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Search results 1 to 100 out of 1091 for Smad4

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: rat
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
GXD Expression  
Probe: MGI:6715564
Assay Type: Immunohistochemistry
Annotation Date: 2021-06-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640619
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6715568
Age: embryonic day 11.5
Image: 5B Smad4 WT
Specimen Label: 5B Smad4 WT
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:6715564
Assay Type: Immunohistochemistry
Annotation Date: 2021-06-16
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1640619
Stage: TS19
Assay Id: MGI:6715568
Age: embryonic day 11.5
Image: 5B Smad4 PS4
Note: Expression largely undetectable.
Specimen Label: 5B Smad4 PS4
Detected: false
Specimen Num: 2
GXD Expression  
Probe: MGI:2023256
Assay Type: RNA in situ
Annotation Date: 2009-08-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271122
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:4354857
Age: embryonic day 14.5
Note: Expression is present in the upper, but not the lower, cortical plate.
Specimen Label: Table S5 - Smad4
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:2023256
Assay Type: RNA in situ
Annotation Date: 2009-08-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4354857
Age: embryonic day 14.5
Specimen Label: Table S5 - Smad4
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:2023256
Assay Type: RNA in situ
Annotation Date: 2009-08-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3270422
Stage: TS22
Assay Id: MGI:4354857
Age: embryonic day 14.5
Specimen Label: Table S5 - Smad4
Detected: false
Specimen Num: 1
Publication
First Author: Narula A
Year: 2002
Journal: Am J Pathol
Title: Smad4 overexpression causes germ cell ablation and leydig cell hyperplasia in transgenic mice.
Volume: 161
Issue: 5
Pages: 1723-34
Publication
First Author: Kojima K
Year: 2007
Journal: Cancer Res
Title: Inactivation of Smad4 accelerates Kras(G12D)-mediated pancreatic neoplasia.
Volume: 67
Issue: 17
Pages: 8121-30
Publication
First Author: Taketo MM
Year: 2000
Journal: Cytokine Growth Factor Rev
Title: Gastro-intestinal tumorigenesis in Smad4 mutant mice.
Volume: 11
Issue: 1-2
Pages: 147-57
Publication
First Author: Taketo MM
Year: 2000
Journal: Hum Cell
Title: Gastrointestinal tumorigenesis in Smad4 (Dpc4) mutant mice.
Volume: 13
Issue: 3
Pages: 85-95
Publication
First Author: Kim TH
Year: 2015
Journal: Biochem Biophys Res Commun
Title: Temporo-spatial requirement of Smad4 in dentin formation.
Volume: 459
Issue: 4
Pages: 706-12
Publication
First Author: Chen X
Year: 1997
Journal: Nature
Title: Smad4 and FAST-1 in the assembly of activin-responsive factor.
Volume: 389
Issue: 6646
Pages: 85-9
Publication
First Author: Alberici P
Year: 2006
Journal: Oncogene
Title: Smad4 haploinsufficiency in mouse models for intestinal cancer.
Volume: 25
Issue: 13
Pages: 1841-51
Publication
First Author: Tong K
Year: 2021
Journal: Oncogene
Title: SMAD4 is critical in suppression of BRAF-V600E serrated tumorigenesis.
Volume: 40
Issue: 41
Pages: 6034-6048
Publication
First Author: Lan Y
Year: 2007
Journal: Mol Cell Biol
Title: Essential role of endothelial Smad4 in vascular remodeling and integrity.
Volume: 27
Issue: 21
Pages: 7683-92
Publication
First Author: Li J
Year: 2020
Journal: EMBO Rep
Title: Smad4 promotes diabetic nephropathy by modulating glycolysis and OXPHOS.
Volume: 21
Issue: 2
Pages: e48781
Publication
First Author: Karlsson G
Year: 2007
Journal: J Exp Med
Title: Smad4 is critical for self-renewal of hematopoietic stem cells.
Volume: 204
Issue: 3
Pages: 467-74
Publication
First Author: Moon YJ
Year: 2016
Journal: Exp Mol Med
Title: Smad4 controls bone homeostasis through regulation of osteoblast/osteocyte viability.
Volume: 48
Issue: 9
Pages: e256
Publication
First Author: Simeone DM
Year: 2006
Journal: Am J Physiol Endocrinol Metab
Title: Islet hypertrophy following pancreatic disruption of Smad4 signaling.
Volume: 291
Issue: 6
Pages: E1305-16
Publication  
First Author: Karner CM
Year: 2017
Journal: Mol Cell Biol
Title: Bmp Induces Osteoblast Differentiation through both Smad4 and mTORC1 Signaling.
Volume: 37
Issue: 4
Publication
First Author: Owens P
Year: 2010
Journal: Am J Pathol
Title: Epidermal Smad4 deletion results in aberrant wound healing.
Volume: 176
Issue: 1
Pages: 122-33
Publication
First Author: Biondi CA
Year: 2007
Journal: Biochem J
Title: Mice develop normally in the absence of Smad4 nucleocytoplasmic shuttling.
Volume: 404
Issue: 2
Pages: 235-45
Publication  
First Author: Morita M
Year: 2016
Journal: Sci Rep
Title: Smad4 is required to inhibit osteoclastogenesis and maintain bone mass.
Volume: 6
Pages: 35221
Publication
First Author: Fortin J
Year: 2014
Journal: FASEB J
Title: Follicle-stimulating hormone synthesis and fertility depend on SMAD4 and FOXL2.
Volume: 28
Issue: 8
Pages: 3396-410
Publication
First Author: Hu W
Year: 2021
Journal: Sci Rep
Title: Smad4 regulates the nuclear translocation of Nkx2-5 in cardiac differentiation.
Volume: 11
Issue: 1
Pages: 3588
Publication
First Author: Means AL
Year: 2018
Journal: Cell Mol Gastroenterol Hepatol
Title: Epithelial Smad4 Deletion Up-Regulates Inflammation and Promotes Inflammation-Associated Cancer.
Volume: 6
Issue: 3
Pages: 257-276
Publication
First Author: Takaku K
Year: 1999
Journal: Cancer Res
Title: Gastric and duodenal polyps in Smad4 (Dpc4) knockout mice.
Volume: 59
Issue: 24
Pages: 6113-7
Publication
First Author: Tan X
Year: 2007
Journal: J Cell Sci
Title: Smad4 is required for maintaining normal murine postnatal bone homeostasis.
Volume: 120
Issue: Pt 13
Pages: 2162-70
Publication
First Author: Zhou F
Year: 2017
Journal: EMBO J
Title: USP4 inhibits SMAD4 monoubiquitination and promotes activin and BMP signaling.
Volume: 36
Issue: 11
Pages: 1623-1639
Publication  
First Author: Zhang S
Year: 2019
Journal: Mol Immunol
Title: SKI and SMAD4 are essential for IL-21-induced Th17 differentiation.
Volume: 114
Pages: 260-268
Publication  
First Author: McCarthy SS
Year: 2022
Journal: Development
Title: Smad4 controls proliferation of interstitial cells in the neonatal kidney.
Volume: 149
Issue: 1
Publication
First Author: Whitaker AT
Year: 2017
Journal: Biol Open
Title: Smad4 regulates growth plate matrix production and chondrocyte polarity.
Volume: 6
Issue: 3
Pages: 358-364
Publication
First Author: Yan J
Year: 2014
Journal: PLoS One
Title: Smad4 regulates ureteral smooth muscle cell differentiation during mouse embryogenesis.
Volume: 9
Issue: 8
Pages: e104503
Publication
First Author: Petit FG
Year: 2016
Journal: Int J Biol Sci
Title: Partial Müllerian Duct Retention in Smad4 Conditional Mutant Male Mice.
Volume: 12
Issue: 6
Pages: 667-76
Publication
First Author: Li J
Year: 2016
Journal: PLoS One
Title: Requirement of Smad4 from Ocular Surface Ectoderm for Retinal Development.
Volume: 11
Issue: 8
Pages: e0159639
Publication
First Author: Büchmann-Møller S
Year: 2009
Journal: Dev Biol
Title: Multiple lineage-specific roles of Smad4 during neural crest development.
Volume: 330
Issue: 2
Pages: 329-38
Publication
First Author: Song L
Year: 2007
Journal: Circ Res
Title: Myocardial smad4 is essential for cardiogenesis in mouse embryos.
Volume: 101
Issue: 3
Pages: 277-85
Publication
First Author: Chen Y
Year: 2006
Journal: Mamm Genome
Title: A novel mouse Smad4 mutation reduces protein stability and wild-type protein levels.
Volume: 17
Issue: 3
Pages: 211-9
GXD Expression    
Probe: MGI:6183813
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6191342
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Smad4
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6183813
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6191342
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Smad4
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6183813
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6191342
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Smad4
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6183813
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6191342
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Smad4
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6183813
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191342
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Smad4
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6183813
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191342
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Smad4
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6183813
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191342
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Smad4
Detected: true
Specimen Num: 7
Publication
First Author: Pangas SA
Year: 2006
Journal: Mol Endocrinol
Title: Premature luteinization and cumulus cell defects in ovarian-specific Smad4 knockout mice.
Volume: 20
Issue: 6
Pages: 1406-22
Publication
First Author: Cullingworth J
Year: 2002
Journal: Oncogene
Title: Carcinogen-induced pancreatic lesions in the mouse: effect of Smad4 and Apc genotypes.
Volume: 21
Issue: 30
Pages: 4696-701
Publication
First Author: Zhang J
Year: 2005
Journal: Dev Biol
Title: Smad4 is required for the normal organization of the cartilage growth plate.
Volume: 284
Issue: 2
Pages: 311-22
Publication
First Author: Ma X
Year: 2019
Journal: J Biol Chem
Title: SMAD family member 3 (SMAD3) and SMAD4 repress HIF2α-dependent iron-regulatory genes.
Volume: 294
Issue: 11
Pages: 3974-3986
Publication
First Author: Inoshita H
Year: 2013
Journal: PLoS One
Title: Disruption of Smad4 expression in T cells leads to IgA nephropathy-like manifestations.
Volume: 8
Issue: 11
Pages: e78736
Publication
First Author: Kim BG
Year: 2006
Journal: Nature
Title: Smad4 signalling in T cells is required for suppression of gastrointestinal cancer.
Volume: 441
Issue: 7096
Pages: 1015-9
Publication      
First Author: Liu J
Year: 2015
Journal: Cell Rep
Title: ErbB2 Pathway Activation upon Smad4 Loss Promotes Lung Tumor Growth and Metastasis.
Publication
First Author: Li F
Year: 2011
Journal: Dev Cell
Title: Endothelial Smad4 maintains cerebrovascular integrity by activating N-cadherin through cooperation with Notch.
Volume: 20
Issue: 3
Pages: 291-302
Publication
First Author: Cao Y
Year: 2018
Journal: Neoplasia
Title: Cooperation Between Pten and Smad4 in Murine Salivary Gland Tumor Formation and Progression.
Volume: 20
Issue: 8
Pages: 764-774
Publication
First Author: Ola R
Year: 2018
Journal: Circulation
Title: SMAD4 Prevents Flow Induced Arteriovenous Malformations by Inhibiting Casein Kinase 2.
Volume: 138
Issue: 21
Pages: 2379-2394
Publication
First Author: Zhang P
Year: 2016
Journal: Circ Res
Title: Smad4 Deficiency in Smooth Muscle Cells Initiates the Formation of Aortic Aneurysm.
Volume: 118
Issue: 3
Pages: 388-99
Publication
First Author: Perekatt AO
Year: 2018
Journal: Cancer Res
Title: SMAD4 Suppresses WNT-Driven Dedifferentiation and Oncogenesis in the Differentiated Gut Epithelium.
Volume: 78
Issue: 17
Pages: 4878-4890
Publication
First Author: Baburajendran N
Year: 2011
Journal: Nucleic Acids Res
Title: Structural basis for the cooperative DNA recognition by Smad4 MH1 dimers.
Volume: 39
Issue: 18
Pages: 8213-22
Publication
First Author: Yang SM
Year: 2009
Journal: Dev Dyn
Title: Chondrocyte-specific Smad4 gene conditional knockout results in hearing loss and inner ear malformation in mice.
Volume: 238
Issue: 8
Pages: 1897-908
Publication
First Author: Wang B
Year: 2008
Journal: Biochem Biophys Res Commun
Title: Roles of mono-ubiquitinated Smad4 in the formation of Smad transcriptional complexes.
Volume: 376
Issue: 2
Pages: 288-92
Publication
First Author: Kook SH
Year: 2016
Journal: Leukemia
Title: Smad4 in osteoblasts exerts a differential impact on HSC fate depending on osteoblast maturation stage.
Volume: 30
Issue: 10
Pages: 2039-2046
Publication
First Author: Wang Y
Year: 2018
Journal: J Clin Invest
Title: SMAD4 promotes TGF-β-independent NK cell homeostasis and maturation and antitumor immunity.
Volume: 128
Issue: 11
Pages: 5123-5136
Publication    
First Author: Paris ND
Year: 2016
Journal: Elife
Title: Smad4 restricts differentiation to promote expansion of satellite cell derived progenitors during skeletal muscle regeneration.
Volume: 5
Publication  
First Author: Hurwitz E
Year: 2023
Journal: J Cell Biol
Title: Antagonism between Prdm16 and Smad4 specifies the trajectory and progression of pancreatic cancer.
Volume: 222
Issue: 4
Publication
First Author: Qiao W
Year: 2006
Journal: Oncogene
Title: Hair follicle defects and squamous cell carcinoma formation in Smad4 conditional knockout mouse skin.
Volume: 25
Issue: 2
Pages: 207-17
Publication
First Author: Hahn JN
Year: 2011
Journal: J Clin Invest
Title: Smad4 deficiency in T cells leads to the Th17-associated development of premalignant gastroduodenal lesions in mice.
Volume: 121
Issue: 10
Pages: 4030-42
Publication
First Author: Qi X
Year: 2007
Journal: Dev Biol
Title: Essential role of Smad4 in maintaining cardiomyocyte proliferation during murine embryonic heart development.
Volume: 311
Issue: 1
Pages: 136-46
Publication
First Author: Gao Y
Year: 2009
Journal: Mol Cell Biol
Title: Disruption of Smad4 in odontoblasts causes multiple keratocystic odontogenic tumors and tooth malformation in mice.
Volume: 29
Issue: 21
Pages: 5941-51
Publication
First Author: Wang J
Year: 2005
Journal: Circ Res
Title: Targeted disruption of Smad4 in cardiomyocytes results in cardiac hypertrophy and heart failure.
Volume: 97
Issue: 8
Pages: 821-8
Publication
First Author: Yu C
Year: 2013
Journal: Mol Endocrinol
Title: Selective Smad4 knockout in ovarian preovulatory follicles results in multiple defects in ovulation.
Volume: 27
Issue: 6
Pages: 966-78
Publication
First Author: Lane J
Year: 2015
Journal: Dev Biol
Title: Tak1, Smad4 and Trim33 redundantly mediate TGF-β3 signaling during palate development.
Volume: 398
Issue: 2
Pages: 231-41
Publication
First Author: Falk S
Year: 2014
Journal: Cereb Cortex
Title: Smad4 and Trim33/Tif1γ redundantly regulate neural stem cells in the developing cortex.
Volume: 24
Issue: 11
Pages: 2951-63
Publication
First Author: Fernandes M
Year: 2012
Journal: Dev Biol
Title: SMAD4 is essential for generating subtypes of neurons during cerebellar development.
Volume: 365
Issue: 1
Pages: 82-90
Publication
First Author: Ko SO
Year: 2007
Journal: Dev Biol
Title: Smad4 is required to regulate the fate of cranial neural crest cells.
Volume: 312
Issue: 1
Pages: 435-47
Publication
First Author: Chu GC
Year: 2004
Journal: Development
Title: Differential requirements for Smad4 in TGFbeta-dependent patterning of the early mouse embryo.
Volume: 131
Issue: 15
Pages: 3501-12
Publication
First Author: Lan Y
Year: 2014
Journal: Blood
Title: Endothelial Smad4 restrains the transition to hematopoietic progenitors via suppression of ERK activation.
Volume: 123
Issue: 14
Pages: 2161-71
Publication
First Author: Tan X
Year: 2021
Journal: Nat Commun
Title: Loss of Smad4 promotes aggressive lung cancer metastasis by de-repression of PAK3 via miRNA regulation.
Volume: 12
Issue: 1
Pages: 4853
Publication
First Author: Wang A
Year: 2013
Journal: J Immunol
Title: Cutting edge: Smad2 and Smad4 regulate TGF-β-mediated Il9 gene expression via EZH2 displacement.
Volume: 191
Issue: 10
Pages: 4908-12
Publication
First Author: Shimada K
Year: 2009
Journal: Biochem Biophys Res Commun
Title: Traf2 interacts with Smad4 and regulates BMP signaling pathway in MC3T3-E1 osteoblasts.
Volume: 390
Issue: 3
Pages: 775-9
Publication
First Author: Crist AM
Year: 2018
Journal: Angiogenesis
Title: Vascular deficiency of Smad4 causes arteriovenous malformations: a mouse model of Hereditary Hemorrhagic Telangiectasia.
Volume: 21
Issue: 2
Pages: 363-380
Publication
First Author: Takeda H
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Sleeping Beauty transposon mutagenesis identifies genes that cooperate with mutant Smad4 in gastric cancer development.
Volume: 113
Issue: 14
Pages: E2057-65
Publication
First Author: Azar R
Year: 2009
Journal: EMBO J
Title: 4E-BP1 is a target of Smad4 essential for TGFbeta-mediated inhibition of cell proliferation.
Volume: 28
Issue: 22
Pages: 3514-22
Publication
First Author: Sirard C
Year: 2000
Journal: J Biol Chem
Title: Targeted disruption in murine cells reveals variable requirement for Smad4 in transforming growth factor beta-related signaling.
Volume: 275
Issue: 3
Pages: 2063-70
Publication
First Author: Cortez VS
Year: 2017
Journal: Nat Immunol
Title: SMAD4 impedes the conversion of NK cells into ILC1-like cells by curtailing non-canonical TGF-β signaling.
Volume: 18
Issue: 9
Pages: 995-1003
Publication
First Author: Song L
Year: 2011
Journal: Dev Dyn
Title: Cell autonomous requirement of endocardial Smad4 during atrioventricular cushion development in mouse embryos.
Volume: 240
Issue: 1
Pages: 211-20
Publication
First Author: Wang RH
Year: 2005
Journal: Cell Metab
Title: A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression.
Volume: 2
Issue: 6
Pages: 399-409
Publication
First Author: Hohenstein P
Year: 2003
Journal: Genes Chromosomes Cancer
Title: Serrated adenomas and mixed polyposis caused by a splice acceptor deletion in the mouse Smad4 gene.
Volume: 36
Issue: 3
Pages: 273-82
Publication
First Author: Salazar VS
Year: 2013
Journal: J Cell Sci
Title: Postnatal ablation of osteoblast Smad4 enhances proliferative responses to canonical Wnt signaling through interactions with β-catenin.
Volume: 126
Issue: Pt 24
Pages: 5598-609
Publication
First Author: Xu X
Year: 2010
Journal: Oncogene
Title: Synergistic action of Smad4 and Pten in suppressing pancreatic ductal adenocarcinoma formation in mice.
Volume: 29
Issue: 5
Pages: 674-86
Publication
First Author: Xu X
Year: 2006
Journal: J Clin Invest
Title: Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice.
Volume: 116
Issue: 7
Pages: 1843-52
Publication  
First Author: Banerjee K
Year: 2023
Journal: J Clin Invest
Title: SMAD4 maintains the fluid shear stress set point to protect against arterial-venous malformations.
Volume: 133
Issue: 18
Publication
First Author: Teng Y
Year: 2006
Journal: Cancer Res
Title: Synergistic function of Smad4 and PTEN in suppressing forestomach squamous cell carcinoma in the mouse.
Volume: 66
Issue: 14
Pages: 6972-81