year: 1999
Journal: Biochem Biophys Res Commun
Title: Human placental sodium-dependent vitamin C transporter (SVCT2): molecular cloning and transport function.
Volume: 262
Issue: 3
Pages: 762-8
Publication
First Author: Fan X
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Vitamin C mediates chemical aging of lens crystallins by the Maillard reaction in a humanized mouse model.
Volume: 103
Issue: 45
Pages: 16912-7
Publication  
First Author: Qiao H
Year: 2008
Journal: Brain Res
Title: Development of ascorbate transporters in brain cortical capillary endothelial cells in culture.
Volume: 1208
Pages: 79-86
Publication
First Author: Chi X
Year: 2009
Journal: Arch Biochem Biophys
Title: Oxidized lipoprotein induces the macrophage ascorbate transporter (SVCT2): protection by intracellular ascorbate against oxidant stress and apoptosis.
Volume: 485
Issue: 2
Pages: 174-82
Publication  
First Author: Sangani R
Year: 2015
Journal: Mol Cell Endocrinol
Title: MicroRNAs-141 and 200a regulate the SVCT2 transporter in bone marrow stromal cells.
Volume: 410
Pages: 19-26
Publication
First Author: Pierce MR
Year: 2015
Journal: J Neurosci Res
Title: Sodium-dependent vitamin C transporter-2 mediates vitamin C transport at the cortical nerve terminal.
Volume: 93
Issue: 12
Pages: 1881-90
Publication  
First Author: Fan X
Year: 2020
Journal: Aging Cell
Title: Vitamin C is a source of oxoaldehyde and glycative stress in age-related cataract and neurodegenerative diseases.
Volume: 19
Issue: 7
GXD Expression      
Probe: MGI:6726082
Assay Type: RT-PCR
Annotation Date: 2021-07-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:6726125
Age: postnatal adult
Specimen Label: mK
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6726082
Assay Type: RT-PCR
Annotation Date: 2021-07-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737326
Stage: TS26
Assay Id: MGI:6726125
Age: embryonic day 19.0
Specimen Label: E19
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:6726082
Assay Type: RT-PCR
Annotation Date: 2021-07-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737325
Stage: TS25
Assay Id: MGI:6726125
Age: embryonic day 17.0
Specimen Label: E17
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:6726082
Assay Type: RT-PCR
Annotation Date: 2021-07-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737323
Stage: TS23
Assay Id: MGI:6726125
Age: embryonic day 15.0
Specimen Label: E15
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:6726082
Assay Type: RT-PCR
Annotation Date: 2021-07-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737327
Stage: TS27
Assay Id: MGI:6726126
Age: postnatal day 1
Specimen Label: P1
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6726082
Assay Type: RT-PCR
Annotation Date: 2021-07-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:6726126
Age: postnatal day 5
Specimen Label: P5
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6726082
Assay Type: RT-PCR
Annotation Date: 2021-07-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:6726126
Age: postnatal day 10
Specimen Label: P10
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:6726082
Assay Type: RT-PCR
Annotation Date: 2021-07-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:6726126
Age: postnatal day 15
Specimen Label: P15
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:6726082
Assay Type: RT-PCR
Annotation Date: 2021-07-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:6726126
Age: postnatal adult
Specimen Label: mK
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:7516373
Assay Type: RT-PCR
Annotation Date: 2023-08-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778723
Stage: TS23
Assay Id: MGI:7516378
Age: embryonic day 15.5
Specimen Label: E15.5
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7516373
Assay Type: RT-PCR
Annotation Date: 2023-08-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778726
Stage: TS26
Assay Id: MGI:7516378
Age: embryonic day 18.5
Specimen Label: E18.5
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:7516373
Assay Type: RT-PCR
Annotation Date: 2023-08-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778727
Stage: TS27
Assay Id: MGI:7516378
Age: postnatal day 1
Specimen Label: P1
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:7516373
Assay Type: RT-PCR
Annotation Date: 2023-08-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:7516378
Age: postnatal day 10
Specimen Label: P10
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:7516373
Assay Type: RT-PCR
Annotation Date: 2023-08-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:7516378
Age: postnatal day 18
Specimen Label: P18
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:7516373
Assay Type: RT-PCR
Annotation Date: 2023-08-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:7516378
Age: postnatal day 32
Specimen Label: P32
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:7516375
Assay Type: Western blot
Annotation Date: 2023-08-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778723
Stage: TS23
Assay Id: MGI:7516381
Age: embryonic day 15.5
Specimen Label: E15.5
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7516375
Assay Type: Western blot
Annotation Date: 2023-08-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778726
Stage: TS26
Assay Id: MGI:7516381
Age: embryonic day 18.5
Specimen Label: E18.5
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:7516375
Assay Type: Western blot
Annotation Date: 2023-08-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778727
Stage: TS27
Assay Id: MGI:7516381
Age: postnatal day 1
Specimen Label: P1
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:7516375
Assay Type: Western blot
Annotation Date: 2023-08-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:7516381
Age: postnatal day 10
Specimen Label: P10
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:7516375
Assay Type: Western blot
Annotation Date: 2023-08-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:7516381
Age: postnatal day 18
Specimen Label: P18
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:7516375
Assay Type: Western blot
Annotation Date: 2023-08-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:7516381
Age: postnatal day 32
Specimen Label: P32
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:6726082
Assay Type: RT-PCR
Annotation Date: 2023-08-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754421
Stage: TS21
Assay Id: MGI:7516166
Age: embryonic day 13.0
Specimen Label: 2
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6726082
Assay Type: RT-PCR
Annotation Date: 2023-08-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754423
Stage: TS23
Assay Id: MGI:7516166
Age: embryonic day 15.0
Specimen Label: 3
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:6726082
Assay Type: RT-PCR
Annotation Date: 2023-08-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754425
Stage: TS25
Assay Id: MGI:7516166
Age: embryonic day 17.0
Specimen Label: 4
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:6726082
Assay Type: RT-PCR
Annotation Date: 2023-08-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754426
Stage: TS26
Assay Id: MGI:7516166
Age: embryonic day 19.0
Specimen Label: 5
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:6726082
Assay Type: RT-PCR
Annotation Date: 2023-08-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:7516166
Age: postnatal adult
Specimen Label: 6
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:6726082
Assay Type: RT-PCR
Annotation Date: 2023-08-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754420
Stage: TS20
Assay Id: MGI:7516167
Age: embryonic day 12.0
Specimen Label: E12
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6726082
Assay Type: RT-PCR
Annotation Date: 2023-08-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754422
Stage: TS22
Assay Id: MGI:7516167
Age: embryonic day 14.0
Specimen Label: E14
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6726082
Assay Type: RT-PCR
Annotation Date: 2023-08-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754425
Stage: TS25
Assay Id: MGI:7516167
Age: embryonic day 17.0
Specimen Label: E17
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6726088
Assay Type: Western blot
Annotation Date: 2023-08-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754421
Stage: TS21
Assay Id: MGI:7516172
Age: embryonic day 13.0
Specimen Label: E13
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6726088
Assay Type: Western blot
Annotation Date: 2023-08-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754423
Stage: TS23
Assay Id: MGI:7516172
Age: embryonic day 15.0
Specimen Label: E15
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6726088
Assay Type: Western blot
Annotation Date: 2023-08-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754425
Stage: TS25
Assay Id: MGI:7516172
Age: embryonic day 17.0
Specimen Label: E17
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6726088
Assay Type: Western blot
Annotation Date: 2023-08-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754426
Stage: TS26
Assay Id: MGI:7516172
Age: embryonic day 19.0
Specimen Label: E19
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:6726088
Assay Type: Western blot
Annotation Date: 2023-08-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:7516172
Age: postnatal adult
Specimen Label: Adults
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:6726082
Assay Type: RT-PCR
Annotation Date: 2023-08-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754425
Stage: TS25
Assay Id: MGI:7516184
Age: embryonic day 17.0
Specimen Label: CC mouse E17
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6726088
Assay Type: Western blot
Annotation Date: 2023-08-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:7516185
Age: postnatal adult
Specimen Label: CC Adults
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7516373
Assay Type: RT-PCR
Annotation Date: 2023-08-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754423
Stage: TS23
Assay Id: MGI:7516377
Age: embryonic day 15.5
Specimen Label: E15.5
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7516373
Assay Type: RT-PCR
Annotation Date: 2023-08-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754426
Stage: TS26
Assay Id: MGI:7516377
Age: embryonic day 18.5
Specimen Label: E18.5
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:7516373
Assay Type: RT-PCR
Annotation Date: 2023-08-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754427
Stage: TS27
Assay Id: MGI:7516377
Age: postnatal day 1
Specimen Label: P1
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:7516373
Assay Type: RT-PCR
Annotation Date: 2023-08-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:7516377
Age: postnatal day 10
Specimen Label: P10
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:7516373
Assay Type: RT-PCR
Annotation Date: 2023-08-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:7516377
Age: postnatal day 18
Specimen Label: P18
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:7516373
Assay Type: RT-PCR
Annotation Date: 2023-08-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:7516377
Age: postnatal day 32
Specimen Label: P32
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:7516375
Assay Type: Western blot
Annotation Date: 2023-08-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754423
Stage: TS23
Assay Id: MGI:7516380
Age: embryonic day 15.5
Specimen Label: E15.5
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7516375
Assay Type: Western blot
Annotation Date: 2023-08-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754426
Stage: TS26
Assay Id: MGI:7516380
Age: embryonic day 18.5
Specimen Label: E18.5
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:7516375
Assay Type: Western blot
Annotation Date: 2023-08-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754427
Stage: TS27
Assay Id: MGI:7516380
Age: postnatal day 1
Specimen Label: P1
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:7516375
Assay Type: Western blot
Annotation Date: 2023-08-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:7516380
Age: postnatal day 10
Specimen Label: P10
Detected: true
Specimen Num: 4