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Search results 1 to 100 out of 1060 for Smo

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Hits by Category

Type Details Score
Gene
6608 | SMO
Type: gene
Organism: human
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Gene
539308 | SMO
Type: gene
Organism: cattle
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Gene
395949 | SMO
Type: gene
Organism: chicken
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Gene
30225 | smo
Type: gene
Organism: zebrafish
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Gene
701334 | SMO
Type: gene
Organism: macaque, rhesus
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Gene
100491644 | smo
Type: gene
Organism: frog, western clawed
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Gene
25273 | Smo
Type: gene
Organism: rat
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Gene
482262 | SMO
Type: gene
Organism: dog, domestic
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Gene
463718 | SMO
Type: gene
Organism: chimpanzee
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Protein Domain
IPR026544 | SMO
Type: Family
Description: This entry represents smoothened (SMO) and its homologues, which are related to the frizzled protein family. Smoothened is a G protein-coupled receptor that is involved in the hedgehog signalling pathway. Smoothened probably associates with the patched protein to transduce the hedgehog's proteins signal []. Mutated smoothened can function as an oncogene [].
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Protein Coding Gene
MGI:108075 | Smo
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P56726
Organism: Mus musculus/domesticus
Length: 793  
Fragment?: false
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Protein
Q80VD0
Organism: Mus musculus/domesticus
Length: 439  
Fragment?: false
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Protein
Q8K2P8
Organism: Mus musculus/domesticus
Length: 310  
Fragment?: true
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GXD Expression
GXD Expression
   
Probe: MGI:6466563
Assay Type: Immunohistochemistry
Annotation Date: 2022-05-19
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1609217
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:7279114
Age: embryonic day 10.5
Image: S6C SMO Control Dorsal
Specimen Label: S6C SMO Control Dorsal
Specimen Num: 8
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GXD Expression
GXD Expression
Probe: MGI:6466563
Assay Type: Immunohistochemistry
Annotation Date: 2022-05-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609217
Pattern: Widespread
Stage: TS17
Assay Id: MGI:7279114
Age: embryonic day 10.5
Image: S6C SMO Mosmo-/- Dorsal
Note: Markedly elevated expression along entire-dorsal ventral axis of spinal cord.
Specimen Label: S6C SMO Mosmo-/- Dorsal
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
   
Probe: MGI:6466563
Assay Type: Immunohistochemistry
Annotation Date: 2022-05-19
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1609217
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:7279114
Age: embryonic day 10.5
Image: S6C SMO Control
Specimen Label: S6C SMO Control
Specimen Num: 7
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GXD Expression
GXD Expression
   
Probe: MGI:6466563
Assay Type: Immunohistochemistry
Annotation Date: 2022-05-19
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1609217
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:7279114
Age: embryonic day 10.5
Image: S6C SMO Control Ventral
Specimen Label: S6C SMO Control Ventral
Specimen Num: 9
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GXD Expression
GXD Expression
Probe: MGI:6466563
Assay Type: Immunohistochemistry
Annotation Date: 2022-05-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609217
Pattern: Widespread
Stage: TS17
Assay Id: MGI:7279114
Age: embryonic day 10.5
Image: S6C SMO Mosmo-/-
Note: Markedly elevated expression along entire-dorsal ventral axis of spinal cord.
Specimen Label: S6C SMO Mosmo-/-
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
Probe: MGI:6466563
Assay Type: Immunohistochemistry
Annotation Date: 2022-05-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609217
Pattern: Widespread
Stage: TS17
Assay Id: MGI:7279114
Age: embryonic day 10.5
Image: S6C SMO Mosmo-/- Ventral
Note: Markedly elevated expression along entire-dorsal ventral axis of spinal cord.
Specimen Label: S6C SMO Mosmo-/- Ventral
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
Probe: MGI:6436822
Assay Type: Immunohistochemistry
Annotation Date: 2020-10-26
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1616517
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:6469357
Age: embryonic day 10.5
Image: 6C Smo cbb
Note: Expression in ~25% of ciliated cells.
Specimen Label: 6C Smo cbb
Detected: true
Specimen Num: 2
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Publication
19592253 | J:152551
First Author: Endoh-Yamagami S
Year: 2009
Journal: Curr Biol
Title: The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development.
Volume: 19
Issue: 15
Pages: 1320-6
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Publication
9422511 | J:87306
First Author: Xie J
Year: 1998
Journal: Nature
Title: Activating Smoothened mutations in sporadic basal-cell carcinoma.
Volume: 391
Issue: 6662
Pages: 90-2
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GXD Expression
GXD Expression
 
Probe: MGI:7572373
Assay Type: RNA in situ
Annotation Date: 2024-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603916
Pattern: Ubiquitous
Stage: TS16
Assay Id: MGI:7572391
Age: embryonic day 10.0
Note: Authors report ubiquitous expression in embryo.
Specimen Label: 3E Smo
Detected: true
Specimen Num: 1
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Publication
35353806 | J:323230
First Author: Di Minin G
Year: 2022
Journal: PLoS Biol
Title: TMED2 binding restricts SMO to the ER and Golgi compartments.
Volume: 20
Issue: 3
Pages: e3001596
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Protein
Q4VBD5
Organism: Mus musculus/domesticus
Length: 793  
Fragment?: false
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Protein
Q8BJN8
Organism: Mus musculus/domesticus
Length: 360  
Fragment?: true
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Publication
29571613 | J:262122
First Author: Gigante ED
Year: 2018
Journal: Dev Biol
Title: Hypomorphic Smo mutant with inefficient ciliary enrichment disrupts the highest level of vertebrate Hedgehog response.
Volume: 437
Issue: 2
Pages: 152-162
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Publication
29789719 | J:317887
First Author: Boetto J
Year: 2018
Journal: Oncogene
Title: Selective vulnerability of the primitive meningeal layer to prenatal Smo activation for skull base meningothelial meningioma formation.
Volume: 37
Issue: 36
Pages: 4955-4963
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GXD Expression
GXD Expression
   
Probe: MGI:5811060
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640619
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:5823721
Age: embryonic day 11.5
Specimen Label: Supplemental Data - Smo
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:7606839
Assay Type: Immunohistochemistry
Annotation Date: 2024-02-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3275717
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:7606876
Age: embryonic day 10.5
Specimen Label: 4I +/+ Smo
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:7606839
Assay Type: Immunohistochemistry
Annotation Date: 2024-02-27
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3275717
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:7606876
Age: embryonic day 10.5
Note: Expression significantly increased compared to wild type.
Specimen Label: 4I -/- Smo
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:6448405
Assay Type: Immunohistochemistry
Annotation Date: 2020-08-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284228
Pattern: Single cells
Stage: TS28
Assay Id: MGI:6448422
Age: postnatal day 4
Image: 7A Smo fl/fl
Note: Expression is in proliferating cells.
Specimen Label: 7A Smo fl/fl
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:5700547
Assay Type: Immunohistochemistry
Annotation Date: 2020-10-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616517
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:6469356
Age: embryonic day 10.5
Image: 6C Smo cbb
Note: Expression in ciliated cells.
Specimen Label: 6C Smo cbb
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:6448402
Assay Type: Immunohistochemistry
Annotation Date: 2020-08-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3558925
Pattern: Single cells
Stage: TS25
Assay Id: MGI:6448412
Age: embryonic day 17.5
Image: 2B Smo fl/fl
Note: The number of positive oligodendrocytes in the somatosensory cortex is significantly reduced and are ventrally-derived in this mutant compared to controls.
Specimen Label: 2B Smo fl/fl
Detected: true
Specimen Num: 2
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Publication
16229832 | J:103514
First Author: May SR
Year: 2005
Journal: Dev Biol
Title: Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli.
Volume: 287
Issue: 2
Pages: 378-89
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GXD Expression
GXD Expression
   
Probe: MGI:6183861
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6191348
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Smo
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6183861
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6191348
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Smo
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6183861
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6191348
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Smo
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6183861
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6191348
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Smo
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6183861
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191348
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Smo
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6183861
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191348
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Smo
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6183861
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191348
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Smo
Detected: true
Specimen Num: 7
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Publication
37029430 | J:335078
First Author: Kunhiraman H
Year: 2023
Journal: Acta Neuropathol Commun
Title: IGFBP2 promotes proliferation and cell migration through STAT3 signaling in Sonic hedgehog medulloblastoma.
Volume: 11
Issue: 1
Pages: 62
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Publication
22869526 | J:189258
First Author: Dey J
Year: 2012
Journal: Mol Cell Biol
Title: A distinct Smoothened mutation causes severe cerebellar developmental defects and medulloblastoma in a novel transgenic mouse model.
Volume: 32
Issue: 20
Pages: 4104-15
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Publication
31873117 | J:297831
First Author: Petroni M
Year: 2019
Journal: Sci Rep
Title: SMO-M2 mutation does not support cell-autonomous Hedgehog activity in cerebellar granule cell precursors.
Volume: 9
Issue: 1
Pages: 19623
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Publication
18328428 | J:132944
First Author: Kimura H
Year: 2008
Journal: Cancer Cell
Title: Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure.
Volume: 13
Issue: 3
Pages: 249-60
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Publication
17641202 | J:123161
First Author: Rohatgi R
Year: 2007
Journal: Science
Title: Patched1 regulates hedgehog signaling at the primary cilium.
Volume: 317
Issue: 5836
Pages: 372-6
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Publication
11748145 | J:73071
First Author: Long F
Year: 2001
Journal: Development
Title: Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation.
Volume: 128
Issue: 24
Pages: 5099-108
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Publication
9196051 | J:41023
First Author: Akiyama H
Year: 1997
Journal: Biochem Biophys Res Commun
Title: Cloning of a mouse smoothened cDNA and expression patterns of hedgehog signalling molecules during chondrogenesis and cartilage differentiation in clonal mouse EC cells, ATDC5.
Volume: 235
Issue: 1
Pages: 142-7
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Publication
34568800 | J:311868
First Author: Dalton GD
Year: 2021
Journal: iScience
Title: Hepatocyte activity of the cholesterol sensor smoothened regulates cholesterol and bile acid homeostasis in mice.
Volume: 24
Issue: 9
Pages: 103089
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Publication
23831757 | J:340660
First Author: Nedelcu D
Year: 2013
Journal: Nat Chem Biol
Title: Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling.
Volume: 9
Issue: 9
Pages: 557-64
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Publication
24171105 | J:341399
 
First Author: Nachtergaele S
Year: 2013
Journal: Elife
Title: Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling.
Volume: 2
Pages: e01340
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Publication
33886552 | J:341400
First Author: Arveseth CD
Year: 2021
Journal: PLoS Biol
Title: Smoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits.
Volume: 19
Issue: 4
Pages: e3001191
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Publication
16136078 | J:102118
First Author: Corbit KC
Year: 2005
Journal: Nature
Title: Vertebrate Smoothened functions at the primary cilium.
Volume: 437
Issue: 7061
Pages: 1018-21
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Publication
19365551 | J:223639
First Author: Wilson CW
Year: 2009
Journal: PLoS One
Title: Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium.
Volume: 4
Issue: 4
Pages: e5182
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Publication
34161574 | J:338992
 
First Author: Lv B
Year: 2021
Journal: J Cell Biol
Title: E3 ubiquitin ligase Wwp1 regulates ciliary dynamics of the Hedgehog receptor Smoothened.
Volume: 220
Issue: 9
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Publication
26901434 | J:244372
First Author: Jung B
Year: 2016
Journal: PLoS One
Title: Pitchfork and Gprasp2 Target Smoothened to the Primary Cilium for Hedgehog Pathway Activation.
Volume: 11
Issue: 2
Pages: e0149477
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Publication
23877428 | J:203703
First Author: Barakat B
Year: 2013
Journal: EMBO Rep
Title: Interaction of smoothened with integrin-linked kinase in primary cilia mediates Hedgehog signalling.
Volume: 14
Issue: 9
Pages: 837-44
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Publication
26345456 | J:318862
 
First Author: Bhatia S
Year: 2015
Journal: J Hematol Oncol
Title: Effects of altered ephrin-A5 and EphA4/EphA7 expression on tumor growth in a medulloblastoma mouse model.
Volume: 8
Pages: 105
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Publication
16518394 | J:112555
First Author: El Andaloussi A
Year: 2006
Journal: Nat Immunol
Title: Hedgehog signaling controls thymocyte progenitor homeostasis and differentiation in the thymus.
Volume: 7
Issue: 4
Pages: 418-26
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Publication
26996322 | J:236749
 
First Author: Yuan X
Year: 2016
Journal: Nat Commun
Title: Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation.
Volume: 7
Pages: 11024
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Publication
19497283 | J:149820
First Author: Gao J
Year: 2009
Journal: Cell Stem Cell
Title: Hedgehog signaling is dispensable for adult hematopoietic stem cell function.
Volume: 4
Issue: 6
Pages: 548-58
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Publication
18772113 | J:141160
First Author: Dierks C
Year: 2008
Journal: Cancer Cell
Title: Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation.
Volume: 14
Issue: 3
Pages: 238-49
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Publication
19948480 | J:155450
First Author: Milenkovic L
Year: 2009
Journal: J Cell Biol
Title: Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium.
Volume: 187
Issue: 3
Pages: 365-74
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Publication
27705744 | J:238638
   
First Author: Luchetti G
Year: 2016
Journal: Elife
Title: Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling.
Volume: 5
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Publication
26931153 | J:250737
 
First Author: Jung B
Year: 2016
Journal: Sci Rep
Title: Novel small molecules targeting ciliary transport of Smoothened and oncogenic Hedgehog pathway activation.
Volume: 6
Pages: 22540
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Publication
17560974 | J:123971
First Author: Hilton MJ
Year: 2007
Journal: Dev Biol
Title: Tamoxifen-inducible gene deletion reveals a distinct cell type associated with trabecular bone, and direct regulation of PTHrP expression and chondrocyte morphology by Ihh in growth region cartilage.
Volume: 308
Issue: 1
Pages: 93-105
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Publication
22983747 | J:210149
First Author: Cho ES
Year: 2012
Journal: Mol Cells
Title: Constitutive activation of smoothened leads to impaired developments of postnatal bone in mice.
Volume: 34
Issue: 4
Pages: 399-405
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Publication
21276786 | J:171474
First Author: Visbal AP
Year: 2011
Journal: Dev Biol
Title: Altered differentiation and paracrine stimulation of mammary epithelial cell proliferation by conditionally activated Smoothened.
Volume: 352
Issue: 1
Pages: 116-27
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Publication
30366594 | J:270391
First Author: Wang Y
Year: 2018
Journal: Am J Pathol
Title: Adult Hepatocytes Are Hedgehog-Responsive Cells in the Setting of Liver Injury: Evidence for Smoothened-Mediated Activation of NF-κB/Epidermal Growth Factor Receptor/Akt in Hepatocytes that Counteract Fas-Induced Apoptosis.
Volume: 188
Issue: 11
Pages: 2605-2616
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Publication
19169242 | J:147298
First Author: Zhao C
Year: 2009
Journal: Nature
Title: Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia.
Volume: 458
Issue: 7239
Pages: 776-9
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Publication
25140582 | J:232286
First Author: Hu B
Year: 2015
Journal: Am J Respir Cell Mol Biol
Title: Reemergence of hedgehog mediates epithelial-mesenchymal crosstalk in pulmonary fibrosis.
Volume: 52
Issue: 4
Pages: 418-28
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Publication
34984806 | J:327754
First Author: Maeso-Díaz R
Year: 2022
Journal: Aging Cell
Title: Aging reduces liver resiliency by dysregulating Hedgehog signaling.
Volume: 21
Issue: 2
Pages: e13530
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Publication
21177415 | J:175319
First Author: Roudaut H
Year: 2011
Journal: Mol Pharmacol
Title: Identification and mechanism of action of the acylguanidine MRT-83, a novel potent Smoothened antagonist.
Volume: 79
Issue: 3
Pages: 453-60
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Publication
23288923 | J:196906
First Author: González-Gugel E
Year: 2013
Journal: Carcinogenesis
Title: Down-regulation of specific miRNAs enhances the expression of the gene Smoothened and contributes to T-cell lymphoblastic lymphoma development.
Volume: 34
Issue: 4
Pages: 902-8
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Publication
21859383 | J:202662
First Author: Du J
Year: 2012
Journal: Biotech Histochem
Title: Expression of smoothened in mouse embryonic maxillofacial development.
Volume: 87
Issue: 3
Pages: 187-94
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Publication
21976698 | J:206912
First Author: Larkins CE
Year: 2011
Journal: Mol Biol Cell
Title: Arl13b regulates ciliogenesis and the dynamic localization of Shh signaling proteins.
Volume: 22
Issue: 23
Pages: 4694-703
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Publication
27633013 | J:235647
First Author: Liu X
Year: 2016
Journal: Genes Dev
Title: Genetic ablation of Smoothened in pancreatic fibroblasts increases acinar-ductal metaplasia.
Volume: 30
Issue: 17
Pages: 1943-55
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Publication
26100903 | J:223737
First Author: Milenkovic L
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