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Search results 1 to 100 out of 932 for Smo

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Danio rerio
Gene
Type: gene
Organism: Drosophila melanogaster
Gene
Type: gene
Organism: Rattus norvegicus
Protein Domain
Type: Family
Description: This entry represents smoothened (SMO) and its homologues, which are related to the frizzled protein family. Smoothened is a G protein-coupled receptor that is involved in the hedgehog signalling pathway. Smoothened probably associates with the patched protein to transduce the hedgehog's proteins signal []. Mutated smoothened can function as an oncogene [].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein
Organism: Mus musculus
Length: 793  
Fragment?: false
Protein
Organism: Mus musculus
Length: 439  
Fragment?: false
Protein
Organism: Mus musculus
Length: 310  
Fragment?: true
Publication
First Author: Xie J
Year: 1998
Journal: Nature
Title: Activating Smoothened mutations in sporadic basal-cell carcinoma.
Volume: 391
Issue: 6662
Pages: 90-2
Publication
First Author: Endoh-Yamagami S
Year: 2009
Journal: Curr Biol
Title: The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development.
Volume: 19
Issue: 15
Pages: 1320-6
GXD Expression
Probe: MGI:6436822
Assay Type: Immunohistochemistry
Annotation Date: 2020-10-26
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1616517
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:6469357
Age: embryonic day 10.5
Image: 6C Smo cbb
Note: Expression in ~25% of ciliated cells.
Detected: true
Specimen Num: 2
Protein
Organism: Mus musculus
Length: 793  
Fragment?: false
Publication
First Author: Gigante ED
Year: 2018
Journal: Dev Biol
Title: Hypomorphic Smo mutant with inefficient ciliary enrichment disrupts the highest level of vertebrate Hedgehog response.
Volume: 437
Issue: 2
Pages: 152-162
Protein
Organism: Mus musculus
Length: 360  
Fragment?: true
Publication
First Author: May SR
Year: 2005
Journal: Dev Biol
Title: Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli.
Volume: 287
Issue: 2
Pages: 378-89
Publication
First Author: Dey J
Year: 2012
Journal: Mol Cell Biol
Title: A distinct Smoothened mutation causes severe cerebellar developmental defects and medulloblastoma in a novel transgenic mouse model.
Volume: 32
Issue: 20
Pages: 4104-15
Publication
First Author: Kimura H
Year: 2008
Journal: Cancer Cell
Title: Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure.
Volume: 13
Issue: 3
Pages: 249-60
Publication
First Author: Petroni M
Year: 2019
Journal: Sci Rep
Title: SMO-M2 mutation does not support cell-autonomous Hedgehog activity in cerebellar granule cell precursors.
Volume: 9
Issue: 1
Pages: 19623
Publication
First Author: Long F
Year: 2001
Journal: Development
Title: Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation.
Volume: 128
Issue: 24
Pages: 5099-108
Publication
First Author: Rohatgi R
Year: 2007
Journal: Science
Title: Patched1 regulates hedgehog signaling at the primary cilium.
Volume: 317
Issue: 5836
Pages: 372-6
Publication
First Author: Akiyama H
Year: 1997
Journal: Biochem Biophys Res Commun
Title: Cloning of a mouse smoothened cDNA and expression patterns of hedgehog signalling molecules during chondrogenesis and cartilage differentiation in clonal mouse EC cells, ATDC5.
Volume: 235
Issue: 1
Pages: 142-7
Publication
First Author: Corbit KC
Year: 2005
Journal: Nature
Title: Vertebrate Smoothened functions at the primary cilium.
Volume: 437
Issue: 7061
Pages: 1018-21
Publication
First Author: Wilson CW
Year: 2009
Journal: PLoS One
Title: Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium.
Volume: 4
Issue: 4
Pages: e5182
Publication
First Author: Jung B
Year: 2016
Journal: PLoS One
Title: Pitchfork and Gprasp2 Target Smoothened to the Primary Cilium for Hedgehog Pathway Activation.
Volume: 11
Issue: 2
Pages: e0149477
Publication
First Author: Barakat B
Year: 2013
Journal: EMBO Rep
Title: Interaction of smoothened with integrin-linked kinase in primary cilia mediates Hedgehog signalling.
Volume: 14
Issue: 9
Pages: 837-44
Publication
First Author: Wang Y
Year: 2018
Journal: Am J Pathol
Title: Adult Hepatocytes Are Hedgehog-Responsive Cells in the Setting of Liver Injury: Evidence for Smoothened-Mediated Activation of NF-κB/Epidermal Growth Factor Receptor/Akt in Hepatocytes that Counteract Fas-Induced Apoptosis.
Volume: 188
Issue: 11
Pages: 2605-2616
Publication
First Author: Cho ES
Year: 2012
Journal: Mol Cells
Title: Constitutive activation of smoothened leads to impaired developments of postnatal bone in mice.
Volume: 34
Issue: 4
Pages: 399-405
Publication
First Author: Visbal AP
Year: 2011
Journal: Dev Biol
Title: Altered differentiation and paracrine stimulation of mammary epithelial cell proliferation by conditionally activated Smoothened.
Volume: 352
Issue: 1
Pages: 116-27
Publication
First Author: Hilton MJ
Year: 2007
Journal: Dev Biol
Title: Tamoxifen-inducible gene deletion reveals a distinct cell type associated with trabecular bone, and direct regulation of PTHrP expression and chondrocyte morphology by Ihh in growth region cartilage.
Volume: 308
Issue: 1
Pages: 93-105
Publication
First Author: Hu B
Year: 2015
Journal: Am J Respir Cell Mol Biol
Title: Reemergence of hedgehog mediates epithelial-mesenchymal crosstalk in pulmonary fibrosis.
Volume: 52
Issue: 4
Pages: 418-28
Publication
First Author: Roudaut H
Year: 2011
Journal: Mol Pharmacol
Title: Identification and mechanism of action of the acylguanidine MRT-83, a novel potent Smoothened antagonist.
Volume: 79
Issue: 3
Pages: 453-60
Publication
First Author: González-Gugel E
Year: 2013
Journal: Carcinogenesis
Title: Down-regulation of specific miRNAs enhances the expression of the gene Smoothened and contributes to T-cell lymphoblastic lymphoma development.
Volume: 34
Issue: 4
Pages: 902-8
Publication
First Author: Du J
Year: 2012
Journal: Biotech Histochem
Title: Expression of smoothened in mouse embryonic maxillofacial development.
Volume: 87
Issue: 3
Pages: 187-94
Publication  
First Author: Yuan X
Year: 2016
Journal: Nat Commun
Title: Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation.
Volume: 7
Pages: 11024
Publication
First Author: El Andaloussi A
Year: 2006
Journal: Nat Immunol
Title: Hedgehog signaling controls thymocyte progenitor homeostasis and differentiation in the thymus.
Volume: 7
Issue: 4
Pages: 418-26
Publication
First Author: Gao J
Year: 2009
Journal: Cell Stem Cell
Title: Hedgehog signaling is dispensable for adult hematopoietic stem cell function.
Volume: 4
Issue: 6
Pages: 548-58
Publication
First Author: Dierks C
Year: 2008
Journal: Cancer Cell
Title: Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation.
Volume: 14
Issue: 3
Pages: 238-49
Publication
First Author: Larkins CE
Year: 2011
Journal: Mol Biol Cell
Title: Arl13b regulates ciliogenesis and the dynamic localization of Shh signaling proteins.
Volume: 22
Issue: 23
Pages: 4694-703
Publication
First Author: Milenkovic L
Year: 2009
Journal: J Cell Biol
Title: Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium.
Volume: 187
Issue: 3
Pages: 365-74
Publication    
First Author: Luchetti G
Year: 2016
Journal: Elife
Title: Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling.
Volume: 5
Publication  
First Author: Jung B
Year: 2016
Journal: Sci Rep
Title: Novel small molecules targeting ciliary transport of Smoothened and oncogenic Hedgehog pathway activation.
Volume: 6
Pages: 22540
Publication
First Author: Zhao C
Year: 2009
Journal: Nature
Title: Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia.
Volume: 458
Issue: 7239
Pages: 776-9
Publication
First Author: Liu X
Year: 2016
Journal: Genes Dev
Title: Genetic ablation of Smoothened in pancreatic fibroblasts increases acinar-ductal metaplasia.
Volume: 30
Issue: 17
Pages: 1943-55
Publication
First Author: Milenkovic L
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Single-molecule imaging of Hedgehog pathway protein Smoothened in primary cilia reveals binding events regulated by Patched1.
Volume: 112
Issue: 27
Pages: 8320-5
Publication
First Author: Reiter JF
Year: 2006
Journal: Genes Dev
Title: Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition.
Volume: 20
Issue: 1
Pages: 22-7
Publication
First Author: Franco HL
Year: 2010
Journal: Biol Reprod
Title: Constitutive activation of smoothened leads to female infertility and altered uterine differentiation in the mouse.
Volume: 82
Issue: 5
Pages: 991-9
Publication
First Author: Michelotti GA
Year: 2013
Journal: J Clin Invest
Title: Smoothened is a master regulator of adult liver repair.
Volume: 123
Issue: 6
Pages: 2380-94
Publication
First Author: Xu X
Year: 2020
Journal: Glia
Title: Stage-specific regulation of oligodendrocyte development by Hedgehog signaling in the spinal cord.
Volume: 68
Issue: 2
Pages: 422-434
Publication
First Author: Lao Z
Year: 2012
Journal: Cell Rep
Title: MASTR: a technique for mosaic mutant analysis with spatial and temporal control of recombination using conditional floxed alleles in mice.
Volume: 2
Issue: 2
Pages: 386-96
Publication
First Author: Heller E
Year: 2012
Journal: Cancer Res
Title: Hedgehog signaling inhibition blocks growth of resistant tumors through effects on tumor microenvironment.
Volume: 72
Issue: 4
Pages: 897-907
Publication
First Author: Akiyama H
Year: 1999
Journal: Biochem Biophys Res Commun
Title: Indian hedgehog in the late-phase differentiation in mouse chondrogenic EC cells, ATDC5: upregulation of type X collagen and osteoprotegerin ligand mRNAs.
Volume: 257
Issue: 3
Pages: 814-20
Publication
First Author: Koebernick K
Year: 2001
Journal: Mech Dev
Title: Molecular cloning and expression analysis of the Hedgehog receptors XPtc1 and XSmo in Xenopus laevis.
Volume: 100
Issue: 2
Pages: 303-8
Publication
First Author: Chen Y
Year: 2011
Journal: PLoS Biol
Title: Sonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of smoothened.
Volume: 9
Issue: 6
Pages: e1001083
Publication
First Author: Wu VM
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Small molecule inhibitors of Smoothened ciliary localization and ciliogenesis.
Volume: 109
Issue: 34
Pages: 13644-9
Publication
First Author: Lu J
Year: 2013
Journal: PLoS One
Title: Regulation of hedgehog signaling by Myc-interacting zinc finger protein 1, Miz1.
Volume: 8
Issue: 5
Pages: e63353
Publication
First Author: Charron F
Year: 2003
Journal: Cell
Title: The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance.
Volume: 113
Issue: 1
Pages: 11-23
Publication
First Author: Han YG
Year: 2008
Journal: Nat Neurosci
Title: Hedgehog signaling and primary cilia are required for the formation of adult neural stem cells.
Volume: 11
Issue: 3
Pages: 277-84
Publication
First Author: Park KS
Year: 2011
Journal: Nat Med
Title: A crucial requirement for Hedgehog signaling in small cell lung cancer.
Volume: 17
Issue: 11
Pages: 1504-8
Publication
First Author: Ocbina PJ
Year: 2008
Journal: Dev Dyn
Title: Intraflagellar transport, cilia, and mammalian Hedgehog signaling: analysis in mouse embryonic fibroblasts.
Volume: 237
Issue: 8
Pages: 2030-8
Publication
First Author: Maurya DK
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Hedgehog signaling regulates ciliary localization of mouse odorant receptors.
Volume: 114
Issue: 44
Pages: E9386-E9394
Publication    
First Author: Roberts B
Year: 2016
Journal: Elife
Title: Patched1 and Patched2 inhibit Smoothened non-cell autonomously.
Volume: 5
Publication
First Author: Evron T
Year: 2011
Journal: J Biol Chem
Title: Growth Arrest Specific 8 (Gas8) and G protein-coupled receptor kinase 2 (GRK2) cooperate in the control of Smoothened signaling.
Volume: 286
Issue: 31
Pages: 27676-86
Publication
First Author: Cooper CL
Year: 2012
Journal: Blood
Title: Non-cell-autonomous hedgehog signaling promotes murine B lymphopoiesis from hematopoietic progenitors.
Volume: 119
Issue: 23
Pages: 5438-48
Publication
First Author: Bijlsma MF
Year: 2012
Journal: Sci Signal
Title: Hedgehog-stimulated chemotaxis is mediated by smoothened located outside the primary cilium.
Volume: 5
Issue: 238
Pages: ra60
Publication
First Author: Lee H
Year: 2016
Journal: Biochem Biophys Res Commun
Title: Ciliary smoothened-mediated noncanonical hedgehog signaling promotes tubulin acetylation.
Volume: 480
Issue: 4
Pages: 574-579
Publication
First Author: Ho Wei L
Year: 2018
Journal: PLoS One
Title: Activation of the Gi protein-RHOA axis by non-canonical Hedgehog signaling is independent of primary cilia.
Volume: 13
Issue: 8
Pages: e0203170
Publication
First Author: Franco I
Year: 2014
Journal: Dev Cell
Title: PI3K class II α controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function.
Volume: 28
Issue: 6
Pages: 647-58
Publication
First Author: Lin L
Year: 2006
Journal: Dev Biol
Title: Isl1 is upstream of sonic hedgehog in a pathway required for cardiac morphogenesis.
Volume: 295
Issue: 2
Pages: 756-63
Publication
First Author: Liem KF Jr
Year: 2012
Journal: J Cell Biol
Title: The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking.
Volume: 197
Issue: 6
Pages: 789-800
Publication
First Author: Xu H
Year: 2020
Journal: Hum Mol Genet
Title: Tbx5 inhibits hedgehog signaling in determination of digit identity.
Volume: 29
Issue: 9
Pages: 1405-1416
Publication
First Author: Sasaki N
Year: 2010
Journal: Mol Cell Neurosci
Title: Sonic hedgehog signaling regulates actin cytoskeleton via Tiam1-Rac1 cascade during spine formation.
Volume: 45
Issue: 4
Pages: 335-44
Publication
First Author: Xiao X
Year: 2017
Journal: Mol Cell
Title: Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling.
Volume: 66
Issue: 1
Pages: 154-162.e10
Publication
First Author: Machold R
Year: 2003
Journal: Neuron
Title: Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches.
Volume: 39
Issue: 6
Pages: 937-50
Publication
First Author: Petrova R
Year: 2013
Journal: J Neurosci
Title: Titration of GLI3 repressor activity by sonic hedgehog signaling is critical for maintaining multiple adult neural stem cell and astrocyte functions.
Volume: 33
Issue: 44
Pages: 17490-505
Publication
First Author: Villanueva H
Year: 2015
Journal: Sci Signal
Title: An essential role for Gα(i2) in Smoothened-stimulated epithelial cell proliferation in the mammary gland.
Volume: 8
Issue: 394
Pages: ra92
Publication
First Author: Gu D
Year: 2012
Journal: J Biol Chem
Title: A role for transcription factor STAT3 signaling in oncogene smoothened-driven carcinogenesis.
Volume: 287
Issue: 45
Pages: 38356-66
Publication
First Author: Choi H
Year: 2020
Journal: Sci Rep
Title: Suppression of Hedgehog signaling is required for cementum apposition.
Volume: 10
Issue: 1
Pages: 7285
Publication
First Author: Chapouly C
Year: 2016
Journal: Cardiovasc Res
Title: Impaired Hedgehog signalling-induced endothelial dysfunction is sufficient to induce neuropathy: implication in diabetes.
Volume: 109
Issue: 2
Pages: 217-27
Publication
First Author: Kumari A
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Recovery of taste organs and sensory function after severe loss from Hedgehog/Smoothened inhibition with cancer drug sonidegib.
Volume: 114
Issue: 48
Pages: E10369-E10378
Publication
First Author: Woo WM
Year: 2012
Journal: Genes Dev
Title: Shh maintains dermal papilla identity and hair morphogenesis via a Noggin-Shh regulatory loop.
Volume: 26
Issue: 11
Pages: 1235-46
Publication  
First Author: Yang H
Year: 2019
Journal: Int J Mol Sci
Title: Inhibition of Ihh Reverses Temporomandibular Joint Osteoarthritis via a PTH1R Signaling Dependent Mechanism.
Volume: 20
Issue: 15
Publication
First Author: Harman RM
Year: 2011
Journal: Reproduction
Title: Reduced signaling through the hedgehog pathway in the uterine stroma causes deferred implantation and embryonic loss.
Volume: 141
Issue: 5
Pages: 665-74
Publication
First Author: Abe Y
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2.
Volume: 105
Issue: 12
Pages: 4838-43
Publication
First Author: Masdeu C
Year: 2006
Journal: Biochem Biophys Res Commun
Title: Identification and characterization of Hedgehog modulator properties after functional coupling of Smoothened to G15.
Volume: 349
Issue: 2
Pages: 471-9
Publication
First Author: Takada S
Year: 2020
Journal: J Orthop Res
Title: Attenuation of Post-Traumatic Osteoarthritis After Anterior Cruciate Ligament Injury Via Inhibition of Hedgehog Signaling.
Volume: 38
Issue: 3
Pages: 609-619
Publication
First Author: Zhang XM
Year: 2001
Journal: Cell
Title: Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node.
Volume: 106
Issue: 2
Pages: 781-92
Publication
First Author: Chong YC
Year: 2015
Journal: Genes Dev
Title: Bifurcating action of Smoothened in Hedgehog signaling is mediated by Dlg5.
Volume: 29
Issue: 3
Pages: 262-76
Publication
First Author: Liu J
Year: 2019
Journal: PLoS Genet
Title: Gata4 regulates hedgehog signaling and Gata6 expression for outflow tract development.
Volume: 15
Issue: 5
Pages: e1007711
Publication
First Author: Wang Q
Year: 2010
Journal: Am J Pathol
Title: Activation of the Hh pathway in periosteum-derived mesenchymal stem cells induces bone formation in vivo: implication for postnatal bone repair.
Volume: 177
Issue: 6
Pages: 3100-11
Publication
First Author: Nolan-Stevaux O
Year: 2009
Journal: Genes Dev
Title: GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation.
Volume: 23
Issue: 1
Pages: 24-36
Publication
First Author: Pitarresi JR
Year: 2018
Journal: Life Sci Alliance
Title: Disruption of stromal hedgehog signaling initiates RNF5-mediated proteasomal degradation of PTEN and accelerates pancreatic tumor growth.
Volume: 1
Issue: 5
Pages: e201800190
Publication
First Author: Tian H
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis.
Volume: 106
Issue: 11
Pages: 4254-9
Publication
First Author: Liu CF
Year: 2013
Journal: PLoS One
Title: A role for hedgehog signaling in the differentiation of the insertion site of the patellar tendon in the mouse.
Volume: 8
Issue: 6
Pages: e65411
Publication
First Author: Lin C
Year: 2009
Journal: Development
Title: Temporal and spatial dissection of Shh signaling in genital tubercle development.
Volume: 136
Issue: 23
Pages: 3959-67
Publication  
First Author: Ankamreddy H
Year: 2019
Journal: Development
Title: Region-specific endodermal signals direct neural crest cells to form the three middle ear ossicles.
Volume: 146
Issue: 2
Publication
First Author: Hu MC
Year: 2006
Journal: Development
Title: GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis.
Volume: 133
Issue: 3
Pages: 569-78
Publication
First Author: Zhao L
Year: 2010
Journal: Mech Dev
Title: Sonic hedgehog is involved in formation of the ventral optic cup by limiting Bmp4 expression to the dorsal domain.
Volume: 127
Issue: 1-2
Pages: 62-72
Publication
First Author: Evangelista M
Year: 2008
Journal: Sci Signal
Title: Kinome siRNA screen identifies regulators of ciliogenesis and hedgehog signal transduction.
Volume: 1
Issue: 39
Pages: ra7
Publication
First Author: Long F
Year: 2004
Journal: Development
Title: Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton.
Volume: 131
Issue: 6
Pages: 1309-18