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Search results 1 to 54 out of 54 for Slc9a3r2

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Hits by Category

Type Details Score
Gene
416550 | SLC9A3R2
Type: gene
Organism: chicken
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Publication
9831664 | J:52359
First Author: Imai K
Year: 1998
Journal: Gene
Title: Genomic structure and sequence of a human homologue (NTHL1/NTH1) of Escherichia coli endonuclease III with those of the adjacent parts of TSC2 and SLC9A3R2 genes.
Volume: 222
Issue: 2
Pages: 287-95
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Protein Coding Gene
MGI:1890662 | Nherf2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
11535586 | -
First Author: Forwood JK
Year: 2001
Journal: J Biol Chem
Title: The C-terminal nuclear localization signal of the sex-determining region Y (SRY) high mobility group domain mediates nuclear import through importin beta 1.
Volume: 276
Issue: 49
Pages: 46575-82
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Publication
5297880 | -
First Author: Anson BJ
Year: 1967
Journal: Arch Otolaryngol
Title: The vestibular system. Anatomic considerations.
Volume: 85
Issue: 5
Pages: 497-514
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Publication
16504207 | -
First Author: Phillips NB
Year: 2006
Journal: J Mol Biol
Title: SRY and human sex determination: the basic tail of the HMG box functions as a kinetic clamp to augment DNA bending.
Volume: 358
Issue: 1
Pages: 172-92
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Publication
16106197 | -
First Author: Kellermayer R
Year: 2005
Journal: Diagn Mol Pathol
Title: A novel frame shift mutation in the HMG box of the SRY gene in a patient with complete 46,XY pure gonadal dysgenesis.
Volume: 14
Issue: 3
Pages: 159-63
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Publication
7789944 | -
First Author: Ogata T
Year: 1995
Journal: Hum Genet
Title: Turner syndrome and female sex chromosome aberrations: deduction of the principal factors involved in the development of clinical features.
Volume: 95
Issue: 6
Pages: 607-29
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Publication
12793612 | -
First Author: Maier EM
Year: 2003
Journal: J Pediatr Endocrinol Metab
Title: True hermaphroditism in an XY individual due to a familial point mutation of the SRY gene.
Volume: 16
Issue: 4
Pages: 575-80
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Protein Domain
IPR017253 | SRY
Type: Family
Description: This entry represents the testis-determining factor Sry (Sex-determining Region Y). Sry is a transcriptional activator that regulates a genetic switch inmale development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells []. Sry is involved in different aspects of gene regulation including promoter activation or repression and contains a high-mobility-group (HMG) box that recognises DNA by partial intercalation in the minor groove []. It binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. Sry also facilitates DNA bending and is involved in pre-mRNA splicing. It is also involved in maintenance of motor functions of dopaminergic neurons in the male adult brain. Sry interacts with a number of partners, including CALM, EP300 (modulates Sry DNA-binding activity), HDAC3, KPNB1, ZNF208 isoform KRAB-O, PARP1 (impaired Sry DNA-binding activity), SLC9A3R2 and WT1. The C-terminal nuclear localization signal in Sry HMG-box domain mediates nuclear import through importin beta 1 [].Defects in Sry can cause gonadal dysgenesis XY female type (GDXY) (OMIM:306100), which is also known as 'XY females' or Swyer syndrome []. Patients suffer rapid and early degeneration of their gonads, which prevents the development secondary sexual characteristics at puberty. Defects in Sry are also found Turner's Syndrome, a disease characterised by gonadal dysgenesis in a 45,X female type []. Defects in Sry can also cause true hermaphroditism (OMIM:235600), genetically heterogeneous condition whre patients have both mature ovarian and mature testicular tissue (46,XX, 46,XY or a mosaic of 46,XX/46,XY) [].
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Protein
Q05738
Organism: Mus musculus/domesticus
Length: 392  
Fragment?: false
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Protein
O35858
Organism: Mus musculus/domesticus
Length: 234  
Fragment?: false
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Protein
O35860
Organism: Mus musculus/domesticus
Length: 233  
Fragment?: false
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Protein
O35957
Organism: Mus musculus/domesticus
Length: 416  
Fragment?: false
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Protein
H8ZX66
Organism: Mus musculus/domesticus
Length: 302  
Fragment?: true
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Protein
H8ZX96
Organism: Mus musculus/domesticus
Length: 300  
Fragment?: true
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Protein
H8ZX84
Organism: Mus musculus/domesticus
Length: 232  
Fragment?: true
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Protein
O35966
Organism: Mus musculus/domesticus
Length: 231  
Fragment?: false
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Protein
Q53WV7
Organism: Mus musculus/domesticus
Length: 395  
Fragment?: false
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Protein
H8ZX83
Organism: Mus musculus/domesticus
Length: 315  
Fragment?: true
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Protein
H8ZX57
Organism: Mus musculus/domesticus
Length: 304  
Fragment?: true
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Protein
H8ZX72
Organism: Mus musculus/domesticus
Length: 232  
Fragment?: true
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Protein
H8ZX79
Organism: Mus musculus/domesticus
Length: 317  
Fragment?: true
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Protein
H8ZX63
Organism: Mus musculus/domesticus
Length: 306  
Fragment?: true
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Protein
Q2T9H0
Organism: Mus musculus/domesticus
Length: 374  
Fragment?: false
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Protein
H8ZX99
Organism: Mus musculus/domesticus
Length: 303  
Fragment?: true
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Protein
H8ZX59
Organism: Mus musculus/domesticus
Length: 315  
Fragment?: true
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Protein
H8ZX91
Organism: Mus musculus/domesticus
Length: 233  
Fragment?: true
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Protein
Q62272
Organism: Mus musculus/domesticus
Length: 143  
Fragment?: true
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Protein
H8ZX62
Organism: Mus musculus/domesticus
Length: 315  
Fragment?: true
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Protein
H8ZX82
Organism: Mus musculus/domesticus
Length: 314  
Fragment?: true
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Protein
H8ZX58
Organism: Mus musculus/domesticus
Length: 314  
Fragment?: true
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Protein
H8ZX61
Organism: Mus musculus/domesticus
Length: 318  
Fragment?: true
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Protein
H8ZX69
Organism: Mus musculus/domesticus
Length: 303  
Fragment?: true
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Protein
H8ZX80
Organism: Mus musculus/domesticus
Length: 318  
Fragment?: true
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Protein
H8ZX77
Organism: Mus musculus/domesticus
Length: 315  
Fragment?: true
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Protein
H8ZX87
Organism: Mus musculus/domesticus
Length: 316  
Fragment?: true
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Protein
H8ZXA3
Organism: Mus musculus/domesticus
Length: 232  
Fragment?: true
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Protein
H8ZX88
Organism: Mus musculus/domesticus
Length: 321  
Fragment?: true
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Protein
O35862
Organism: Mus musculus/domesticus
Length: 418  
Fragment?: false
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Protein
O35863
Organism: Mus musculus/domesticus
Length: 399  
Fragment?: false
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Protein
H8ZX78
Organism: Mus musculus/domesticus
Length: 314  
Fragment?: true
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Protein
H8ZX60
Organism: Mus musculus/domesticus
Length: 306  
Fragment?: true
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Protein
H8ZX70
Organism: Mus musculus/domesticus
Length: 304  
Fragment?: true
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Protein
H8ZX98
Organism: Mus musculus/domesticus
Length: 299  
Fragment?: true
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Protein
H8ZX68
Organism: Mus musculus/domesticus
Length: 314  
Fragment?: true
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Protein
H8ZX97
Organism: Mus musculus/domesticus
Length: 300  
Fragment?: true
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Protein
O35861
Organism: Mus musculus/domesticus
Length: 420  
Fragment?: false
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Protein
O35859
Organism: Mus musculus/domesticus
Length: 234  
Fragment?: false
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Protein
Q91V39
Organism: Mus musculus/domesticus
Length: 230  
Fragment?: false
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Protein
H8ZXA2
Organism: Mus musculus/domesticus
Length: 231  
Fragment?: true
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Protein
O35968
Organism: Mus musculus/domesticus
Length: 232  
Fragment?: false
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Protein
H8ZX67
Organism: Mus musculus/domesticus
Length: 299  
Fragment?: true
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Protein
H8ZX76
Organism: Mus musculus/domesticus
Length: 321  
Fragment?: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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