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Search results 1 to 100 out of 505 for Slc3a2

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0.049s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Domain
Type: Family
Description: Heteromeric amino acid transporters (HATs) are composed of two subunits, a heavy (SLC3 family) and a light subunit [SLC7 or L-type amino acid transporter (LAT) family]linked by a conserved disulfide bridge []. HATs are amino acid exchangers, and the transport activity resides in the light subunit. The heavy chain of the surface antigen 4F2 (4F2hc), also known as solute carrier family 3 member 2 protein (Slc3a2), is a HAT heavy subunit [, ]. 4F2hc controls the cell surface expression as well as the membrane topology of the 4F2 heterodimer [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Nakamura E
Year: 1999
Journal: J Biol Chem
Title: 4F2 (CD98) heavy chain is associated covalently with an amino acid transporter and controls intracellular trafficking and membrane topology of 4F2 heterodimer.
Volume: 274
Issue: 5
Pages: 3009-16
Publication
First Author: Ikeda K
Year: 2017
Journal: Cell Rep
Title: Slc3a2 Mediates Branched-Chain Amino-Acid-Dependent Maintenance of Regulatory T Cells.
Volume: 21
Issue: 7
Pages: 1824-1838
Publication
First Author: Tissot FS
Year: 2018
Journal: J Invest Dermatol
Title: Dermal Fibroblast SLC3A2 Deficiency Leads to Premature Aging and Loss of Epithelial Homeostasis.
Volume: 138
Issue: 12
Pages: 2511-2521
Protein
Organism: Mus musculus/domesticus
Length: 526  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 113  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 400  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 109  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 80  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 126  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 99  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 526  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 303  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 532  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 231  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 526  
Fragment?: false
Publication
First Author: Rosell A
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Structural bases for the interaction and stabilization of the human amino acid transporter LAT2 with its ancillary protein 4F2hc.
Volume: 111
Issue: 8
Pages: 2966-71
Publication
First Author: Fotiadis D
Year: 2013
Journal: Mol Aspects Med
Title: The SLC3 and SLC7 families of amino acid transporters.
Volume: 34
Issue: 2-3
Pages: 139-58
Publication
First Author: Nguyen HT
Year: 2011
Journal: J Clin Invest
Title: CD98 expression modulates intestinal homeostasis, inflammation, and colitis-associated cancer in mice.
Volume: 121
Issue: 5
Pages: 1733-47
Publication
First Author: Uemura T
Year: 2010
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Polyamine transport is mediated by both endocytic and solute carrier transport mechanisms in the gastrointestinal tract.
Volume: 299
Issue: 2
Pages: G517-22
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Parmacek MS
Year: 1989
Journal: Nucleic Acids Res
Title: Structure, expression and regulation of the murine 4F2 heavy chain.
Volume: 17
Issue: 5
Pages: 1915-31
Publication
First Author: Liu Z
Year: 2012
Journal: Transplantation
Title: Deletion of CD98 heavy chain in T cells results in cardiac allograft acceptance by increasing regulatory T cells.
Volume: 93
Issue: 11
Pages: 1116-24
Publication
First Author: Tsumura H
Year: 2003
Journal: Biochem Biophys Res Commun
Title: The targeted disruption of the CD98 gene results in embryonic lethality.
Volume: 308
Issue: 4
Pages: 847-51
Publication
First Author: Cantor J
Year: 2011
Journal: J Immunol
Title: Loss of T cell CD98 H chain specifically ablates T cell clonal expansion and protects from autoimmunity.
Volume: 187
Issue: 2
Pages: 851-60
Publication
First Author: Boulter E
Year: 2013
Journal: J Exp Med
Title: CD98hc (SLC3A2) regulation of skin homeostasis wanes with age.
Volume: 210
Issue: 1
Pages: 173-90
Publication
First Author: Boulter E
Year: 2018
Journal: Nat Commun
Title: Cell metabolism regulates integrin mechanosensing via an SLC3A2-dependent sphingolipid biosynthesis pathway.
Volume: 9
Issue: 1
Pages: 4862
Publication
First Author: Liao Z
Year: 2016
Journal: Arterioscler Thromb Vasc Biol
Title: Endothelial Cells Require CD98 for Efficient Angiogenesis-Brief Report.
Volume: 36
Issue: 11
Pages: 2163-2166
Publication
First Author: Bajaj J
Year: 2016
Journal: Cancer Cell
Title: CD98-Mediated Adhesive Signaling Enables the Establishment and Propagation of Acute Myelogenous Leukemia.
Volume: 30
Issue: 5
Pages: 792-805
Publication
First Author: Bhuyan ZA
Year: 2014
Journal: Biochem Biophys Res Commun
Title: CD98hc regulates the development of experimental colitis by controlling effector and regulatory CD4(+) T cells.
Volume: 444
Issue: 4
Pages: 628-33
Publication
First Author: Charania MA
Year: 2012
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Intestinal epithelial CD98 synthesis specifically modulates expression of colonic microRNAs during colitis.
Volume: 302
Issue: 11
Pages: G1282-91
Publication
First Author: Quackenbush E
Year: 1987
Journal: Proc Natl Acad Sci U S A
Title: Molecular cloning of complementary DNAs encoding the heavy chain of the human 4F2 cell-surface antigen: a type II membrane glycoprotein involved in normal and neoplastic cell growth.
Volume: 84
Issue: 18
Pages: 6526-30
Publication  
First Author: Bröer S
Year: 1995
Journal: Biochem J
Title: The 4F2hc surface antigen is necessary for expression of system L-like neutral amino acid-transport activity in C6-BU-1 rat glioma cells: evidence from expression studies in Xenopus laevis oocytes.
Volume: 312 ( Pt 3)
Pages: 863-70
Publication
First Author: Tsumura H
Year: 1999
Journal: Immunol Cell Biol
Title: Isolation and characterization of monoclonal antibodies directed against murine FRP-1/CD98/4F2 heavy chain: murine FRP-1 is an alloantigen and amino acid change at 129 (P<-->R) is related to the alloantigenicity.
Volume: 77
Issue: 1
Pages: 19-27
Publication
First Author: Feral CC
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: CD98hc (SLC3A2) mediates integrin signaling.
Volume: 102
Issue: 2
Pages: 355-60
GXD Expression      
Probe: MGI:7536949
Assay Type: RT-PCR
Annotation Date: 2023-10-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716128
Stage: TS28
Assay Id: MGI:7538893
Age: postnatal week 3-6
Specimen Label: WT
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:7536949
Assay Type: RT-PCR
Annotation Date: 2023-10-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716128
Stage: TS28
Assay Id: MGI:7538893
Age: postnatal week 3-6
Specimen Label: KO
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:7536964
Assay Type: Western blot
Annotation Date: 2023-10-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716128
Stage: TS28
Assay Id: MGI:7538969
Age: postnatal week 3-6
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7536964
Assay Type: Western blot
Annotation Date: 2023-10-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716128
Stage: TS28
Assay Id: MGI:7538969
Age: postnatal week 3-6
Specimen Label: KO
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6259154
Assay Type: Northern blot
Annotation Date: 2018-12-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:6259150
Age: postnatal adult
Specimen Label: spleen
Detected: true
Specimen Num: 11
GXD Expression      
Probe: MGI:6259154
Assay Type: Northern blot
Annotation Date: 2018-12-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:6259150
Age: postnatal adult
Specimen Label: kidney
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:6259141
Assay Type: Western blot
Annotation Date: 2018-12-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:6259160
Age: postnatal adult
Specimen Label: kidney +/+
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:6259141
Assay Type: Western blot
Annotation Date: 2018-12-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:6259160
Age: postnatal adult
Specimen Label: kidney delta/+
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:6259405
Assay Type: RT-PCR
Annotation Date: 2018-12-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:6259407
Age: postnatal adult
Specimen Label: kidney
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:6259154
Assay Type: Northern blot
Annotation Date: 2018-12-05
Strength: Present
Sex: Female
Emaps: EMAPS:3568928
Stage: TS28
Assay Id: MGI:6259150
Age: postnatal adult
Specimen Label: placenta
Detected: true
Specimen Num: 15
GXD Expression      
Probe: MGI:7536949
Assay Type: RT-PCR
Annotation Date: 2023-10-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1783828
Stage: TS28
Assay Id: MGI:7538894
Age: postnatal week 3-6
Specimen Label: WT
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:7536949
Assay Type: RT-PCR
Annotation Date: 2023-10-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1783828
Stage: TS28
Assay Id: MGI:7538894
Age: postnatal week 3-6
Specimen Label: KO
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:7536964
Assay Type: Western blot
Annotation Date: 2023-10-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1783828
Stage: TS28
Assay Id: MGI:7538974
Age: postnatal week 3-6
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7536964
Assay Type: Western blot
Annotation Date: 2023-10-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1783828
Stage: TS28
Assay Id: MGI:7538974
Age: postnatal week 3-6
Specimen Label: KO
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:7536949
Assay Type: RT-PCR
Annotation Date: 2023-10-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Stage: TS28
Assay Id: MGI:7538895
Age: postnatal week 3-6
Specimen Label: WT
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:7536949
Assay Type: RT-PCR
Annotation Date: 2023-10-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Stage: TS28
Assay Id: MGI:7538895
Age: postnatal week 3-6
Specimen Label: KO
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:7536964
Assay Type: Western blot
Annotation Date: 2023-10-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Stage: TS28
Assay Id: MGI:7538979
Age: postnatal week 3-6
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7536964
Assay Type: Western blot
Annotation Date: 2023-10-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Stage: TS28
Assay Id: MGI:7538979
Age: postnatal week 3-6
Specimen Label: KO
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6259154
Assay Type: Northern blot
Annotation Date: 2018-12-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:6259150
Age: postnatal adult
Specimen Label: lung
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:6259405
Assay Type: RT-PCR
Annotation Date: 2018-12-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:6259407
Age: postnatal adult
Specimen Label: lung
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:6259154
Assay Type: Northern blot
Annotation Date: 2018-12-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:6259150
Age: postnatal adult
Specimen Label: skeletal muscle
Detected: true
Specimen Num: 10
GXD Expression      
Probe: MGI:6259154
Assay Type: Northern blot
Annotation Date: 2018-12-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:6259150
Age: postnatal adult
Specimen Label: heart
Detected: true
Specimen Num: 8
GXD Expression        
Probe: MGI:6259405
Assay Type: RT-PCR
Annotation Date: 2018-12-06
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:6259407
Age: postnatal adult
Specimen Label: heart
Specimen Num: 3
GXD Expression      
Probe: MGI:6259154
Assay Type: Northern blot
Annotation Date: 2018-12-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603916
Stage: TS16
Assay Id: MGI:6259155
Age: embryonic day 10.0
Specimen Label: E10
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6259154
Assay Type: Northern blot
Annotation Date: 2018-12-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603918
Stage: TS18
Assay Id: MGI:6259155
Age: embryonic day 11.0
Specimen Label: E11
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6259154
Assay Type: Northern blot
Annotation Date: 2018-12-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:6259155
Age: embryonic day 12.0
Specimen Label: E12
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6259154
Assay Type: Northern blot
Annotation Date: 2018-12-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603921
Stage: TS21
Assay Id: MGI:6259155
Age: embryonic day 13.0
Specimen Label: E13
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:6259154
Assay Type: Northern blot
Annotation Date: 2018-12-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:6259155
Age: embryonic day 14.0
Specimen Label: E14
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:6259154
Assay Type: Northern blot
Annotation Date: 2018-12-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:6259155
Age: embryonic day 15.0
Specimen Label: E15
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:6259154
Assay Type: Northern blot
Annotation Date: 2018-12-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6259150
Age: postnatal adult
Specimen Label: liver
Detected: true
Specimen Num: 5
GXD Expression        
Probe: MGI:6259405
Assay Type: RT-PCR
Annotation Date: 2018-12-06
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6259407
Age: postnatal adult
Specimen Label: liver
Specimen Num: 4
GXD Expression      
Probe: MGI:6259154
Assay Type: Northern blot
Annotation Date: 2018-12-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1893928
Stage: TS28
Assay Id: MGI:6259150
Age: postnatal adult
Specimen Label: colon
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:6259405
Assay Type: RT-PCR
Annotation Date: 2018-12-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1893928
Stage: TS28
Assay Id: MGI:6259407
Age: postnatal adult
Specimen Label: colon
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:6259154
Assay Type: Northern blot
Annotation Date: 2018-12-05
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:6259150
Age: postnatal adult
Specimen Label: testis
Detected: true
Specimen Num: 12
GXD Expression      
Probe: MGI:6259141
Assay Type: Western blot
Annotation Date: 2018-12-05
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:6259160
Age: postnatal adult
Specimen Label: testis +/+
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:6259141
Assay Type: Western blot
Annotation Date: 2018-12-05
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:6259160
Age: postnatal adult
Specimen Label: testis delta/+
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:6259405
Assay Type: RT-PCR
Annotation Date: 2018-12-06
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:6259407
Age: postnatal adult
Specimen Label: testis
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:6259154
Assay Type: Northern blot
Annotation Date: 2018-12-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3287428
Stage: TS28
Assay Id: MGI:6259150
Age: postnatal adult
Specimen Label: intest.
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6259141
Assay Type: Western blot
Annotation Date: 2018-12-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3287428
Stage: TS28
Assay Id: MGI:6259160
Age: postnatal adult
Specimen Label: intestine +/+
Detected: true
Specimen Num: 4