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Search results 1 to 100 out of 445 for Smarca2

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
6595 | SMARCA2
Type: gene
Organism: human
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Gene
734002 | smarca2
Type: gene
Organism: frog, western clawed
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Gene
361745 | Smarca2
Type: gene
Organism: rat
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Gene
464965 | SMARCA2
Type: gene
Organism: chimpanzee
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Gene
476335 | SMARCA2
Type: gene
Organism: dog, domestic
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Gene
540904 | SMARCA2
Type: gene
Organism: cattle
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Gene
396040 | SMARCA2
Type: gene
Organism: chicken
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Gene
334032 | smarca2
Type: gene
Organism: zebrafish
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Gene
696973 | SMARCA2
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR030088 | SMARCA2
Type: Family
Description: BRM (also know as SMARCA2, BAF190B, SNF2A or SNF2L2) contains the Snf2 family ATPase domain and is a core enzymatic subunit of the SWI/SNF complex, an ATP-dependent chromatin remodelling complex that regulates gene expression through regulating nucleosome remodelling []. In humans SMARCA2 shares 73%sequence identity with BRG1 and has similar ATPase function in the SWI/SNF complex []. Similar to BRG1, SMARCA2 contains a C-terminal bromodomain that may anchor the entire SWI/SNF complex to promoter nucleosomes []. SMARCA2 may function as tumour suppressor []. Heterozygous variants in SMARCA2 gene cause Nicolaides-Baraitser syndrome, which is characterised by sparse hair, distinctive facial morphology, distal-limb anomalies and intellectual disability []. The ATP-dependent helicase brm from Drosophila, which is the ATPase subunit of the Brahma complex for remodeling chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA [], is also included in this entry.
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Protein Coding Gene
MGI:99603 | Smarca2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q99KH6
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: false
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Protein
Q8R1W7
Organism: Mus musculus/domesticus
Length: 495  
Fragment?: true
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Protein
Q7TND4
Organism: Mus musculus/domesticus
Length: 978  
Fragment?: true
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Gene
100996645 | LNCBRM
Type: gene
Organism: human
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Gene
123706518 | SMARCA2-AS1
Type: gene
Organism: human
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Publication
22366787 | -
First Author: Van Houdt JK
Year: 2012
Journal: Nat Genet
Title: Heterozygous missense mutations in SMARCA2 cause Nicolaides-Baraitser syndrome.
Volume: 44
Issue: 4
Pages: 445-9, S1
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Protein
A0A140LHL7
Organism: Mus musculus/domesticus
Length: 93  
Fragment?: true
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Publication
1346755 | J:19594
First Author: Tamkun JW
Year: 1992
Journal: Cell
Title: brahma: a regulator of Drosophila homeotic genes structurally related to the yeast transcriptional activator SNF2/SWI2.
Volume: 68
Issue: 3
Pages: 561-72
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Publication
19234488 | -
First Author: Reisman D
Year: 2009
Journal: Oncogene
Title: The SWI/SNF complex and cancer.
Volume: 28
Issue: 14
Pages: 1653-68
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Protein
A0A140LHJ8
Organism: Mus musculus/domesticus
Length: 68  
Fragment?: true
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Protein
O35846
Organism: Mus musculus/domesticus
Length: 279  
Fragment?: true
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Protein
H3BKD2
Organism: Mus musculus/domesticus
Length: 173  
Fragment?: true
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Protein
H3BKN5
Organism: Mus musculus/domesticus
Length: 299  
Fragment?: true
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Publication
17274598 | -
First Author: Shen W
Year: 2007
Journal: Biochemistry
Title: Solution structure of human Brg1 bromodomain and its specific binding to acetylated histone tails.
Volume: 46
Issue: 8
Pages: 2100-10
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Publication
24421395 | J:222133
First Author: Wilson BG
Year: 2014
Journal: Mol Cell Biol
Title: Residual complexes containing SMARCA2 (BRM) underlie the oncogenic drive of SMARCA4 (BRG1) mutation.
Volume: 34
Issue: 6
Pages: 1136-44
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Protein
Q6DIC0
Organism: Mus musculus/domesticus
Length: 1577  
Fragment?: false
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Protein
Q9CTU8
Organism: Mus musculus/domesticus
Length: 570  
Fragment?: true
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Protein
H3BK47
Organism: Mus musculus/domesticus
Length: 276  
Fragment?: false
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Protein
A0A140LI14
Organism: Mus musculus/domesticus
Length: 244  
Fragment?: true
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Protein
H3BJI1
Organism: Mus musculus/domesticus
Length: 201  
Fragment?: true
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Protein
A0A140LIQ9
Organism: Mus musculus/domesticus
Length: 229  
Fragment?: true
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Protein
A0A140LHF4
Organism: Mus musculus/domesticus
Length: 296  
Fragment?: true
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Protein
A0A140LHZ8
Organism: Mus musculus/domesticus
Length: 200  
Fragment?: true
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Protein
A0A140LIV3
Organism: Mus musculus/domesticus
Length: 170  
Fragment?: true
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Protein
A0A140LIM0
Organism: Mus musculus/domesticus
Length: 260  
Fragment?: false
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Protein
H3BLI4
Organism: Mus musculus/domesticus
Length: 211  
Fragment?: true
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Protein
A0A140LHP6
Organism: Mus musculus/domesticus
Length: 278  
Fragment?: false
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Protein
Q9D007
Organism: Mus musculus/domesticus
Length: 236  
Fragment?: false
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Protein
A0A140LJK1
Organism: Mus musculus/domesticus
Length: 169  
Fragment?: true
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Protein
H3BJM2
Organism: Mus musculus/domesticus
Length: 149  
Fragment?: true
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Protein
A0A140LHE2
Organism: Mus musculus/domesticus
Length: 228  
Fragment?: true
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Protein
H3BKJ3
Organism: Mus musculus/domesticus
Length: 254  
Fragment?: false
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Protein
A0A140LID0
Organism: Mus musculus/domesticus
Length: 267  
Fragment?: true
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Protein
A0A140LJD7
Organism: Mus musculus/domesticus
Length: 228  
Fragment?: true
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Protein
Q3UX55
Organism: Mus musculus/domesticus
Length: 517  
Fragment?: true
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Protein
E9QAB8
Organism: Mus musculus/domesticus
Length: 1510  
Fragment?: false
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Protein
Q3UHL2
Organism: Mus musculus/domesticus
Length: 1510  
Fragment?: false
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Protein
H3BJK2
Organism: Mus musculus/domesticus
Length: 1525  
Fragment?: false
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Protein
H3BLH0
Organism: Mus musculus/domesticus
Length: 1601  
Fragment?: false
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Protein
F2Z4A9
Organism: Mus musculus/domesticus
Length: 1583  
Fragment?: false
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Publication
19363039 | J:149322
First Author: Koga M
Year: 2009
Journal: Hum Mol Genet
Title: Involvement of SMARCA2/BRM in the SWI/SNF chromatin-remodeling complex in schizophrenia.
Volume: 18
Issue: 13
Pages: 2483-94
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Publication
20107077 | J:157855
First Author: Harikrishnan KN
Year: 2010
Journal: J Neurosci
Title: Alleviating transcriptional inhibition of the norepinephrine slc6a2 transporter gene in depolarized neurons.
Volume: 30
Issue: 4
Pages: 1494-501
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Protein Coding Gene
MGP_CAROLIEiJ_G0022841 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0025005 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0024982 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0024950 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0024981 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0024737 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_99603 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0025422 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0024207 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0024715 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0024847 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0024809 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0024932 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0024836 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0025477 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0023955 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0024274 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0014334 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0023759 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
19074882 | J:142239
First Author: Shen H
Year: 2008
Journal: Cancer Res
Title: The SWI/SNF ATPase Brm is a gatekeeper of proliferative control in prostate cancer.
Volume: 68
Issue: 24
Pages: 10154-62
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Publication
24876151 | J:216016
First Author: Kahali B
Year: 2014
Journal: Carcinogenesis
Title: Flavonoids from each of the six structural groups reactivate BRM, a possible cofactor for the anticancer effects of flavonoids.
Volume: 35
Issue: 10
Pages: 2183-93
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Publication
26059320 | J:228696
First Author: Nguyen KH
Year: 2015
Journal: Stem Cells
Title: SWI/SNF-Mediated Lineage Determination in Mesenchymal Stem Cells Confers Resistance to Osteoporosis.
Volume: 33
Issue: 10
Pages: 3028-38
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Publication
25026375 | J:230126
 
First Author: Mehrotra A
Year: 2014
Journal: Arch Biochem Biophys
Title: Modulation of Brahma expression by the mitogen-activated protein kinase/extracellular signal regulated kinase pathway is associated with changes in melanoma proliferation.
Volume: 563
Pages: 125-35
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Publication
30522882 | J:319306
First Author: Farrell AW
Year: 2018
Journal: J Dermatol Sci
Title: Brahma deficiency in keratinocytes promotes UV carcinogenesis by accelerating the escape from cell cycle arrest and the formation of DNA photolesions.
Volume: 92
Issue: 3
Pages: 254-263
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GXD Expression
GXD Expression
     
Probe: MGI:2661951
Assay Type: Western blot
Annotation Date: 2003-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:2661971
Age: embryonic day 7.5
Specimen Label: embryonic 7.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:2661951
Assay Type: Western blot
Annotation Date: 2003-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603914
Stage: TS14
Assay Id: MGI:2661971
Age: embryonic day 9.0
Specimen Label: embryonic 9
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:2661951
Assay Type: Western blot
Annotation Date: 2003-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:2661971
Age: embryonic day 12.0
Specimen Label: embryonic 12
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:2661951
Assay Type: Western blot
Annotation Date: 2003-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:2661971
Age: embryonic day 15.0
Specimen Label: embryonic 15
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:2661951
Assay Type: Western blot
Annotation Date: 2003-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603926
Stage: TS26
Assay Id: MGI:2661971
Age: embryonic day 18.0
Specimen Label: embryonic 18
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:2661951
Assay Type: Western blot
Annotation Date: 2003-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1604211
Stage: TS11
Assay Id: MGI:2661971
Age: embryonic day 7.5
Specimen Label: extraembryonic 7.5
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:2661951
Assay Type: Western blot
Annotation Date: 2003-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1604214
Stage: TS14
Assay Id: MGI:2661971
Age: embryonic day 9.0
Specimen Label: extraembryonic 9
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
     
Probe: MGI:2661951
Assay Type: Western blot
Annotation Date: 2003-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1604220
Stage: TS20
Assay Id: MGI:2661971
Age: embryonic day 12.0
Specimen Label: extraembryonic 12
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
     
Probe: MGI:2661951
Assay Type: Western blot
Annotation Date: 2003-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1604223
Stage: TS23
Assay Id: MGI:2661971
Age: embryonic day 15.0
Specimen Label: extraembryonic 15
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
     
Probe: MGI:2661951
Assay Type: Western blot
Annotation Date: 2003-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1604226
Stage: TS26
Assay Id: MGI:2661971
Age: embryonic day 18.0
Specimen Label: extraembryonic 18
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
     
Probe: MGI:2661951
Assay Type: Western blot
Annotation Date: 2003-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2661973
Age: postnatal adult
Specimen Label: +/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:2661951
Assay Type: Western blot
Annotation Date: 2003-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2661973
Age: postnatal adult
Specimen Label: +/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:2661951
Assay Type: Western blot
Annotation Date: 2003-06-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2661973
Age: postnatal adult
Specimen Label: -/-
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:2661951
Assay Type: Western blot
Annotation Date: 2003-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2661973
Age: postnatal adult
Specimen Label: +/+
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:2661951
Assay Type: Western blot
Annotation Date: 2003-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2661973
Age: postnatal adult
Specimen Label: +/-
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:2661951
Assay Type: Western blot
Annotation Date: 2003-06-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2661973
Age: postnatal adult
Specimen Label: -/-
Detected: false
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:2661953
Assay Type: Western blot
Annotation Date: 2003-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2661974
Age: postnatal adult
Specimen Label: WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:2661953
Assay Type: Western blot
Annotation Date: 2003-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2661974
Age: postnatal adult
Specimen Label: -/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:2661953
Assay Type: Western blot
Annotation Date: 2003-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2661974
Age: postnatal adult
Specimen Label: -/-
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:2661953
Assay Type: Western blot
Annotation Date: 2003-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2661974
Age: postnatal adult
Specimen Label: WT
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:2661951
Assay Type: Western blot
Annotation Date: 2003-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2661979
Age: postnatal adult
Specimen Label: LIVER WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:2661951
Assay Type: Western blot
Annotation Date: 2003-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2661979
Age: postnatal adult
Specimen Label: LIVER WT
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:2661951
Assay Type: Western blot
Annotation Date: 2003-06-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2661979
Age: postnatal adult
Specimen Label: LIVER -/-
Detected: false
Specimen Num: 3
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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Cambridge CB2 3EH, United Kingdom