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Search results 1 to 100 out of 113 for Slc26a3

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
1811 | SLC26A3
Type: gene
Organism: human
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Gene
114629 | Slc26a3
Type: gene
Organism: rat
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Gene
483261 | SLC26A3
Type: gene
Organism: dog, domestic
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Gene
472483 | SLC26A3
Type: gene
Organism: chimpanzee
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Gene
512856 | SLC26A3
Type: gene
Organism: cattle
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Gene
417700 | SLC26A3
Type: gene
Organism: chicken
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Gene
701873 | SLC26A3
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:107181 | Slc26a3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR030321 | SLC26A3
Type: Family
Description: SLC26A3 or DRA (Down Regulated in Adenoma) is a member of the solute carrier family 26 (SLC26) that plays a major role in mediating Cl-absorption in the intestine. DRA absorbs Cl- and exports HCO3-in the small intestine in a partly carbonic anhydrase II-dependent fashion []. DRA also contributes to sulfate secretion []. Deletion of DRA results in reduced colonic HCO3-secretion, loss of colonic fluid absorption, and a lack of adherent mucus layer []. Mutations in DRA cause congenital chloride diarrhea, characterised by chronic secretory diarrhea containing an excess of chloride [].DRA is also involved in sperm capacitation [, ].
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Publication
21976599 | J:185780
First Author: Chávez JC
Year: 2012
Journal: Biol Reprod
Title: Participation of the Cl-/HCO(3)- exchangers SLC26A3 and SLC26A6, the Cl- channel CFTR, and the regulatory factor SLC9A3R1 in mouse sperm capacitation.
Volume: 86
Issue: 1
Pages: 1-14
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Publication
24233434 | J:243842
First Author: Xia W
Year: 2014
Journal: Pflugers Arch
Title: The distinct roles of anion transporters Slc26a3 (DRA) and Slc26a6 (PAT-1) in fluid and electrolyte absorption in the murine small intestine.
Volume: 466
Issue: 8
Pages: 1541-56
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Publication
23660504 | J:204021
First Author: Whittamore JM
Year: 2013
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Sulfate secretion and chloride absorption are mediated by the anion exchanger DRA (Slc26a3) in the mouse cecum.
Volume: 305
Issue: 2
Pages: G172-84
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Protein
Q8R224
Organism: Mus musculus/domesticus
Length: 211  
Fragment?: true
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Protein
Q8JZU8
Organism: Mus musculus/domesticus
Length: 301  
Fragment?: false
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Publication
22627094 | J:333132
First Author: Lee JH
Year: 2012
Journal: Cell Signal
Title: Regulation of SLC26A3 activity by NHERF4 PDZ-mediated interaction.
Volume: 24
Issue: 9
Pages: 1821-30
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Publication
21394828 | -
First Author: Wedenoja S
Year: 2011
Journal: Hum Mutat
Title: Update on SLC26A3 mutations in congenital chloride diarrhea.
Volume: 32
Issue: 7
Pages: 715-22
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Publication
24177028 | J:210909
First Author: Anbazhagan AN
Year: 2014
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Translational repression of SLC26A3 by miR-494 in intestinal epithelial cells.
Volume: 306
Issue: 2
Pages: G123-31
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Publication
28572085 | J:253734
First Author: Chatterjee I
Year: 2017
Journal: Am J Physiol Gastrointest Liver Physiol
Title: CDX2 upregulates SLC26A3 gene expression in intestinal epithelial cells.
Volume: 313
Issue: 3
Pages: G256-G264
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Publication
30118583 | J:307576
First Author: El Khouri E
Year: 2018
Journal: Mol Reprod Dev
Title: Slc26a3 deficiency is associated with epididymis dysplasia and impaired sperm fertilization potential in the mouse.
Volume: 85
Issue: 8-9
Pages: 682-695
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Publication
33189700 | J:313177
First Author: Kumar A
Year: 2021
Journal: Gastroenterology
Title: A Novel Role of SLC26A3 in the Maintenance of Intestinal Epithelial Barrier Integrity.
Volume: 160
Issue: 4
Pages: 1240-1255.e3
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Publication
17001077 | J:117587
First Author: Schweinfest CW
Year: 2006
Journal: J Biol Chem
Title: slc26a3 (dra)-deficient mice display chloride-losing diarrhea, enhanced colonic proliferation, and distinct up-regulation of ion transporters in the colon.
Volume: 281
Issue: 49
Pages: 37962-71
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Publication
24373192 | -
First Author: Xiao F
Year: 2014
Journal: Acta Physiol (Oxf)
Title: Slc26a3 deficiency is associated with loss of colonic HCO3 (-) secretion, absence of a firm mucus layer and barrier impairment in mice.
Volume: 211
Issue: 1
Pages: 161-75
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Publication
19546193 | J:152260
First Author: Borenshtein D
Year: 2009
Journal: Infect Immun
Title: Decreased expression of colonic Slc26a3 and carbonic anhydrase iv as a cause of fatal infectious diarrhea in mice.
Volume: 77
Issue: 9
Pages: 3639-50
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Publication
21068358 | J:168506
First Author: Alper SL
Year: 2011
Journal: Am J Physiol Cell Physiol
Title: Native and recombinant Slc26a3 (downregulated in adenoma, Dra) do not exhibit properties of 2Cl-/1HCO3- exchange.
Volume: 300
Issue: 2
Pages: C276-86
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Publication
24115633 | -
First Author: Chan HC
Year: 2014
Journal: Cell Biol Int
Title: SLC26 anion exchangers in uterine epithelial cells and spermatozoa: clues from the past and hints to the future.
Volume: 38
Issue: 1
Pages: 1-7
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Protein
E9QAZ3
Organism: Mus musculus/domesticus
Length: 235  
Fragment?: true
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Protein
Q9WVC8
Organism: Mus musculus/domesticus
Length: 757  
Fragment?: false
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Publication
23886857 | J:210569
First Author: Freel RW
Year: 2013
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Transcellular oxalate and Cl- absorption in mouse intestine is mediated by the DRA anion exchanger Slc26a3, and DRA deletion decreases urinary oxalate.
Volume: 305
Issue: 7
Pages: G520-7
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Publication
16901991 | J:120597
First Author: Ishiguro H
Year: 2007
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Effect of Slc26a6 deletion on apical Cl-/HCO3- exchanger activity and cAMP-stimulated bicarbonate secretion in pancreatic duct.
Volume: 292
Issue: 1
Pages: G447-55
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Publication
17170027 | J:121543
First Author: Simpson JE
Year: 2007
Journal: Am J Physiol Gastrointest Liver Physiol
Title: PAT-1 (Slc26a6) is the predominant apical membrane Cl-/HCO3- exchanger in the upper villous epithelium of the murine duodenum.
Volume: 292
Issue: 4
Pages: G1079-88
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Publication
27118869 | J:239473
First Author: Bhutia YD
Year: 2016
Journal: Biochem J
Title: SLC transporters as a novel class of tumour suppressors: identity, function and molecular mechanisms.
Volume: 473
Issue: 9
Pages: 1113-24
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Publication
20164375 | J:159251
First Author: Singh AK
Year: 2010
Journal: Am J Physiol Cell Physiol
Title: The switch of intestinal Slc26 exchangers from anion absorptive to HCOFormula secretory mode is dependent on CFTR anion channel function.
Volume: 298
Issue: 5
Pages: C1057-65
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Publication
20969732 | J:333128
First Author: Walker NM
Year: 2011
Journal: Acta Physiol (Oxf)
Title: Functional activity of Pat-1 (Slc26a6) Cl(−)/HCO₃(−) exchange in the lower villus epithelium of murine duodenum.
Volume: 201
Issue: 1
Pages: 21-31
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Publication
24018950 | J:215845
First Author: Singh AK
Year: 2013
Journal: J Physiol
Title: Molecular transport machinery involved in orchestrating luminal acid-induced duodenal bicarbonate secretion in vivo.
Volume: 591
Issue: 21
Pages: 5377-91
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Publication
22674389 | J:192414
First Author: Dawson PA
Year: 2012
Journal: Biol Reprod
Title: Placental, renal, and ileal sulfate transporter gene expression in mouse gestation.
Volume: 87
Issue: 2
Pages: 43
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Protein Coding Gene
MGP_CAROLIEiJ_G0017676 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0019660 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0019627 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0019598 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0019604 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0019408 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_107181 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0020051 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0018963 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0019379 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0019493 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0019484 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0019563 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0019519 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0020091 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0018730 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0019013 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0029434 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0018518 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
30615234 | J:277389
First Author: Stephens CE
Year: 2019
Journal: Exp Physiol
Title: 125 Iodide as a surrogate tracer for epithelial chloride transport by the mouse large intestine in vitro.
Volume: 104
Issue: 3
Pages: 334-344
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Publication
10803366 | J:60762
First Author: Kunieda T
Year: 2000
Journal: Exp Anim
Title: The down-regulated in adenoma (Dra) gene encoding intestine-specific anion transporter maps to mouse chromosome 12.
Volume: 49
Issue: 1
Pages: 67-8
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Publication
7744840 | J:25525
First Author: Silberg DG
Year: 1995
Journal: J Biol Chem
Title: The Down regulated in Adenoma (dra) gene encodes an intestine-specific membrane sulfate transport protein.
Volume: 270
Issue: 20
Pages: 11897-902
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Publication
11875004 | J:75017
First Author: Jacob P
Year: 2002
Journal: Gastroenterology
Title: Down-regulated in adenoma mediates apical Cl-/HCO3- exchange in rabbit, rat, and human duodenum.
Volume: 122
Issue: 3
Pages: 709-24
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Publication
31634391 | J:305508
First Author: Priyamvada S
Year: 2020
Journal: Inflamm Bowel Dis
Title: All-trans Retinoic Acid Counteracts Diarrhea and Inhibition of Downregulated in Adenoma Expression in Gut Inflammation.
Volume: 26
Issue: 4
Pages: 534-545
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GXD Expression
GXD Expression
   
Probe: MGI:4425674
Assay Type: RNA in situ
Annotation Date: 2011-02-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:4888656
Age: embryonic day 14.5
Image: Table S1
Specimen Label: Table S1
Detected: false
Specimen Num: 1
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Publication
10428871 | J:56643
First Author: Melvin JE
Year: 1999
Journal: J Biol Chem
Title: Mouse down-regulated in adenoma (DRA) is an intestinal Cl(-)/HCO(3)(-) exchanger and is up-regulated in colon of mice lacking the NHE3 Na(+)/H(+) exchanger.
Volume: 274
Issue: 32
Pages: 22855-61
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Publication
28526688 | J:250103
First Author: Whittamore JM
Year: 2017
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Loss of the anion exchanger DRA (Slc26a3), or PAT1 (Slc26a6), alters sulfate transport by the distal ileum and overall sulfate homeostasis.
Volume: 313
Issue: 3
Pages: G166-G179
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Publication
26394631 | J:288339
First Author: Jalali R
Year: 2015
Journal: J Dent Res
Title: Slc26a3/Dra and Slc26a6 in Murine Ameloblasts.
Volume: 94
Issue: 12
Pages: 1732-9
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Publication
22895259 | J:192779
First Author: Song Y
Year: 2012
Journal: Am J Physiol Cell Physiol
Title: Deletion of Slc26a6 alters the stoichiometry of apical Cl-/HCO-3 exchange in mouse pancreatic duct.
Volume: 303
Issue: 8
Pages: C815-24
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Publication
19121635 | J:146913
First Author: Walker NM
Year: 2009
Journal: Gastroenterology
Title: Role of down-regulated in adenoma anion exchanger in HCO3- secretion across murine duodenum.
Volume: 136
Issue: 3
Pages: 893-901
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Publication
18930060 | J:145623
First Author: Walker NM
Year: 2008
Journal: Gastroenterology
Title: Down-regulated in adenoma Cl/HCO3 exchanger couples with Na/H exchanger 3 for NaCl absorption in murine small intestine.
Volume: 135
Issue: 5
Pages: 1645-1653.e3
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Publication
11597142 | J:72227
First Author: Kratz CP
Year: 2001
Journal: Genomics
Title: Candidate gene isolation and comparative analysis of a commonly deleted segment of 7q22 implicated in myeloid malignancies.
Volume: 77
Issue: 3
Pages: 171-80
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Publication
20388655 | J:160162
First Author: D'Angelo A
Year: 2010
Journal: Development
Title: Hepatocyte nuclear factor 1alpha and beta control terminal differentiation and cell fate commitment in the gut epithelium.
Volume: 137
Issue: 9
Pages: 1573-82
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Publication
27371534 | J:291945
First Author: De Arcangelis A
Year: 2017
Journal: Gut
Title: Hemidesmosome integrity protects the colon against colitis and colorectal cancer.
Volume: 66
Issue: 10
Pages: 1748-1760
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Publication
37471646 | J:342643
First Author: Oh Y
Year: 2023
Journal: Biol Reprod
Title: Rhox8 homeobox gene ablation leads to rete testis abnormality and male subfertility in mice†.
Volume: 109
Issue: 4
Pages: 520-532
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:68100
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: RIKEN Data Curation in Mouse Genome Informatics
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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