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Search results 1 to 100 out of 124 for Slc5a5

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0.064s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Domain
Type: Family
Description: NIS (product of the SLC5A5 gene) transports iodide (I-), and other anions including ClO4-, SCN-, and Br-. NIS is expressed in the thyroid, colon, ovary, and in human breast cancers. It mediates the active transport and the concentration of iodide from the blood into thyroid follicular cells, a fundamental step in thyroid hormone biosynthesis, and is the basis of radioiodine therapy for thyroid cancer []. Mutation in the SLC5A5 gene can result in a form of thyroid hormone dysgenesis [, ]. Human NIS exists mainly as a dimer stabilized by a disulfide bridge []. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Dohán O
Year: 2003
Journal: Endocr Rev
Title: The sodium/iodide Symporter (NIS): characterization, regulation, and medical significance.
Volume: 24
Issue: 1
Pages: 48-77
Publication
First Author: Huc-Brandt S
Year: 2011
Journal: Biochim Biophys Acta
Title: Characterisation of the purified human sodium/iodide symporter reveals that the protein is mainly present in a dimeric form and permits the detailed study of a native C-terminal fragment.
Volume: 1808
Issue: 1
Pages: 65-77
Publication
First Author: Kosugi S
Year: 1999
Journal: J Clin Endocrinol Metab
Title: A novel mutation in the sodium/iodide symporter gene in the largest family with iodide transport defect.
Volume: 84
Issue: 9
Pages: 3248-53
Publication
First Author: Pohlenz J
Year: 1998
Journal: J Clin Invest
Title: Congenital hypothyroidism due to mutations in the sodium/iodide symporter. Identification of a nonsense mutation producing a downstream cryptic 3' splice site.
Volume: 101
Issue: 5
Pages: 1028-35
Protein
Organism: Mus musculus/domesticus
Length: 618  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 618  
Fragment?: false
Publication
First Author: Ferrandino G
Year: 2017
Journal: Sci Rep
Title: An extremely high dietary iodide supply forestalls severe hypothyroidism in Na+/I- symporter (NIS) knockout mice.
Volume: 7
Issue: 1
Pages: 5329
Publication
First Author: Afink GB
Year: 2010
Journal: Thyroid
Title: Initial characterization of C16orf89, a novel thyroid-specific gene.
Volume: 20
Issue: 7
Pages: 811-21
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Pinke LA
Year: 2001
Journal: Thyroid
Title: Cloning of the mouse sodium iodide symporter.
Volume: 11
Issue: 10
Pages: 935-9
Publication
First Author: Perron B
Year: 2001
Journal: J Endocrinol
Title: Cloning of the mouse sodium iodide symporter and its expression in the mammary gland and other tissues.
Volume: 170
Issue: 1
Pages: 185-96
Publication
First Author: Dayem M
Year: 2008
Journal: J Endocrinol
Title: Comparison of expressed human and mouse sodium/iodide symporters reveals differences in transport properties and subcellular localization.
Volume: 197
Issue: 1
Pages: 95-109
Publication
First Author: Concilio SC
Year: 2020
Journal: PLoS One
Title: Inter-species variation in monovalent anion substrate selectivity and inhibitor sensitivity in the sodium iodide symporter (NIS).
Volume: 15
Issue: 2
Pages: e0229085
GXD Expression      
Probe: MGI:6114167
Assay Type: RT-PCR
Annotation Date: 2018-02-06
Strength: Present
Sex: Male
Emaps: EMAPS:1706828
Stage: TS28
Assay Id: MGI:6114663
Age: postnatal month 2
Specimen Label: Cre-/0
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6114167
Assay Type: RT-PCR
Annotation Date: 2018-02-06
Strength: Present
Sex: Male
Emaps: EMAPS:1706828
Stage: TS28
Assay Id: MGI:6114663
Age: postnatal month 2
Specimen Label: Cre+/0
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6114167
Assay Type: RT-PCR
Annotation Date: 2018-02-06
Strength: Present
Sex: Male
Emaps: EMAPS:1706828
Stage: TS28
Assay Id: MGI:6114663
Age: postnatal month 12
Specimen Label: Cre-/0
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6114167
Assay Type: RT-PCR
Annotation Date: 2018-02-06
Strength: Present
Sex: Male
Emaps: EMAPS:1706828
Stage: TS28
Assay Id: MGI:6114663
Age: postnatal month 12
Specimen Label: Cre+/0
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:6114167
Assay Type: RT-PCR
Annotation Date: 2018-02-06
Strength: Present
Sex: Male
Emaps: EMAPS:1706828
Stage: TS28
Assay Id: MGI:6114693
Age: postnatal month 2
Specimen Label: Thyr-TRB<+/+>
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6114167
Assay Type: RT-PCR
Annotation Date: 2018-02-06
Strength: Present
Sex: Male
Emaps: EMAPS:1706828
Stage: TS28
Assay Id: MGI:6114693
Age: postnatal month 2
Specimen Label: Thyr-TRB<+/->
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6114167
Assay Type: RT-PCR
Annotation Date: 2018-02-06
Strength: Present
Sex: Male
Emaps: EMAPS:1706828
Stage: TS28
Assay Id: MGI:6114693
Age: postnatal month 2
Specimen Label: Thyr-TRB<-/->
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6149782
Assay Type: Western blot
Annotation Date: 2018-04-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1706828
Stage: TS28
Assay Id: MGI:6150283
Age: postnatal
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6149782
Assay Type: Western blot
Annotation Date: 2018-04-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1706828
Stage: TS28
Assay Id: MGI:6150283
Age: postnatal
Specimen Label: WT
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6149782
Assay Type: Western blot
Annotation Date: 2018-04-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1706828
Stage: TS28
Assay Id: MGI:6150289
Age: postnatal adult
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6149782
Assay Type: Western blot
Annotation Date: 2018-04-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1706828
Stage: TS28
Assay Id: MGI:6150289
Age: postnatal adult
Specimen Label: WT
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6149782
Assay Type: Western blot
Annotation Date: 2018-04-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1706828
Stage: TS28
Assay Id: MGI:6150289
Age: postnatal adult
Specimen Label: WT
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:6149782
Assay Type: Western blot
Annotation Date: 2018-04-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1706828
Stage: TS28
Assay Id: MGI:6150289
Age: postnatal adult
Specimen Label: WT
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:6149782
Assay Type: Western blot
Annotation Date: 2018-04-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1706828
Stage: TS28
Assay Id: MGI:6150295
Age: postnatal adult
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6149782
Assay Type: Western blot
Annotation Date: 2018-04-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1706828
Stage: TS28
Assay Id: MGI:6150295
Age: postnatal adult
Specimen Label: WT
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6149782
Assay Type: Western blot
Annotation Date: 2018-04-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1706828
Stage: TS28
Assay Id: MGI:6150295
Age: postnatal adult
Specimen Label: WT
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:6149782
Assay Type: Western blot
Annotation Date: 2018-04-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1706828
Stage: TS28
Assay Id: MGI:6150295
Age: postnatal adult
Specimen Label: WT
Detected: true
Specimen Num: 8
GXD Expression  
Probe: MGI:4424007
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1702123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828253
Age: embryonic day 14.5
Image: euxassay_012146_05
Specimen Label: euxassay_012146_05
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4424007
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1702123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828253
Age: embryonic day 14.5
Image: euxassay_012146_06
Specimen Label: euxassay_012146_06
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4424007
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1702123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828253
Age: embryonic day 14.5
Image: euxassay_012146_07
Specimen Label: euxassay_012146_07
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4424007
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1702123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828253
Age: embryonic day 14.5
Image: euxassay_012146_08
Specimen Label: euxassay_012146_08
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4428438
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1702123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828254
Age: embryonic day 14.5
Image: euxassay_019729_09
Specimen Label: euxassay_019729_09
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4428438
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1702123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828254
Age: embryonic day 14.5
Image: euxassay_019729_10
Specimen Label: euxassay_019729_10
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4428438
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1804323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828254
Age: embryonic day 14.5
Image: euxassay_019729_15
Specimen Label: euxassay_019729_15
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4428438
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1804323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828254
Age: embryonic day 14.5
Image: euxassay_019729_16
Specimen Label: euxassay_019729_16
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:5286051
Assay Type: RNA in situ
Annotation Date: 2011-09-21
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1706820
Stage: TS20
Assay Id: MGI:5286063
Age: embryonic day 12.5
Note: Data also shown in Table 2.
Specimen Label: E12.5 Thyroid
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5286051
Assay Type: RNA in situ
Annotation Date: 2011-09-21
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1685320
Stage: TS20
Assay Id: MGI:5286063
Age: embryonic day 12.5
Specimen Label: E12.5 Trachea
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:5286051
Assay Type: RNA in situ
Annotation Date: 2011-09-21
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1706822
Stage: TS22
Assay Id: MGI:5286063
Age: embryonic day 14.5
Note: Data also shown in Table 2.
Specimen Label: E14.5 Thyroid
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:5286051
Assay Type: RNA in situ
Annotation Date: 2011-09-21
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1685322
Stage: TS22
Assay Id: MGI:5286063
Age: embryonic day 14.5
Specimen Label: E14.5 Trachea
Detected: false
Specimen Num: 4
GXD Expression  
Probe: MGI:5286051
Assay Type: RNA in situ
Annotation Date: 2011-09-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1706825
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:5286063
Age: embryonic day 17.5
Note: Data also shown in Table 2.
Specimen Label: E17.5 Thyroid
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:5286051
Assay Type: RNA in situ
Annotation Date: 2011-09-21
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1685325
Stage: TS25
Assay Id: MGI:5286063
Age: embryonic day 17.5
Specimen Label: E17.5 Trachea
Detected: false
Specimen Num: 6
GXD Expression      
Probe: MGI:6149773
Assay Type: Immunohistochemistry
Annotation Date: 2018-04-10
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1706822
Stage: TS22
Assay Id: MGI:6150277
Age: embryonic day 14.5
Specimen Label: 1A E14.5
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:6149773
Assay Type: Immunohistochemistry
Annotation Date: 2018-04-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1706823
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6150277
Age: embryonic day 15.5
Specimen Label: 1A E15.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:6149773
Assay Type: Immunohistochemistry
Annotation Date: 2018-04-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1706828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6150277
Age: postnatal
Note: Expression was detected at the basal pole of thyrocytes.
Specimen Label: 3C
Detected: true
Specimen Num: 3
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692446
Age: postnatal adult
Image: JAX_1371973
Specimen Label: JAX_1371973
Detected: true
Specimen Num: 1
Publication
First Author: Ferrandino G
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Pathogenesis of hypothyroidism-induced NAFLD is driven by intra- and extrahepatic mechanisms.
Volume: 114
Issue: 43
Pages: E9172-E9180
Publication
First Author: Kaspari RR
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: The paradoxical lean phenotype of hypothyroid mice is marked by increased adaptive thermogenesis in the skeletal muscle.
Volume: 117
Issue: 36
Pages: 22544-22551
Publication
First Author: De Felice M
Year: 2004
Journal: Endocrinology
Title: Minireview: thyrotropin receptor signaling in development and differentiation of the thyroid gland: insights from mouse models and human diseases.
Volume: 145
Issue: 9
Pages: 4062-7
Publication
First Author: Milenkovic M
Year: 2007
Journal: J Endocrinol
Title: Duox expression and related H2O2 measurement in mouse thyroid: onset in embryonic development and regulation by TSH in adult.
Volume: 192
Issue: 3
Pages: 615-26
Publication  
First Author: Didier-Mathon H
Year: 2023
Journal: Front Endocrinol (Lausanne)
Title: Borealin/CDCA8 deficiency alters thyroid development and results in papillary tumor-like structures.
Volume: 14
Pages: 1286747
Publication
First Author: Postiglione MP
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Role of the thyroid-stimulating hormone receptor signaling in development and differentiation of the thyroid gland.
Volume: 99
Issue: 24
Pages: 15462-7
Publication  
First Author: Silberschmidt D
Year: 2011
Journal: BMC Dev Biol
Title: In vivo role of different domains and of phosphorylation in the transcription factor Nkx2-1.
Volume: 11
Pages: 9
Publication
First Author: Frezzetti D
Year: 2011
Journal: PLoS One
Title: The microRNA-processing enzyme Dicer is essential for thyroid function.
Volume: 6
Issue: 11
Pages: e27648
Publication
First Author: Carre A
Year: 2011
Journal: PLoS One
Title: Hes1 is required for appropriate morphogenesis and differentiation during mouse thyroid gland development.
Volume: 6
Issue: 2
Pages: e16752
Publication
First Author: Marotta P
Year: 2014
Journal: Mol Cell Endocrinol
Title: The paired box transcription factor Pax8 is essential for function and survival of adult thyroid cells.
Volume: 396
Issue: 1-2
Pages: 26-36
Publication
First Author: Selmi-Ruby S
Year: 2014
Journal: Endocrinology
Title: The targeted inactivation of TRβ gene in thyroid follicular cells suggests a new mechanism of regulation of thyroid hormone production.
Volume: 155
Issue: 2
Pages: 635-46
Publication
First Author: Hick AC
Year: 2013
Journal: Dev Biol
Title: Reciprocal epithelial:endothelial paracrine interactions during thyroid development govern follicular organization and C-cells differentiation.
Volume: 381
Issue: 1
Pages: 227-40
Publication
First Author: Watson LA
Year: 2013
Journal: J Clin Invest
Title: Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span.
Volume: 123
Issue: 5
Pages: 2049-63
Publication  
First Author: Stoupa A
Year: 2018
Journal: EMBO Mol Med
Title: TUBB1 mutations cause thyroid dysgenesis associated with abnormal platelet physiology.
Volume: 10
Issue: 12
Publication      
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
Publication
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
Publication      
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database