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Search results 1 to 100 out of 128 for Smc5

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
23137 | SMC5
Type: gene
Organism: human
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Gene
100485531 | smc5
Type: gene
Organism: frog, western clawed
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Gene
293967 | Smc5
Type: gene
Organism: rat
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Gene
476327 | SMC5
Type: gene
Organism: dog, domestic
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Gene
464519 | SMC5
Type: gene
Organism: chimpanzee
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Gene
508938 | SMC5
Type: gene
Organism: cattle
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Gene
431608 | SMC5
Type: gene
Organism: chicken
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Gene
566749 | smc5
Type: gene
Organism: zebrafish
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Gene
702219 | SMC5
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:2385088 | Smc5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR027131 | SMC5
Type: Family
Description: SMC5 is a core component of the SMC5-SMC6 complex [, ], a complex involved in repair of DNA double-strand breaks by homologous recombination [, ]. In humans, the SMC5-SMC6 complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks []. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs) []. SMC5 is required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6 [].
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Gene
100507299 | SMC5-DT
Type: gene
Organism: human
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Publication
- | J:82362
   
First Author: Cobbe N
Year: 2002
Journal: GenBank Submission
Title: Mus musculus mRNA for SMC5 protein
Pages: AJ534941
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Publication
38203602 | J:351168
 
First Author: O'Brien MP
Year: 2023
Journal: Int J Mol Sci
Title: SMC5 Plays Independent Roles in Congenital Heart Disease and Neurodevelopmental Disability.
Volume: 25
Issue: 1
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Publication
19502785 | -
First Author: Behlke-Steinert S
Year: 2009
Journal: Cell Cycle
Title: SMC5 and MMS21 are required for chromosome cohesion and mitotic progression.
Volume: 8
Issue: 14
Pages: 2211-8
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Publication
26919979 | J:240155
First Author: Pryzhkova MV
Year: 2016
Journal: J Cell Sci
Title: Conditional mutation of Smc5 in mouse embryonic stem cells perturbs condensin localization and mitotic progression.
Volume: 129
Issue: 8
Pages: 1619-34
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Publication
10747036 | -
First Author: Fousteri MI
Year: 2000
Journal: EMBO J
Title: A novel SMC protein complex in Schizosaccharomyces pombe contains the Rad18 DNA repair protein.
Volume: 19
Issue: 7
Pages: 1691-702
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Publication
15738391 | -
First Author: Zhao X
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization.
Volume: 102
Issue: 13
Pages: 4777-82
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Publication
16810316 | -
First Author: Potts PR
Year: 2006
Journal: EMBO J
Title: Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double-strand breaks.
Volume: 25
Issue: 14
Pages: 3377-88
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Publication
17589526 | -
First Author: Potts PR
Year: 2007
Journal: Nat Struct Mol Biol
Title: The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins.
Volume: 14
Issue: 7
Pages: 581-90
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Publication
15010319 | -
First Author: Onoda F
Year: 2004
Journal: DNA Repair (Amst)
Title: SMC6 is required for MMS-induced interchromosomal and sister chromatid recombinations in Saccharomyces cerevisiae.
Volume: 3
Issue: 4
Pages: 429-39
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Publication
18086888 | -
First Author: Taylor EM
Year: 2008
Journal: Mol Cell Biol
Title: Identification of the proteins, including MAGEG1, that make up the human SMC5-6 protein complex.
Volume: 28
Issue: 4
Pages: 1197-206
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Protein
Q8CG46
Organism: Mus musculus/domesticus
Length: 1101  
Fragment?: false
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Protein
A0A286YDG5
Organism: Mus musculus/domesticus
Length: 1011  
Fragment?: false
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Publication
30281394 | J:299559
First Author: Hwang G
Year: 2018
Journal: Mol Biol Cell
Title: Depletion of SMC5/6 sensitizes male germ cells to DNA damage.
Volume: 29
Issue: 25
Pages: 3003-3016
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Publication
33200984 | J:299451
   
First Author: Atkins A
Year: 2020
Journal: Elife
Title: SMC5/6 is required for replication fork stability and faithful chromosome segregation during neurogenesis.
Volume: 9
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Publication
28302748 | J:241574
First Author: Hwang G
Year: 2017
Journal: Development
Title: SMC5/6 is required for the formation of segregation-competent bivalent chromosomes during meiosis I in mouse oocytes.
Volume: 144
Issue: 9
Pages: 1648-1660
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Protein Coding Gene
MGP_CAROLIEiJ_G0022821 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0024984 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0024961 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0024931 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0024960 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0024718 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2385088 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0025402 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0024186 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0024696 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0024828 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0024789 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0024912 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0025457 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0023935 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0024254 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0014315 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0023740 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
     
Probe: MGI:6457039
Assay Type: RT-PCR
Annotation Date: 2020-09-24
Strength: Present
Sex: Female
Emaps: EMAPS:1796223
Stage: TS23
Assay Id: MGI:6457075
Age: embryonic day 15.5
Specimen Label: Ovary Fetal
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
       
Probe: MGI:6457039
Assay Type: RT-PCR
Annotation Date: 2020-09-24
Strength: Not Specified
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:6457075
Age: postnatal adult
Specimen Label: Ovary Adult
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:6457039
Assay Type: RT-PCR
Annotation Date: 2020-09-24
Strength: Present
Sex: Male
Emaps: EMAPS:1797223
Stage: TS23
Assay Id: MGI:6457075
Age: embryonic day 15.5
Specimen Label: Testis Fetal
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:6457039
Assay Type: RT-PCR
Annotation Date: 2020-09-24
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:6457075
Age: postnatal adult
Specimen Label: Testis Adult
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:6457055
Assay Type: RNA in situ
Annotation Date: 2020-09-24
Strength: Present
Sex: Male
Emaps: EMAPS:3575728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6457091
Age: postnatal adult
Note: Expression specifically in meiotic spermatocytes.
Specimen Label: 3 MLZ-452
Detected: true
Specimen Num: 1
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Publication
11408570 | J:162301
First Author: Taylor EM
Year: 2001
Journal: Mol Biol Cell
Title: Characterization of a novel human SMC heterodimer homologous to the Schizosaccharomyces pombe Rad18/Spr18 complex.
Volume: 12
Issue: 6
Pages: 1583-94
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Publication
19793919 | J:238456
First Author: Brouwer AK
Year: 2009
Journal: Mol Biol Cell
Title: Telomeric DNA mediates de novo PML body formation.
Volume: 20
Issue: 22
Pages: 4804-15
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Publication
20339383 | J:187568
First Author: Kogo H
Year: 2010
Journal: J Hum Genet
Title: Screening of genes involved in chromosome segregation during meiosis I: toward the identification of genes responsible for infertility in humans.
Volume: 55
Issue: 5
Pages: 293-9
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Publication
- | J:77000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
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Publication
27626380 | J:236599
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
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Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
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Publication
- | J:73796
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Function or Process or Component Unknown following Literature Review
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
17005570 | -
First Author: Palecek J
Year: 2006
Journal: J Biol Chem
Title: The Smc5-Smc6 DNA repair complex. bridging of the Smc5-Smc6 heads by the KLEISIN, Nse4, and non-Kleisin subunits.
Volume: 281
Issue: 48
Pages: 36952-9
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Protein Domain
IPR014854 | Nse4_C
Type: Domain
Description: Nse4 is the kleisin component of the Smc5/6 DNA repair complex. It bridges the heads of Smc5 and Smc6 []. This entry represents the highly conserved C-terminal domain which interacts with the head domain of Smc5 [].
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Protein Domain
IPR041741 | SMC3_ABC_euk
Type: Domain
Description: The structural maintenance of chromosomes (SMC) proteins are large (approximately 110 to 170kDa), and each is arranged into five recognizable domains. Amino-acid sequence homology of SMC proteins between species is largely confined to the amino- and carboxy-terminal globular domains. The amino-terminal domain contains a 'WalkerA' nucleotide-binding domain (GxxGxGKS/T), which by mutational studies has been shown to be essential in several proteins. The carboxy-terminal domain contains a sequence (the DA-box) that resembles a 'Walker B' motif, and a motif with homology to the signature sequence of the ATP-binding cassette (ABC) family of ATPases. The sequence homology within the carboxy-terminal domain is relatively high within the SMC1-SMC4 group, whereas SMC5 and SMC6 show some divergence in both of these sequences. In eukaryotic cells, the proteins are found as heterodimers of SMC1 paired with SMC3, SMC2 with SMC4, and SMC5 with SMC6 [].This entry represents the ATP-binding cassette domain of eukaryotic SMC3 proteins, which is found at the N terminus.
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Protein Domain
IPR041738 | SMC4_ABC_euk
Type: Domain
Description: The structural maintenance of chromosomes (SMC) proteins are large (approximately 110 to 170kDa), and each is arranged into five recognizable domains. Amino-acid sequence homology of SMC proteins between species is largely confined to the amino- and carboxy-terminal globular domains. The amino-terminal domain contains a 'Walker A' nucleotide-binding domain (GxxGxGKS/T), which by mutational studies has been shown to be essential in several proteins. The carboxy-terminal domain contains a sequence (the DA-box) that resembles a 'Walker B' motif, and a motif with homology to the signature sequence of the ATP-binding cassette (ABC) family of ATPases. The sequence homology within the carboxy-terminal domain is relatively high within the SMC1-SMC4 group, whereas SMC5 and SMC6 show some divergence in both of these sequences. In eukaryotic cells, the proteins are found as heterodimers of SMC1 paired with SMC3, SMC2 with SMC4, and SMC5 with SMC6 [].This entry represents the ATP-binding cassette domain of eukaryotic SMC4 proteins.
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Protein
Q5EBG4
Organism: Mus musculus/domesticus
Length: 202  
Fragment?: true
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Protein
Q3V124
Organism: Mus musculus/domesticus
Length: 375  
Fragment?: false
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Protein
G3XA30
Organism: Mus musculus/domesticus
Length: 381  
Fragment?: false
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Publication
15601841 | -
First Author: Andrews EA
Year: 2005
Journal: Mol Cell Biol
Title: Nse2, a component of the Smc5-6 complex, is a SUMO ligase required for the response to DNA damage.
Volume: 25
Issue: 1
Pages: 185-96
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Publication
16055714 | -
First Author: Potts PR
Year: 2005
Journal: Mol Cell Biol
Title: Human MMS21/NSE2 is a SUMO ligase required for DNA repair.
Volume: 25
Issue: 16
Pages: 7021-32
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Publication
19682286 | -
First Author: Huang L
Year: 2009
Journal: Plant J
Title: The Arabidopsis SUMO E3 ligase AtMMS21, a homologue of NSE2/MMS21, regulates cell proliferation in the root.
Volume: 60
Issue: 4
Pages: 666-78
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Publication
22921571 | -
First Author: Kliszczak M
Year: 2012
Journal: DNA Repair (Amst)
Title: SUMO ligase activity of vertebrate Mms21/Nse2 is required for efficient DNA repair but not for Smc5/6 complex stability.
Volume: 11
Issue: 10
Pages: 799-810
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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