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Search results 1 to 100 out of 727 for Snca

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0.041s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Gene
Type: gene
Organism: human
Publication
First Author: Cabin DE
Year: 2005
Journal: Neurobiol Aging
Title: Exacerbated synucleinopathy in mice expressing A53T SNCA on a Snca null background.
Volume: 26
Issue: 1
Pages: 25-35
Publication      
First Author: The Michael J. Fox Foundation
Year: 2012
Journal: MGI Direct Data Submission
Title: A targeted mutation of the Snca (synuclein, alpha) gene
Publication
First Author: McClymont SA
Year: 2018
Journal: Am J Hum Genet
Title: Parkinson-Associated SNCA Enhancer Variants Revealed by Open Chromatin in Mouse Dopamine Neurons.
Volume: 103
Issue: 6
Pages: 874-892
Publication  
First Author: Ninkina N
Year: 2015
Journal: Sci Rep
Title: A novel resource for studying function and dysfunction of α-synuclein: mouse lines for modulation of endogenous Snca gene expression.
Volume: 5
Pages: 16615
GXD Expression    
Probe: MGI:6183906
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6191350
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Snca
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6183906
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6191350
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Snca
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6183906
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191350
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Snca
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:6183906
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6191350
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Snca
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6183906
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6191350
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Snca
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6183906
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191350
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Snca
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6183906
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191350
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Snca
Detected: true
Specimen Num: 6
Publication
First Author: Roman AY
Year: 2017
Journal: Transgenic Res
Title: Generation of mouse lines with conditionally or constitutively inactivated Snca gene and Rosa26-stop-lacZ reporter located in cis on the mouse chromosome 6.
Volume: 26
Issue: 2
Pages: 301-307
Publication
First Author: Hentrich T
Year: 2018
Journal: Aging (Albany NY)
Title: SNCA overexpression disturbs hippocampal gene expression trajectories in midlife.
Volume: 10
Issue: 12
Pages: 4024-4041
Publication
First Author: Ryan T
Year: 2018
Journal: Nat Commun
Title: Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein.
Volume: 9
Issue: 1
Pages: 817
Publication
First Author: Specht CG
Year: 2004
Journal: Genomics
Title: Deletion of multimerin-1 in alpha-synuclein-deficient mice.
Volume: 83
Issue: 6
Pages: 1176-8
Publication
First Author: Liron T
Year: 2018
Journal: J Cell Physiol
Title: Bone loss in C57BL/6J-OlaHsd mice, a substrain of C57BL/6J carrying mutated alpha-synuclein and multimerin-1 genes.
Volume: 233
Issue: 1
Pages: 371-377
Publication
First Author: Griffioen KJ
Year: 2013
Journal: Neurobiol Aging
Title: Dietary energy intake modifies brainstem autonomic dysfunction caused by mutant α-synuclein.
Volume: 34
Issue: 3
Pages: 928-35
Publication
First Author: Mak SK
Year: 2010
Journal: J Biol Chem
Title: Lysosomal degradation of alpha-synuclein in vivo.
Volume: 285
Issue: 18
Pages: 13621-9
Publication      
First Author: Nussbaum RL
Year: 2009
Journal: MGI Direct Data Submission
Title: Generation of an SNCA (wild-type) transgene
Publication  
First Author: Pfeffer M
Year: 2018
Journal: Int J Mol Sci
Title: Impaired Photic Entrainment of Spontaneous Locomotor Activity in Mice Overexpressing Human Mutant α-Synuclein.
Volume: 19
Issue: 6
Publication
First Author: Zhang XM
Year: 2019
Journal: Hum Mol Genet
Title: The A30P α-synuclein mutation decreases subventricular zone proliferation.
Volume: 28
Issue: 14
Pages: 2283-2294
Publication
First Author: Janezic S
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model.
Volume: 110
Issue: 42
Pages: E4016-25
Publication  
First Author: Taylor TN
Year: 2014
Journal: Neurobiol Dis
Title: Region-specific deficits in dopamine, but not norepinephrine, signaling in a novel A30P α-synuclein BAC transgenic mouse.
Volume: 62
Pages: 193-207
Publication      
First Author: Nussbaum RL
Year: 2009
Journal: MGI Direct Data Submission
Title: Generation of SNCA transgenes carrying A3OP mutations
Publication  
First Author: Kang SS
Year: 2018
Journal: EMBO J
Title: α-Synuclein stimulation of monoamine oxidase-B and legumain protease mediates the pathology of Parkinson's disease.
Volume: 37
Issue: 12
Publication
First Author: Gispert S
Year: 2015
Journal: Hum Mol Genet
Title: Potentiation of neurotoxicity in double-mutant mice with Pink1 ablation and A53T-SNCA overexpression.
Volume: 24
Issue: 4
Pages: 1061-76
Publication      
First Author: Nussbaum RL
Year: 2009
Journal: MGI Direct Data Submission
Title: Generation of SNCA transgenes carrying A53T mutations
Publication
First Author: Gureviciene I
Year: 2007
Journal: Neurobiol Dis
Title: Role of alpha-synuclein in synaptic glutamate release.
Volume: 28
Issue: 1
Pages: 83-9
Publication
First Author: Reheman A
Year: 2010
Journal: Thromb Res
Title: Mice with deleted multimerin 1 and alpha-synuclein genes have impaired platelet adhesion and impaired thrombus formation that is corrected by multimerin 1.
Volume: 125
Issue: 5
Pages: e177-83
Publication
First Author: Oksman M
Year: 2006
Journal: Neuroreport
Title: Brain reward in the absence of alpha-synuclein.
Volume: 17
Issue: 11
Pages: 1191-4
Publication
First Author: López-Jiménez A
Year: 2013
Journal: Synapse
Title: A spontaneous deletion of α-synuclein is associated with an increase in CB1 mRNA transcript and receptor expression in the hippocampus and amygdala: effects on alcohol consumption.
Volume: 67
Issue: 6
Pages: 280-9
Publication
First Author: Yavich L
Year: 2004
Journal: J Neurosci
Title: Role of alpha-synuclein in presynaptic dopamine recruitment.
Volume: 24
Issue: 49
Pages: 11165-70
Publication
First Author: Asuni AA
Year: 2010
Journal: Neuroscience
Title: Alpha-synuclein deficiency in the C57BL/6JOlaHsd strain does not modify disease progression in the ME7-model of prion disease.
Volume: 165
Issue: 3
Pages: 662-74
Publication
First Author: Gomez-Isla T
Year: 2003
Journal: Neurobiol Aging
Title: Motor dysfunction and gliosis with preserved dopaminergic markers in human alpha-synuclein A30P transgenic mice.
Volume: 24
Issue: 2
Pages: 245-58
Publication
First Author: Nieto M
Year: 2006
Journal: Neurobiol Aging
Title: Increased sensitivity to MPTP in human alpha-synuclein A30P transgenic mice.
Volume: 27
Issue: 6
Pages: 848-56
Publication
First Author: Kuo YM
Year: 2010
Journal: Hum Mol Genet
Title: Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated alpha-synuclein gene mutations precede central nervous system changes.
Volume: 19
Issue: 9
Pages: 1633-50
Publication
First Author: Kéri S
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: {alpha}-Synuclein gene duplication impairs reward learning.
Volume: 107
Issue: 36
Pages: 15992-4
Publication  
First Author: Specht CG
Year: 2001
Journal: BMC Neurosci
Title: Deletion of the alpha-synuclein locus in a subpopulation of C57BL/6J inbred mice.
Volume: 2
Pages: 11
Publication
First Author: Schlüter OM
Year: 2003
Journal: Neuroscience
Title: Role of alpha-synuclein in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice.
Volume: 118
Issue: 4
Pages: 985-1002
Publication
First Author: Dauer W
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP.
Volume: 99
Issue: 22
Pages: 14524-9
Publication
First Author: Liu S
Year: 2004
Journal: EMBO J
Title: alpha-Synuclein produces a long-lasting increase in neurotransmitter release.
Volume: 23
Issue: 22
Pages: 4506-16
Publication
First Author: Stefanis L
Year: 2004
Journal: Eur J Neurosci
Title: Lack of alpha-synuclein does not alter apoptosis of neonatal catecholaminergic neurons.
Volume: 20
Issue: 7
Pages: 1969-72
Publication
First Author: Fishbein I
Year: 2014
Journal: Brain
Title: Augmentation of phenotype in a transgenic Parkinson mouse heterozygous for a Gaucher mutation.
Volume: 137
Issue: Pt 12
Pages: 3235-47
Publication
First Author: Liu S
Year: 2007
Journal: Eur J Neurosci
Title: Alpha-synuclein involvement in hippocampal synaptic plasticity: role of NO, cGMP, cGK and CaMKII.
Volume: 25
Issue: 12
Pages: 3583-96
Publication
First Author: Mucibabic M
Year: 2020
Journal: Sci Rep
Title: α-Synuclein promotes IAPP fibril formation in vitro and β-cell amyloid formation in vivo in mice.
Volume: 10
Issue: 1
Pages: 20438
Publication
First Author: Chaprov KD
Year: 2020
Journal: Dokl Biol Sci
Title: Increased Expression of the Multimerin-1 Gene in α-Synuclein Knokout Mice.
Volume: 494
Issue: 1
Pages: 260-263
Publication      
First Author: Chaprov KD
Year: 2021
Journal: Transgenic Res
Title: Kinetics of alpha-synuclein depletion in three brain regions following conditional pan-neuronal inactivation of the encoding gene (Snca) by tamoxifen-induced Cre-recombination in adult mice.
Publication  
First Author: Zarbiv Y
Year: 2014
Journal: Neurobiol Dis
Title: Lysine residues at the first and second KTKEGV repeats mediate α-Synuclein binding to membrane phospholipids.
Volume: 70
Pages: 90-8
Publication
First Author: Emmanouilidou E
Year: 2011
Journal: PLoS One
Title: Assessment of α-synuclein secretion in mouse and human brain parenchyma.
Volume: 6
Issue: 7
Pages: e22225
Publication
First Author: Tozzi A
Year: 2012
Journal: Neurobiol Aging
Title: Mechanisms underlying altered striatal synaptic plasticity in old A53T-α synuclein overexpressing mice.
Volume: 33
Issue: 8
Pages: 1792-9
Publication  
First Author: Vinueza-Gavilanes R
Year: 2023
Journal: Neurobiol Dis
Title: Stabilization of 14-3-3 protein-protein interactions with Fusicoccin-A decreases alpha-synuclein dependent cell-autonomous death in neuronal and mouse models.
Volume: 183
Pages: 106166
Publication
First Author: Loeb V
Year: 2010
Journal: J Biol Chem
Title: The transgenic overexpression of alpha-synuclein and not its related pathology associates with complex I inhibition.
Volume: 285
Issue: 10
Pages: 7334-43
Publication
First Author: Ben Gedalya T
Year: 2009
Journal: Traffic
Title: Alpha-synuclein and polyunsaturated fatty acids promote clathrin-mediated endocytosis and synaptic vesicle recycling.
Volume: 10
Issue: 2
Pages: 218-34
Publication
First Author: Amorim IS
Year: 2017
Journal: J Cell Sci
Title: Sideroflexin 3 is an α-synuclein-dependent mitochondrial protein that regulates synaptic morphology.
Volume: 130
Issue: 2
Pages: 325-331
Publication
First Author: Bozic M
Year: 2020
Journal: Nat Commun
Title: Protective role of renal proximal tubular alpha-synuclein in the pathogenesis of kidney fibrosis.
Volume: 11
Issue: 1
Pages: 1943
Publication
First Author: Trudler D
Year: 2020
Journal: J Neurochem
Title: Alpha synuclein deficiency increases CD4+ T-cells pro-inflammatory profile in a Nurr1-dependent manner.
Volume: 152
Issue: 1
Pages: 61-71
Publication  
First Author: Ruiz R
Year: 2014
Journal: Neuropharmacology
Title: α-Synuclein A30P decreases neurodegeneration and increases synaptic vesicle release probability in CSPα-null mice.
Volume: 76 Pt A
Pages: 106-17
Publication
First Author: Subramaniam M
Year: 2014
Journal: J Neurosci
Title: Mutant α-synuclein enhances firing frequencies in dopamine substantia nigra neurons by oxidative impairment of A-type potassium channels.
Volume: 34
Issue: 41
Pages: 13586-99
Publication
First Author: Sharon R
Year: 2003
Journal: J Biol Chem
Title: Altered fatty acid composition of dopaminergic neurons expressing alpha-synuclein and human brains with alpha-synucleinopathies.
Volume: 278
Issue: 50
Pages: 49874-81
Publication  
First Author: Garcia-Reitboeck P
Year: 2013
Journal: Exp Neurol
Title: Endogenous alpha-synuclein influences the number of dopaminergic neurons in mouse substantia nigra.
Volume: 248
Pages: 541-5
Publication
First Author: Pelkonen A
Year: 2011
Journal: Neurosci Lett
Title: Neuromuscular pathology in mice lacking alpha-synuclein.
Volume: 487
Issue: 3
Pages: 350-3
Publication  
First Author: Chadchankar H
Year: 2011
Journal: Brain Res
Title: Decreased reuptake of dopamine in the dorsal striatum in the absence of α-synuclein.
Volume: 1382
Pages: 37-44
Publication
First Author: Nicot S
Year: 2019
Journal: FASEB J
Title: Seeded propagation of α-synuclein aggregation in mouse brain using protein misfolding cyclic amplification.
Volume: 33
Issue: 11
Pages: 12073-12086
Publication
First Author: Kang SS
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: TrkB neurotrophic activities are blocked by α-synuclein, triggering dopaminergic cell death in Parkinson's disease.
Volume: 114
Issue: 40
Pages: 10773-10778
Publication
First Author: Luo S
Year: 2019
Journal: J Neurosci
Title: Akt Phosphorylates NQO1 and Triggers its Degradation, Abolishing Its Antioxidative Activities in Parkinson's Disease.
Volume: 39
Issue: 37
Pages: 7291-7305
Publication
First Author: Doucet M
Year: 2017
Journal: PLoS One
Title: Preclinical development of a vaccine against oligomeric alpha-synuclein based on virus-like particles.
Volume: 12
Issue: 8
Pages: e0181844
Publication
First Author: Kurz A
Year: 2010
Journal: PLoS One
Title: A53T-alpha-synuclein overexpression impairs dopamine signaling and striatal synaptic plasticity in old mice.
Volume: 5
Issue: 7
Pages: e11464
Publication
First Author: Martìn-Clemente B
Year: 2004
Journal: J Biol Chem
Title: alpha-Synuclein expression levels do not significantly affect proteasome function and expression in mice and stably transfected PC12 cell lines.
Volume: 279
Issue: 51
Pages: 52984-90
Publication
First Author: Prusiner SB
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism.
Volume: 112
Issue: 38
Pages: E5308-17
Publication
First Author: Touchman JW
Year: 2001
Journal: Genome Res
Title: Human and mouse alpha-synuclein genes: comparative genomic sequence analysis and identification of a novel gene regulatory element.
Volume: 11
Issue: 1
Pages: 78-86
Publication  
First Author: Figueroa CA
Year: 2020
Journal: Bone
Title: Deletion of α-Synuclein in Prrx1-positive cells causes partial loss of function in the central nervous system (CNS) but does not affect ovariectomy induced bone loss.
Volume: 137
Pages: 115428
Publication  
First Author: Schaffner SL
Year: 2023
Journal: Neurobiol Dis
Title: Distinct impacts of alpha-synuclein overexpression on the hippocampal epigenome of mice in standard and enriched environments.
Volume: 186
Pages: 106274
Publication
First Author: Goloborshcheva VV
Year: 2020
Journal: Mol Brain
Title: Reduced complement of dopaminergic neurons in the substantia nigra pars compacta of mice with a constitutive "low footprint" genetic knockout of alpha-synuclein.
Volume: 13
Issue: 1
Pages: 75
Publication
First Author: Takami Y
Year: 2022
Journal: FASEB J
Title: Novel pathophysiological roles of α-synuclein in age-related vascular endothelial dysfunction.
Volume: 36
Issue: 10
Pages: e22555
Publication  
First Author: Caputo A
Year: 2020
Journal: eNeuro
Title: Snca-GFP Knock-In Mice Reflect Patterns of Endogenous Expression and Pathological Seeding.
Volume: 7
Issue: 4
Publication
First Author: McGlinchey RP
Year: 2019
Journal: J Biol Chem
Title: C-terminal α-synuclein truncations are linked to cysteine cathepsin activity in Parkinson's disease.
Volume: 294
Issue: 25
Pages: 9973-9984
Publication
First Author: Plaas M
Year: 2008
Journal: J Physiol Pharmacol
Title: Alpha-synuclein A30P point-mutation generates age-dependent nigrostriatal deficiency in mice.
Volume: 59
Issue: 2
Pages: 205-16
Publication  
First Author: Escobar VD
Year: 2014
Journal: Neurosci Lett
Title: Transgenic mice expressing S129 phosphorylation mutations in α-synuclein.
Volume: 563
Pages: 96-100
Publication
First Author: Barceló-Coblijn G
Year: 2007
Journal: J Neurochem
Title: Brain neutral lipids mass is increased in alpha-synuclein gene-ablated mice.
Volume: 101
Issue: 1
Pages: 132-41
Publication  
First Author: Häbig K
Year: 2009
Journal: Brain Res
Title: Microarray expression analysis of human dopaminergic neuroblastoma cells after RNA interference of SNCA--a key player in the pathogenesis of Parkinson's disease.
Volume: 1256
Pages: 19-33
Publication
First Author: Renella R
Year: 2014
Journal: Am J Hematol
Title: Genetic deletion of the GATA1-regulated protein α-synuclein reduces oxidative stress and nitric oxide synthase levels in mature erythrocytes.
Volume: 89
Issue: 10
Pages: 974-7
Publication
First Author: Bellucci A
Year: 2011
Journal: PLoS One
Title: Redistribution of DAT/α-synuclein complexes visualized by "in situ" proximity ligation assay in transgenic mice modelling early Parkinson's disease.
Volume: 6
Issue: 12
Pages: e27959
Publication
First Author: Zaltieri M
Year: 2015
Journal: J Cell Sci
Title: α-synuclein and synapsin III cooperatively regulate synaptic function in dopamine neurons.
Volume: 128
Issue: 13
Pages: 2231-43
Publication
First Author: Khan SS
Year: 2018
Journal: Acta Neuropathol
Title: Bidirectional modulation of Alzheimer phenotype by alpha-synuclein in mice and primary neurons.
Volume: 136
Issue: 4
Pages: 589-605
Publication
First Author: Du TT
Year: 2015
Journal: Autophagy
Title: GBA deficiency promotes SNCA/α-synuclein accumulation through autophagic inhibition by inactivated PPP2A.
Volume: 11
Issue: 10
Pages: 1803-20
Publication  
First Author: Pavia-Collado R
Year: 2021
Journal: Int J Mol Sci
Title: Intracerebral Administration of a Ligand-ASO Conjugate Selectively Reduces α-Synuclein Accumulation in Monoamine Neurons of Double Mutant Human A30P*A53T*α-Synuclein Transgenic Mice.
Volume: 22
Issue: 6
Publication  
First Author: Alvarez-Castelao B
Year: 2014
Journal: Front Aging Neurosci
Title: Epitope Mapping of Antibodies to Alpha-Synuclein in LRRK2 Mutation Carriers, Idiopathic Parkinson Disease Patients, and Healthy Controls.
Volume: 6
Pages: 169
Publication  
First Author: Piltonen M
Year: 2013
Journal: Neuroscience
Title: Comparison of motor performance, brain biochemistry and histology of two A30P α-synuclein transgenic mouse strains.
Volume: 231
Pages: 157-68
Publication
First Author: Ryan BJ
Year: 2021
Journal: J Neurosci
Title: REST Protects Dopaminergic Neurons from Mitochondrial and α-Synuclein Oligomer Pathology in an Alpha Synuclein Overexpressing BAC-Transgenic Mouse Model.
Volume: 41
Issue: 16
Pages: 3731-3746
Publication
First Author: Tofaris GK
Year: 2006
Journal: J Neurosci
Title: Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120): implications for Lewy body disorders.
Volume: 26
Issue: 15
Pages: 3942-50