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Search results 1 to 100 out of 100 for Snx2

0.235s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
6643 | SNX2
Type: gene
Organism: human
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Gene
100492702 | snx2
Type: gene
Organism: frog, western clawed
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Gene
291464 | Snx2
Type: gene
Organism: rat
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Gene
474657 | SNX2
Type: gene
Organism: dog, domestic
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Gene
462022 | SNX2
Type: gene
Organism: chimpanzee
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Gene
509769 | SNX2
Type: gene
Organism: cattle
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Gene
426797 | SNX2
Type: gene
Organism: chicken
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Gene
568737 | snx2
Type: gene
Organism: zebrafish
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Gene
700507 | SNX2
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1915054 | Snx2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR028653 | SNX2
Type: Family
Description: Sorting nexin-2 (SNX2) belongs to the sorting nexin family, which contains a conserved PX (phox homology) domain that is responsible for binding to specific phosphoinositides []. SNX1 and SNX2 are orthologues of yeast Vps5, which is a component of retromercomplex that is essential in endosome-to-Golgi retrograde transport []. The mammalian retromer complex is composed of the SNX1/2 alternative heterodimer or homodimer and the a Vps26-Vps29-Vps35 obligate heterotrimer []. Like SNX1, SNX2 also has an additional C-terminal BAR domain. SNX1 and SNX2 play interchangeable but essential roles in retromer structure and function [].
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GXD Expression
GXD Expression
   
Probe: MGI:3613084
Assay Type: RT-PCR
Annotation Date: 2006-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608513
Stage: TS13
Assay Id: MGI:3613298
Age: embryonic day 8.5
Image: 1
Specimen Label: Snx2
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
   
Probe: MGI:3613084
Assay Type: RT-PCR
Annotation Date: 2006-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:3613298
Age: embryonic day 8.5
Image: 1
Specimen Label: Snx2
Detected: true
Specimen Num: 2
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Publication
17101778 | -
First Author: Rojas R
Year: 2007
Journal: Mol Cell Biol
Title: Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors.
Volume: 27
Issue: 3
Pages: 1112-24
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Publication
16179610 | -
First Author: Carlton JG
Year: 2005
Journal: J Cell Sci
Title: Sorting nexin-2 is associated with tubular elements of the early endosome, but is not essential for retromer-mediated endosome-to-TGN transport.
Volume: 118
Issue: Pt 19
Pages: 4527-39
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Protein
Q9CWK8
Organism: Mus musculus/domesticus
Length: 519  
Fragment?: false
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Protein
Q91VZ1
Organism: Mus musculus/domesticus
Length: 519  
Fragment?: false
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Protein
Q3U5L3
Organism: Mus musculus/domesticus
Length: 519  
Fragment?: false
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Publication
16243015 | -
First Author: Carlton JG
Year: 2005
Journal: Curr Biol
Title: Sorting nexins.
Volume: 15
Issue: 20
Pages: R819-20
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Publication
25183008 | J:238911
First Author: Zhang A
Year: 2014
Journal: J Biol Chem
Title: Biogenesis of lysosome-related organelles complex-1 subunit 1 (BLOS1) interacts with sorting nexin 2 and the endosomal sorting complex required for transport-I (ESCRT-I) component TSG101 to mediate the sorting of epidermal growth factor receptor into endosomal compartments.
Volume: 289
Issue: 42
Pages: 29180-94
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Publication
16214895 | J:102476
First Author: Griffin CT
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Genetic evidence for a mammalian retromer complex containing sorting nexins 1 and 2.
Volume: 102
Issue: 42
Pages: 15173-7
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Publication
12388759 | J:103556
First Author: Schwarz DG
Year: 2002
Journal: Mol Biol Cell
Title: Genetic analysis of sorting nexins 1 and 2 reveals a redundant and essential function in mice.
Volume: 13
Issue: 10
Pages: 3588-600
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Publication
9819414 | J:212820
First Author: Haft CR
Year: 1998
Journal: Mol Cell Biol
Title: Identification of a family of sorting nexin molecules and characterization of their association with receptors.
Volume: 18
Issue: 12
Pages: 7278-87
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Protein Coding Gene
MGP_CAROLIEiJ_G0022277 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0024433 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0024399 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0024369 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0024399 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0024166 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1915054 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0024845 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0023640 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0024136 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0024266 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0024233 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0024351 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0024263 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0024892 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0023384 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0023703 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0019010 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0023190 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
     
Probe: MGI:7484736
Assay Type: RT-PCR
Annotation Date: 2023-05-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3283426
Stage: TS26
Assay Id: MGI:7484768
Age: embryonic day 18.5
Specimen Label: WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:7484736
Assay Type: RT-PCR
Annotation Date: 2023-05-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3283426
Stage: TS26
Assay Id: MGI:7484768
Age: embryonic day 18.5
Specimen Label: KO
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7543016
Assay Type: RT-PCR
Annotation Date: 2023-10-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284226
Stage: TS26
Assay Id: MGI:7543251
Age: embryonic day 19.0
Image: S4
Specimen Label: WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7543016
Assay Type: RT-PCR
Annotation Date: 2023-10-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284226
Stage: TS26
Assay Id: MGI:7543251
Age: embryonic day 19.0
Image: S4
Specimen Label: dMut
Detected: true
Specimen Num: 2
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Publication
7536044 | J:22350
First Author: Yuan L
Year: 1995
Journal: Biol Reprod
Title: Rapid cDNA sequencing in combination with RNA expression studies in mice identifies a large number of male germ cell-specific sequence tags.
Volume: 52
Issue: 1
Pages: 131-8
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Publication
17983586 | J:130260
First Author: Van Dyck F
Year: 2007
Journal: Cell Metab
Title: Loss of the PlagL2 transcription factor affects lacteal uptake of chylomicrons.
Volume: 6
Issue: 5
Pages: 406-13
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Publication
23554936 | J:199892
First Author: Rhee S
Year: 2013
Journal: PLoS One
Title: Visceral endoderm expression of Yin-Yang1 (YY1) is required for VEGFA maintenance and yolk sac development.
Volume: 8
Issue: 3
Pages: e58828
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Publication
38310234 | J:345099
First Author: Wang X
Year: 2024
Journal: BMC Genomics
Title: Identification and analysis of key circRNAs in the mouse embryonic ovary provides insight into primordial follicle development.
Volume: 25
Issue: 1
Pages: 139
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Publication
11172053 | J:67552
First Author: Jiang CH
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: The effects of aging on gene expression in the hypothalamus and cortex of mice.
Volume: 98
Issue: 4
Pages: 1930-4
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Publication
30995482 | J:281311
First Author: Nakano Y
Year: 2019
Journal: Cell Rep
Title: Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.
Volume: 27
Issue: 3
Pages: 860-871.e8
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Publication
- | J:68100
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: RIKEN Data Curation in Mouse Genome Informatics
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Protein Domain
IPR037918 | SNX2_PX
Type: Domain
Description: Sorting nexin-2 (SNX2) belongs to the sorting nexin family, which contains a conserved PX (phox homology) domain that is responsible for binding to specific phosphoinositides []. SNX1 and SNX2 are orthologues of yeast Vps5, which is a component of retromer complex that is essential in endosome-to-Golgi retrograde transport []. The mammalian retromer complex is composed of the SNX1/2 alternative heterodimer or homodimer and the a Vps26-Vps29-Vps35 obligate heterotrimer []. Like SNX1, SNX2 also has an additional C-terminal BAR domain. SNX1 and SNX2 play interchangeable but essential roles in retromer structure and function [].This entry represents the PX domain of SNX2.
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GO Term
GO:0030905 | retromer, tubulation complex
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Publication
15695093 | -
First Author: Seaman MN
Year: 2005
Journal: Trends Cell Biol
Title: Recycle your receptors with retromer.
Volume: 15
Issue: 2
Pages: 68-75
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Protein Domain
IPR028660 | SNX1
Type: Family
Description: Sorting nexin-1 (SNX1) belongs to the sorting nexin family, which contains a conserved PX (phox homology) domain that is responsible for binding to specific phosphoinositides []. SNX1 and SNX2 are orthologues of yeast Vps5, which is a component of retromer complex that is essential in endosome-to-Golgi retrograde transport []. The mammalian retromer complex is composed of the SNX1/SNX2 alternative heterodimer or homodimer and the Vps26-Vps29-Vps35 obligate heterotrimer []. Like SNX2, SNX1 also has an additional C-terminal BAR domain. SNX1 and SNX2 play interchangeable but essential roles in retromer structure and function [].SNX1 may have a role in sensing membrane curvature and inducing the formation of tubules [, ].
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Publication
15498486 | -
First Author: Carlton J
Year: 2004
Journal: Curr Biol
Title: Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high- curvature membranes and 3-phosphoinositides.
Volume: 14
Issue: 20
Pages: 1791-800
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Publication
25138534 | J:316288
 
First Author: Wallingford MC
Year: 2014
Journal: Mech Dev
Title: Loss of PiT-1 results in abnormal endocytosis in the yolk sac visceral endoderm.
Volume: 133
Pages: 189-202
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Protein
A0A494B910
Organism: Mus musculus/domesticus
Length: 40  
Fragment?: false
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Protein Domain
IPR005329 | Sorting_nexin_N
Type: Domain
Description: Sorting nexins (SNXs) are hydrophilic molecules that are localized in the cytoplasm and have the potential for membrane association either through their lipid-binding PX domains () or through protein-protein interactions with membrane-associated protein complexes []. Indeed, several of the SNXs require several targeting motifs for their appropriate cellular localization. In almost every case studied, mammalian SNXs can be shown to have a role in protein sorting, with the most commonly used experimental model being plasma-membrane receptor endocytosis and sorting through the endosomal pathway. However, it is equally probable that SNXs sort vesicles that are not derived from the plasma membrane, and have a function in the accurate targeting of these vesicles and their cargo. The N-terminal domain appears to be specific to sorting nexins 1 and 2. SNX1 and SNX2 are members of the retromer complex involved in protein sorting within the endocytic pathway []. SNX1 is both membrane-associated and cytosolic, where it probably exists as a tetramer in large protein complexes and may hetero-oligomerize with SNX2.
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Protein
D3YWH1
Organism: Mus musculus/domesticus
Length: 192  
Fragment?: true
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Protein
Q9WV80
Organism: Mus musculus/domesticus
Length: 522  
Fragment?: false
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Protein
Q6NZD2
Organism: Mus musculus/domesticus
Length: 521  
Fragment?: false
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Protein
Q3TI63
Organism: Mus musculus/domesticus
Length: 522  
Fragment?: false
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Protein
Q3U4S1
Organism: Mus musculus/domesticus
Length: 522  
Fragment?: false
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Protein
Q3UDY9
Organism: Mus musculus/domesticus
Length: 492  
Fragment?: true
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Protein Coding Gene
MGI:1928395 | Snx1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
12461558 | -
First Author: Worby CA
Year: 2002
Journal: Nat Rev Mol Cell Biol
Title: Sorting out the cellular functions of sorting nexins.
Volume: 3
Issue: 12
Pages: 919-31
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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