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Search results 1 to 86 out of 86 for Smyd4

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Xiao D
Year: 2018
Journal: PLoS Genet
Title: The roles of SMYD4 in epigenetic regulation of cardiac development in zebrafish.
Volume: 14
Issue: 8
Pages: e1007578
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Wang K
Year: 2017
Journal: Cell Death Differ
Title: Circular RNA mediates cardiomyocyte death via miRNA-dependent upregulation of MTP18 expression.
Volume: 24
Issue: 6
Pages: 1111-1120
GXD Expression      
Probe: MGI:2672801
Assay Type: RT-PCR
Annotation Date: 2003-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603910
Stage: TS10
Assay Id: MGI:2672824
Age: embryonic day 7.0
Specimen Label: E7
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:2672801
Assay Type: RT-PCR
Annotation Date: 2003-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:2672824
Age: embryonic day 12.0
Specimen Label: E12
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:2672801
Assay Type: RT-PCR
Annotation Date: 2003-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689424
Stage: TS24
Assay Id: MGI:2672824
Age: embryonic day 16.0
Specimen Label: E16
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:2672801
Assay Type: RT-PCR
Annotation Date: 2003-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:2672824
Age: postnatal day 1
Specimen Label: P1
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:2672801
Assay Type: RT-PCR
Annotation Date: 2003-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2672824
Age: postnatal day 4
Specimen Label: P4
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:2672801
Assay Type: RT-PCR
Annotation Date: 2003-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2672824
Age: postnatal day 7
Specimen Label: P7
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:2672801
Assay Type: RT-PCR
Annotation Date: 2003-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2672824
Age: postnatal day 10
Specimen Label: P10
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:2672801
Assay Type: RT-PCR
Annotation Date: 2003-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2672824
Age: postnatal day 14
Specimen Label: P14
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:2672801
Assay Type: RT-PCR
Annotation Date: 2003-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2672824
Age: postnatal adult
Specimen Label: Ad
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:1339782
Assay Type: Northern blot
Annotation Date: 2005-12-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2576528
Stage: TS28
Assay Id: MGI:3607176
Age: postnatal adult
Specimen Label: Adult
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6306661
Assay Type: RT-PCR
Annotation Date: 2019-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1733128
Stage: TS28
Assay Id: MGI:6306712
Age: postnatal day 5
Image: 4
Specimen Label: Smyd2fl/fl
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6306661
Assay Type: RT-PCR
Annotation Date: 2019-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1733128
Stage: TS28
Assay Id: MGI:6306712
Age: postnatal day 5
Image: 4
Specimen Label: Smyd2fl/flCre
Detected: true
Specimen Num: 2
Publication
First Author: Liu H
Year: 1999
Journal: J Neurochem
Title: Isolation of 10 differentially expressed cDNAs in differentiated Neuro2a cells induced through controlled expression of the GD3 synthase gene.
Volume: 72
Issue: 5
Pages: 1781-90
Publication
First Author: Diehl F
Year: 2010
Journal: PLoS One
Title: Cardiac deletion of Smyd2 is dispensable for mouse heart development.
Volume: 5
Issue: 3
Pages: e9748
Publication
First Author: Saita S
Year: 2014
Journal: J Biol Chem
Title: Role of the ANKMY2-FKBP38 axis in regulation of the Sonic hedgehog (Shh) signaling pathway.
Volume: 289
Issue: 37
Pages: 25639-54
Publication
First Author: Adissu HA
Year: 2014
Journal: Dis Model Mech
Title: Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen.
Volume: 7
Issue: 5
Pages: 515-24
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
Publication      
First Author: Mouse Genome Informatics and the Wellcome Trust Sanger Institute Mouse Genetics Project (MGP)
Year: 2011
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the Wellcome Trust Sanger Institute (WTSI) Mouse Resources Portal
Publication
First Author: Araki K
Year: 1999
Journal: Cell Mol Biol (Noisy-le-grand)
Title: Exchangeable gene trap using the Cre/mutated lox system.
Volume: 45
Issue: 5
Pages: 737-50
Publication
First Author: Taniwaki T
Year: 2005
Journal: Dev Growth Differ
Title: Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.
Volume: 47
Issue: 3
Pages: 163-72
Publication
First Author: Ingham NJ
Year: 2019
Journal: PLoS Biol
Title: Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Volume: 17
Issue: 4
Pages: e3000194
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Function or Process or Component Unknown following Literature Review
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication
First Author: Hu L
Year: 2009
Journal: Cancer Res
Title: Identification of Smyd4 as a potential tumor suppressor gene involved in breast cancer development.
Volume: 69
Issue: 9
Pages: 4067-72
Allele
Name: SET and MYND domain containing 4; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Protein Domain
Type: Domain
Description: This entry represents the SET domain of SET and MYND domain-containing protein 4 (SMYD4). SMYD4 functions as a potential tumour suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha []. In zebrafish, SMYD4 is ubiquitously expressed in early embryos and becomes enriched in the developing heart; mutants show a strong defect in cardiomyocyte proliferation, which lead to a severe cardiac malformation [].The SMYD family consists of five members including SMYD1/2/3/4/5. They contain two highly conserved structural and functional domains, the SET and MYND domains. The SET domain is involved in lysine methylation, while the MYND domain is involved in protein-protein interaction. They are essential in several mammalian developmental pathways [, , , ].
Publication
First Author: Du SJ
Year: 2014
Journal: Anat Rec (Hoboken)
Title: SMYD proteins: key regulators in skeletal and cardiac muscle development and function.
Volume: 297
Issue: 9
Pages: 1650-62
Publication
First Author: Mitchell LH
Year: 2016
Journal: ACS Med Chem Lett
Title: Novel Oxindole Sulfonamides and Sulfamides: EPZ031686, the First Orally Bioavailable Small Molecule SMYD3 Inhibitor.
Volume: 7
Issue: 2
Pages: 134-8
Publication
First Author: Sweis RF
Year: 2015
Journal: ACS Med Chem Lett
Title: Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2.
Volume: 6
Issue: 6
Pages: 695-700
Publication  
First Author: Jarrell DK
Year: 2020
Journal: Vet Sci
Title: Characterizing the Role of SMYD2 in Mammalian Embryogenesis-Future Directions.
Volume: 7
Issue: 2
Protein
Organism: Mus musculus/domesticus
Length: 799  
Fragment?: false