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Search results 1 to 69 out of 69 for Snx14

0.024s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Huang HS
Year: 2014
Journal: PLoS One
Title: Snx14 regulates neuronal excitability, promotes synaptic transmission, and is imprinted in the brain of mice.
Volume: 9
Issue: 5
Pages: e98383
Publication
First Author: Carroll P
Year: 2001
Journal: Dev Dyn
Title: Sorting nexin-14, a gene expressed in motoneurons trapped by an in vitro preselection method.
Volume: 221
Issue: 4
Pages: 431-42
Publication
First Author: Bryant D
Year: 2020
Journal: Sci Rep
Title: Diverse species-specific phenotypic consequences of loss of function sorting nexin 14 mutations.
Volume: 10
Issue: 1
Pages: 13763
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression    
Probe: MGI:5640736
Assay Type: RT-PCR
Annotation Date: 2015-06-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:5641083
Age: postnatal day 15
Image: S7
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5640736
Assay Type: RT-PCR
Annotation Date: 2015-06-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:5641083
Age: postnatal day 15
Image: S7
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5640736
Assay Type: RT-PCR
Annotation Date: 2015-06-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3647224
Stage: TS24
Assay Id: MGI:5640833
Age: embryonic day 16.5
Image: S5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5640736
Assay Type: RT-PCR
Annotation Date: 2015-06-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3647224
Stage: TS24
Assay Id: MGI:5640833
Age: embryonic day 16.5
Image: S5
Detected: true
Specimen Num: 2
Publication
First Author: Nakano Y
Year: 2012
Journal: PLoS Genet
Title: A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse.
Volume: 8
Issue: 10
Pages: e1002966
Publication      
First Author: MGI and IMPC
Year: 2017
Journal: MGI Direct Data Submission
Title: MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication          
First Author: MGD Nomenclature Committee
Year: 1995
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Protein
Organism: Mus musculus
Length: 462  
Fragment?: false
Publication
First Author: Akizu N
Year: 2015
Journal: Nat Genet
Title: Biallelic mutations in SNX14 cause a syndromic form of cerebellar atrophy and lysosome-autophagosome dysfunction.
Volume: 47
Issue: 5
Pages: 528-34
Publication
First Author: Ha CM
Year: 2015
Journal: J Cell Sci
Title: SNX14 is a bifunctional negative regulator for neuronal 5-HT6 receptor signaling.
Volume: 128
Issue: 9
Pages: 1848-61
DO Term
Publication
First Author: Watson N
Year: 1996
Journal: Nature
Title: RGS family members: GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.
Volume: 383
Issue: 6596
Pages: 172-5
Protein Domain
Type: Domain
Description: This entry represents the RGS domain of SNX14 (Sorting Nexin14). RGS domain is a small alpha-helical structure that acts as GAPs for Galpha subunits of heterotrimeric G-proteins, and thus plays critical roles in attenuating G-protein coupled receptor (GPCR) signaling []. SNX14 is believed to regulate membrane trafficking in motor neurons []. It has been found localized to lysosomes and associated with phosphatidylinositol (3,5)-bisphosphate, a key component of late endosomes/lysosomes [].
Publication
First Author: Mas C
Year: 2014
Journal: J Biol Chem
Title: Structural basis for different phosphoinositide specificities of the PX domains of sorting nexins regulating G-protein signaling.
Volume: 289
Issue: 41
Pages: 28554-68
Protein Domain
Type: Domain
Description: SNX14 (sorting nexin-14) is expressed in the embryonic nervous system of mammals such as mice, being co-expressed with homoprotein islet-1 in several tissues []. SNX14 levels increase progressively during neuronal development and its knockdown impairs both excitatory and inhibitory synaptic transmission, suggesting a role in neuronal development and function []. SNX14 contains an N-terminal PXA domain, a regulator of G protein signaling (RGS) domain, a PX domain, and a C-terminal PXC domain []. Its RGS domain is non-functional as a GTPase activator for Galpha, but it binds to and sequesters Galpha, thus inhibiting downstream cAMP production [].This entry represents the PX domain of SNX14. The PX domain is a phosphoinositide (PI) binding module present in many proteins with diverse functions [, ].
Publication
First Author: Bravo J
Year: 2001
Journal: Mol Cell
Title: The crystal structure of the PX domain from p40(phox) bound to phosphatidylinositol 3-phosphate.
Volume: 8
Issue: 4
Pages: 829-39
Publication
First Author: Hollinger S
Year: 2002
Journal: Pharmacol Rev
Title: Cellular regulation of RGS proteins: modulators and integrators of G protein signaling.
Volume: 54
Issue: 3
Pages: 527-59
Publication
First Author: Willars GB
Year: 2006
Journal: Semin Cell Dev Biol
Title: Mammalian RGS proteins: multifunctional regulators of cellular signalling.
Volume: 17
Issue: 3
Pages: 363-76
Protein
Organism: Mus musculus
Length: 964  
Fragment?: false
Protein
Organism: Mus musculus
Length: 946  
Fragment?: false
Protein
Organism: Mus musculus
Length: 893  
Fragment?: false
Protein
Organism: Mus musculus
Length: 937  
Fragment?: false
Protein
Organism: Mus musculus
Length: 495  
Fragment?: true
Publication
First Author: Seet LF
Year: 2006
Journal: Biochim Biophys Acta
Title: The Phox (PX) domain proteins and membrane traffic.
Volume: 1761
Issue: 8
Pages: 878-96
Publication
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7