Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Retinal rod and cone photoreceptors express two distinct sodium/potassium/calcium exchanger (NCKX) gene products [, ]. Both the rod NCKX1 and cone NCKX2 are critical components of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness []. This entry represents NCKX2, also known as SLC24A2, which is found in cones, in retinal ganglion cells, and in various parts of the brain [, ]. Both NCKX1 and NCKX2 transport 1 Ca2+ and 1 K+ in exchange for 4 Na+. |
|
•
•
•
•
•
|
Publication |
First Author: |
Tsoi M |
Year: |
1998 |
Journal: |
J Biol Chem |
Title: |
Molecular cloning of a novel potassium-dependent sodium-calcium exchanger from rat brain. |
Volume: |
273 |
Issue: |
7 |
Pages: |
4155-62 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
666
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
168
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
449
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
394
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
299
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Kang K |
Year: |
2003 |
Journal: |
Biochemistry |
Title: |
Signal sequence cleavage and plasma membrane targeting of the retinal rod NCKX1 and cone NCKX2 Na+/Ca2+ - K+ exchangers. |
Volume: |
42 |
Issue: |
31 |
Pages: |
9438-45 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schnetkamp PP |
Year: |
2004 |
Journal: |
Pflugers Arch |
Title: |
The SLC24 Na+/Ca2+-K+ exchanger family: vision and beyond. |
Volume: |
447 |
Issue: |
5 |
Pages: |
683-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kinjo TG |
Year: |
2003 |
Journal: |
Biochemistry |
Title: |
Topology of the retinal cone NCKX2 Na/Ca-K exchanger. |
Volume: |
42 |
Issue: |
8 |
Pages: |
2485-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Paillart C |
Year: |
2007 |
Journal: |
J Gen Physiol |
Title: |
Functional characterization and molecular cloning of the K+-dependent Na+/Ca2+ exchanger in intact retinal cone photoreceptors. |
Volume: |
129 |
Issue: |
1 |
Pages: |
1-16 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang Y |
Year: |
2015 |
Journal: |
Neuroscience |
Title: |
Anatomical evidence for a non-synaptic influence of the K+ -dependent Na+/Ca2+ -exchanger, NCKX2, on hippocampal plasticity. |
Volume: |
310 |
|
Pages: |
372-88 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6865709 |
Assay Type: |
RT-PCR |
Annotation Date: |
2022-02-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3287128 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6865719 |
Age: |
postnatal month 1 |
Image: |
1 |
|
Specimen Label: |
epithelium |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6865709 |
Assay Type: |
RT-PCR |
Annotation Date: |
2022-02-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1784128 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6865719 |
Age: |
postnatal month 1 |
Image: |
1 |
|
Specimen Label: |
fibers |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6865709 |
Assay Type: |
RT-PCR |
Annotation Date: |
2022-02-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1783828 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6865726 |
Age: |
postnatal month 1 |
Image: |
1 |
|
Specimen Label: |
Slc24a4+/+ |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6865709 |
Assay Type: |
RT-PCR |
Annotation Date: |
2022-02-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1783828 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6865726 |
Age: |
postnatal month 1 |
Image: |
1 |
|
Specimen Label: |
Slc24a4-/- |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4424897 |
Assay Type: |
RNA in situ |
Annotation Date: |
2011-02-18 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603923 |
|
Stage: |
TS23 |
Assay Id: |
MGI:4888641 |
Age: |
embryonic day 14.5 |
Image: |
Table S1 |
|
Specimen Label: |
Table S1 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee KH |
Year: |
2012 |
Journal: |
J Neurosci |
Title: |
KIF21A-mediated axonal transport and selective endocytosis underlie the polarized targeting of NCKX2. |
Volume: |
32 |
Issue: |
12 |
Pages: |
4102-17 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ginger RS |
Year: |
2008 |
Journal: |
J Biol Chem |
Title: |
SLC24A5 encodes a trans-Golgi network protein with potassium-dependent sodium-calcium exchange activity that regulates human epidermal melanogenesis. |
Volume: |
283 |
Issue: |
9 |
Pages: |
5486-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vinberg F |
Year: |
2017 |
Journal: |
Elife |
Title: |
The Na+/Ca2+, K+ exchanger NCKX4 is required for efficient cone-mediated vision. |
Volume: |
6 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Li XF |
Year: |
2006 |
Journal: |
J Biol Chem |
Title: |
Importance of K+-dependent Na+/Ca2+-exchanger 2, NCKX2, in motor learning and memory. |
Volume: |
281 |
Issue: |
10 |
Pages: |
6273-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
De Maria A |
Year: |
2018 |
Journal: |
Exp Eye Res |
Title: |
Expression of potassium-dependent sodium-calcium exchanger in the murine lens. |
Volume: |
167 |
|
Pages: |
18-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pyrski M |
Year: |
2007 |
Journal: |
J Comp Neurol |
Title: |
Sodium/calcium exchanger expression in the mouse and rat olfactory systems. |
Volume: |
501 |
Issue: |
6 |
Pages: |
944-58 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ding Y |
Year: |
2022 |
Journal: |
Elife |
Title: |
A phenotype-based forward genetic screen identifies Dnajb6 as a sick sinus syndrome gene. |
Volume: |
11 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Larimore J |
Year: |
2017 |
Journal: |
Front Genet |
Title: |
Dysbindin Deficiency Modifies the Expression of GABA Neuron and Ion Permeation Transcripts in the Developing Hippocampus. |
Volume: |
8 |
|
Pages: |
28 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gómez-Del Arco P |
Year: |
2024 |
Journal: |
Nat Commun |
Title: |
The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and ventricular conduction system development. |
Volume: |
15 |
Issue: |
1 |
Pages: |
8602 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mammalian Functional Genomics Centre |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the NorCOMM project by the Mammalian Functional Genomics Centre (Mfgc), University of Manitoba |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2001 |
|
Title: |
RIKEN Data Curation in Mouse Genome Informatics |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Visel A |
Year: |
2004 |
Journal: |
Nucleic Acids Res |
Title: |
GenePaint.org: an atlas of gene expression patterns in the mouse embryo. |
Volume: |
32 |
Issue: |
Database issue |
Pages: |
D552-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2009 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
|
Title: |
Cyagen Biosciences Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|