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Search results 1 to 100 out of 149 for Snta1

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Hits by Strain

Hits by Category

Type Details Score
Gene
6640 | SNTA1
Type: gene
Organism: human
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Gene
458181 | SNTA1
Type: gene
Organism: chimpanzee
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Gene
527488 | SNTA1
Type: gene
Organism: cattle
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Gene
426448 | SNTA1
Type: gene
Organism: chicken
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Gene
100332905 | snta1
Type: gene
Organism: zebrafish
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Gene
709824 | SNTA1
Type: gene
Organism: macaque, rhesus
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Gene
780141 | snta1
Type: gene
Organism: frog, western clawed
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Gene
362242 | Snta1
Type: gene
Organism: rat
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Gene
485837 | SNTA1
Type: gene
Organism: dog, domestic
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Protein Coding Gene
MGI:101772 | Snta1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR028552 | SNTA1
Type: Family
Description: Alpha-1-syntrophin (SNTA1) is an adapter protein that binds to and probably organises the subcellular localisation of a variety of membrane proteins. It may link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex [, , ]. It is partly involved in the pathophysiology of dystrophin-deficient Duchenne muscular dystrophy [].The syntrophin family are intracellular membrane-associated proteins that interact with both ion channels and signalling proteins. As such, syntrophins appear to be important for linking ion channels to intracellular signalling pathways. Syntrophins are concentrated at postsynaptic sites at the neuromuscular junction and may be involved in clustering acetylcholine receptors. In muscle and non-muscle tissues, syntrophin is associated with dystrophin, utrophin, and two homologues of the dystrophin carboxy-terminal region [].The five known syntrophin isoforms share a common domain organisation which includes two tandem pleckstrin homology (PH) domains at the N terminus, a PDZ domain and a C-terminal domain of ~70 amino acids that is unique to syntrophins (syntrophin unique, SU) [].
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Publication
7691103 | J:20636
First Author: Adams ME
Year: 1993
Journal: Neuron
Title: Two forms of mouse syntrophin, a 58 kd dystrophin-associated protein, differ in primary structure and tissue distribution.
Volume: 11
Issue: 3
Pages: 531-40
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Publication
11551227 | J:213907
First Author: Oak SA
Year: 2001
Journal: Biochemistry
Title: Mouse alpha1-syntrophin binding to Grb2: further evidence of a role for syntrophin in cell signaling.
Volume: 40
Issue: 37
Pages: 11270-8
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Protein
Q61234
Organism: Mus musculus/domesticus
Length: 503  
Fragment?: false
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Protein
A2AKD7
Organism: Mus musculus/domesticus
Length: 499  
Fragment?: false
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Protein
Q3UVD6
Organism: Mus musculus/domesticus
Length: 499  
Fragment?: false
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Publication
9210230 | -
 
First Author: Froehner SC
Year: 1997
Journal: Soc Gen Physiol Ser
Title: Syntrophins: modular adapter proteins at the neuromuscular junction and the sarcolemma.
Volume: 52
Pages: 197-207
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Publication
24037898 | -
First Author: Yokota T
Year: 2014
Journal: Muscle Nerve
Title: α1-Syntrophin-deficient mice exhibit impaired muscle force recovery after osmotic shock.
Volume: 49
Issue: 5
Pages: 728-35
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Publication
18034856 | -
First Author: Okumura A
Year: 2008
Journal: FEBS J
Title: Interaction of alpha1-syntrophin with multiple isoforms of heterotrimeric G protein alpha subunits.
Volume: 275
Issue: 1
Pages: 22-33
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Publication
14722086 | -
First Author: Munehira Y
Year: 2004
Journal: J Biol Chem
Title: Alpha1-syntrophin modulates turnover of ABCA1.
Volume: 279
Issue: 15
Pages: 15091-5
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Publication
18591664 | J:198910
First Author: Ueda K
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Syntrophin mutation associated with long QT syndrome through activation of the nNOS-SCN5A macromolecular complex.
Volume: 105
Issue: 27
Pages: 9355-60
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Protein Coding Gene
MGP_CAROLIEiJ_G0024508 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0026714 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0026680 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0026651 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0026689 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0026432 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_101772 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0027138 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0025893 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0026409 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0026546 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0026513 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0026651 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0026534 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0027194 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0025627 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0025963 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0025952 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0025430 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
9063877 | J:38353
First Author: Newbell BJ
Year: 1997
Journal: Biochemistry
Title: Ca2+-calmodulin binding to mouse alpha1 syntrophin: syntrophin is also a Ca2+-binding protein.
Volume: 36
Issue: 6
Pages: 1295-305
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Publication
10220348 | J:54511
First Author: Chockalingam PS
Year: 1999
Journal: Biochemistry
Title: Pleckstrin homology domain 1 of mouse alpha 1-syntrophin binds phosphatidylinositol 4,5-bisphosphate.
Volume: 38
Issue: 17
Pages: 5596-602
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Publication
25426721 | J:225278
First Author: Anderova M
Year: 2014
Journal: PLoS One
Title: Altered astrocytic swelling in the cortex of α-syntrophin-negative GFAP/EGFP mice.
Volume: 9
Issue: 11
Pages: e113444
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Publication
11717465 | J:82162
First Author: Neely JD
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Syntrophin-dependent expression and localization of Aquaporin-4 water channel protein.
Volume: 98
Issue: 24
Pages: 14108-13
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Publication
29474931 | J:262293
First Author: Rein-Fischboeck L
Year: 2018
Journal: Biochim Biophys Acta
Title: Alpha-syntrophin null mice are protected from non-alcoholic steatohepatitis in the methionine-choline-deficient diet model but not the atherogenic diet model.
Volume: 1863
Issue: 5
Pages: 526-537
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Publication
23861848 | J:204290
First Author: Dmytrenko L
Year: 2013
Journal: PLoS One
Title: The impact of alpha-syntrophin deletion on the changes in tissue structure and extracellular diffusion associated with cell swelling under physiological and pathological conditions.
Volume: 8
Issue: 7
Pages: e68044
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Publication
29702112 | J:273916
First Author: Eisinger K
Year: 2018
Journal: Exp Mol Pathol
Title: Alpha-syntrophin deficient mice are protected from adipocyte hypertrophy and ectopic triglyceride deposition in obesity.
Volume: 104
Issue: 3
Pages: 212-221
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Publication
16257493 | J:104553
First Author: Puwarawuttipanit W
Year: 2006
Journal: Neuroscience
Title: Differential effect of alpha-syntrophin knockout on aquaporin-4 and Kir4.1 expression in retinal macroglial cells in mice.
Volume: 137
Issue: 1
Pages: 165-75
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Publication
10221915 | J:159090
First Author: Hillier BJ
Year: 1999
Journal: Science
Title: Unexpected modes of PDZ domain scaffolding revealed by structure of nNOS-syntrophin complex.
Volume: 284
Issue: 5415
Pages: 812-5
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GXD Expression
GXD Expression
   
Probe: MGI:6456751
Assay Type: RT-PCR
Annotation Date: 2020-09-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610519
Stage: TS19
Assay Id: MGI:6456791
Age: embryonic day 11.5
Image: S3
Specimen Label: Control
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6456751
Assay Type: RT-PCR
Annotation Date: 2020-09-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610519
Stage: TS19
Assay Id: MGI:6456791
Age: embryonic day 11.5
Image: S3
Specimen Label: Tnnt2::Cre; fl/fl
Detected: true
Specimen Num: 2
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Publication
10747910 | J:62307
First Author: Piluso G
Year: 2000
Journal: J Biol Chem
Title: Gamma1- and gamma2-syntrophins, two novel dystrophin-binding proteins localized in neuronal cells.
Volume: 275
Issue: 21
Pages: 15851-60
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Publication
15548643 | J:96569
First Author: Adams ME
Year: 2004
Journal: J Neurosci
Title: Structural abnormalities at neuromuscular synapses lacking multiple syntrophin isoforms.
Volume: 24
Issue: 46
Pages: 10302-9
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Publication
8576247 | J:31580
First Author: Ahn AH
Year: 1996
Journal: J Biol Chem
Title: The three human syntrophin genes are expressed in diverse tissues, have distinct chromosomal locations, and each bind to dystrophin and its relatives.
Volume: 271
Issue: 5
Pages: 2724-30
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Publication
16609960 | J:156125
First Author: Bragg AD
Year: 2006
Journal: Glia
Title: Assembly of a perivascular astrocyte protein scaffold at the mammalian blood-brain barrier is dependent on alpha-syntrophin.
Volume: 53
Issue: 8
Pages: 879-90
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Publication
22031904 | J:177264
First Author: Martinez-Pena y Valenzuela I
Year: 2011
Journal: J Neurosci
Title: Nicotinic acetylcholine receptor stability at the NMJ deficient in α-syntrophin in vivo.
Volume: 31
Issue: 43
Pages: 15586-96
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Publication
30256963 | J:270001
First Author: Kim MJ
Year: 2019
Journal: Hum Mol Genet
Title: Mice lacking α-, β1- and β2-syntrophins exhibit diminished function and reduced dystrophin expression in both cardiac and skeletal muscle.
Volume: 28
Issue: 3
Pages: 386-395
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Publication
15939763 | J:99645
First Author: Luo S
Year: 2005
Journal: J Cell Biol
Title: {alpha}-Syntrophin regulates ARMS localization at the neuromuscular junction and enhances EphA4 signaling in an ARMS-dependent manner.
Volume: 169
Issue: 5
Pages: 813-24
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Publication
21179410 | J:168998
First Author: Kim MJ
Year: 2010
Journal: PLoS One
Title: Α-syntrophin modulates myogenin expression in differentiating myoblasts.
Volume: 5
Issue: 12
Pages: e15355
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Publication
8183929 | J:18139
First Author: Ahn AH
Year: 1994
Journal: Proc Natl Acad Sci U S A
Title: Cloning of human basic A1, a distinct 59-kDa dystrophin-associated protein encoded on chromosome 8q23-24.
Volume: 91
Issue: 10
Pages: 4446-50
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Publication
9182949 | J:42318
First Author: Górecki DC
Year: 1997
Journal: Eur J Neurosci
Title: Differential expression of syntrophins and analysis of alternatively spliced dystrophin transcripts in the mouse brain.
Volume: 9
Issue: 5
Pages: 965-76
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Publication
15385269 | J:101258
First Author: Zhou YW
Year: 2005
Journal: Am J Physiol Cell Physiol
Title: Laminin-alpha1 globular domains 3 and 4 induce heterotrimeric G protein binding to alpha-syntrophin's PDZ domain and alter intracellular Ca2+ in muscle.
Volume: 288
Issue: 2
Pages: C377-88
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Publication
27751903 | J:260928
 
First Author: Vindedal GF
Year: 2016
Journal: Mol Cell Neurosci
Title: Removal of aquaporin-4 from glial and ependymal membranes causes brain water accumulation.
Volume: 77
Pages: 47-52
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Publication
30561329 | J:277304
   
First Author: Mestre H
Year: 2018
Journal: Elife
Title: Aquaporin-4-dependent glymphatic solute transport in the rodent brain.
Volume: 7
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Publication
8625413 | J:31846
First Author: Brenman JE
Year: 1996
Journal: Cell
Title: Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains.
Volume: 84
Issue: 5
Pages: 757-67
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Publication
31333492 | J:286963
 
First Author: Rougier JS
Year: 2019
Journal: Front Physiol
Title: A Distinct Pool of Nav1.5 Channels at the Lateral Membrane of Murine Ventricular Cardiomyocytes.
Volume: 10
Pages: 834
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Publication
22131281 | J:179735
First Author: Eilert-Olsen M
Year: 2012
Journal: Glia
Title: Deletion of aquaporin-4 changes the perivascular glial protein scaffold without disrupting the brain endothelial barrier.
Volume: 60
Issue: 3
Pages: 432-40
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Publication
27629271 | J:311066
First Author: Hoddevik EH
Year: 2017
Journal: Brain Struct Funct
Title: Factors determining the density of AQP4 water channel molecules at the brain-blood interface.
Volume: 222
Issue: 4
Pages: 1753-1766
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Publication
32178707 | J:288773
First Author: Katoozi S
Year: 2020
Journal: Mol Brain
Title: Functional specialization of retinal Müller cell endfeet depends on an interplay between two syntrophin isoforms.
Volume: 13
Issue: 1
Pages: 40
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Publication
20124730 | J:158716
First Author: Percival JM
Year: 2010
Journal: J Clin Invest
Title: Golgi and sarcolemmal neuronal NOS differentially regulate contraction-induced fatigue and vasoconstriction in exercising mouse skeletal muscle.
Volume: 120
Issue: 3
Pages: 816-26
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Publication
22987438 | J:187957
First Author: Enger R
Year: 2012
Journal: Glia
Title: Molecular scaffolds underpinning macroglial polarization: an analysis of retinal Müller cells and brain astrocytes in mouse.
Volume: 60
Issue: 12
Pages: 2018-26
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Publication
16857961 | J:124861
First Author: Gavillet B
Year: 2006
Journal: Circ Res
Title: Cardiac sodium channel Nav1.5 is regulated by a multiprotein complex composed of syntrophins and dystrophin.
Volume: 99
Issue: 4
Pages: 407-14
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Publication
18286648 | J:156278
First Author: Albrecht DE
Year: 2008
Journal: Glia
Title: The ABCA1 cholesterol transporter associates with one of two distinct dystrophin-based scaffolds in Schwann cells.
Volume: 56
Issue: 6
Pages: 611-8
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Publication
9890982 | J:52275
First Author: Kameya S
Year: 1999
Journal: J Biol Chem
Title: alpha1-syntrophin gene disruption results in the absence of neuronal-type nitric-oxide synthase at the sarcolemma but does not induce muscle degeneration.
Volume: 274
Issue: 4
Pages: 2193-200
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Publication
30803043 | J:274735
First Author: Rao SB
Year: 2019
Journal: Glia
Title: Targeted deletion of β1-syntrophin causes a loss of Kir 4.1 from Müller cell endfeet in mouse retina.
Volume: 67
Issue: 6
Pages: 1138-1149
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Publication
12600881 | J:115511
First Author: Thomas GD
Year: 2003
Journal: Circ Res
Title: Vasomodulation by skeletal muscle-derived nitric oxide requires alpha-syntrophin-mediated sarcolemmal localization of neuronal Nitric oxide synthase.
Volume: 92
Issue: 5
Pages: 554-60
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Publication
23346911 | J:195167
First Author: Cruz NF
Year: 2013
Journal: J Neurochem
Title: Regional registration of [6-(14)C]glucose metabolism during brain activation of α-syntrophin knockout mice.
Volume: 125
Issue: 2
Pages: 247-59
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Publication
14734638 | J:117993
First Author: Amiry-Moghaddam M
Year: 2004
Journal: FASEB J
Title: Alpha-syntrophin deletion removes the perivascular but not endothelial pool of aquaporin-4 at the blood-brain barrier and delays the development of brain edema in an experimental model of acute hyponatremia.
Volume: 18
Issue: 3
Pages: 542-4
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Publication
25625330 | J:234586
First Author: Hebel T
Year: 2015
Journal: Biochim Biophys Acta
Title: Lipid abnormalities in alpha/beta2-syntrophin null mice are independent from ABCA1.
Volume: 1851
Issue: 5
Pages: 527-36
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Publication
14597704 | J:86558
First Author: Amiry-Moghaddam M
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Delayed K+ clearance associated with aquaporin-4 mislocalization: phenotypic defects in brains of alpha-syntrophin-null mice.
Volume: 100
Issue: 23
Pages: 13615-20
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Publication
12578959 | J:81976
First Author: Amiry-Moghaddam M
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: An alpha-syntrophin-dependent pool of AQP4 in astroglial end-feet confers bidirectional water flow between blood and brain.
Volume: 100
Issue: 4
Pages: 2106-11
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Publication
31881201 | J:292508
 
First Author: Rein-Fischboeck L
Year: 2020
Journal: Exp Mol Pathol
Title: Alpha-syntrophin deficiency protects against non-alcoholic steatohepatitis associated increase of macrophages, CD8+ T-cells and galectin-3 in the liver.
Volume: 113
Pages: 104363
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Publication
22001117 | J:178524
First Author: Kim MJ
Year: 2011
Journal: Exp Cell Res
Title: α-Syntrophin is required for the hepatocyte growth factor-induced migration of cultured myoblasts.
Volume: 317
Issue: 20
Pages: 2914-24
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Publication
16533813 | J:277860
First Author: Chen Z
Year: 2006
Journal: J Biol Chem
Title: Syntrophins regulate alpha1D-adrenergic receptors through a PDZ domain-mediated interaction.
Volume: 281
Issue: 18
Pages: 12414-20
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Publication
11571312 | J:71899
First Author: Adams ME
Year: 2001
Journal: J Cell Biol
Title: In vivo requirement of the alpha-syntrophin PDZ domain for the sarcolemmal localization of nNOS and aquaporin-4.
Volume: 155
Issue: 1
Pages: 113-22
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Publication
19812031 | J:158225
First Author: Sabourin J
Year: 2009
Journal: J Biol Chem
Title: Regulation of TRPC1 and TRPC4 cation channels requires an alpha1-syntrophin-dependent complex in skeletal mouse myotubes.
Volume: 284
Issue: 52
Pages: 36248-61
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Publication
10893187 | J:119852
 
First Author: Loh NY
Year: 2000
Journal: J Cell Sci
Title: Assembly of multiple dystrobrevin-containing complexes in the kidney.
Volume: 113 ( Pt 15)
Pages: 2715-24
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Publication
23152929 | J:195023
First Author: Fuhrmann-Stroissnigg H
Year: 2012
Journal: PLoS One
Title: The light chains of microtubule-associated proteins MAP1A and MAP1B interact with α1-syntrophin in the central and peripheral nervous system.
Volume: 7
Issue: 11
Pages: e49722
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Publication
7592771 | J:29543
First Author: Adams ME
Year: 1995
Journal: J Biol Chem
Title: Mouse alpha 1- and beta 2-syntrophin gene structure, chromosome localization, and homology with a discs large domain.
Volume: 270
Issue: 43
Pages: 25859-65
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Publication
22371502 | J:184367
First Author: Joe MK
Year: 2012
Journal: J Biol Chem
Title: Myocilin interacts with syntrophins and is member of dystrophin-associated protein complex.
Volume: 287
Issue: 16
Pages: 13216-27
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Publication
28039592 | J:323046
First Author: Pavlin T
Year: 2017
Journal: Neurochem Res
Title: Loss or Mislocalization of Aquaporin-4 Affects Diffusion Properties and Intermediary Metabolism in Gray Matter of Mice.
Volume: 42
Issue: 1
Pages: 77-91
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Publication
15238508 | J:92094
First Author: Shiao T
Year: 2004
Journal: Hum Mol Genet
Title: Defects in neuromuscular junction structure in dystrophic muscle are corrected by expression of a NOS transgene in dystrophin-deficient muscles, but not in muscles lacking alpha- and beta1-syntrophins.
Volume: 13
Issue: 17
Pages: 1873-84
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Publication
28364093 | J:249478
First Author: Aittaleb M
Year: 2017
Journal: J Cell Sci
Title: Spatial distribution and molecular dynamics of dystrophin glycoprotein components at the neuromuscular junction in vivo.
Volume: 130
Issue: 10
Pages: 1752-1759
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Publication
32072250 | J:298482
First Author: Hoddevik EH
Year: 2020
Journal: Brain Struct Funct
Title: Organisation of extracellular matrix proteins laminin and agrin in pericapillary basal laminae in mouse brain.
Volume: 225
Issue: 2
Pages: 805-816
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Publication
20720107 | J:163306
First Author: Adams ME
Year: 2010
Journal: J Neurosci
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