Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
The Schlafen (SLFN) family includes several mouse and human member genes that have been implicated in important functions, such as the control of cell proliferation, induction of immune responses, and the regulation of viral replication [, , , ]. Mouse and human SLFN proteins are regulated by interferons (IFNs) []. All SLFNs contain an unique Slfn box. SLFN family is comprised of 3 groups, based on the size of the encoded proteins [, , , ]:Group1: Slfn1, Slfn2, and Slfn Like 1.Group2: Slfn3, Slfn4 and Slfn12.Group3: Slfn5, Slfn8-11, Slfn13 and Slfn14.Comparing to group1 proteins, group2 and 3 proteins contain an extra SWADL domain C terminus to the AAA domain. Group3 proteins also possess a large extension C terminus to their SWADL domain. This C-terminal extension is homologous to the superfamily I of DNA/RNA helicases []. It has been proposed that the divergent AAA ATPase domain may function as an RNA-binding domain []. This entry represents SlfnL1 protein. Its function is not clear. |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
410
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Geserick P |
Year: |
2004 |
Journal: |
Int Immunol |
Title: |
Modulation of T cell development and activation by novel members of the Schlafen (slfn) gene family harbouring an RNA helicase-like motif. |
Volume: |
16 |
Issue: |
10 |
Pages: |
1535-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mavrommatis E |
Year: |
2013 |
Journal: |
J Interferon Cytokine Res |
Title: |
The schlafen family of proteins and their regulation by interferons. |
Volume: |
33 |
Issue: |
4 |
Pages: |
206-10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Neumann B |
Year: |
2008 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Subcellular localization of the Schlafen protein family. |
Volume: |
370 |
Issue: |
1 |
Pages: |
62-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen J |
Year: |
2021 |
Journal: |
Nat Commun |
Title: |
Structure of PDE3A-SLFN12 complex and structure-based design for a potent apoptosis inducer of tumor cells. |
Volume: |
12 |
Issue: |
1 |
Pages: |
6204 |
|
•
•
•
•
•
|
Publication |
First Author: |
Garvie CW |
Year: |
2021 |
Journal: |
Nat Commun |
Title: |
Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase. |
Volume: |
12 |
Issue: |
1 |
Pages: |
4375 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu F |
Year: |
2018 |
Journal: |
Cell Biol Int |
Title: |
The Schlafen family: complex roles in different cell types and virus replication. |
Volume: |
42 |
Issue: |
1 |
Pages: |
2-8 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3619742 |
Assay Type: |
RT-PCR |
Annotation Date: |
2006-04-17 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:3619902 |
Age: |
postnatal adult |
Image: |
1 |
|
Specimen Label: |
Brain |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3619742 |
Assay Type: |
RT-PCR |
Annotation Date: |
2006-04-17 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1684628 |
|
Stage: |
TS28 |
Assay Id: |
MGI:3619902 |
Age: |
postnatal adult |
Image: |
1 |
|
Specimen Label: |
Liver |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3619742 |
Assay Type: |
RT-PCR |
Annotation Date: |
2006-04-17 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1797228 |
|
Stage: |
TS28 |
Assay Id: |
MGI:3619902 |
Age: |
postnatal adult |
Image: |
1 |
|
Specimen Label: |
Testis |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3619742 |
Assay Type: |
RT-PCR |
Annotation Date: |
2006-04-17 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1737328 |
|
Stage: |
TS28 |
Assay Id: |
MGI:3619902 |
Age: |
postnatal adult |
Image: |
1 |
|
Specimen Label: |
Kidney |
Detected: |
false |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3619742 |
Assay Type: |
RT-PCR |
Annotation Date: |
2006-04-17 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1610528 |
|
Stage: |
TS28 |
Assay Id: |
MGI:3619902 |
Age: |
postnatal adult |
Image: |
1 |
|
Specimen Label: |
Heart |
Detected: |
false |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3619742 |
Assay Type: |
RT-PCR |
Annotation Date: |
2006-04-17 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:3557728 |
|
Stage: |
TS28 |
Assay Id: |
MGI:3619902 |
Age: |
postnatal adult |
Image: |
1 |
|
Specimen Label: |
Muscle |
Detected: |
false |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3619742 |
Assay Type: |
RT-PCR |
Annotation Date: |
2006-04-17 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:3287428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:3619902 |
Age: |
postnatal adult |
Image: |
1 |
|
Specimen Label: |
Intestine |
Detected: |
false |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3619742 |
Assay Type: |
RT-PCR |
Annotation Date: |
2006-04-17 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1672828 |
|
Stage: |
TS28 |
Assay Id: |
MGI:3619902 |
Age: |
postnatal adult |
Image: |
1 |
|
Specimen Label: |
Lung |
Detected: |
false |
Specimen Num: |
8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Park S |
Year: |
2020 |
Journal: |
Biol Reprod |
Title: |
CRISPR/Cas9-mediated genome-edited mice reveal 10 testis-enriched genes are dispensable for male fecundity. |
Volume: |
103 |
Issue: |
2 |
Pages: |
195-204 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ferguson DA |
Year: |
2005 |
Journal: |
Gene Expr Patterns |
Title: |
eXPRESSION: an in silico tool to predict patterns of gene expression. |
Volume: |
5 |
Issue: |
5 |
Pages: |
619-28 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Function or Process or Component Unknown following Literature Review |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
International Knockout Mouse Consortium |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of modified allele data from IKMC and creation of new knockout alleles |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
International Mouse Strain Resource |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of germline transmission data for alleles from IMSR strain data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Magdaleno S |
Year: |
2006 |
Journal: |
PLoS Biol |
Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
Volume: |
4 |
Issue: |
4 |
Pages: |
e86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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•
•
•
•
•
|