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Search results 1 to 100 out of 229 for Smg1

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Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
100145499 | smg1
Type: gene
Organism: frog, western clawed
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Gene
525143 | SMG1
Type: gene
Organism: cattle
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Gene
569810 | smg1
Type: gene
Organism: zebrafish
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Gene
693542 | SMG1
Type: gene
Organism: macaque, rhesus
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Gene
23049 | SMG1
Type: gene
Organism: human
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Gene
691397 | Smg1
Type: gene
Organism: rat
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Gene
416605 | SMG1
Type: gene
Organism: chicken
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Gene
479832 | SMG1
Type: gene
Organism: dog, domestic
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Gene
453961 | SMG1
Type: gene
Organism: chimpanzee
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Protein Domain
IPR031559 | SMG1
Type: Family
Description: Serine/threonine-protein kinase SMG1 is a phosphatidylinositol kinase-related protein that acts as an mRNA-surveillance protein and is a key component of nonsense-mediated decay (NMD) [, , , ]. In C.elegans, SMG1 is a key regulator of growth. Loss of SMG1 leads to hyperactive responses to injury and subsequent growth that continues out of control. It has an antagonistic role to mTOR signalling in worms []and possibly also in higher eukaryotes.
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Protein Coding Gene
MGI:1919742 | Smg1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q8BKX6
Organism: Mus musculus/domesticus
Length: 3658  
Fragment?: false
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Publication
23277562 | J:193626
First Author: Roberts TL
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Smg1 haploinsufficiency predisposes to tumor formation and inflammation.
Volume: 110
Issue: 4
Pages: E285-94
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Publication
12881430 | -
First Author: Gatfield D
Year: 2003
Journal: EMBO J
Title: Nonsense-mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathways.
Volume: 22
Issue: 15
Pages: 3960-70
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Publication
11331269 | -
First Author: Denning G
Year: 2001
Journal: J Biol Chem
Title: Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein.
Volume: 276
Issue: 25
Pages: 22709-14
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Publication
15175154 | -
First Author: Brumbaugh KM
Year: 2004
Journal: Mol Cell
Title: The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells.
Volume: 14
Issue: 5
Pages: 585-98
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Publication
15314158 | -
First Author: Grimson A
Year: 2004
Journal: Mol Cell Biol
Title: SMG-1 is a phosphatidylinositol kinase-related protein kinase required for nonsense-mediated mRNA Decay in Caenorhabditis elegans.
Volume: 24
Issue: 17
Pages: 7483-90
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Publication
22479207 | -
First Author: González-Estévez C
Year: 2012
Journal: PLoS Genet
Title: SMG-1 and mTORC1 act antagonistically to regulate response to injury and growth in planarians.
Volume: 8
Issue: 3
Pages: e1002619
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Publication
20566848 | J:196053
First Author: McIlwain DR
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Smg1 is required for embryogenesis and regulates diverse genes via alternative splicing coupled to nonsense-mediated mRNA decay.
Volume: 107
Issue: 27
Pages: 12186-91
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Publication
24185201 | J:210040
First Author: Cho H
Year: 2013
Journal: Biochim Biophys Acta
Title: SMG1 regulates adipogenesis via targeting of staufen1-mediated mRNA decay.
Volume: 1829
Issue: 12
Pages: 1276-87
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Publication
31565865 | J:296513
First Author: Ho U
Year: 2019
Journal: J Cell Mol Med
Title: SMG1 heterozygosity exacerbates haematopoietic cancer development in Atm null mice by increasing persistent DNA damage and oxidative stress.
Volume: 23
Issue: 12
Pages: 8151-8160
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Gene
440354 | SMG1P2
Type: gene
Organism: human
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Gene
595101 | SMG1P5
Type: gene
Organism: human
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Gene
641298 | SMG1P1
Type: gene
Organism: human
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Gene
100271836 | SMG1P3
Type: gene
Organism: human
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Gene
100422558 | SMG1P6
Type: gene
Organism: human
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Gene
100506060 | SMG1P7
Type: gene
Organism: human
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Gene
100507526 | SMG1P4
Type: gene
Organism: human
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Gene
107984844 | SMG1-DT
Type: gene
Organism: human
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Publication
20864032 | J:165255
First Author: Horejsí Z
Year: 2010
Journal: Mol Cell
Title: CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability.
Volume: 39
Issue: 6
Pages: 839-50
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Publication
32665638 | J:294176
First Author: Snyder E
Year: 2020
Journal: Sci Rep
Title: ADAD1 and ADAD2, testis-specific adenosine deaminase domain-containing proteins, are required for male fertility.
Volume: 10
Issue: 1
Pages: 11536
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Protein Coding Gene
MGP_CAROLIEiJ_G0030362 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0032896 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0032879 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0032811 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0032884 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0032594 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1919742 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0033390 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0031922 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0032567 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0032719 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0032672 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0032813 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0032704 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0033410 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0031630 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0032035 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0013573 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0031477 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
   
Probe: MGI:7451077
Assay Type: RT-PCR
Annotation Date: 2023-04-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160331
Stage: TS01
Assay Id: MGI:7451112
Age: embryonic day 0.5
Image: 2
Specimen Label: Zygote
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7451077
Assay Type: RT-PCR
Annotation Date: 2023-04-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:7451112
Age: embryonic day 2.0
Image: 2
Specimen Label: 4-cell
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7451077
Assay Type: RT-PCR
Annotation Date: 2023-04-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160403
Stage: TS03
Assay Id: MGI:7451112
Age: embryonic day 3.0
Image: 2
Specimen Label: Morula
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:6470844
Assay Type: Immunohistochemistry
Annotation Date: 2020-11-18
Strength: Present
Sex: Male
Emaps: EMAPS:3148428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6472902
Age: postnatal adult
Image: 5A XI WT
Note: Expression is in cytoplasmic granules in late pachytene spermatocytes.
Specimen Label: 5A XI WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:6470844
Assay Type: Immunohistochemistry
Annotation Date: 2020-11-18
Strength: Present
Sex: Male
Emaps: EMAPS:3148428
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6472902
Age: postnatal adult
Image: 5A XI Adad2
Note: Expression in this mutant is the same as in wild-type.
Specimen Label: 5A XI Adad2
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:4426014
Assay Type: RNA in situ
Annotation Date: 2023-11-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7549173
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:6470844
Assay Type: Immunohistochemistry
Annotation Date: 2020-11-18
Strength: Present
Sex: Male
Emaps: EMAPS:3148628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6472902
Age: postnatal adult
Image: 5A IV WT
Note: Expression is in cytoplasmic granules in early round spermatids.
Specimen Label: 5A IV WT
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:6470844
Assay Type: Immunohistochemistry
Annotation Date: 2020-11-18
Strength: Present
Sex: Male
Emaps: EMAPS:3148628
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6472902
Age: postnatal adult
Image: 5A IV Adad2
Note: Expression in this mutant is the same as in wild-type.
Specimen Label: 5A IV Adad2
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:4426014
Assay Type: RNA in situ
Annotation Date: 2023-11-17
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7549173
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
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Publication
25770585 | J:222980
First Author: Li T
Year: 2015
Journal: EMBO J
Title: Smg6/Est1 licenses embryonic stem cell differentiation via nonsense-mediated mRNA decay.
Volume: 34
Issue: 12
Pages: 1630-47
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Publication
36563685 | J:332882
First Author: Li N
Year: 2023
Journal: Stem Cell Reports
Title: CFIm-mediated alternative polyadenylation safeguards the development of mammalian pre-implantation embryos.
Volume: 18
Issue: 1
Pages: 81-96
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Publication
29539633 | J:261316
First Author: Perez-Garcia V
Year: 2018
Journal: Nature
Title: Placentation defects are highly prevalent in embryonic lethal mouse mutants.
Volume: 555
Issue: 7697
Pages: 463-468
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Publication
14621295 | J:86686
First Author: Okazaki N
Year: 2003
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 10
Issue: 4
Pages: 167-80
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Strain
MGI:5701712 | B6.129P2-Smg1<Gt(RRT449)Byg>/Cnbc
Attribute String: congenic, mutant strain, targeted mutation, gene trap
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Publication
- | J:165964
     
First Author: Mammalian Functional Genomics Centre
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the NorCOMM project by the Mammalian Functional Genomics Centre (Mfgc), University of Manitoba
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Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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