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Search results 1 to 92 out of 92 for Slc26a3

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Domain
Type: Family
Description: SLC26A3 or DRA (Down Regulated in Adenoma) is a member of the solute carrier family 26 (SLC26) that plays a major role in mediating Cl-absorption in the intestine. DRA absorbs Cl- and exports HCO3-in the small intestine in a partly carbonic anhydrase II-dependent fashion []. DRA also contributes to sulfate secretion []. Deletion of DRA results in reduced colonic HCO3-secretion, loss of colonic fluid absorption, and a lack of adherent mucus layer []. Mutations in DRA cause congenital chloride diarrhea, characterised by chronic secretory diarrhea containing an excess of chloride [].DRA is also involved in sperm capacitation [, ].
Publication
First Author: Chávez JC
Year: 2012
Journal: Biol Reprod
Title: Participation of the Cl-/HCO(3)- exchangers SLC26A3 and SLC26A6, the Cl- channel CFTR, and the regulatory factor SLC9A3R1 in mouse sperm capacitation.
Volume: 86
Issue: 1
Pages: 1-14
Publication
First Author: Xia W
Year: 2014
Journal: Pflugers Arch
Title: The distinct roles of anion transporters Slc26a3 (DRA) and Slc26a6 (PAT-1) in fluid and electrolyte absorption in the murine small intestine.
Volume: 466
Issue: 8
Pages: 1541-56
Publication
First Author: Whittamore JM
Year: 2013
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Sulfate secretion and chloride absorption are mediated by the anion exchanger DRA (Slc26a3) in the mouse cecum.
Volume: 305
Issue: 2
Pages: G172-84
Protein
Organism: Mus musculus
Length: 301  
Fragment?: false
Protein
Organism: Mus musculus
Length: 211  
Fragment?: true
Publication
First Author: Anbazhagan AN
Year: 2014
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Translational repression of SLC26A3 by miR-494 in intestinal epithelial cells.
Volume: 306
Issue: 2
Pages: G123-31
Publication
First Author: Wedenoja S
Year: 2011
Journal: Hum Mutat
Title: Update on SLC26A3 mutations in congenital chloride diarrhea.
Volume: 32
Issue: 7
Pages: 715-22
Publication
First Author: Chatterjee I
Year: 2017
Journal: Am J Physiol Gastrointest Liver Physiol
Title: CDX2 upregulates SLC26A3 gene expression in intestinal epithelial cells.
Volume: 313
Issue: 3
Pages: G256-G264
Publication
First Author: Schweinfest CW
Year: 2006
Journal: J Biol Chem
Title: slc26a3 (dra)-deficient mice display chloride-losing diarrhea, enhanced colonic proliferation, and distinct up-regulation of ion transporters in the colon.
Volume: 281
Issue: 49
Pages: 37962-71
Publication
First Author: Borenshtein D
Year: 2009
Journal: Infect Immun
Title: Decreased expression of colonic Slc26a3 and carbonic anhydrase iv as a cause of fatal infectious diarrhea in mice.
Volume: 77
Issue: 9
Pages: 3639-50
Publication
First Author: Xiao F
Year: 2014
Journal: Acta Physiol (Oxf)
Title: Slc26a3 deficiency is associated with loss of colonic HCO3 (-) secretion, absence of a firm mucus layer and barrier impairment in mice.
Volume: 211
Issue: 1
Pages: 161-75
Publication
First Author: Alper SL
Year: 2011
Journal: Am J Physiol Cell Physiol
Title: Native and recombinant Slc26a3 (downregulated in adenoma, Dra) do not exhibit properties of 2Cl-/1HCO3- exchange.
Volume: 300
Issue: 2
Pages: C276-86
Publication
First Author: Chan HC
Year: 2014
Journal: Cell Biol Int
Title: SLC26 anion exchangers in uterine epithelial cells and spermatozoa: clues from the past and hints to the future.
Volume: 38
Issue: 1
Pages: 1-7
Protein
Organism: Mus musculus
Length: 58  
Fragment?: false
Protein
Organism: Mus musculus
Length: 235  
Fragment?: true
Protein
Organism: Mus musculus
Length: 757  
Fragment?: false
Publication
First Author: Freel RW
Year: 2013
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Transcellular oxalate and Cl- absorption in mouse intestine is mediated by the DRA anion exchanger Slc26a3, and DRA deletion decreases urinary oxalate.
Volume: 305
Issue: 7
Pages: G520-7
Publication
First Author: Ishiguro H
Year: 2007
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Effect of Slc26a6 deletion on apical Cl-/HCO3- exchanger activity and cAMP-stimulated bicarbonate secretion in pancreatic duct.
Volume: 292
Issue: 1
Pages: G447-55
Publication
First Author: Simpson JE
Year: 2007
Journal: Am J Physiol Gastrointest Liver Physiol
Title: PAT-1 (Slc26a6) is the predominant apical membrane Cl-/HCO3- exchanger in the upper villous epithelium of the murine duodenum.
Volume: 292
Issue: 4
Pages: G1079-88
Publication
First Author: Bhutia YD
Year: 2016
Journal: Biochem J
Title: SLC transporters as a novel class of tumour suppressors: identity, function and molecular mechanisms.
Volume: 473
Issue: 9
Pages: 1113-24
Publication
First Author: Singh AK
Year: 2010
Journal: Am J Physiol Cell Physiol
Title: The switch of intestinal Slc26 exchangers from anion absorptive to HCOFormula secretory mode is dependent on CFTR anion channel function.
Volume: 298
Issue: 5
Pages: C1057-65
Publication
First Author: Singh AK
Year: 2013
Journal: J Physiol
Title: Molecular transport machinery involved in orchestrating luminal acid-induced duodenal bicarbonate secretion in vivo.
Volume: 591
Issue: 21
Pages: 5377-91
Publication
First Author: Dawson PA
Year: 2012
Journal: Biol Reprod
Title: Placental, renal, and ileal sulfate transporter gene expression in mouse gestation.
Volume: 87
Issue: 2
Pages: 43
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Stephens CE
Year: 2019
Journal: Exp Physiol
Title: 125 Iodide as a surrogate tracer for epithelial chloride transport by the mouse large intestine in vitro.
Volume: 104
Issue: 3
Pages: 334-344
Publication
First Author: Kunieda T
Year: 2000
Journal: Exp Anim
Title: The down-regulated in adenoma (Dra) gene encoding intestine-specific anion transporter maps to mouse chromosome 12.
Volume: 49
Issue: 1
Pages: 67-8
Publication
First Author: Silberg DG
Year: 1995
Journal: J Biol Chem
Title: The Down regulated in Adenoma (dra) gene encodes an intestine-specific membrane sulfate transport protein.
Volume: 270
Issue: 20
Pages: 11897-902
Publication
First Author: Jacob P
Year: 2002
Journal: Gastroenterology
Title: Down-regulated in adenoma mediates apical Cl-/HCO3- exchange in rabbit, rat, and human duodenum.
Volume: 122
Issue: 3
Pages: 709-24
GXD Expression    
Probe: MGI:4425674
Assay Type: RNA in situ
Annotation Date: 2011-02-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:4888656
Age: embryonic day 14.5
Image: Table S1
Detected: false
Specimen Num: 1
Publication
First Author: Melvin JE
Year: 1999
Journal: J Biol Chem
Title: Mouse down-regulated in adenoma (DRA) is an intestinal Cl(-)/HCO(3)(-) exchanger and is up-regulated in colon of mice lacking the NHE3 Na(+)/H(+) exchanger.
Volume: 274
Issue: 32
Pages: 22855-61
Publication
First Author: Whittamore JM
Year: 2017
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Loss of the anion exchanger DRA (Slc26a3), or PAT1 (Slc26a6), alters sulfate transport by the distal ileum and overall sulfate homeostasis.
Volume: 313
Issue: 3
Pages: G166-G179
Publication
First Author: Song Y
Year: 2012
Journal: Am J Physiol Cell Physiol
Title: Deletion of Slc26a6 alters the stoichiometry of apical Cl-/HCO-3 exchange in mouse pancreatic duct.
Volume: 303
Issue: 8
Pages: C815-24
Publication
First Author: Walker NM
Year: 2008
Journal: Gastroenterology
Title: Down-regulated in adenoma Cl/HCO3 exchanger couples with Na/H exchanger 3 for NaCl absorption in murine small intestine.
Volume: 135
Issue: 5
Pages: 1645-1653.e3
Publication
First Author: Walker NM
Year: 2009
Journal: Gastroenterology
Title: Role of down-regulated in adenoma anion exchanger in HCO3- secretion across murine duodenum.
Volume: 136
Issue: 3
Pages: 893-901
Publication
First Author: Kratz CP
Year: 2001
Journal: Genomics
Title: Candidate gene isolation and comparative analysis of a commonly deleted segment of 7q22 implicated in myeloid malignancies.
Volume: 77
Issue: 3
Pages: 171-80
Publication
First Author: D'Angelo A
Year: 2010
Journal: Development
Title: Hepatocyte nuclear factor 1alpha and beta control terminal differentiation and cell fate commitment in the gut epithelium.
Volume: 137
Issue: 9
Pages: 1573-82
Publication
First Author: Zhao F
Year: 2017
Journal: Science
Title: Elimination of the male reproductive tract in the female embryo is promoted by COUP-TFII in mice.
Volume: 357
Issue: 6352
Pages: 717-720
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: RIKEN Data Curation in Mouse Genome Informatics
Publication
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication          
First Author: MGD Nomenclature Committee
Year: 1995
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics, the Protein Information Resource and the Protein Ontology Consortium
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Allele
Name: solute carrier family 26, member 3; targeted mutation 1, Manoocher Soleimani
Allele Type: Targeted
Attribute String: Null/knockout
Publication categories: ProxyCollection
Genotype
Symbol: Slc26a3/Slc26a3
Background: involves: 129S6/SvEvTac * C57BL/6
Zygosity: hm
Has Mutant Allele: true
DO Term
Publication
First Author: Shcheynikov N
Year: 2006
Journal: J Gen Physiol
Title: Coupling modes and stoichiometry of Cl-/HCO3- exchange by slc26a3 and slc26a6.
Volume: 127
Issue: 5
Pages: 511-24
Interaction Experiment
Description: Participation of the Cl-/HCO(3)- exchangers SLC26A3 and SLC26A6, the Cl- channel CFTR, and the regulatory factor SLC9A3R1 in mouse sperm capacitation.
Interaction Experiment
Description: Participation of the Cl-/HCO(3)- exchangers SLC26A3 and SLC26A6, the Cl- channel CFTR, and the regulatory factor SLC9A3R1 in mouse sperm capacitation.
Publication
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7