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Search results 1 to 100 out of 126 for Slfn4

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Categories

Hits by Category

Hits by Strain

Type Details Score
Gene
114247 | Slfn4
Type: gene
Organism: rat
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Protein Coding Gene
MGI:1329010 | Slfn4
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
27427984 | J:237121
First Author: Ding L
Year: 2016
Journal: J Clin Invest
Title: Schlafen 4-expressing myeloid-derived suppressor cells are induced during murine gastric metaplasia.
Volume: 126
Issue: 8
Pages: 2867-80
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Publication
37334372 | J:337060
 
First Author: Ding L
Year: 2023
Journal: Front Immunol
Title: Schlafen4(+)-MDSC in Helicobacter-induced gastric metaplasia reveals role for GTPases.
Volume: 14
Pages: 1139391
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Publication
18355440 | J:134155
First Author: Neumann B
Year: 2008
Journal: Biochem Biophys Res Commun
Title: Subcellular localization of the Schlafen protein family.
Volume: 370
Issue: 1
Pages: 62-6
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Publication
19619625 | J:152085
First Author: Bustos O
Year: 2009
Journal: Gene
Title: Evolution of the Schlafen genes, a gene family associated with embryonic lethality, meiotic drive, immune processes and orthopoxvirus virulence.
Volume: 447
Issue: 1
Pages: 1-11
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Allele
Tg(Slfn4-EGFP/cre/ERT2)1Jmer | MGI:5908382
Name: transgene insertion 1, Juanita L Merchant
Allele Type: Transgenic
Attribute String: Inducible, Recombinase, Reporter
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Protein Coding Gene
MGP_CAROLIEiJ_G0016867 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0018841 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0018808 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0018778 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0018781 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0018595 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1329010 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0019233 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0018150 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0018566 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0018674 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0018663 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0018744 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0018690 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0019273 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0017920 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0018201 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_SPRETEiJ_G0017711 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
9846487 | J:51308
First Author: Schwarz DA
Year: 1998
Journal: Immunity
Title: Schlafen, a new family of growth regulatory genes that affect thymocyte development.
Volume: 9
Issue: 5
Pages: 657-68
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
23520544 | J:199910
First Author: El-Zaatari M
Year: 2013
Journal: PLoS One
Title: Gli1 deletion prevents Helicobacter-induced gastric metaplasia and expansion of myeloid cell subsets.
Volume: 8
Issue: 3
Pages: e58935
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
27626380 | J:236599
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
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Publication
23012479 | J:190322
First Author: Archambaud C
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Impact of lactobacilli on orally acquired listeriosis.
Volume: 109
Issue: 41
Pages: 16684-9
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:73796
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Function or Process or Component Unknown following Literature Review
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691350
Age: postnatal adult
Image: MRC Harwell_891769
Specimen Label: MRC Harwell_891769
Detected: true
Specimen Num: 1
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Protein
Q80UG3
Organism: Mus musculus/domesticus
Length: 209  
Fragment?: false
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Publication
38076659 | J:344682
 
First Author: Vomhof-DeKrey EE
Year: 2023
Journal: Biochem Biophys Rep
Title: Vil-Cre specific Slfn3KO mice exhibit sex-specific differences in lung, stomach, cecum, kidney, and proximal colon differentiation markers and Slfn family members expression levels.
Volume: 36
Pages: 101552
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Protein Domain
IPR029667 | SLFNL1
Type: Family
Description: The Schlafen (SLFN) family includes several mouse and human member genes that have been implicated in important functions, such as the control of cell proliferation, induction of immune responses, and the regulation of viral replication [, , , ]. Mouse and human SLFN proteins are regulated by interferons (IFNs) []. All SLFNs contain an unique Slfn box. SLFN family is comprised of 3 groups, based on the size of the encoded proteins [, , , ]:Group1: Slfn1, Slfn2, and Slfn Like 1.Group2: Slfn3, Slfn4 and Slfn12.Group3: Slfn5, Slfn8-11, Slfn13 and Slfn14.Comparing to group1 proteins, group2 and 3 proteins contain an extra SWADL domain C terminus to the AAA domain. Group3 proteins also possess a large extension C terminus to their SWADL domain. This C-terminal extension is homologous to the superfamily I of DNA/RNA helicases []. It has been proposed that the divergent AAA ATPase domain may function as an RNA-binding domain []. This entry represents SlfnL1 protein. Its function is not clear.
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Protein Domain
IPR029677 | SLFN14
Type: Family
Description: The Schlafen (SLFN) family includes several mouse and human member genes that have been implicated in important functions, such as the control of cell proliferation, induction of immune responses, and the regulation of viral replication [, , , ]. Mouse and human SLFN proteins are regulated by interferons (IFNs) []. All SLFNs contain an unique Slfn box. SLFN family is comprised of 3 groups, based on the size of the encoded proteins [, , , ]:Group1: Slfn1, Slfn2, and Slfn Like 1.Group2: Slfn3, Slfn4 and Slfn12.Group3: Slfn5, Slfn8-11, Slfn13 and Slfn14.Comparing to group1 proteins, group2 and 3 proteins contain an extra SWADL domain C terminus to the AAA domain. Group3 proteins also possess a large extension C terminus to their SWADL domain. This C-terminal extension is homologous to the superfamily I of DNA/RNA helicases []. It has been proposed that the divergent AAA ATPase domain may function as an RNA-binding domain []. This entry represents Slfn14. Its function is not clear.
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Protein Domain
IPR029679 | SLFN13
Type: Family
Description: The Schlafen (SLFN) family includes several mouse and human member genes that have been implicated in important functions, such as the control of cell proliferation, induction of immune responses, and the regulation of viral replication [, , , ]. Mouse and human SLFN proteins are regulated by interferons (IFNs) []. All SLFNs contain an unique Slfn box. SLFN family is comprised of 3 groups, based on the size of the encoded proteins [, , , ]:Group1: Slfn1, Slfn2, and Slfn Like 1.Group2: Slfn3, Slfn4 and Slfn12.Group3: Slfn5, Slfn8-11, Slfn13 and Slfn14.Comparing to group1 proteins, group2 and 3 proteins contain an extra SWADL domain C terminus to the AAA domain. Group3 proteins also possess a large extension C terminus to their SWADL domain. This C-terminal extension is homologous to the superfamily I of DNA/RNA helicases []. It has been proposed that the divergent AAA ATPase domain may function as an RNA-binding domain []. This entry represents Slfn13.
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Publication
15351786 | J:93660
First Author: Geserick P
Year: 2004
Journal: Int Immunol
Title: Modulation of T cell development and activation by novel members of the Schlafen (slfn) gene family harbouring an RNA helicase-like motif.
Volume: 16
Issue: 10
Pages: 1535-48
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Publication
23570387 | -
First Author: Mavrommatis E
Year: 2013
Journal: J Interferon Cytokine Res
Title: The schlafen family of proteins and their regulation by interferons.
Volume: 33
Issue: 4
Pages: 206-10
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Publication
34707099 | -
First Author: Chen J
Year: 2021
Journal: Nat Commun
Title: Structure of PDE3A-SLFN12 complex and structure-based design for a potent apoptosis inducer of tumor cells.
Volume: 12
Issue: 1
Pages: 6204
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Publication
34272366 | -
First Author: Garvie CW
Year: 2021
Journal: Nat Commun
Title: Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase.
Volume: 12
Issue: 1
Pages: 4375
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Publication
28460425 | -
First Author: Liu F
Year: 2018
Journal: Cell Biol Int
Title: The Schlafen family: complex roles in different cell types and virus replication.
Volume: 42
Issue: 1
Pages: 2-8
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Protein
Q8BHW9
Organism: Mus musculus/domesticus
Length: 410  
Fragment?: false
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Protein
A0A1G5SL81
Organism: Mus musculus/domesticus
Length: 432  
Fragment?: false
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Protein
A0A1G5SJC9
Organism: Mus musculus/domesticus
Length: 399  
Fragment?: false
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Protein
Q3V3J5
Organism: Mus musculus/domesticus
Length: 237  
Fragment?: true
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Protein
F8WH72
Organism: Mus musculus/domesticus
Length: 378  
Fragment?: true
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Protein
Q3TAE9
Organism: Mus musculus/domesticus
Length: 378  
Fragment?: true
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Protein
A0A1G5SJD9
Organism: Mus musculus/domesticus
Length: 209  
Fragment?: false
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Protein
A0A1G5SJW1
Organism: Mus musculus/domesticus
Length: 378  
Fragment?: false
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Protein
Q3UV66
Organism: Mus musculus/domesticus
Length: 602  
Fragment?: false
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Protein
E9Q0R4
Organism: Mus musculus/domesticus
Length: 407  
Fragment?: false
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Protein
Q9Z0I6
Organism: Mus musculus/domesticus
Length: 378  
Fragment?: false
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Protein
A0A1G5SJK5
Organism: Mus musculus/domesticus
Length: 448  
Fragment?: false
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Protein
A0A1G5SJ71
Organism: Mus musculus/domesticus
Length: 337  
Fragment?: false
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Protein
A0A1G5SK74
Organism: Mus musculus/domesticus
Length: 517  
Fragment?: false
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Protein
A0A1G5SLK1
Organism: Mus musculus/domesticus
Length: 589  
Fragment?: false
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Protein
Q3UU73
Organism: Mus musculus/domesticus
Length: 235  
Fragment?: true
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Protein
A0A1G5SJF9
Organism: Mus musculus/domesticus
Length: 640  
Fragment?: false
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Protein
A0A1G5SJ49
Organism: Mus musculus/domesticus
Length: 420  
Fragment?: false
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Protein
Q3V0E6
Organism: Mus musculus/domesticus
Length: 393  
Fragment?: false
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Protein
A0A1G5SJS3
Organism: Mus musculus/domesticus
Length: 602  
Fragment?: false
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Protein
A0A1G5SLM1
Organism: Mus musculus/domesticus
Length: 517  
Fragment?: false
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Protein
A0A1L1STQ7
Organism: Mus musculus/domesticus
Length: 640  
Fragment?: false
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Protein
A0A1G5SJU0
Organism: Mus musculus/domesticus
Length: 627  
Fragment?: false
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Protein
A0A1L1SUL4
Organism: Mus musculus/domesticus
Length: 209  
Fragment?: false
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Protein
B2RWZ6
Organism: Mus musculus/domesticus
Length: 602  
Fragment?: false
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Protein
Q3UV10
Organism: Mus musculus/domesticus
Length: 602  
Fragment?: false
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Protein
Q9TNV1
Organism: Mus musculus/domesticus
Length: 95  
Fragment?: true
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Protein
Q9Z0I4
Organism: Mus musculus/domesticus
Length: 459  
Fragment?: true
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Protein
Q9Z0I3
Organism: Mus musculus/domesticus
Length: 152  
Fragment?: true
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Protein
A0A1G5SLP0
Organism: Mus musculus/domesticus
Length: 627  
Fragment?: false
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Protein
A0A1G5SJH7
Organism: Mus musculus/domesticus
Length: 337  
Fragment?: false
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Protein
Q9Z0I7
Organism: Mus musculus/domesticus
Length: 337  
Fragment?: false
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Protein
Q9Z0I5
Organism: Mus musculus/domesticus
Length: 517  
Fragment?: false
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Publication
20956525 | -
First Author: Katsoulidis E
Year: 2010
Journal: J Biol Chem
Title: Role of interferon {alpha} (IFN{alpha})-inducible Schlafen-5 in regulation of anchorage-independent growth and invasion of malignant melanoma cells.
Volume: 285
Issue: 51
Pages: 40333-41
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Protein Domain
IPR029684 | Schlafen
Type: Family
Description: The Schlafen (SLFN) family includes several mouse and human member genes that have been implicated in important functions, such as the control of cell proliferation, induction of immune responses, and the regulation of viral replication [, , , ]. Mouse and human SLFN proteins are regulated by interferons (IFNs) []. All SLFNs contain an unique Slfn box. SLFN family is comprised of 3 groups, based on the size of the encoded proteins [, , , ]:Group1: Slfn1, Slfn2, and Slfn Like 1.Group2: Slfn3, Slfn4 and Slfn12.Group3: Slfn5, Slfn8-11, Slfn13 and Slfn14.Comparing to group1 proteins, group2 and 3 proteins contain an extra SWADL domain C terminus to the AAA domain. Group3 proteins also possess a large extension C terminus to their SWADL domain. This C-terminal extension is homologous to the superfamily I of DNA/RNA helicases []. It has been proposed that the divergent AAA ATPase domain may function as an RNA-binding domain []. This entry also includes orthopoxvirus sequences. Analyses indicate that a member of the Schlafen family was horizontally transferred from murine rodents to orthopoxviruses, where it is hypothesised to play a role in allowing the virus to survive host immune defense mechanisms [].
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom